Strain Name:
C57BL/6J-MtgxR9021Btlr/Mmmh
Stock Number:
068851-MU
Citation ID:
RRID:MMRRC_068851-MU
Other Names:
R9021 (G1)
Major Collection:

Strain Information

Pitx2
Name: paired-like homeodomain transcription factor 2
Synonyms: Brx1b, Brx1a, Brx1, solurshin, Pitx2a, Pitx2b, Pitx2c, Rieg, Otlx2, Ptx2, Munc30
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18741
HGNC: HGNC:9005
Homologene: 55454
Etv1
Name: ets variant 1
Synonyms: Etsrp81, ER81
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14009
HGNC: HGNC:3490
Homologene: 3636
Zfp384
Name: zinc finger protein 384
Synonyms: Nmp4, C130073D16Rik, Ciz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269800
Homologene: 15849
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, Phr1, C130061D10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Zranb2
Name: zinc finger, RAN-binding domain containing 2
Synonyms: Znf265, Zis, Zfp265
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53861
Dop1a
Name: DOP1 leucine zipper like protein A
Synonyms: Dopey1, B130005I07Rik, D9Ertd809e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320615
Homologene: 26645
Supt5
Name: suppressor of Ty 5, DSIF elongation factor subunit
Synonyms: Spt5, Supt5h
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20924
Homologene: 2384
Map2k2
Name: mitogen-activated protein kinase kinase 2
Synonyms: MAP kinase/Erk kinase, MEK2, Prkmk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26396
HGNC: HGNC:6842
Homologene: 48591
Atxn2l
Name: ataxin 2-like
Synonyms: A2LG, A2D, A2lp, A2RP
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233871
Homologene: 16513
Trim24
Name: tripartite motif-containing 24
Synonyms: Tif1a, A130082H20Rik, D430004I05Rik, TIF1alpha
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21848
Homologene: 20830
Rpa2
Name: replication protein A2
Synonyms: 30-kDa protein, Rf-A2, RPA34
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19891
Homologene: 37712
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Bltp1
Name: bridge-like lipid transfer protein family member 1
Synonyms: 4932438A13Rik, Tweek, FSA
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229227
Homologene: 52105
Ccnf
Name: cyclin F
Synonyms: Fbxo1, CycF
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12449
VEGA: 17
HGNC: HGNC:1591
Homologene: 1335
Inppl1
Name: inositol polyphosphate phosphatase-like 1
Synonyms: SHIP2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16332
HGNC: HGNC:6080
Homologene: 1204
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, skax26, Cd, ska26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Mcm10
Name: minichromosome maintenance 10 replication initiation factor
Synonyms: C330019M07Rik, 2410041F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70024
Homologene: 41275
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Ripk1
Name: receptor (TNFRSF)-interacting serine-threonine kinase 1
Synonyms: Rip1, Rinp
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19766
Homologene: 2820
Fam81a
Name: family with sequence similarity 81, member A
Synonyms: 6430514L14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76886
Homologene: 17584
Mmp14
Name: matrix metallopeptidase 14 (membrane-inserted)
Synonyms: Membrane type 1-MMP, MT1-MMP, sabe
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17387
HGNC: HGNC:7160
Homologene: 21040
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Clint1
Name: clathrin interactor 1
Synonyms: Epn4, C530049I24Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216705
Homologene: 133740
Chd2
Name: chromodomain helicase DNA binding protein 2
Synonyms: 5630401D06Rik, 2810040A01Rik, 2810013C04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244059
HGNC: HGNC:1917
Homologene: 37462
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: DNA mismatch repair, mismatch repair
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18861
Homologene: 133560
Nfatc3
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3
Synonyms: NFAT4, NFATx, D8Ertd281e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18021
HGNC: HGNC:7777
Homologene: 27827
Amph
Name: amphiphysin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218038
HGNC: HGNC:471
Homologene: 121585
Klf6
Name: Kruppel-like transcription factor 6
Synonyms: FM6, Zf9, BCD1, Ierepo1, Ierepo3, CPBP, FM2, Copeb
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 23849
VEGA: 13
HGNC: HGNC:2235
Homologene: 996
Osbpl10
Name: oxysterol binding protein-like 10
Synonyms: 4933433D06Rik, C820004B04Rik, OPR-10
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74486
Homologene: 69240
