Strain Name:
C57BL/6J-MtgxR9223Btlr/Mmmh
Stock Number:
068959-MU
Citation ID:
RRID:MMRRC_068959-MU
Other Names:
R9223 (G1)
Major Collection:

Strain Information

Tfap2b
Name: transcription factor AP-2 beta
Synonyms: E130018K07Rik, AP-2(beta), Tcfap2b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21419
Homologene: 20688
Thbs4
Name: thrombospondin 4
Synonyms: TSP-4, TSP4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21828
Homologene: 20691
Ccn2
Name: cellular communication network factor 2
Synonyms: Ctgf, Hcs24, Ccn2, hypertrophic chondrocyte-specific gene product 24, Fisp12
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14219
HGNC: HGNC:2500
Homologene: 1431
Mkrn1
Name: makorin, ring finger protein, 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54484
HGNC: HGNC:7112
Homologene: 32175
Chst5
Name: carbohydrate sulfotransferase 5
Synonyms: GST-4, I-GlcNAc6ST
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56773
Homologene: 56927
Serinc3
Name: serine incorporator 3
Synonyms: AIGP1, TMS-1, DIFF33, Tde1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26943
Homologene: 38230
Sik3
Name: SIK family kinase 3
Synonyms: 5730525O22Rik, 9030204A07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70661
Homologene: 57023
Rtn4
Name: reticulon 4
Synonyms: Nogo-B, NOGO, C130026I10Rik, NgA, Nogo-A, 1110020G17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68585
Homologene: 10743
Helz
Name: helicase with zinc finger domain
Synonyms: 9430093I07Rik, 3110078M01Rik, 9630002H22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78455
Homologene: 8918
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Nav2
Name: neuron navigator 2
Synonyms: RAINB2, 5330421F07Rik, HELAD1, POMFIL2, Rainb1, Unc53H2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Tomm70a
Name: translocase of outer mitochondrial membrane 70A
Synonyms: D16Ium22e, D16Wsu109e, D16Ium22, Tomm70a, Tom70, 2610044B22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 28185
VEGA: 16
Homologene: 40112
Helq
Name: helicase, POLQ-like
Synonyms: D430018E21Rik, Hel308
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 191578
Homologene: 14667
Lrrtm3
Name: leucine rich repeat transmembrane neuronal 3
Synonyms: 9630044H04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216028
Homologene: 37110
Htt
Name: huntingtin
Synonyms: HD, IT15, htt, C430023I11Rik, Hdh, huntingtin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Mpdz
Name: multiple PDZ domain crumbs cell polarity complex component
Synonyms: MUPP1, B930003D11Rik, multiple PDZ domain protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17475
HGNC: HGNC:7208
Homologene: 2841
Nol8
Name: nucleolar protein 8
Synonyms: D13Ertd548e, 5730412B09Rik, 4921532D18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70930
VEGA: 13
Homologene: 41210
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: D12Ertd364e, C730036B14Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 9530009M10Rik, 1810037O03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Naip5
Name: NLR family, apoptosis inhibitory protein 5
Synonyms: Birc1e, Naip-rs3, Lgn1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17951
HGNC: HGNC:7634
Homologene: 113589
Or2d3b
Name: olfactory receptor family 2 subfamily D member 3B
Synonyms: MOR260-6P, GA_x6K02T2PBJ9-9297671-9298594, Olfr1532, MOR260-9P, MOR260-9P, Olfr708, Olfr1532-ps1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258173
Homologene: 133899
Or4f62
Name: olfactory receptor family 4 subfamily F member 62
Synonyms: Olfr1318, GA_x6K02T2Q125-73202172-73203134, MOR245-16
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258022
Homologene: 134079
Clspn
Name: claspin
Synonyms: E130314M08Rik, C85083
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269582
Homologene: 11138
Vmn2r116
Name: vomeronasal 2, receptor 116
Synonyms: V2Rp5, EG619697
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619697
Homologene: 86604
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207618
