Strain Name:
C57BL/6J-MtgxR9142Btlr/Mmmh
Stock Number:
068934-MU
Citation ID:
RRID:MMRRC_068934-MU
Other Names:
R9142 (G1)
Major Collection:

Strain Information

Uso1
Name: USO1 vesicle docking factor
Synonyms: TAP, transcytosis associated protein p115, Vdp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56041
Homologene: 2754
Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Foxm1
Name: forkhead box M1
Synonyms: WIN, Fkh16, Foxm1b, HFH-11B, Trident, Mpm2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14235
HGNC: HGNC:3818
Homologene: 7318
App
Name: amyloid beta precursor protein
Synonyms: Cvap, betaAPP, Abeta, protease nexin II, E030013M08Rik, appican, Adap
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11820
VEGA: 16
HGNC: HGNC:620
Homologene: 56379
Ggnbp2
Name: gametogenetin binding protein 2
Synonyms: Zfp403, D330017P12Rik, DIF-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217039
Homologene: 11750
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: 90kDa, Rsk3, p90rsk, Rps6ka-rs1, pp90rsk, D17Wsu134e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Mhdadsk9, Dsk9, Nf-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Bnc2
Name: basonuclin zinc finger protein 2
Synonyms: 5031434M05Rik, 8430420F16Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242509
Homologene: 18243
Top3b
Name: topoisomerase (DNA) III beta
Synonyms: Topo III beta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 21976
Homologene: 2923
Gpbp1
Name: GC-rich promoter binding protein 1
Synonyms: 1700034P14Rik, D230035M11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73274
Homologene: 11292
Psmd1
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
Synonyms: P112, S1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70247
HGNC: HGNC:9554
Homologene: 2100
Sec23ip
Name: Sec23 interacting protein
Synonyms: D7Ertd373e, p125
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207352
Homologene: 38288
Kdm2b
Name: lysine (K)-specific demethylase 2B
Synonyms: Jhdm1b, Cxxc2, Fbxl10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 30841
Homologene: 13069
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71472
Homologene: 41730
Zfp106
Name: zinc finger protein 106
Synonyms: sirm, H3a, Sh3bp3, Cd-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20402
Homologene: 40787
Cdc37l1
Name: cell division cycle 37-like 1
Synonyms: Hsp90-associating relative of Cdc37, Harc, 2700033A15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67072
VEGA: 19
Homologene: 9912
Dennd4c
Name: DENN domain containing 4C
Synonyms: 1700065A05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329877
Homologene: 23057
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: trichorhinophalangeal syndrome I (human), D15Ertd586e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Ttk
Name: Ttk protein kinase
Synonyms: Mps1, Esk1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22137
Homologene: 2489
Ppp1r15a
Name: protein phosphatase 1, regulatory subunit 15A
Synonyms: Gadd34, Myd116
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17872
Homologene: 8639
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Spag5
Name: sperm associated antigen 5
Synonyms: MAP126, D11Bhm180e, Deepest, Astrin, S17, s17, Mastrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 54141
Homologene: 4718
Gper1
Name: G protein-coupled estrogen receptor 1
Synonyms: 6330420K13Rik, FEG-1, CMKRL2, Gpr30, Ceprl, GPCR-Br, Gper
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76854
HGNC: HGNC:4485
Homologene: 15855
Lrrtm4
Name: leucine rich repeat transmembrane neuronal 4
Synonyms: 7530419J18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243499
Homologene: 11807
Kif7
Name: kinesin family member 7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16576
Homologene: 72555
Tenm3
Name: teneurin transmembrane protein 3
Synonyms: Odz3, Ten-m3, 2610100B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23965
Homologene: 22673
Rabgef1
Name: RAB guanine nucleotide exchange factor (GEF) 1
Synonyms: Ras negative regulator Rabex-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56715
Homologene: 8720
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: 9930021N24Rik, MOZ, Myst3, Zfp220
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244349
Homologene: 4924
Nrde2
Name: nrde-2 necessary for RNA interference, domain containing
Synonyms: BC002230, 6720454P05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217827
