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Strain Name:
C57BL/6J-MtgxR9200Btlr/Mmmh
Stock Number:
068957-MU
Citation ID:
RRID:MMRRC_068957-MU
Other Names:
R9200 (G1)
Major Collection:

Strain Information

Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Ddc
Name: dopa decarboxylase
Synonyms: aromatic L-amino acid decarboxylase, Aadc
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13195
HGNC: HGNC:2719
Homologene: 618
Zmynd8
Name: zinc finger, MYND-type containing 8
Synonyms: 1110013E22Rik, 2010005I16Rik, ZMYND8, RACK7, 3632413B07Rik, Prkcbp1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228880
HGNC: HGNC:9397
Homologene: 32679
Dnmt1
Name: DNA methyltransferase 1
Synonyms: MTase, Dnmt1o, Cxxc9, MommeD2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13433
VEGA: 9
HGNC: HGNC:2976
Homologene: 124071
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Rxra
Name: retinoid X receptor alpha
Synonyms: RXRalpha1, RXR alpha 1, 9530071D11Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20181
Homologene: 2220
Ppp6r3
Name: protein phosphatase 6, regulatory subunit 3
Synonyms: 9130026N02Rik, D19Bwg1430e, 4930528G08Rik, D19Ertd703e, Pp6r3, Pptcs3, Saps3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52036
VEGA: 19
HGNC: HGNC:1173
Homologene: 115911
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 40,543,017 bp
  • T to A, chromosome 1 at 52,490,366 bp
  • A to C, chromosome 1 at 54,260,038 bp
  • T to C, chromosome 1 at 60,281,266 bp
  • C to T, chromosome 1 at 133,386,005 bp
  • T to C, chromosome 1 at 179,405,398 bp
  • A to T, chromosome 2 at 4,927,436 bp
  • A to G, chromosome 2 at 20,781,891 bp
  • A to G, chromosome 2 at 26,090,106 bp
  • G to A, chromosome 2 at 27,737,484 bp
  • T to A, chromosome 2 at 87,269,711 bp
  • T to A, chromosome 2 at 137,087,124 bp
  • A to T, chromosome 2 at 164,613,788 bp
  • A to T, chromosome 2 at 165,840,085 bp
  • C to T, chromosome 3 at 138,221,806 bp
  • A to T, chromosome 4 at 14,811,712 bp
  • A to G, chromosome 4 at 32,760,791 bp
  • A to G, chromosome 4 at 43,257,352 bp
  • A to G, chromosome 4 at 43,447,307 bp
  • A to T, chromosome 4 at 98,357,963 bp
  • A to G, chromosome 4 at 140,718,353 bp
  • G to A, chromosome 4 at 143,697,286 bp
  • T to C, chromosome 4 at 154,023,819 bp
  • T to C, chromosome 5 at 16,801,661 bp
  • T to C, chromosome 5 at 89,445,377 bp
  • A to G, chromosome 6 at 5,240,863 bp
  • A to G, chromosome 6 at 40,612,560 bp
  • A to G, chromosome 6 at 60,976,876 bp
  • G to A, chromosome 6 at 73,027,514 bp
  • G to A, chromosome 6 at 125,140,880 bp
  • C to A, chromosome 7 at 19,523,758 bp
  • T to C, chromosome 7 at 21,349,391 bp
  • A to C, chromosome 7 at 25,272,515 bp
  • T to A, chromosome 7 at 26,611,648 bp
  • T to G, chromosome 7 at 29,095,099 bp
  • A to G, chromosome 7 at 65,652,265 bp
  • T to C, chromosome 7 at 79,841,122 bp
  • T to C, chromosome 7 at 80,382,392 bp
  • A to T, chromosome 7 at 103,418,898 bp
  • C to A, chromosome 7 at 119,580,616 bp
  • C to T, chromosome 7 at 143,575,917 bp
  • A to G, chromosome 8 at 105,331,440 bp
  • T to C, chromosome 8 at 105,890,419 bp
  • A to T, chromosome 8 at 119,748,260 bp
  • T to A, chromosome 9 at 20,908,600 bp
  • G to A, chromosome 9 at 31,357,142 bp
  • A to G, chromosome 9 at 35,503,321 bp
  • T to C, chromosome 9 at 53,686,365 bp
  • C to T, chromosome 10 at 41,487,565 bp
  • A to G, chromosome 10 at 50,645,691 bp
  • G to A, chromosome 10 at 91,009,240 bp
  • T to G, chromosome 10 at 127,457,652 bp
  • T to C, chromosome 11 at 11,815,388 bp
  • C to A, chromosome 11 at 60,230,116 bp
  • T to C, chromosome 11 at 121,069,647 bp
  • A to T, chromosome 13 at 114,968,461 bp
  • G to T, chromosome 14 at 97,828,307 bp
  • G to T, chromosome 15 at 86,033,085 bp
  • T to C, chromosome 16 at 8,856,034 bp
  • G to T, chromosome 16 at 15,705,289 bp
  • C to G, chromosome 16 at 96,037,954 bp
  • T to A, chromosome 17 at 27,107,662 bp
  • A to G, chromosome 17 at 31,217,997 bp
  • A to G, chromosome 17 at 33,951,410 bp
  • G to T, chromosome 17 at 36,268,775 bp
  • T to A, chromosome 17 at 56,628,229 bp
  • A to G, chromosome 17 at 71,274,234 bp
  • G to A, chromosome 17 at 71,810,889 bp
  • A to T, chromosome 17 at 89,046,675 bp
  • A to G, chromosome 18 at 12,472,240 bp
  • A to G, chromosome 18 at 60,916,764 bp
  • T to C, chromosome 19 at 3,469,748 bp
  • A to G, chromosome 19 at 13,633,231 bp
  • A to T, chromosome 19 at 42,040,432 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9200 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068957-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.