Homologene: 52304
Htra4
Name: HtrA serine peptidase 4
Synonyms: B430206E18Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330723
Homologene: 17801
Or2h15
Name: olfactory receptor family 2 subfamily H member 15
Synonyms: GA_x6K02T2PSCP-2579687-2578746, Olfr132, MOR256-49
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 257889
Homologene: 46430
Cerkl
Name: ceramide kinase-like
Synonyms: Rp26
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228094
Homologene: 52396
Yipf3
Name: Yip1 domain family, member 3
Synonyms: D17Wsu94e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 28064
Homologene: 9117
Tmem144
Name: transmembrane protein 144
Synonyms: 5730537D05Rik, 1110057I03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 70652
Homologene: 41250
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Aldh3a2
Name: aldehyde dehydrogenase family 3, subfamily A2
Synonyms: Ahd-3r, Ahd-3, Aldh4, FALDH, Ahd3, Ahd3-r, Aldh4-r
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11671
HGNC: HGNC:403
Homologene: 55458
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mamdc1, Mdga2, Adp, 9330209L04Rik, 6720489L24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Kcna2
Name: potassium voltage-gated channel, shaker-related subfamily, member 2
Synonyms: Kv1.2, Kca1-2, Akr6a4, Mk-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16490
HGNC: HGNC:6220
Homologene: 21034
Or1ak2
Name: olfactory receptor family 1 subfamily AK member 2
Synonyms: GA_x6K02T2NLDC-33631647-33632594, Olfr356, MOR134-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258617
Homologene: 85948
Serpina3f
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3F
Synonyms: antitrypsin, 2A1, alpha-1 antiproteinasin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238393
HGNC: HGNC:16
Homologene: 115927
Fbxo11
Name: F-box protein 11
Synonyms: Jf, GENA 104
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225055
Homologene: 11843
Col20a1
Name: collagen, type XX, alpha 1
Synonyms: 1700051I12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73368
Homologene: 75138
Krtap16-1
Name: keratin associated protein 16-1
Synonyms: AI450886
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 100504183
Homologene: 99988
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: Clip 170, restin, Rsn, Clip50, CLIP-170, 1110007I12Rik, cytoplasmic linker protein 50, 4631429H07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
Mrc2
Name: mannose receptor, C type 2
Synonyms: uPARAP, Endo180, novel lectin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17534
Homologene: 4408
Cel
Name: carboxyl ester lipase
Synonyms: 1810036E18Rik, BAL
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12613
HGNC: HGNC:1848
Homologene: 37529
Fbxw13
Name: F-box and WD-40 domain protein 13
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 211305
Homologene: 110776
Gm5239
Name: predicted pseudogene 5239
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 383341
VEGA: 18
Gabrb3
Name: GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3
Synonyms: A230092K12Rik, beta3, Gabrb-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14402
HGNC: HGNC:4083
Homologene: 633
Kndc1
Name: kinase non-catalytic C-lobe domain (KIND) containing 1
Synonyms: VKIND, 2410012C07Rik, B830014K08Rik, very-kind
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76484
Homologene: 45138
Hook3
Name: hook microtubule tethering protein 3
Synonyms: 5830454D03Rik, E330005F07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320191
Homologene: 13022
9630041A04Rik
Name: RIKEN cDNA 9630041A04 gene
Type: Gene
Species: Mouse
Chromosome: 9
Or4f58
Name: olfactory receptor family 4 subfamily F member 58
Synonyms: GA_x6K02T2Q125-73069292-73068354, Olfr1311, MOR245-21
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258271
Homologene: 133656
Fam24b
Name: family with sequence similarity 24 member B
Synonyms: 1700007K09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69318
