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Strain Name:
C57BL/6J-MtgxR9124Btlr/Mmmh
Stock Number:
069008-MU
Citation ID:
RRID:MMRRC_069008-MU
Other Names:
R9124 (G1)
Major Collection:

Strain Information

Tgfb1
Name: transforming growth factor, beta 1
Synonyms: TGF-beta 1, Tgfb-1, Tgfb, TGFbeta1, TGF-beta1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 21803
Homologene: 540
Sncg
Name: synuclein, gamma
Synonyms: persyn, C79089
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20618
Homologene: 2322
Plk3
Name: polo like kinase 3
Synonyms: Cnk
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12795
HGNC: HGNC:2154
Homologene: 20865
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: TRPC2b, TRPC2a, mTrp2, trp2, Trrp2, 3010009O07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22064
Homologene: 135989
Slit1
Name: slit guidance ligand 1
Synonyms: Slil1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20562
Homologene: 2302
Cr1l
Name: complement C3b/C4b receptor 1 like
Synonyms: mCRY, Crry
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12946
Homologene: 128275
Arhgap39
Name: Rho GTPase activating protein 39
Synonyms: D15Wsu169e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223666
Homologene: 27825
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 34,440,047 bp (GRCm38)
  • A to G, chromosome 1 at 74,347,443 bp (GRCm38)
  • C to T, chromosome 1 at 173,751,627 bp (GRCm38)
  • T to C, chromosome 1 at 174,089,775 bp (GRCm38)
  • A to G, chromosome 1 at 195,117,617 bp (GRCm38)
  • A to T, chromosome 2 at 82,985,759 bp (GRCm38)
  • A to G, chromosome 2 at 120,394,360 bp (GRCm38)
  • A to G, chromosome 2 at 129,209,222 bp (GRCm38)
  • T to A, chromosome 2 at 144,603,878 bp (GRCm38)
  • C to A, chromosome 2 at 157,297,538 bp (GRCm38)
  • C to G, chromosome 2 at 173,155,225 bp (GRCm38)
  • T to C, chromosome 3 at 18,055,178 bp (GRCm38)
  • C to T, chromosome 3 at 89,521,229 bp (GRCm38)
  • C to A, chromosome 4 at 43,681,982 bp (GRCm38)
  • C to A, chromosome 4 at 68,829,345 bp (GRCm38)
  • ACACTCAC to ACAC, chromosome 4 at 117,131,893 bp (GRCm38)
  • A to G, chromosome 4 at 129,465,275 bp (GRCm38)
  • T to C, chromosome 5 at 4,061,284 bp (GRCm38)
  • C to A, chromosome 5 at 33,215,591 bp (GRCm38)
  • T to C, chromosome 5 at 34,634,596 bp (GRCm38)
  • A to G, chromosome 5 at 92,964,542 bp (GRCm38)
  • A to C, chromosome 5 at 120,774,105 bp (GRCm38)
  • T to C, chromosome 5 at 138,276,522 bp (GRCm38)
  • T to G, chromosome 5 at 139,245,366 bp (GRCm38)
  • C to A, chromosome 6 at 73,121,899 bp (GRCm38)
  • A to C, chromosome 6 at 90,409,348 bp (GRCm38)
  • T to A, chromosome 6 at 98,341,938 bp (GRCm38)
  • A to T, chromosome 6 at 116,540,455 bp (GRCm38)
  • T to C, chromosome 6 at 123,742,079 bp (GRCm38)
  • A to G, chromosome 6 at 128,424,807 bp (GRCm38)
  • A to G, chromosome 6 at 141,723,104 bp (GRCm38)
  • A to G, chromosome 7 at 4,811,511 bp (GRCm38)
  • A to T, chromosome 7 at 20,167,584 bp (GRCm38)
  • A to T, chromosome 7 at 23,320,978 bp (GRCm38)
  • A to T, chromosome 7 at 25,689,155 bp (GRCm38)
  • T to C, chromosome 7 at 30,873,237 bp (GRCm38)
  • C to T, chromosome 7 at 45,708,394 bp (GRCm38)
