Strain Name:
C57BL/6J-MtgxR9068Btlr/Mmmh
Stock Number:
068892-MU
Citation ID:
RRID:MMRRC_068892-MU
Other Names:
R9068 (G1)
Major Collection:

Strain Information

Neurod1
Name: neurogenic differentiation 1
Synonyms: Neurod, Nd1, bHLHa3, BETA2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18012
HGNC: HGNC:7762
Homologene: 1871
Syt6
Name: synaptotagmin VI
Synonyms: 3110037A08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 54524
Homologene: 10301
Tfpi
Name: tissue factor pathway inhibitor
Synonyms: A630013F22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21788
Homologene: 4579
Slit3
Name: slit guidance ligand 3
Synonyms: b2b2362.1Clo, Slit1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20564
Homologene: 2303
Abtb3
Name: ankyrin repeat and BTB domain containing 3
Synonyms: Btbd11, 6330404E16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74007
Homologene: 72536
Map3k8
Name: mitogen-activated protein kinase kinase kinase 8
Synonyms: Tpl2, Cot, Cot/Tpl2, Tpl-2, c-COT
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 26410
HGNC: HGNC:6860
Homologene: 3812
Wdfy3
Name: WD repeat and FYVE domain containing 3
Synonyms: D5Ertd66e, Bwf1, 2610509D04Rik, Bchs, Ggtb3, Alfy
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72145
Homologene: 22855
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Zc3h3
Name: zinc finger CCCH type containing 3
Synonyms: Smicl
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223642
VEGA: 15
Homologene: 9029
Zwilch
Name: zwilch kinetochore protein
Synonyms: 2310031L18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68014
Homologene: 32381
Cc2d1b
Name: coiled-coil and C2 domain containing 1B
Synonyms: A830039B04Rik, Freud2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 319965
Homologene: 70951
Usp24
Name: ubiquitin specific peptidase 24
Synonyms: 2810030C21Rik, 2700066K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329908
Homologene: 35420
Naa16
Name: N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms: 1300019C06Rik, Narg1l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66897
Homologene: 134838
Actr10
Name: ARP10 actin-related protein 10
Synonyms: Arp11
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56444
VEGA: 12
Homologene: 10220
Sun2
Name: Sad1 and UNC84 domain containing 2
Synonyms: B230369L08Rik, Unc84b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223697
Homologene: 9113
Pigr
Name: polymeric immunoglobulin receptor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18703
HGNC: HGNC:8968
Homologene: 1984
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 4930413O22Rik, 2310020J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211660
Homologene: 23487
Clec3a
Name: C-type lectin domain family 3, member a
Synonyms: 1110019O10Rik, Clecsf1, LOC330844
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 403395
HGNC: HGNC:2052
Homologene: 4205
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233552
Homologene: 32741
Dnah8
Name: dynein, axonemal, heavy chain 8
Synonyms: Hst6.7b, Dnahc8, P1-Loop
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13417
VEGA: 17
HGNC: HGNC:2952
Homologene: 1049
Dedd2
Name: death effector domain-containing DNA binding protein 2
Synonyms: 2410050E11Rik, FLAME-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67379
Homologene: 23569
Cwf19l1
Name: CWF19 like cell cycle control factor 1
Synonyms: 2610528C06Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 72502
VEGA: 19
Homologene: 41244
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104570
Homologene: 68886
Cnnm3
Name: cyclin M3
Synonyms: Acdp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94218
HGNC: HGNC:104
Homologene: 23029
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229473
Homologene: 9057
Fbxo46
Name: F-box protein 46
Synonyms: Fbxo34l, 20D7-FC4, 4932704E22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243867
