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Strain Name:
C57BL/6J-MtgxR9183Btlr/Mmmh
Stock Number:
068950-MU
Citation ID:
RRID:MMRRC_068950-MU
Other Names:
R9183 (G1)
Major Collection:

Strain Information

Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Arpp21
Name: cyclic AMP-regulated phosphoprotein, 21
Synonyms: ARPP-21, Tarpp, D9Bwg1012e, 0710001E13Rik, R3hdm3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74100
Homologene: 32306
Clybl
Name: citrate lyase beta like
Synonyms: Clb, 2310014M14Rik, 0610033J05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 69634
VEGA: 14
Homologene: 49925
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: 4432411E13Rik, Edd1, Edd
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Zmat5
Name: zinc finger, matrin type 5
Synonyms: D11Bwg1548e, D11Bwg0572e, 2610510L01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67178
Homologene: 32439
Fbxo28
Name: F-box protein 28
Synonyms: 5730505P19Rik, 4833428J17Rik, Fbx28, D1Ertd578e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67948
Homologene: 9050
Wdr48
Name: WD repeat domain 48
Synonyms: 8430408H12Rik, Uaf1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67561
VEGA: 9
Homologene: 10830
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 45,909,511 bp
  • T to A, chromosome 1 at 97,069,050 bp
  • A to G, chromosome 1 at 182,329,961 bp
  • C to A, chromosome 2 at 24,003,643 bp
  • C to T, chromosome 2 at 32,757,317 bp
  • T to C, chromosome 2 at 33,005,068 bp
  • T to A, chromosome 2 at 153,397,920 bp
  • T to C, chromosome 2 at 158,217,192 bp
  • T to C, chromosome 2 at 177,475,743 bp
  • C to T, chromosome 3 at 53,520,065 bp
  • C to T, chromosome 3 at 59,077,077 bp
  • A to C, chromosome 3 at 75,298,112 bp
  • C to T, chromosome 3 at 98,290,916 bp
  • G to A, chromosome 4 at 132,325,254 bp
  • G to T, chromosome 4 at 133,253,623 bp
  • G to A, chromosome 5 at 33,871,452 bp
  • A to C, chromosome 5 at 67,767,035 bp
  • C to A, chromosome 5 at 103,864,245 bp
  • A to G, chromosome 5 at 107,725,953 bp
  • A to G, chromosome 5 at 121,299,488 bp
  • T to A, chromosome 5 at 130,013,471 bp
  • A to T, chromosome 6 at 3,711,463 bp
  • A to G, chromosome 6 at 28,243,173 bp
  • A to T, chromosome 6 at 87,287,043 bp
  • T to C, chromosome 6 at 119,317,423 bp
  • A to T, chromosome 7 at 79,594,816 bp
  • G to A, chromosome 7 at 139,875,800 bp
  • A to T, chromosome 7 at 141,798,900 bp
  • T to A, chromosome 8 at 104,734,142 bp
  • C to A, chromosome 8 at 105,231,208 bp
  • A to G, chromosome 8 at 105,723,021 bp
  • T to A, chromosome 8 at 107,061,758 bp
  • T to C, chromosome 8 at 114,706,370 bp
  • T to C, chromosome 9 at 108,829,396 bp
  • C to T, chromosome 9 at 112,065,998 bp
  • A to G, chromosome 9 at 119,920,664 bp
  • T to A, chromosome 10 at 61,863,979 bp
  • A to T, chromosome 10 at 80,709,793 bp
  • A to G, chromosome 10 at 129,093,332 bp
  • A to T, chromosome 11 at 4,722,431 bp
  • A to T, chromosome 11 at 73,244,213 bp
  • A to G, chromosome 11 at 80,155,056 bp
  • G to T, chromosome 11 at 101,457,265 bp
  • A to G, chromosome 11 at 119,427,622 bp
  • T to A, chromosome 12 at 11,249,185 bp
  • A to G, chromosome 13 at 12,421,385 bp
  • A to G, chromosome 14 at 8,251,559 bp
  • A to G, chromosome 14 at 51,455,044 bp
  • T to C, chromosome 14 at 122,401,975 bp
  • A to T, chromosome 15 at 5,176,488 bp
  • T to C, chromosome 15 at 23,226,979 bp
  • C to A, chromosome 15 at 37,997,176 bp
  • T to C, chromosome 15 at 64,822,267 bp
  • T to C, chromosome 15 at 101,693,011 bp
  • T to C, chromosome 16 at 20,720,535 bp
  • T to C, chromosome 17 at 14,676,264 bp
  • C to T, chromosome 17 at 14,928,389 bp
  • T to A, chromosome 17 at 21,020,092 bp
  • C to T, chromosome 17 at 23,994,618 bp
  • T to C, chromosome 17 at 32,700,231 bp
  • T to A, chromosome 17 at 36,081,490 bp
  • ACTTCTTCT to ACTTCT, chromosome 17 at 56,571,292 bp
  • T to C, chromosome 18 at 43,261,340 bp
  • T to C, chromosome 18 at 45,561,312 bp
  • T to A, chromosome 18 at 78,111,383 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9183 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068950-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.