  • A to G, chromosome 7 at 56,184,308 bp (GRCm38)
  • T to A, chromosome 7 at 72,259,430 bp (GRCm38)
  • C to T, chromosome 7 at 80,257,003 bp (GRCm38)
  • A to G, chromosome 7 at 102,095,883 bp (GRCm38)
  • A to T, chromosome 7 at 103,603,656 bp (GRCm38)
  • G to T, chromosome 7 at 127,560,702 bp (GRCm38)
  • T to A, chromosome 7 at 140,504,309 bp (GRCm38)
  • T to C, chromosome 7 at 141,809,792 bp (GRCm38)
  • A to G, chromosome 8 at 10,006,966 bp (GRCm38)
  • A to G, chromosome 8 at 15,984,806 bp (GRCm38)
  • T to A, chromosome 8 at 25,570,169 bp (GRCm38)
  • T to A, chromosome 8 at 44,950,326 bp (GRCm38)
  • T to A, chromosome 8 at 45,025,027 bp (GRCm38)
  • T to A, chromosome 8 at 75,124,790 bp (GRCm38)
  • G to A, chromosome 8 at 121,605,230 bp (GRCm38)
  • A to G, chromosome 9 at 58,651,215 bp (GRCm38)
  • T to A, chromosome 9 at 75,625,793 bp (GRCm38)
  • G to A, chromosome 9 at 80,288,071 bp (GRCm38)
  • G to A, chromosome 9 at 95,464,415 bp (GRCm38)
  • A to G, chromosome 10 at 58,492,897 bp (GRCm38)
  • T to A, chromosome 10 at 59,750,513 bp (GRCm38)
  • A to G, chromosome 10 at 82,379,041 bp (GRCm38)
  • T to A, chromosome 10 at 121,296,811 bp (GRCm38)
  • C to T, chromosome 10 at 121,750,511 bp (GRCm38)
  • A to G, chromosome 10 at 127,519,692 bp (GRCm38)
  • C to T, chromosome 11 at 46,469,561 bp (GRCm38)
  • T to C, chromosome 11 at 51,234,654 bp (GRCm38)
  • A to T, chromosome 11 at 60,479,126 bp (GRCm38)
  • T to G, chromosome 11 at 69,369,336 bp (GRCm38)
  • T to C, chromosome 11 at 69,794,231 bp (GRCm38)
  • T to C, chromosome 11 at 70,540,870 bp (GRCm38)
  • C to A, chromosome 11 at 77,504,672 bp (GRCm38)
  • A to T, chromosome 11 at 99,492,929 bp (GRCm38)
  • T to C, chromosome 11 at 103,618,895 bp (GRCm38)
  • G to A, chromosome 11 at 109,937,767 bp (GRCm38)
  • A to T, chromosome 11 at 110,298,179 bp (GRCm38)
  • A to T, chromosome 12 at 55,735,096 bp (GRCm38)
  • C to A, chromosome 12 at 98,254,164 bp (GRCm38)
  • T to A, chromosome 13 at 38,193,300 bp (GRCm38)
  • T to C, chromosome 13 at 48,491,081 bp (GRCm38)
  • T to C, chromosome 13 at 67,671,338 bp (GRCm38)
  • A to T, chromosome 13 at 93,147,652 bp (GRCm38)
  • A to G, chromosome 14 at 13,864,354 bp (GRCm38)
  • T to C, chromosome 14 at 34,373,683 bp (GRCm38)
  • A to T, chromosome 14 at 44,503,394 bp (GRCm38)
  • A to T, chromosome 15 at 12,136,671 bp (GRCm38)
  • G to T, chromosome 15 at 60,920,830 bp (GRCm38)
  • T to C, chromosome 15 at 75,973,619 bp (GRCm38)
  • G to A, chromosome 15 at 76,735,267 bp (GRCm38)
  • A to T, chromosome 15 at 98,720,982 bp (GRCm38)
  • A to G, chromosome 16 at 36,033,274 bp (GRCm38)
  • A to T, chromosome 16 at 90,938,625 bp (GRCm38)
  • A to G, chromosome 16 at 94,435,530 bp (GRCm38)
  • G to A, chromosome 17 at 25,937,259 bp (GRCm38)
  • A to T, chromosome 17 at 46,248,969 bp (GRCm38)
  • C to G, chromosome 18 at 49,939,572 bp (GRCm38)
  • C to T, chromosome 19 at 41,606,512 bp (GRCm38)
  • C to A, chromosome 19 at 42,607,660 bp (GRCm38)
  • T to C, chromosome 19 at 47,086,139 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9124 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069008-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.