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Strain Name:
C57BL/6J-MtgxR9110Btlr/Mmmh
Stock Number:
068919-MU
Citation ID:
RRID:MMRRC_068919-MU
Other Names:
R9110 (G1)
Major Collection:

Strain Information

Dntt
Name: deoxynucleotidyltransferase, terminal
Synonyms: Tdt
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21673
VEGA: 19
HGNC: HGNC:2983
Homologene: 3014
Otx2
Name: orthodenticle homeobox 2
Synonyms: E130306E05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18424
HGNC: HGNC:8522
Homologene: 11026
Prkd3
Name: protein kinase D3
Synonyms: 4930557O20Rik, 5730497N19Rik, PKD3, Prkcn
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75292
HGNC: HGNC:9408
Homologene: 2055
Fancd2
Name: Fanconi anemia, complementation group D2
Synonyms: 2410150O07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 211651
HGNC: HGNC:3585
Homologene: 13212
Arhgap12
Name: Rho GTPase activating protein 12
Synonyms: 2810011M08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75415
Homologene: 23089
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 44,129,366 bp
  • T to G, chromosome 1 at 158,668,757 bp
  • T to A, chromosome 1 at 180,117,693 bp
  • T to C, chromosome 2 at 10,187,020 bp
  • T to A, chromosome 2 at 30,332,449 bp
  • T to A, chromosome 2 at 87,868,199 bp
  • C to T, chromosome 2 at 128,842,695 bp
  • T to A, chromosome 2 at 150,408,173 bp
  • T to A, chromosome 2 at 157,213,685 bp
  • A to G, chromosome 2 at 173,012,223 bp
  • T to A, chromosome 2 at 180,973,537 bp
  • C to T, chromosome 2 at 181,206,257 bp
  • G to A, chromosome 3 at 87,927,671 bp
  • C to T, chromosome 3 at 119,747,609 bp
  • C to A, chromosome 4 at 118,385,433 bp
  • C to T, chromosome 4 at 126,355,036 bp
  • T to C, chromosome 5 at 32,364,058 bp
  • T to G, chromosome 5 at 64,103,816 bp
  • G to C, chromosome 5 at 113,613,982 bp
  • T to A, chromosome 5 at 143,289,565 bp
  • T to C, chromosome 5 at 143,894,941 bp
  • T to C, chromosome 6 at 28,445,202 bp
  • T to C, chromosome 6 at 87,476,272 bp
  • T to C, chromosome 6 at 113,535,801 bp
  • A to G, chromosome 7 at 19,191,695 bp
  • G to A, chromosome 7 at 73,766,623 bp
  • A to G, chromosome 7 at 80,289,995 bp
  • A to G, chromosome 7 at 120,232,392 bp
  • T to C, chromosome 7 at 141,279,094 bp
  • T to C, chromosome 8 at 22,535,441 bp
  • T to A, chromosome 8 at 24,703,805 bp
  • A to G, chromosome 8 at 40,795,870 bp
  • A to G, chromosome 8 at 121,789,462 bp
  • T to A, chromosome 10 at 129,625,951 bp
  • T to G, chromosome 11 at 4,065,007 bp
  • C to A, chromosome 11 at 6,398,271 bp
  • T to A, chromosome 11 at 58,817,133 bp
  • T to G, chromosome 11 at 69,544,382 bp
  • C to T, chromosome 11 at 99,986,560 bp
  • T to C, chromosome 11 at 113,653,981 bp
  • T to C, chromosome 13 at 22,556,394 bp
  • A to G, chromosome 13 at 27,808,415 bp
  • A to T, chromosome 13 at 36,246,419 bp
  • C to T, chromosome 13 at 55,472,761 bp
  • T to C, chromosome 14 at 48,658,770 bp
  • A to T, chromosome 15 at 97,884,872 bp
  • T to A, chromosome 16 at 19,624,993 bp
  • T to C, chromosome 16 at 20,652,244 bp
  • T to A, chromosome 16 at 44,435,560 bp
  • G to A, chromosome 16 at 91,505,262 bp
  • T to A, chromosome 17 at 33,780,826 bp
  • C to A, chromosome 17 at 38,335,543 bp
  • T to A, chromosome 17 at 78,985,322 bp
  • G to A, chromosome 17 at 90,561,805 bp
  • T to C, chromosome 18 at 6,034,539 bp
  • T to C, chromosome 18 at 73,649,870 bp
  • A to T, chromosome 19 at 8,767,754 bp
  • A to T, chromosome 19 at 12,462,650 bp
  • A to T, chromosome 19 at 41,055,758 bp
  • T to A, chromosome 19 at 45,050,288 bp
  • A to T, chromosome 19 at 59,293,894 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9110 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068919-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.