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Strain Name:
C57BL/6J-MtgxR9159Btlr/Mmmh
Stock Number:
069020-MU
Citation ID:
RRID:MMRRC_069020-MU
Other Names:
R9159 (G1)
Major Collection:

Strain Information

Matr3
Name: matrin 3
Synonyms: D030046F20Rik, 2810017I02Rik, 1110061A14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17184
HGNC: HGNC:6912
Homologene: 7830
Il23a
Name: interleukin 23, alpha subunit p19
Synonyms: p19, IL-23, IL-23p19
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83430
VEGA: 10
Homologene: 12832
Nphs1
Name: nephrosis 1, nephrin
Synonyms: nephrin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54631
HGNC: HGNC:7908
Homologene: 20974
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 39,405,393 bp (GRCm38)
  • A to G, chromosome 1 at 82,943,066 bp (GRCm38)
  • A to G, chromosome 1 at 163,986,945 bp (GRCm38)
  • T to A, chromosome 2 at 23,173,046 bp (GRCm38)
  • C to T, chromosome 2 at 58,777,984 bp (GRCm38)
  • T to C, chromosome 2 at 109,093,099 bp (GRCm38)
  • T to G, chromosome 2 at 122,738,628 bp (GRCm38)
  • G to T, chromosome 3 at 5,399,252 bp (GRCm38)
  • C to T, chromosome 3 at 5,401,157 bp (GRCm38)
  • C to A, chromosome 3 at 36,165,753 bp (GRCm38)
  • T to A, chromosome 3 at 51,451,381 bp (GRCm38)
  • T to C, chromosome 3 at 89,995,820 bp (GRCm38)
  • A to T, chromosome 3 at 129,678,377 bp (GRCm38)
  • A to G, chromosome 4 at 58,785,320 bp (GRCm38)
  • T to C, chromosome 4 at 121,319,403 bp (GRCm38)
  • T to C, chromosome 4 at 124,854,018 bp (GRCm38)
  • C to T, chromosome 4 at 147,331,993 bp (GRCm38)
  • T to C, chromosome 4 at 148,579,459 bp (GRCm38)
  • T to C, chromosome 5 at 98,186,316 bp (GRCm38)
  • T to A, chromosome 5 at 103,842,265 bp (GRCm38)
  • T to C, chromosome 5 at 112,465,958 bp (GRCm38)
  • A to G, chromosome 5 at 114,132,105 bp (GRCm38)
  • T to A, chromosome 5 at 123,104,503 bp (GRCm38)
  • T to C, chromosome 5 at 146,231,739 bp (GRCm38)
  • T to A, chromosome 6 at 8,014,993 bp (GRCm38)
  • T to C, chromosome 6 at 41,626,140 bp (GRCm38)
  • A to G, chromosome 6 at 82,091,874 bp (GRCm38)
  • A to C, chromosome 6 at 91,482,309 bp (GRCm38)
  • A to G, chromosome 6 at 127,966,754 bp (GRCm38)
  • G to A, chromosome 7 at 26,267,120 bp (GRCm38)
  • T to A, chromosome 7 at 30,442,350 bp (GRCm38)
  • T to G, chromosome 7 at 30,465,601 bp (GRCm38)
  • T to A, chromosome 7 at 45,742,110 bp (GRCm38)
  • A to T, chromosome 7 at 85,872,723 bp (GRCm38)
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp (GRCm38)
  • G to A, chromosome 7 at 105,765,919 bp (GRCm38)
  • A to T, chromosome 7 at 107,968,317 bp (GRCm38)
  • T to C, chromosome 7 at 118,634,041 bp (GRCm38)
  • T to C, chromosome 7 at 122,990,205 bp (GRCm38)
  • T to C, chromosome 7 at 141,809,792 bp (GRCm38)
  • A to G, chromosome 8 at 3,924,245 bp (GRCm38)
  • T to C, chromosome 8 at 119,462,564 bp (GRCm38)
  • A to G, chromosome 9 at 8,972,318 bp (GRCm38)
  • A to G, chromosome 9 at 15,341,608 bp (GRCm38)
  • C to T, chromosome 9 at 46,212,241 bp (GRCm38)
  • T to A, chromosome 9 at 104,020,781 bp (GRCm38)
  • T to C, chromosome 9 at 110,545,317 bp (GRCm38)
  • A to G, chromosome 10 at 26,854,890 bp (GRCm38)
  • A to T, chromosome 10 at 61,661,005 bp (GRCm38)
  • T to A, chromosome 10 at 81,271,033 bp (GRCm38)
  • T to A, chromosome 10 at 82,109,072 bp (GRCm38)
  • G to A, chromosome 10 at 82,282,690 bp (GRCm38)
  • T to A, chromosome 10 at 128,297,558 bp (GRCm38)
  • A to G, chromosome 11 at 58,490,524 bp (GRCm38)
  • G to A, chromosome 11 at 69,615,604 bp (GRCm38)
  • T to C, chromosome 12 at 65,226,144 bp (GRCm38)
  • T to G, chromosome 12 at 78,964,674 bp (GRCm38)
  • G to A, chromosome 12 at 84,791,090 bp (GRCm38)
  • T to A, chromosome 12 at 113,136,405 bp (GRCm38)
  • T to C, chromosome 13 at 13,825,311 bp (GRCm38)
  • A to G, chromosome 13 at 47,242,872 bp (GRCm38)
  • A to G, chromosome 13 at 70,753,289 bp (GRCm38)
  • A to T, chromosome 13 at 114,877,762 bp (GRCm38)
  • A to T, chromosome 14 at 70,156,789 bp (GRCm38)
  • A to G, chromosome 15 at 75,597,981 bp (GRCm38)
  • A to G, chromosome 15 at 82,454,371 bp (GRCm38)
  • A to T, chromosome 16 at 18,621,325 bp (GRCm38)
  • G to A, chromosome 16 at 22,081,752 bp (GRCm38)
  • G to A, chromosome 16 at 36,217,699 bp (GRCm38)
  • A to G, chromosome 17 at 24,217,731 bp (GRCm38)
  • A to G, chromosome 17 at 42,662,402 bp (GRCm38)
  • T to A, chromosome 18 at 35,579,302 bp (GRCm38)
  • C to A, chromosome 18 at 53,464,947 bp (GRCm38)
  • T to A, chromosome 18 at 74,283,201 bp (GRCm38)
  • T to A, chromosome 18 at 76,262,502 bp (GRCm38)
  • T to A, chromosome 19 at 37,609,030 bp (GRCm38)
  • A to T, chromosome 19 at 39,773,873 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9159 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069020-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.