VEGA: 12
Homologene: 41213
Sez6l
Name: seizure related 6 homolog like
Synonyms: Acig1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56747
Homologene: 10895
Btbd16
Name: BTB domain containing 16
Synonyms: E330040A16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330660
Homologene: 77327
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Cfap58
Name: cilia and flagella associated protein 58
Synonyms: Ccdc147, LOC381229
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 381229
VEGA: 19
Homologene: 77312
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Scart2
Name: scavenger receptor family member expressed on T cells 2
Synonyms: 5830411N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244234
Homologene: 133218
Arid3a
Name: AT-rich interaction domain 3A
Synonyms: Dri1, Bright
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13496
HGNC: HGNC:3031
Homologene: 124247
Dazl
Name: deleted in azoospermia-like
Synonyms: Dazla, Tpx2, Daz-like, Tpx-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13164
VEGA: 17
Homologene: 86954
Serpina3n
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3N
Synonyms: Spi2/eb.4, alpha-1 antiproteinase, Spi2-2, Spi2.2, antitrypsin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20716
HGNC: HGNC:16
Homologene: 111129
Adprs
Name: ADP-ribosylserine hydrolase
Synonyms: Arh3, Adprhl2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100206
Homologene: 9863
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213402
Homologene: 41848
Fbxw21
Name: F-box and WD-40 domain protein 21
Synonyms: E330009P21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320082
Homologene: 110776
Zfp932
Name: zinc finger protein 932
Synonyms: 2310001H12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69504
Homologene: 137770
Mcrip1
Name: MAPK regulated corepressor interacting protein 1
Synonyms: Fam195b, BC003940
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192173
Homologene: 19571
Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Synonyms: c-neu, HER-2, Neu, Neu oncogene, ErbB-2, l11Jus8, c-erbB2, HER2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13866
HGNC: HGNC:3430
Homologene: 3273
Fktn
Name: fukutin
Synonyms: Fukutin, Fcmd
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246179
HGNC: HGNC:3622
Homologene: 31402
Ptprr
Name: protein tyrosine phosphatase receptor type R
Synonyms: PTPBR7, PTP-SL, RPTPRR
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19279
HGNC: HGNC:9680
Homologene: 2135
Or6c1
Name: olfactory receptor family 6 subfamily C member 1
Synonyms: Olfr802, GA_x6K02T2PULF-11361362-11360424, MOR111-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258934
HGNC: HGNC:8355
Homologene: 105151
Ctnna2
Name: catenin alpha 2
Synonyms: chp, Catna2, alpha N-catenin, alpha(N)-catenin, Catna, catenin (cadherin associated protein), alpha 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12386
HGNC: HGNC:2510
Homologene: 68394
Prss42
Name: serine protease 42
Synonyms: Tessp2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235628
Homologene: 27410
Gja3
Name: gap junction protein, alpha 3
Synonyms: Cx46, Gja-3, connexin 46, alpha 3 connexin
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14611
VEGA: 14
HGNC: HGNC:4277
Homologene: 9670
Or6b2b
Name: olfactory receptor family 6 subfamily B member 2B
Synonyms: GA_x6K02T2R7CC-81266841-81267776, MOR103-12, Olfr1415
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 258228
Homologene: 79367
Or5w12
Name: olfactory receptor family 5 subfamily W member 12
Synonyms: GA_x6K02T2Q125-49177531-49176599, Olfr1135, MOR177-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258654
Homologene: 17331
Prl7c1
Name: prolactin family 7, subfamily c, member 1
Synonyms: Prlpo, 1600017N11Rik, PLP-O
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67505
Homologene: 137377
Atp13a2
Name: ATPase type 13A2
Synonyms: 1110012E06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 74772
Homologene: 56940
Zdhhc2
Name: zinc finger, DHHC domain containing 2
Synonyms: 5730415P04Rik, 6430583A19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70546
Homologene: 81667
Dusp13b
Name: dual specificity phosphatase 13B
Synonyms: LOC382853, LMW-DSP6, Dusp13, TMDP, TS-DSP6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27389
Homologene: 121602
Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Synonyms: Pgc-1alphaa, Pgco1, Pgc1, Gm11133, A830037N07Rik, PPAR Gamma Coactivator-1, Pgc-1alpha
