Strain Name:
C57BL/6J-MtgxR9121Btlr/Mmmh
Stock Number:
069006-MU
Citation ID:
RRID:MMRRC_069006-MU
Other Names:
R9121 (G1)
Major Collection:

Strain Information

Mbd5
Name: methyl-CpG binding domain protein 5
Synonyms: 9430004D19Rik, OTTMUSG00000012483, C030040A15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109241
Homologene: 81861
Epb41l1
Name: erythrocyte membrane protein band 4.1 like 1
Synonyms: 4.1N, Epb4.1l1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13821
HGNC: HGNC:3378
Homologene: 8126
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Gpi1
Name: glucose-6-phosphate isomerase 1
Synonyms: Gpi-1s, Gpi-1t, Gpi-1, autocrine motility factor, AMF, NK, Gpi1-t, maturation factor, Org, neuroleukin, NK/GPI, Gpi-1r, MF, Gpi1-s, Gpi1-r
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14751
HGNC: HGNC:4458
Homologene: 145
Idh3a
Name: isocitrate dehydrogenase 3 (NAD+) alpha
Synonyms: 1500012E04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67834
VEGA: 9
HGNC: HGNC:5384
Homologene: 4037
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Cap1
Name: cyclase associated actin cytoskeleton regulatory protein 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12331
Homologene: 74572
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Tacc1
Name: transforming, acidic coiled-coil containing protein 1
Synonyms: 4833447E04Rik, Tacc1, B230378H13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320165
Homologene: 4575
Mcm2
Name: minichromosome maintenance complex component 2
Synonyms: Mcmd2, BM28, CDCL1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17216
HGNC: HGNC:6944
Homologene: 3325
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70427
Homologene: 18941
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Sfrp5
Name: secreted frizzled-related sequence protein 5
Synonyms: SARP3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 54612
Homologene: 2268
D5Ertd579e
Name: DNA segment, Chr 5, ERATO Doi 579, expressed
Synonyms: 9030221A05Rik, A930018H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320661
Homologene: 19716
Edrf1
Name: erythroid differentiation regulatory factor 1
Synonyms: 2700050L05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214764
Homologene: 27985
Usp54
Name: ubiquitin specific peptidase 54
Synonyms: 4930429G18Rik, C030002J06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 78787
Homologene: 90902
Cnnm3
Name: cyclin M3
Synonyms: Acdp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 94218
HGNC: HGNC:104
Homologene: 23029
Slc44a3
Name: solute carrier family 44, member 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213603
Homologene: 64830
Clvs2
Name: clavesin 2
Synonyms: Rlbp1l2, A330019N05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215890
Homologene: 27894
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Slco1a1
Name: solute carrier organic anion transporter family, member 1a1
Synonyms: Oatp1, Oatp1a1, Slc21a1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28248
Homologene: 137261
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Unc79
Name: unc-79 homolog
Synonyms: 9030205A07Rik, Mlca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217843
Homologene: 41397
Trpm8
Name: transient receptor potential cation channel, subfamily M, member 8
Synonyms: CMR1, TRPP8, Trp-p8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 171382
Homologene: 23433
Fbxw10
Name: F-box and WD-40 domain protein 10
Synonyms: SM2SH2, SM25H2, Fbw10
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213980
Homologene: 32757
Trim7
Name: tripartite motif-containing 7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94089
Homologene: 14113
Qrich2
Name: glutamine rich 2
Synonyms: LOC217341
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217341
Homologene: 12951
Ampd1
Name: adenosine monophosphate deaminase 1
Synonyms: Ampd-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229665
HGNC: HGNC:468
Homologene: 20
Pla2g4c
Name: phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms: CPLA2-gamma
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232889
HGNC: HGNC:9037
Homologene: 115256
Obsl1
Name: obscurin-like 1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98733
Qrfpr
Name: pyroglutamylated RFamide peptide receptor
Synonyms: AQ27, Gpr103
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229214
Homologene: 18865
Hook3
Name: hook microtubule tethering protein 3
Synonyms: 5830454D03Rik, E330005F07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320191
Homologene: 13022
Fbxw19
