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Strain Name:
C57BL/6J-MtgxR9188Btlr/Mmmh
Stock Number:
068980-MU
Citation ID:
RRID:MMRRC_068980-MU
Other Names:
R9188 (G1)
Major Collection:

Strain Information

Lrig3
Name: leucine-rich repeats and immunoglobulin-like domains 3
Synonyms: 9030421L11Rik, 9130004I02Rik, 9430095K15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320398
VEGA: 10
Homologene: 62452
Etv4
Name: ets variant 4
Synonyms: Pea-3, Pea3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18612
HGNC: HGNC:3493
Homologene: 1504
Jak2
Name: Janus kinase 2
Synonyms: C81284
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16452
VEGA: 19
HGNC: HGNC:6192
Homologene: 21033
Zbtb32
Name: zinc finger and BTB domain containing 32
Synonyms: Tzfp, 4930524C15Rik, PLZP, Rog
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 58206
Homologene: 8661
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Prmt7
Name: protein arginine N-methyltransferase 7
Synonyms: 4933402B05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 214572
Homologene: 10382
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 18,122,766 bp
  • A to G, chromosome 1 at 59,484,638 bp
  • A to G, chromosome 1 at 132,515,538 bp
  • C to T, chromosome 1 at 133,292,433 bp
  • G to T, chromosome 1 at 152,519,171 bp
  • A to T, chromosome 2 at 76,903,124 bp
  • A to G, chromosome 2 at 104,608,878 bp
  • T to C, chromosome 2 at 114,050,498 bp
  • G to T, chromosome 2 at 118,880,461 bp
  • C to T, chromosome 2 at 120,402,763 bp
  • C to A, chromosome 3 at 10,420,775 bp
  • T to C, chromosome 3 at 63,731,654 bp
  • A to T, chromosome 3 at 98,852,900 bp
  • T to C, chromosome 4 at 3,585,693 bp
  • T to C, chromosome 4 at 103,082,135 bp
  • T to C, chromosome 4 at 106,709,592 bp
  • T to A, chromosome 4 at 135,698,860 bp
  • G to T, chromosome 4 at 141,019,840 bp
  • T to A, chromosome 4 at 148,558,560 bp
  • C to T, chromosome 5 at 30,376,751 bp
  • C to A, chromosome 5 at 87,843,135 bp
  • G to T, chromosome 5 at 108,774,945 bp
  • G to A, chromosome 5 at 110,252,744 bp
  • A to T, chromosome 5 at 123,445,579 bp
  • T to C, chromosome 5 at 135,765,818 bp
  • T to C, chromosome 5 at 142,575,202 bp
  • G to T, chromosome 6 at 83,162,248 bp
  • A to T, chromosome 6 at 129,831,560 bp
  • T to C, chromosome 6 at 136,723,758 bp
  • A to C, chromosome 6 at 139,622,403 bp
  • T to C, chromosome 6 at 148,865,924 bp
  • A to G, chromosome 7 at 19,719,194 bp
  • C to T, chromosome 7 at 30,591,895 bp
  • C to T, chromosome 7 at 43,190,344 bp
  • T to C, chromosome 7 at 43,885,373 bp
  • A to T, chromosome 7 at 96,772,027 bp
  • T to A, chromosome 7 at 102,887,389 bp
  • A to T, chromosome 8 at 45,245,699 bp
  • G to T, chromosome 8 at 61,361,773 bp
  • T to A, chromosome 8 at 66,456,151 bp
  • T to C, chromosome 8 at 91,305,010 bp
  • A to G, chromosome 8 at 106,234,854 bp
  • A to G, chromosome 9 at 7,579,791 bp
  • T to C, chromosome 9 at 77,455,205 bp
  • T to C, chromosome 9 at 79,602,332 bp
  • A to G, chromosome 10 at 51,718,167 bp
  • A to T, chromosome 10 at 60,773,771 bp
  • T to C, chromosome 10 at 81,507,964 bp
  • A to G, chromosome 10 at 126,003,066 bp
  • A to G, chromosome 11 at 21,660,025 bp
  • A to G, chromosome 11 at 33,567,252 bp
  • G to T, chromosome 11 at 60,358,789 bp
  • A to G, chromosome 11 at 81,151,912 bp
  • T to A, chromosome 11 at 85,345,921 bp
  • A to C, chromosome 11 at 86,737,166 bp
  • A to G, chromosome 11 at 97,500,157 bp
  • T to C, chromosome 11 at 99,591,061 bp
  • A to G, chromosome 11 at 101,775,376 bp
  • A to T, chromosome 11 at 109,981,735 bp
  • A to T, chromosome 12 at 55,490,473 bp
  • A to G, chromosome 13 at 33,202,860 bp
  • G to T, chromosome 13 at 67,182,121 bp
  • T to C, chromosome 14 at 49,894,909 bp
  • G to A, chromosome 15 at 82,182,156 bp
  • A to G, chromosome 15 at 102,522,511 bp
  • G to A, chromosome 16 at 85,802,683 bp
  • A to G, chromosome 16 at 96,154,163 bp
  • T to C, chromosome 17 at 35,265,802 bp
  • G to T, chromosome 17 at 35,821,887 bp
  • G to A, chromosome 18 at 32,080,160 bp
  • A to G, chromosome 18 at 37,423,135 bp
  • A to T, chromosome 19 at 8,887,033 bp
  • A to C, chromosome 19 at 29,310,953 bp
  • G to A, chromosome X at 170,677,850 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9188 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
068980-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.