Asap3
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
Synonyms: UPLC1, Ddefl1, 9430088F20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230837
Homologene: 41190
Eps8l2
Name: EPS8-like 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 98845
Homologene: 69358
Mfng
Name: MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: manic fringe
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17305
HGNC: HGNC:7038
Homologene: 1803
Skic2
Name: SKI2 subunit of superkiller complex
Synonyms: 4930534J06Rik, Skiv2l, Ski2w
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108077
Homologene: 123971
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Poln
Name: DNA polymerase N
Synonyms: POL4P
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 272158
Homologene: 131253
Mroh8
Name: maestro heat-like repeat family member 8
Synonyms: 4922505G16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 629499
Homologene: 51864
Col6a6
Name: collagen, type VI, alpha 6
Synonyms: E330026B02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 245026
Homologene: 18260
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Serpina1a
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1A
Synonyms: Spi1-1, PI1, Aat2, Aat-2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20700
HGNC: HGNC:8941
Homologene: 20103
Acad11
Name: acyl-Coenzyme A dehydrogenase family, member 11
Synonyms: 5730439E10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102632
Homologene: 49896
Narf
Name: nuclear prelamin A recognition factor
Synonyms: 4430402O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67608
Homologene: 57048
Zfp175
Name: zinc finger protein 175
Synonyms: Zfp658
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210104
Homologene: 134007
Or11h4
Name: olfactory receptor family 11 subfamily H member 4
Synonyms: MOR106-1, Olfr749, GA_x6K02T2PMLR-6484046-6483105
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 56858
Homologene: 10652
Asap2
Name: ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms: LOC385250, Ddef2, 6530401G17Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211914
HGNC: HGNC:2721
Homologene: 2888
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230872
Homologene: 16811
Prex1
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Synonyms: P-REX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277360
Homologene: 10821
Dll4
Name: delta like canonical Notch ligand 4
Synonyms: Delta4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 54485
HGNC: HGNC:2910
Homologene: 10411
Nudt13
Name: nudix hydrolase 13
Synonyms: 4933433B15Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 13
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67725
VEGA: 14
Homologene: 22936
Slco6d1
Name: solute carrier organic anion transporter family, member 6d1
Synonyms: 4921511I05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70866
Homologene: 86643
Lrriq4
Name: leucine-rich repeats and IQ motif containing 4
Synonyms: 4930558O21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68307
Homologene: 12260
Flot2
Name: flotillin 2
Synonyms: reggie-2, Esa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14252
HGNC: HGNC:3758
Homologene: 3293
Trabd
Name: TraB domain containing
Synonyms: 5730502D15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 67976
Homologene: 36427
Vmn1r172
Name: vomeronasal 1 receptor 172
Synonyms: V1rd9, V3R9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81010
Homologene: 79577
Vmn2r86
Name: vomeronasal 2, receptor 86
Synonyms: EG625109
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 625109
Homologene: 129606
Mical1
Name: microtubule associated monooxygenase, calponin and LIM domain containing 1
Synonyms: Nical
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 171580
Homologene: 11246
Trim52
Name: tripartite motif-containing 52
Synonyms: 4921513B05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 212085
Homologene: 79723
Ceacam5
Name: CEA cell adhesion molecule 5
Synonyms: Psg30, 1600029H12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73250
HGNC: HGNC:1819
Homologene: 115938
Pdcd2l
Name: programmed cell death 2-like
Synonyms: 6030457N17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68079
Homologene: 41861
Poc1b
Name: POC1 centriolar protein B
Synonyms: 4933430F16Rik, Wdr51b
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 382406
Homologene: 41728
Or10ab5
Name: olfactory receptor family 10 subfamily AB member 5
Synonyms: Olfr509, GA_x6K02T2PBJ9-10976304-10975339, MOR267-14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258369
Homologene: 131128
