Strain Name:
C57BL/6J-MtgxR9012Btlr/Mmmh
Stock Number:
068842-MU
Citation ID:
RRID:MMRRC_068842-MU
Other Names:
R9012 (G1)
Major Collection:

Strain Information

Pank4
Name: pantothenate kinase 4
Synonyms: D030031I12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269614
Homologene: 41235
Agt
Name: angiotensinogen
Synonyms: angiotensin precursor, Aogen, Serpina8
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11606
HGNC: HGNC:333
Homologene: 14
Gad2
Name: glutamic acid decarboxylase 2
Synonyms: GAD65, Gad-2, 6330404F12Rik, GAD(65)
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14417
HGNC: HGNC:4093
Homologene: 20223
Itsn1
Name: intersectin 1 (SH3 domain protein 1A)
Synonyms: Sh3p17, Intersectin-L, EHSH1, Eh domain, SH3 domain regulator of endocytosis 1, Ese1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16443
HGNC: HGNC:6183
Homologene: 2277
Hspa4
Name: heat shock protein 4
Synonyms: Hsp110, 70kDa, Hsp70RY, APG-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15525
HGNC: HGNC:5237
Homologene: 1624
Mast4
Name: microtubule associated serine/threonine kinase family member 4
Synonyms: 4930420O11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 328329
Homologene: 42094
Tmem104
Name: transmembrane protein 104
Synonyms: C630005D06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320534
Homologene: 9802
Coro1c
Name: coronin, actin binding protein 1C
Synonyms: CRN2, coronin 3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23790
HGNC: HGNC:2254
Homologene: 56537
B3gnt3
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
Synonyms: 2210008L19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72297
Homologene: 113516
Iqsec3
Name: IQ motif and Sec7 domain 3
Synonyms: synarfGEF, BRAG3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243621
Homologene: 46091
Sppl3
Name: signal peptide peptidase 3
Synonyms: 4833416I09Rik, Usmg3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74585
Homologene: 15563
Zfp68
Name: zinc finger protein 68
Synonyms: Zfp70, KRAZ2, KRAB3, Zfp68
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 24135
Homologene: 56605
Lzts1
Name: leucine zipper, putative tumor suppressor 1
Synonyms: F37, PSD-Zip70, FEZ1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 211134
Homologene: 10873
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: 2900010L19Rik, mSorLA, LR11, Sorla
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Tox4
Name: TOX high mobility group box family member 4
Synonyms: 5730589K01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268741
Homologene: 8889
Hnrnpul2
Name: heterogeneous nuclear ribonucleoprotein U-like 2
Synonyms: Hnrpul2, 1110031M08Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68693
VEGA: 19
Homologene: 28583
Btbd10
Name: BTB domain containing 10
Synonyms: Gmrp1, 1110056N09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68815
Homologene: 13009
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72333
Homologene: 75052
Siglecg
Name: sialic acid binding Ig-like lectin G
Synonyms: A630096C01Rik, mSiglec-G
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243958
Homologene: 13228
Treml2
Name: triggering receptor expressed on myeloid cells-like 2
Synonyms: LOC328833
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 328833
VEGA: 17
Homologene: 81906
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: STK, Fv-2, friend virus susceptibility 2, Fv2, Ron, PTK8, CDw136
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: auxilin, 2810027M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Ccdc181
Name: coiled-coil domain containing 181
Synonyms: 4930455F23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74895
Homologene: 10912
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: NMF355, nmf355, SMCC1, Clc-1, Clc1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Vwa3b
Name: von Willebrand factor A domain containing 3B
