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Strain Name:
C57BL/6J-MtgxR9171Btlr/Mmmh
Stock Number:
068976-MU
Citation ID:
RRID:MMRRC_068976-MU
Other Names:
R9171 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: dyn, SpbIV, neuroaxonal dystrophy, 5830426A08Rik, ROSA62, nmf261, 1700022P15Rik, Spnb4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Hnrnpab
Name: heterogeneous nuclear ribonucleoprotein A/B
Synonyms: CBF-A, Cgbfa, Hnrpab
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15384
HGNC: HGNC:5034
Homologene: 74950
Stx8
Name: syntaxin 8
Synonyms: 1110002H11Rik, 0610007H08Rik, 4930571E13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55943
Homologene: 37973
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Ezh2
Name: enhancer of zeste 2 polycomb repressive complex 2 subunit
Synonyms: Enx-1, Enx1h, KMT6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14056
HGNC: HGNC:3527
Homologene: 37926
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Fcho2
Name: FCH domain only 2
Synonyms: 5832424M12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218503
VEGA: 13
Homologene: 9030
Tle1
Name: transducin-like enhancer of split 1
Synonyms: Grg1, Estm14, C230057C06Rik, Tle4l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21885
Homologene: 21058
Atxn10
Name: ataxin 10
Synonyms: TEG-169, E46, Sca10, Tex169
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54138
VEGA: 15
Homologene: 40858
Sh3d19
Name: SH3 domain protein D19
Synonyms: Kryn
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 27059
Homologene: 19064
Snap91
Name: synaptosomal-associated protein 91
Synonyms: F1-20, 91kDa, AP180
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20616
Homologene: 8429
Slc39a14
Name: solute carrier family 39 (zinc transporter), member 14
Synonyms: G630015O18Rik, Zip14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213053
Homologene: 15037
Themis
Name: thymocyte selection associated
Synonyms: E430004N04Rik, Tsepa, Gasp
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 210757
Homologene: 72287
Dnmt3l
Name: DNA methyltransferase 3-like
Synonyms: D6Ertd14e, ecat7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54427
HGNC: HGNC:2980
Homologene: 8362
Ighmbp2
Name: immunoglobulin mu DNA binding protein 2
Synonyms: Catf1, AEP, sma, Smbp2, Smubp2, p110 subunit, RIPE3b1, Smbp-2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20589
HGNC: HGNC:5542
Homologene: 1642
Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Synonyms: PERK
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13666
HGNC: HGNC:3255
Homologene: 3557
Cyp20a1
Name: cytochrome P450, family 20, subfamily a, polypeptide 1
Synonyms: A930011N14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77951
Homologene: 18584
Ppp1r12b
Name: protein phosphatase 1, regulatory subunit 12B
Synonyms: 1810037O03Rik, 9530009M10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329251
HGNC: HGNC:7619
Homologene: 135710
Dock2
Name: dedicator of cyto-kinesis 2
Synonyms: MBC, CED-5, Hch
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94176
HGNC: HGNC:2988
Homologene: 37984
Peg10
Name: paternally expressed 10
Synonyms: MEF3L, HB-1, MyEF-3, MyEF-3 like, Edr, Mart2, Mar2, Rtl2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170676
Homologene: 116067
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, nmf112, nmf181, nmf252, bob, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Pou4f2
Name: POU domain, class 4, transcription factor 2
Synonyms: Brn-3.2, Brn-3b, mBrn3-3R, Brn3b, Pou4f-rs1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18997
HGNC: HGNC:9219
Homologene: 20959
Piezo2
Name: piezo-type mechanosensitive ion channel component 2
Synonyms: 9430028L06Rik, 9030411M15Rik, Fam38b2, Piezo2, Fam38b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 667742
Homologene: 49695
Acad10
Name: acyl-Coenzyme A dehydrogenase family, member 10
Synonyms: 2410021P16Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71985