Homologene: 78032
Mmd2
Name: monocyte to macrophage differentiation-associated 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75104
Homologene: 18425
Dmrta2
Name: doublesex and mab-3 related transcription factor like family A2
Synonyms: Dmrt5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242620
Homologene: 100682
Erlin1
Name: ER lipid raft associated 1
Synonyms: Spfh1, Keo4, 2810439N09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226144
Homologene: 4716
Or8k18
Name: olfactory receptor family 8 subfamily K member 18
Synonyms: Olfr1049, MOR187-1, GA_x6K02T2Q125-47735396-47734470
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259018
Homologene: 77387
Spopfm2
Name: speckle-type BTB/POZ protein family member 2
Synonyms: Gm10696
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 100043188
Homologene: 128308
Pcdhgc4
Name: protocadherin gamma subfamily C, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93707
HGNC: HGNC:8717
Homologene: 110932
Bcl6b
Name: B cell CLL/lymphoma 6, member B
Synonyms: Bazf
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12029
HGNC: HGNC:1002
Homologene: 7243
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 19,212,425 bp
  • T to A, chromosome 1 at 46,322,260 bp
  • T to C, chromosome 1 at 134,879,638 bp
  • A to T, chromosome 1 at 157,107,866 bp
  • T to A, chromosome 1 at 173,937,871 bp
  • TTA to TTATA, chromosome 2 at 28,559,429 bp
  • T to C, chromosome 2 at 36,937,899 bp
  • A to T, chromosome 2 at 79,341,330 bp
  • G to T, chromosome 2 at 86,255,200 bp
  • T to A, chromosome 2 at 112,021,172 bp
  • T to A, chromosome 2 at 112,156,128 bp
  • A to G, chromosome 2 at 163,636,892 bp
  • A to T, chromosome 2 at 181,006,735 bp
  • A to T, chromosome 3 at 79,827,657 bp
  • A to C, chromosome 3 at 94,175,643 bp
  • A to T, chromosome 3 at 107,104,990 bp
  • A to G, chromosome 4 at 81,284,630 bp
  • G to A, chromosome 4 at 109,982,582 bp
  • A to G, chromosome 4 at 126,590,618 bp
  • T to A, chromosome 5 at 6,771,496 bp
  • G to T, chromosome 5 at 34,905,348 bp
  • A to T, chromosome 5 at 100,798,437 bp
  • A to T, chromosome 5 at 123,646,274 bp
  • C to T, chromosome 5 at 142,567,911 bp
  • T to C, chromosome 6 at 39,401,249 bp
  • C to A, chromosome 7 at 49,552,851 bp
  • T to G, chromosome 7 at 57,816,404 bp
  • C to A, chromosome 7 at 102,184,960 bp
  • A to G, chromosome 7 at 106,914,773 bp
  • A to G, chromosome 7 at 131,326,140 bp
  • A to G, chromosome 7 at 139,921,441 bp
  • A to G, chromosome 8 at 25,037,032 bp
  • A to G, chromosome 8 at 26,032,524 bp
  • C to A, chromosome 8 at 111,890,860 bp
  • A to G, chromosome 9 at 46,155,474 bp
  • A to C, chromosome 9 at 89,085,610 bp
  • C to A, chromosome 9 at 101,942,994 bp
  • T to C, chromosome 9 at 109,195,048 bp
  • T to C, chromosome 10 at 24,595,958 bp
  • ATTTT to ATTTTT, chromosome 10 at 64,089,256 bp
  • T to A, chromosome 10 at 107,854,344 bp
  • A to G, chromosome 11 at 29,706,778 bp
  • A to G, chromosome 11 at 61,265,211 bp
  • A to T, chromosome 11 at 70,226,574 bp
  • A to T, chromosome 11 at 99,985,245 bp
  • G to A, chromosome 11 at 105,329,267 bp
  • A to G, chromosome 11 at 107,619,092 bp
  • T to A, chromosome 12 at 65,102,584 bp
  • C to T, chromosome 12 at 66,568,860 bp
  • A to G, chromosome 12 at 104,217,185 bp
  • A to G, chromosome 13 at 12,404,921 bp
  • T to A, chromosome 13 at 49,661,262 bp
  • C to T, chromosome 13 at 92,761,490 bp
  • C to T, chromosome 13 at 100,227,676 bp
  • T to A, chromosome 16 at 57,142,803 bp
  • A to T, chromosome 17 at 23,401,167 bp
  • C to T, chromosome 17 at 38,131,121 bp
  • A to T, chromosome 17 at 46,248,872 bp
  • A to T, chromosome 17 at 88,015,696 bp
  • A to T, chromosome 18 at 35,536,619 bp
  • A to G, chromosome 18 at 37,815,632 bp
  • A to G, chromosome 19 at 44,040,745 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9223 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068959-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.