Synonyms: A230074B11Rik, 4921511C04Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70853
Homologene: 27053
Cdc42bpa
Name: CDC42 binding protein kinase alpha
Synonyms: DMPK-like, A930014J19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226751
HGNC: HGNC:1737
Homologene: 55765
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Cul9
Name: cullin 9
Synonyms: Parc, 1810035I07Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78309
Homologene: 56696
Nlrp9c
Name: NLR family, pyrin domain containing 9C
Synonyms: Nalp-zeta, Nalp9c
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330490
Homologene: 116072
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Vmn2r110
Name: vomeronasal 2, receptor 110
Synonyms: EG224582
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224582
Homologene: 129678
Prr35
Name: proline rich 35
Synonyms: A930017K11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100034748
Vmn2r5
Name: vomeronasal 2, receptor 5
Synonyms: EG667060
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667060
Or4c120
Name: olfactory receptor family 4 subfamily C member 120
Synonyms: GA_x6K02T2Q125-50650037-50649102, MOR233-11, Olfr1225
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258893
Homologene: 17427
Trav7-6
Name: T cell receptor alpha variable 7-6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213480
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76795
Homologene: 28106
Myom1
Name: myomesin 1
Synonyms: D430047A17Rik, skelemin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Slco1b2
Name: solute carrier organic anion transporter family, member 1b2
Synonyms: Oatp1b2, 7330442B20Rik, Slc21a10, Slc21a6, mlst-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28253
Homologene: 75119
Fes
Name: feline sarcoma oncogene
Synonyms: c-fes
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14159
HGNC: HGNC:3657
Homologene: 37563
Capn5
Name: calpain 5
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12337
HGNC: HGNC:1482
Homologene: 31212
Zbbx
Name: zinc finger, B-box domain containing
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213234
Homologene: 11661
Psg26
Name: pregnancy-specific beta-1-glycoprotein 26
Synonyms: EG574429, cea14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 574429
Homologene: 110989
Sned1
Name: sushi, nidogen and EGF-like domains 1
Synonyms: 6720455I24Rik, D430044C15Rik, Snep
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 208777
Homologene: 14708
Cyp2c55
Name: cytochrome P450, family 2, subfamily c, polypeptide 55
Synonyms: 2010318C06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72082
HGNC: HGNC:2620
Homologene: 133567
Arl6ip5
Name: ADP-ribosylation factor-like 6 interacting protein 5
Synonyms: 5930404D22Rik, Aip-5, Gtrap3-18, addiscin
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 65106
Homologene: 4673
Ikbke
Name: inhibitor of kappaB kinase epsilon
Synonyms: IKKepsilon, IKK-i
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56489
Homologene: 23168
Zfp936
Name: zinc finger protein 936
Synonyms: Gm9272, EG435970, I1C0022H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668620
Dlgap1
Name: DLG associated protein 1
Synonyms: Sapap1, 4933422O14Rik, DAP-1 beta, SAPAP1, D17Bwg0511e, Gkap, GKAP/SAPAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224997
HGNC: HGNC:2905
Homologene: 31258
Or2ag13
Name: olfactory receptor family 2 subfamily AG member 13
Synonyms: MOR283-6, Olfr695, GA_x6K02T2PBJ9-9092181-9091234
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258591
Homologene: 133597
Apol8
Name: apolipoprotein L 8
Synonyms: Apol2, 9830006J20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239552
VEGA: 15
Homologene: 12785
Or6c215
Name: olfactory receptor family 6 subfamily C member 215
Synonyms: GA_x6K02T2PULF-11481207-11480248, Olfr811, MOR110-6
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258545
Homologene: 133725