Homologene: 18467
Uncx
Name: UNC homeobox
Synonyms: Uncx4.1, Chx4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22255
Homologene: 56598
Htr5a
Name: 5-hydroxytryptamine (serotonin) receptor 5A
Synonyms: Htr5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15563
HGNC: HGNC:5300
Homologene: 22461
Peg10
Name: paternally expressed 10
Synonyms: HB-1, Edr, MyEF-3 like, MEF3L, Mart2, Rtl2, MyEF-3, Mar2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Ankrd52
Name: ankyrin repeat domain 52
Synonyms: G431002C21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237615
Homologene: 18227
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Zfp775
Name: zinc finger protein 775
Synonyms: C130032F08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243372
Homologene: 37089
Slco2b1
Name: solute carrier organic anion transporter family, member 2b1
Synonyms: OATP-B, Slc21a9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101488
Homologene: 21419
Or10d5
Name: olfactory receptor family 10 subfamily D member 5
Synonyms: Olfr975, GA_x6K02T2PVTD-33651220-33650288, MOR224-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258825
VEGA: 9
Homologene: 27275
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666528
Homologene: 12991
Dpp10
Name: dipeptidylpeptidase 10
Synonyms: DPRP3, 6430601K09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269109
Homologene: 41400
Gm136
Name: predicted gene 136
Synonyms: LOC214568
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214568
Homologene: 79759
Grk4
Name: G protein-coupled receptor kinase 4
Synonyms: Gprk2l, A830025H08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14772
HGNC: HGNC:4543
Homologene: 23158
Vmn1r178
Name: vomeronasal 1 receptor 178
Synonyms: LOC232959, V1rd13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232959
Homologene: 104166
Cyp26b1
Name: cytochrome P450, family 26, subfamily b, polypeptide 1
Synonyms: CP26, P450RAI-2, retinoic acid B1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232174
Homologene: 23179
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Adam22
Name: a disintegrin and metallopeptidase domain 22
Synonyms: MDC2, 2900022I03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11496
HGNC: HGNC:201
Homologene: 37898
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: Lorsdh, LOR/SDH
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30956
Homologene: 4212
Gpr180
Name: G protein-coupled receptor 180
Synonyms: E130016I23Rik, ITR
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58245
VEGA: 14
Homologene: 32506
Plch1
Name: phospholipase C, eta 1
Synonyms: Plcl3, PLCeta1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269437
Homologene: 88833
Akr1b7
Name: aldo-keto reductase family 1, member B7
Synonyms: Avdp, MVDP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11997
Homologene: 122176
Or5an9
Name: olfactory receptor family 5 subfamily AN member 9
Synonyms: MOR214-5, Olfr1431, GA_x6K02T2RE5P-2573738-2574676
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258409
Homologene: 115495
Napsa
Name: napsin A aspartic peptidase
Synonyms: NAP1, napsin, Kdap, pronapsin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16541
Homologene: 68418
Zbtb49
Name: zinc finger and BTB domain containing 49
Synonyms: 4930518A03Rik, Zfp509
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75079
Homologene: 34825
Rit2
Name: Ras-like without CAAX 2
Synonyms: Roc2, Rin
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19762
Homologene: 2198
Skint4
Name: selection and upkeep of intraepithelial T cells 4
Synonyms: 9530098N22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320640
Or8b12
Name: olfactory receptor family 8 subfamily B member 12
Synonyms: Olfr874, MOR161-2, GA_x6K02T2PVTD-31428850-31429782
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258882
Homologene: 17377
Zeb2
Name: zinc finger E-box binding homeobox 2