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19017
HGNC: HGNC:9237
Homologene: 7485
Smok2b
Name: sperm motility kinase 2B
Synonyms: LOC236574
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 236574
Homologene: 128738
Mettl25b
Name: methyltransferase like 25B
Synonyms: Rrnad1, BC023814
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229503
Homologene: 9332
Gtf2e1
Name: general transcription factor II E, polypeptide 1 (alpha subunit)
Synonyms: 2610024P03Rik, 56kDa, TFIIE-A, FE
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74197
HGNC: HGNC:4650
Homologene: 38062
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Cc2d2b
Name: coiled-coil and C2 domain containing 2B
Synonyms: EG668310
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 668310
Homologene: 141114
Krtap5-24
Name: keratin associated protein 5-24
Synonyms: Gm40460
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 105244938
Krtap10-30
Name: keratin associated protein 10-30
Synonyms: Gm9736
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 77763
VEGA: 10
Homologene: 131747
H2ac10
Name: H2A clustered histone 10
Synonyms: Hist1h2af, H2a-221
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319173
HGNC: HGNC:4727
Homologene: 88882
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 68,349,393 bp
  • T to G, chromosome 1 at 86,137,095 bp
  • A to T, chromosome 1 at 90,778,844 bp
  • T to G, chromosome 1 at 92,491,689 bp
  • A to C, chromosome 2 at 76,719,122 bp
  • C to T, chromosome 2 at 87,671,969 bp
  • T to A, chromosome 2 at 120,520,454 bp
  • A to G, chromosome 3 at 87,923,888 bp
  • G to A, chromosome 4 at 53,734,854 bp
  • A to G, chromosome 4 at 84,555,874 bp
  • A to T, chromosome 4 at 86,837,400 bp
  • C to A, chromosome 4 at 126,321,567 bp
  • A to G, chromosome 4 at 141,002,053 bp
  • G to A, chromosome 5 at 51,494,804 bp
  • T to A, chromosome 5 at 92,187,266 bp
  • A to T, chromosome 5 at 110,009,654 bp
  • C to T, chromosome 5 at 112,461,217 bp
  • A to T, chromosome 5 at 122,989,049 bp
  • T to A, chromosome 5 at 130,208,713 bp
  • T to C, chromosome 5 at 139,426,557 bp
  • G to T, chromosome 6 at 76,902,440 bp
  • T to A, chromosome 6 at 80,022,443 bp
  • T to A, chromosome 6 at 128,367,335 bp
  • T to C, chromosome 7 at 45,524,496 bp
  • A to T, chromosome 7 at 79,706,837 bp
  • T to A, chromosome 7 at 128,761,502 bp
  • C to T, chromosome 7 at 130,815,786 bp
  • T to A, chromosome 7 at 140,297,893 bp
  • C to A, chromosome 7 at 142,240,762 bp
  • T to A, chromosome 8 at 22,940,056 bp
  • A to G, chromosome 8 at 40,467,522 bp
  • G to A, chromosome 8 at 48,335,513 bp
  • G to A, chromosome 9 at 83,843,688 bp
  • C to T, chromosome 9 at 89,091,399 bp
  • A to G, chromosome 9 at 108,495,085 bp
  • A to G, chromosome 9 at 109,156,345 bp
  • G to T, chromosome 9 at 110,799,160 bp
  • T to G, chromosome 10 at 41,975,408 bp
  • A to G, chromosome 10 at 77,751,015 bp
  • T to C, chromosome 10 at 79,951,778 bp
  • A to T, chromosome 10 at 92,984,235 bp
  • A to T, chromosome 10 at 116,188,214 bp
  • T to C, chromosome 10 at 129,682,416 bp
  • T to A, chromosome 11 at 78,301,997 bp
  • T to A, chromosome 11 at 79,471,489 bp
  • T to A, chromosome 11 at 79,475,862 bp
  • T to C, chromosome 11 at 84,840,060 bp
  • T to A, chromosome 11 at 98,422,058 bp
  • G to A, chromosome 11 at 120,544,716 bp
  • A to C, chromosome 12 at 8,012,705 bp
  • G to T, chromosome 12 at 100,151,259 bp
  • A to G, chromosome 12 at 104,413,451 bp
  • T to C, chromosome 13 at 23,533,981 bp
  • C to T, chromosome 13 at 27,780,768 bp
  • A to T, chromosome 13 at 111,426,499 bp
  • T to A, chromosome 14 at 21,742,688 bp
  • T to C, chromosome 14 at 57,036,591 bp
  • T to G, chromosome 15 at 50,661,262 bp
  • T to C, chromosome 16 at 16,883,435 bp
  • C to T, chromosome 16 at 37,536,002 bp
  • G to A, chromosome 16 at 85,103,239 bp
  • A to G, chromosome 17 at 7,170,394 bp
  • G to A, chromosome 17 at 13,234,750 bp
  • A to G, chromosome 17 at 50,283,150 bp
  • G to A, chromosome 18 at 37,979,881 bp
  • T to A, chromosome 19 at 29,012,002 bp
  • T to C, chromosome 19 at 37,330,499 bp
  • C to T, chromosome 19 at 40,765,401 bp
  • T to C, chromosome 19 at 47,986,554 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9142 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068934-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.