E130311K13Rik
Name: RIKEN cDNA E130311K13 gene
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329659
Homologene: 35262
Stox1
Name: storkhead box 1
Synonyms: 4732470K04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216021
Homologene: 17649
Wdr81
Name: WD repeat domain 81
Synonyms: nur5, shakey 5, MGC32441
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192652
Homologene: 13983
Gm10277
Name: predicted gene 10277
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 791303
Slc25a15
Name: solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15
Synonyms: Ornt1, D630044L02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18408
Homologene: 6957
Cfap91
Name: cilia and flagella associated protein 91
Synonyms: Spata26, 4932425I24Rik, Maats1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 320214
Homologene: 33470
Ldhal6b
Name: lactate dehydrogenase A-like 6B
Synonyms: LDHAL, 4933402O15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106557
Homologene: 69533
Gm21834
Name: predicted gene, 21834
Type: Gene
Species: Mouse
Chromosome: 17
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,085,310 bp
  • T to C, chromosome 1 at 93,284,598 bp
  • T to C, chromosome 1 at 131,273,453 bp
  • C to T, chromosome 1 at 164,282,493 bp
  • T to C, chromosome 1 at 180,031,512 bp
  • A to G, chromosome 2 at 22,690,251 bp
  • A to G, chromosome 2 at 89,170,585 bp
  • A to T, chromosome 3 at 63,915,513 bp
  • A to T, chromosome 3 at 64,504,494 bp
  • A to G, chromosome 3 at 75,061,653 bp
  • G to T, chromosome 3 at 76,659,720 bp
  • T to C, chromosome 4 at 101,612,959 bp
  • C to A, chromosome 4 at 154,978,390 bp
  • T to C, chromosome 5 at 113,850,676 bp
  • C to A, chromosome 5 at 115,088,928 bp
  • A to T, chromosome 5 at 138,607,021 bp
  • A to G, chromosome 6 at 42,291,633 bp
  • T to A, chromosome 6 at 97,210,877 bp
  • T to C, chromosome 6 at 121,413,037 bp
  • T to A, chromosome 6 at 141,656,828 bp
  • T to A, chromosome 7 at 18,482,671 bp
  • T to A, chromosome 7 at 26,375,308 bp
  • T to A, chromosome 7 at 43,189,992 bp
  • T to A, chromosome 7 at 43,411,099 bp
  • T to A, chromosome 7 at 80,383,136 bp
  • C to T, chromosome 7 at 98,164,843 bp
  • T to C, chromosome 7 at 106,713,908 bp
  • T to C, chromosome 7 at 113,322,757 bp
  • A to G, chromosome 8 at 22,377,862 bp
  • T to A, chromosome 8 at 61,720,663 bp
  • C to T, chromosome 8 at 69,140,898 bp
  • G to T, chromosome 8 at 71,693,029 bp
  • T to C, chromosome 8 at 124,564,215 bp
  • A to G, chromosome 9 at 42,071,195 bp
  • A to G, chromosome 9 at 107,914,761 bp
  • A to T, chromosome 10 at 62,664,832 bp
  • C to T, chromosome 10 at 107,653,550 bp
  • A to C, chromosome 10 at 129,801,602 bp
  • A to G, chromosome 11 at 50,149,861 bp
  • A to T, chromosome 11 at 53,268,575 bp
  • T to C, chromosome 11 at 59,130,597 bp
  • A to G, chromosome 11 at 75,449,145 bp
  • C to T, chromosome 11 at 77,786,022 bp
  • T to G, chromosome 11 at 103,499,152 bp
  • G to A, chromosome 11 at 104,820,521 bp
  • A to T, chromosome 11 at 115,201,318 bp
  • T to A, chromosome 13 at 102,798,098 bp
  • T to C, chromosome 14 at 52,285,751 bp
  • A to G, chromosome 14 at 53,717,147 bp
  • T to C, chromosome 15 at 77,750,124 bp
  • T to C, chromosome 16 at 38,301,973 bp
  • C to A, chromosome 16 at 91,848,961 bp
  • A to T, chromosome 17 at 5,417,667 bp
  • T to C, chromosome 17 at 20,583,365 bp
  • A to G, chromosome 17 at 25,947,711 bp
  • A to G, chromosome 17 at 46,543,521 bp
  • A to G, chromosome 17 at 48,308,062 bp
  • T to C, chromosome 17 at 57,742,167 bp
  • G to A, chromosome 17 at 70,516,187 bp
  • T to G, chromosome 17 at 71,100,108 bp
  • T to C, chromosome 19 at 8,824,465 bp
  • C to T, chromosome 19 at 39,042,116 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9012 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068842-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.