Synonyms: 9130203F04Rik, SIP1, Zfhx1b, Zfx1b, D130016B08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 24136
Homologene: 8868
Vmn2r50
Name: vomeronasal 2, receptor 50
Synonyms: EG434117
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434117
Homologene: 113703
Or4c115
Name: olfactory receptor family 4 subfamily C member 115
Synonyms: GA_x6K02T2Q125-50579531-50578596, Olfr1220, MOR233-5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258902
Homologene: 74242
Cd200r3
Name: CD200 receptor 3
Synonyms: 4733401I18Rik, mCD200RLb, 4833409J19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74603
Efna2
Name: ephrin A2
Synonyms: Epl6, LERK-6, ephrin A6, Cek7-L, Elf-1, Ephrin-A2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13637
HGNC: HGNC:3222
Homologene: 1075
Pcdha8
Name: protocadherin alpha 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353235
HGNC: HGNC:8675
Homologene: 129614
Gm7356
Name: predicted gene 7356
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 664821
Homologene: 133217
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,077,244 bp
  • T to C, chromosome 1 at 36,512,881 bp
  • T to C, chromosome 1 at 123,432,938 bp
  • G to A, chromosome 1 at 130,846,494 bp
  • C to A, chromosome 2 at 31,413,673 bp
  • T to A, chromosome 2 at 45,110,028 bp
  • T to A, chromosome 2 at 79,454,874 bp
  • C to A, chromosome 2 at 84,442,891 bp
  • A to T, chromosome 2 at 89,097,025 bp
  • G to A, chromosome 3 at 63,704,615 bp
  • A to T, chromosome 3 at 83,910,468 bp
  • C to A, chromosome 3 at 103,587,509 bp
  • T to C, chromosome 3 at 158,240,501 bp
  • T to G, chromosome 4 at 34,750,928 bp
  • T to C, chromosome 4 at 106,375,678 bp
  • T to A, chromosome 4 at 108,624,865 bp
  • C to T, chromosome 4 at 112,165,735 bp
  • T to C, chromosome 5 at 8,127,343 bp
  • T to A, chromosome 5 at 27,850,801 bp
  • T to C, chromosome 5 at 34,748,309 bp
  • T to C, chromosome 5 at 38,200,945 bp
  • A to T, chromosome 5 at 101,852,585 bp
  • A to G, chromosome 5 at 139,546,818 bp
  • T to TCCG, chromosome 6 at 4,756,451 bp
  • T to C, chromosome 6 at 23,075,829 bp
  • T to C, chromosome 6 at 34,419,042 bp
  • C to A, chromosome 6 at 48,620,217 bp
  • G to A, chromosome 6 at 84,574,397 bp
  • A to G, chromosome 6 at 125,648,829 bp
  • G to T, chromosome 7 at 10,038,134 bp
  • A to G, chromosome 7 at 16,078,451 bp
  • A to G, chromosome 7 at 19,135,400 bp
  • A to T, chromosome 7 at 23,893,979 bp
  • A to G, chromosome 7 at 25,217,667 bp
  • A to T, chromosome 7 at 44,585,799 bp
  • A to T, chromosome 7 at 99,458,841 bp
  • A to G, chromosome 7 at 99,670,964 bp
  • A to G, chromosome 8 at 114,425,635 bp
  • T to A, chromosome 9 at 37,746,667 bp
  • A to T, chromosome 9 at 39,950,791 bp
  • A to G, chromosome 9 at 64,168,660 bp
  • C to T, chromosome 10 at 80,188,690 bp
  • C to A, chromosome 10 at 85,387,898 bp
  • C to T, chromosome 10 at 128,381,981 bp
  • T to A, chromosome 11 at 29,209,396 bp
  • A to G, chromosome 11 at 35,684,090 bp
  • A to G, chromosome 11 at 75,169,506 bp
  • T to C, chromosome 12 at 70,942,299 bp
  • A to T, chromosome 14 at 79,374,849 bp
  • G to T, chromosome 14 at 118,148,246 bp
  • C to T, chromosome 15 at 75,839,650 bp
  • A to G, chromosome 15 at 79,728,051 bp
  • CAC to CACTAC, chromosome 16 at 32,754,076 bp
  • T to A, chromosome 16 at 44,953,387 bp
  • T to A, chromosome 16 at 94,403,360 bp
  • T to A, chromosome 17 at 14,001,425 bp
  • A to G, chromosome 17 at 30,756,755 bp
  • A to T, chromosome 18 at 4,340,557 bp
  • A to T, chromosome 18 at 30,975,415 bp
  • G to T, chromosome 18 at 36,994,270 bp
  • T to C, chromosome 19 at 12,210,339 bp
  • C to T, chromosome 19 at 44,135,835 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9068 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068892-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.