Homologene: 49825
Lrrc37a
Name: leucine rich repeat containing 37A
Synonyms: LOC237954
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237954
Homologene: 138824
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: lrd, b2b598Clo, b2b1289Clo, b2b1727Clo, b2b1203Clo, b2b1279Clo, Dnahc11, avc4
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Izumo2
Name: IZUMO family member 2
Synonyms: 1700023D19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75510
Col7a1
Name: collagen, type VII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12836
HGNC: HGNC:2214
Homologene: 73
Tgfbi
Name: transforming growth factor, beta induced
Synonyms: bIG-h3, 68kDa, Beta-ig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21810
VEGA: 13
Homologene: 37294
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Man2c1
Name: mannosidase, alpha, class 2C, member 1
Synonyms: 1110025H24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73744
HGNC: HGNC:6827
Homologene: 4887
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Cma1
Name: chymase 1, mast cell
Synonyms: MMCP-5, Mcp-5, Mcpt5, Mcp5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17228
VEGA: 14
HGNC: HGNC:2097
Homologene: 55606
Ankrd65
Name: ankyrin repeat domain 65
Synonyms: E230028L10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242805
Homologene: 28427
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Adamts9
Name: ADAM metallopeptidase with thrombospondin type 1 motif 9
Synonyms: 1810011L16Rik, E030027K14Rik, 8430403M15Rik, Mhdaund4, Gsfund3, UND3, Mhdaund3, UND4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101401
Homologene: 18821
Rsph4a
Name: radial spoke head 4 homolog A (Chlamydomonas)
Synonyms: Rshl3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 212892
Homologene: 71779
Atp9a
Name: ATPase, class II, type 9A
Synonyms: Class II, IIa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11981
Homologene: 69194
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: LOC381738, Gm1060, b2b1654Clo, Ccdc164
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381738
Homologene: 35977
Mrpl22
Name: mitochondrial ribosomal protein L22
Synonyms: MRP-L25, Rpml25, HSPC158, E030011D16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216767
Homologene: 56664
Ap1g2
Name: adaptor protein complex AP-1, gamma 2 subunit
Synonyms: gamma 2-adaptin, Adtg2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 11766
HGNC: HGNC:556
Homologene: 49141
Vmn1r80
Name: vomeronasal 1 receptor 80
Synonyms: V1rg3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171238
Prdm13
Name: PR domain containing 13
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230025
Homologene: 11000
Mmp28
Name: matrix metallopeptidase 28 (epilysin)
Synonyms: epilysin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 118453
Homologene: 41559
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Drgx
Name: dorsal root ganglia homeobox
Synonyms: Drg11, Prrxl1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 107751
Tprn
Name: taperin
Synonyms: C430004E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 97031
Homologene: 52156
Kctd20
Name: potassium channel tetramerisation domain containing 20
Synonyms: D17Ertd562e, 2410004N11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66989
Homologene: 12063
Paqr6
Name: progestin and adipoQ receptor family member VI
Synonyms: 1500001B10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68957
Homologene: 19746
Cacng1
Name: calcium channel, voltage-dependent, gamma subunit 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12299
HGNC: HGNC:1405
Homologene: 582
Hexim2
Name: hexamethylene bis-acetamide inducible 2
Synonyms: 4933402L21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71059
Homologene: 16946
Kcnj15
Name: potassium inwardly-rectifying channel, subfamily J, member 15
Synonyms: IRKK, Kir4.2, 4930414N08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16516
HGNC: HGNC:6261
Homologene: 1690
Or8g50
Name: olfactory receptor family 8 subfamily G member 50