Name: F-box and WD-40 domain protein 19
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235612
Homologene: 110776
Cdh10
Name: cadherin 10
Synonyms: C030011H18Rik, A830016G23Rik, C030003B10Rik, T2-cadherin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 320873
HGNC: HGNC:1749
Homologene: 68530
Or5w14
Name: olfactory receptor family 5 subfamily W member 14
Synonyms: MOR40-9P, MOR177-20, Olfr1137, GA_x6K02T2Q125-49215724-49214792
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258101
Homologene: 79380
Dctpp1
Name: dCTP pyrophosphatase 1
Synonyms: 2410015N17Rik, RS21-C6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 66422
Homologene: 11329
Iglc2
Name: immunoglobulin lambda constant 2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110786
Crtc3
Name: CREB regulated transcription coactivator 3
Synonyms: 2610312F20Rik, 6332415K15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70461
Homologene: 11248
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Mettl15
Name: methyltransferase like 15
Synonyms: Mett5d1, 0610027B03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76894
Homologene: 12661
Or8b55
Name: olfactory receptor family 8 subfamily B member 55
Synonyms: GA_x6K02T2PVTD-32518237-32519172, MOR161-3, Olfr922
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258777
VEGA: 9
Homologene: 27262
Rnaset2a
Name: ribonuclease T2A
Synonyms: Rnaset2, 0610007O07Rik, RNASE6PL, 4930532K22Rik, 4833423A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100037283
VEGA: 17
Homologene: 31190
E030025P04Rik
Name: RIKEN cDNA E030025P04 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268498
Mlf1
Name: myeloid leukemia factor 1
Synonyms: HLS7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17349
HGNC: HGNC:7125
Homologene: 7839
Ighv1-56
Name: immunoglobulin heavy variable 1-56
Synonyms: Gm16791
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 382695
HGNC: HGNC:5553
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to A, chromosome 1 at 36,524,077 bp (GRCm38)
  • T to A, chromosome 1 at 46,665,490 bp (GRCm38)
  • C to A, chromosome 1 at 46,777,736 bp (GRCm38)
  • T to C, chromosome 1 at 75,505,992 bp (GRCm38)
  • T to A, chromosome 1 at 88,384,701 bp (GRCm38)
  • TCT to TCTGCT, chromosome 1 at 133,701,725 bp (GRCm38)
  • A to G, chromosome 2 at 49,258,090 bp (GRCm38)
  • T to A, chromosome 2 at 87,711,631 bp (GRCm38)
  • A to T, chromosome 2 at 109,274,603 bp (GRCm38)
  • T to G, chromosome 2 at 156,522,567 bp (GRCm38)
  • A to G, chromosome 3 at 36,181,007 bp (GRCm38)
  • T to C, chromosome 3 at 67,399,721 bp (GRCm38)
  • C to T, chromosome 3 at 103,098,682 bp (GRCm38)
  • A to G, chromosome 3 at 121,461,137 bp (GRCm38)
  • C to T, chromosome 4 at 122,867,723 bp (GRCm38)
  • T to C, chromosome 5 at 30,379,118 bp (GRCm38)
  • A to T, chromosome 5 at 36,615,434 bp (GRCm38)
  • G to A, chromosome 5 at 62,748,983 bp (GRCm38)
  • C to A, chromosome 6 at 88,884,037 bp (GRCm38)
  • C to A, chromosome 6 at 141,946,816 bp (GRCm38)
  • A to G, chromosome 7 at 13,357,085 bp (GRCm38)
  • A to T, chromosome 7 at 34,207,689 bp (GRCm38)
  • A to G, chromosome 7 at 80,592,575 bp (GRCm38)
  • T to C, chromosome 7 at 127,257,284 bp (GRCm38)
  • CGG to CG, chromosome 7 at 133,657,041 bp (GRCm38)
  • G to T, chromosome 8 at 25,169,239 bp (GRCm38)
  • A to G, chromosome 8 at 26,035,167 bp (GRCm38)
  • T to A, chromosome 9 at 38,815,680 bp (GRCm38)
  • T to C, chromosome 9 at 54,586,545 bp (GRCm38)
  • G to A, chromosome 9 at 109,495,822 bp (GRCm38)
  • A to T, chromosome 10 at 33,513,335 bp (GRCm38)
  • G to A, chromosome 10 at 79,541,760 bp (GRCm38)
  • T to A, chromosome 11 at 48,849,847 bp (GRCm38)
  • T to A, chromosome 11 at 62,847,327 bp (GRCm38)
  • T to A, chromosome 11 at 72,866,120 bp (GRCm38)
  • A to G, chromosome 11 at 109,143,912 bp (GRCm38)
  • T to A, chromosome 11 at 116,456,446 bp (GRCm38)
  • C to T, chromosome 12 at 103,001,836 bp (GRCm38)
  • T to A, chromosome 12 at 115,243,014 bp (GRCm38)
  • A to T, chromosome 13 at 68,671,959 bp (GRCm38)
  • A to G, chromosome 14 at 20,581,455 bp (GRCm38)
  • G to A, chromosome 15 at 19,010,988 bp (GRCm38)
  • T to C, chromosome 15 at 47,820,378 bp (GRCm38)
  • A to C, chromosome 16 at 19,198,544 bp (GRCm38)
  • A to T, chromosome 17 at 5,990,324 bp (GRCm38)
  • A to G, chromosome 17 at 8,128,717 bp (GRCm38)
  • T to C, chromosome 19 at 42,201,917 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9121 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069006-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.