Thap11
Name: THAP domain containing 11
Synonyms: 2810036E22Rik, CTG-B45d, Ronin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 59016
Homologene: 10726
Myoz2
Name: myozenin 2
Synonyms: 1110012I24Rik, calsarcin-1, Fatz-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 59006
HGNC: HGNC:1330
Homologene: 9583
Selp
Name: selectin, platelet
Synonyms: Grmp, CD62P, P-selectin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20344
Homologene: 2260
Fam78a
Name: family with sequence similarity 78, member A
Synonyms: A130092J06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241303
Homologene: 14115
Or56b1
Name: olfactory receptor family 56 subfamily B member 1
Synonyms: Olfr657, GA_x6K02T2PBJ9-7263864-7264823, MOR40-13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258309
Homologene: 17189
Or2i1
Name: olfactory receptor family 2 subfamily I member 1
Synonyms: Olfr94, GA_x6K02T2PSCP-1637650-1636712, MOR256-32P
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 258219
HGNC: HGNC:8258
Homologene: 79123
Kbtbd6
Name: kelch repeat and BTB (POZ) domain containing 6
Synonyms: Gm5465
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 432879
Homologene: 45156
Gata3os
Name: GATA binding protein 3 opposite strand
Synonyms: 4930412O13Rik, Gm10853, Gata3as
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 381347
Gm14305
Name: predicted gene 14305
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100043387
Homologene: 134324
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 51,781,983 bp
  • A to G, chromosome 1 at 98,443,671 bp
  • A to T, chromosome 1 at 157,230,944 bp
  • A to G, chromosome 1 at 164,126,608 bp
  • T to C, chromosome 2 at 4,992,971 bp
  • T to A, chromosome 2 at 9,882,534 bp
  • T to C, chromosome 2 at 32,069,301 bp
  • TC to T, chromosome 2 at 119,332,573 bp
  • A to T, chromosome 2 at 157,222,867 bp
  • C to A, chromosome 2 at 166,590,509 bp
  • A to G, chromosome 2 at 176,721,374 bp
  • T to G, chromosome 3 at 30,650,252 bp
  • T to A, chromosome 3 at 36,998,344 bp
  • T to A, chromosome 3 at 123,013,635 bp
  • T to A, chromosome 3 at 129,214,783 bp
  • T to C, chromosome 3 at 157,545,083 bp
  • T to C, chromosome 4 at 132,771,940 bp
  • T to C, chromosome 4 at 136,238,988 bp
  • T to A, chromosome 4 at 141,022,363 bp
  • T to C, chromosome 4 at 141,982,309 bp
  • T to A, chromosome 5 at 34,129,141 bp
  • T to A, chromosome 5 at 96,740,750 bp
  • T to A, chromosome 5 at 143,925,926 bp
  • T to A, chromosome 6 at 37,957,014 bp
  • C to A, chromosome 6 at 125,036,373 bp
  • A to G, chromosome 6 at 134,541,967 bp
  • A to T, chromosome 7 at 17,714,952 bp
  • G to T, chromosome 7 at 23,660,324 bp
  • A to T, chromosome 7 at 28,317,246 bp
  • A to G, chromosome 7 at 34,186,335 bp
  • A to G, chromosome 7 at 43,573,957 bp
  • A to T, chromosome 7 at 73,441,645 bp
  • A to C, chromosome 7 at 101,831,708 bp
  • C to T, chromosome 7 at 104,636,084 bp
  • A to T, chromosome 7 at 108,646,221 bp
  • A to T, chromosome 7 at 126,495,540 bp
  • G to T, chromosome 7 at 141,356,204 bp
  • T to C, chromosome 8 at 105,856,028 bp
  • T to A, chromosome 8 at 106,092,113 bp
  • A to G, chromosome 9 at 70,110,256 bp
  • T to C, chromosome 9 at 86,520,437 bp
  • A to G, chromosome 9 at 104,126,665 bp
  • A to T, chromosome 9 at 105,709,546 bp
  • C to T, chromosome 9 at 114,978,871 bp
  • A to G, chromosome 10 at 41,485,145 bp
  • G to T, chromosome 10 at 81,119,325 bp
  • A to G, chromosome 10 at 99,144,321 bp
  • A to C, chromosome 10 at 130,447,065 bp
  • T to A, chromosome 11 at 45,906,215 bp
  • T to C, chromosome 11 at 78,058,979 bp
  • C to A, chromosome 11 at 121,245,383 bp
  • T to A, chromosome 12 at 21,203,998 bp
  • T to C, chromosome 12 at 38,780,972 bp
  • A to T, chromosome 12 at 103,858,034 bp
  • G to C, chromosome 13 at 5,865,161 bp
  • G to A, chromosome 13 at 19,099,901 bp
  • A to G, chromosome 13 at 34,021,390 bp
  • A to T, chromosome 13 at 38,196,832 bp
  • A to G, chromosome 14 at 20,310,704 bp
  • T to G, chromosome 14 at 50,737,097 bp
  • T to C, chromosome 14 at 54,436,175 bp
  • A to T, chromosome 14 at 79,453,382 bp
  • G to T, chromosome 14 at 103,314,316 bp
  • C to T, chromosome 14 at 106,107,552 bp
  • T to A, chromosome 15 at 78,773,148 bp
  • T to A, chromosome 15 at 89,084,710 bp
  • A to T, chromosome 17 at 24,226,705 bp
  • A to G, chromosome 17 at 34,846,603 bp
  • G to T, chromosome 17 at 37,197,489 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9021 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068851-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.