Synonyms: M93, MOR171-18, GA_x6K02T2PVTD-33434302-33435240, Olfr150
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258602
VEGA: 9
Fam114a1
Name: family with sequence similarity 114, member A1
Synonyms: 1190001N04Rik, 9130005N14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68303
Homologene: 12259
Abra
Name: actin-binding Rho activating protein
Synonyms: C130068O12Rik, STARS
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223513
VEGA: 15
Homologene: 34713
Amot
Name: angiomotin
Synonyms: D0Kist1, E230009N18Rik, Sii6
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 27494
Homologene: 15778
Hsd17b1
Name: hydroxysteroid (17-beta) dehydrogenase 1
Synonyms: 17beta-HSD, Hsd17ba
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15485
HGNC: HGNC:5210
Homologene: 37303
Or6e1
Name: olfactory receptor family 6 subfamily E member 1
Synonyms: IC6, GA_x6K02T2QVSB-39745261-39746202, MOR118-1, Olfr49
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18348
Homologene: 106373
Eid3
Name: EP300 interacting inhibitor of differentiation 3
Synonyms: 1700027M21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66341
Homologene: 81651
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 60,376,184 bp
  • A to T, chromosome 1 at 134,873,987 bp
  • A to G, chromosome 2 at 25,262,787 bp
  • A to G, chromosome 2 at 168,643,860 bp
  • C to T, chromosome 3 at 86,083,611 bp
  • A to G, chromosome 3 at 88,365,759 bp
  • C to G, chromosome 4 at 21,679,659 bp
  • A to T, chromosome 4 at 48,398,149 bp
  • A to T, chromosome 4 at 72,124,995 bp
  • A to G, chromosome 4 at 155,791,343 bp
  • A to C, chromosome 5 at 25,281,311 bp
  • A to G, chromosome 5 at 30,356,450 bp
  • A to C, chromosome 5 at 65,034,370 bp
  • T to A, chromosome 5 at 121,629,918 bp
  • GC to GCTCC, chromosome 6 at 4,756,452 bp
  • A to G, chromosome 6 at 40,768,212 bp
  • A to C, chromosome 6 at 47,554,200 bp
  • T to G, chromosome 6 at 70,858,435 bp
  • T to C, chromosome 6 at 92,872,400 bp
  • A to T, chromosome 7 at 12,193,197 bp
  • C to A, chromosome 7 at 21,427,329 bp
  • A to T, chromosome 7 at 27,442,419 bp
  • A to G, chromosome 7 at 44,719,760 bp
  • T to C, chromosome 8 at 78,436,119 bp
  • C to T, chromosome 9 at 39,737,220 bp
  • C to T, chromosome 9 at 57,137,033 bp
  • T to C, chromosome 9 at 86,798,619 bp
  • G to A, chromosome 9 at 108,978,885 bp
  • C to A, chromosome 10 at 28,782,237 bp
  • C to T, chromosome 10 at 33,909,442 bp
  • T to C, chromosome 10 at 60,326,031 bp
  • A to C, chromosome 10 at 78,059,684 bp
  • C to T, chromosome 10 at 82,867,482 bp
  • A to T, chromosome 11 at 34,698,843 bp
  • A to C, chromosome 11 at 51,601,883 bp
  • T to C, chromosome 11 at 58,179,359 bp
  • A to T, chromosome 11 at 59,061,503 bp
  • A to C, chromosome 11 at 67,984,645 bp
  • A to G, chromosome 11 at 83,444,835 bp
  • A to G, chromosome 11 at 100,516,831 bp
  • A to G, chromosome 11 at 101,079,006 bp
  • G to A, chromosome 11 at 103,138,996 bp
  • A to G, chromosome 11 at 103,502,314 bp
  • A to G, chromosome 11 at 104,909,882 bp
  • A to G, chromosome 11 at 107,716,234 bp
  • C to A, chromosome 12 at 112,601,531 bp
  • A to T, chromosome 12 at 117,931,183 bp
  • A to T, chromosome 13 at 56,625,713 bp
  • G to A, chromosome 13 at 98,755,099 bp
  • C to T, chromosome 14 at 32,608,382 bp
  • T to C, chromosome 14 at 54,282,872 bp
  • T to C, chromosome 14 at 55,099,124 bp
  • T to C, chromosome 14 at 55,943,732 bp
  • T to C, chromosome 14 at 70,310,238 bp
  • T to A, chromosome 15 at 41,869,116 bp
  • T to G, chromosome 15 at 85,393,356 bp
  • T to C, chromosome 16 at 95,296,622 bp
  • A to G, chromosome 17 at 28,966,892 bp
  • T to C, chromosome 18 at 63,045,479 bp
  • T to C, chromosome 19 at 3,265,641 bp
  • A to T, chromosome X at 145,461,749 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9171 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068976-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.