Strain Name:
C57BL/6J-MtgxR9186Btlr/Mmmh
Stock Number:
069034-MU
Citation ID:
RRID:MMRRC_069034-MU
Other Names:
R9186 (G1)
Major Collection:

Strain Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: ru2, Hermansky-Pudlak syndrome 5, ru-2, ruby eye 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 246694
Homologene: 35333
Utrn
Name: utrophin
Synonyms: G-utrophin, DRP, Dmdl
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Zdhhc17
Name: zinc finger, DHHC domain containing 17
Synonyms: Hip14, D130071N24Rik, A230053P19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 320150
VEGA: 10
Homologene: 56324
Colgalt2
Name: collagen beta(1-O)galactosyltransferase 2
Synonyms: Glt25d2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269132
Homologene: 22865
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: trp2, TRPC2a, mTrp2, Trrp2, TRPC2b, 3010009O07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22064
Homologene: 135989
Lgi3
Name: leucine-rich repeat LGI family, member 3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 213469
VEGA: 14
Homologene: 16406
Prtg
Name: protogenin
Synonyms: Igdcc5, A230098A12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235472
Homologene: 54453
Gk5
Name: glycerol kinase 5
Synonyms: G630067D24Rik, C330018K18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235533
Homologene: 15141
Polr1c
Name: polymerase (RNA) I polypeptide C
Synonyms: 40kDa, Rpo1-1, RPA40
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20016
Homologene: 3586
Glcci1
Name: glucocorticoid induced transcript 1
Synonyms: Tssn1, Fam117c, 2310047L21Rik, GIG18, A130036A18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 170772
Homologene: 15773
Myo18a
Name: myosin XVIIIA
Synonyms: MyoPDZ
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 360013
Homologene: 7977
Ankle2
Name: ankyrin repeat and LEM domain containing 2
Synonyms: 1110001J12Rik, D5Ertd585e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71782
Homologene: 35424
Vapa
Name: vesicle-associated membrane protein, associated protein A
Synonyms: VAP33, synaptobrevin-associated protein of 33kDa
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 30960
VEGA: 17
Homologene: 37824
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Wasl
Name: WASP like actin nucleation promoting factor
Synonyms: Wiskott-Aldrich syndrome-like (human), 2900021I12Rik, 3110031I02Rik, N-WASP
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 73178
Homologene: 135996
Esf1
Name: ESF1 nucleolar pre-rRNA processing protein homolog
Synonyms: 2610101J03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66580
Homologene: 5717
Orc5
Name: origin recognition complex, subunit 5
Synonyms: Orc5l, mouse origin recognition complex 5, MmORC5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26429
HGNC: HGNC:8491
Homologene: 37636
Arl10
Name: ADP-ribosylation factor-like 10
Synonyms: ARL10, Arm1, Arl10a
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56795
Homologene: 10550
Fubp1
Name: far upstream element (FUSE) binding protein 1
Synonyms: Fubp4, Fubp, 9530027K12Rik, FBP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51886
HGNC: HGNC:4004
Homologene: 48253
Sun2
Name: Sad1 and UNC84 domain containing 2
Synonyms: B230369L08Rik, Unc84b
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223697
Homologene: 9113
Zap70
Name: zeta-chain (TCR) associated protein kinase
Synonyms: TZK, ZAP-70, Srk
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22637
Homologene: 839
Rbl2
Name: RB transcriptional corepressor like 2
Synonyms: p130, retinoblastoma-like 2, Rb2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 19651
HGNC: HGNC:9894
Homologene: 4098
Cfap97
Name: cilia and flagella associated protein 97
Synonyms: 1110068E21Rik, 4933411K20Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66756
Homologene: 12026
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
Arid3b
Name: AT-rich interaction domain 3B
Synonyms: Bdp, Dri2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56380
Homologene: 4721
Szt2
Name: SZT2 subunit of KICSTOR complex
Synonyms: seaizure threshold 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230676
Homologene: 49413
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: nmf112, 4930542A03Rik, USH1D, sals, ahl, bob, mdfw, nmf252, nmf181
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Trmt2a
Name: TRM2 tRNA methyltransferase 2A
Synonyms: Htf9c
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15547
Homologene: 7374
Tsc2
Name: TSC complex subunit 2
Synonyms: tuberous sclerosis 2, tuberin, Nafld
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22084
VEGA: 17
Homologene: 462
Gstm4
Name: glutathione S-transferase, mu 4
Synonyms: Gstb-4, Gstb4, 1110004G14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14865
HGNC: HGNC:4636
Homologene: 37357
Tatdn2
Name: TatD DNase domain containing 2
Synonyms: mKIAA0218
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 381801
Homologene: 8848
Tmem86b
Name: transmembrane protein 86B
Synonyms: C330014O21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68255
Homologene: 52159
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
F5
Name: coagulation factor V
Synonyms: Cf-5, Cf5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Naip6
Name: NLR family, apoptosis inhibitory protein 6
Synonyms: Naip-rs4, Birc1f, Naip-rs4A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17952
HGNC: HGNC:7634
Homologene: 113589
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Gabrb2
Name: gamma-aminobutyric acid type A receptor subunit beta 2
Synonyms: C030021G16Rik, Gabrb-2, C030002O17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14401
HGNC: HGNC:4082
Homologene: 7327
Ucp1
Name: uncoupling protein 1 (mitochondrial, proton carrier)
Synonyms: Slc25a7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22227
Homologene: 22524
Ankhd1
Name: ankyrin repeat and KH domain containing 1
Synonyms: 9130019P20Rik, 4933432B13Rik, A530027J04Rik, 1110004O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108857
Homologene: 87006
Scamp1
Name: secretory carrier membrane protein 1
Synonyms: 4930505M11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 107767
Homologene: 37975
Plekha6
Name: pleckstrin homology domain containing, family A member 6
Synonyms: Pepp3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240753
Homologene: 135779
Mug2
Name: murinoglobulin 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17837
HGNC: HGNC:9750
Homologene: 136663
Tnrc18
Name: trinucleotide repeat containing 18
Synonyms: Zfp469, EG381742
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231861
Homologene: 45603
Hipk3
Name: homeodomain interacting protein kinase 3
Synonyms: DYRK6, FIST3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15259
HGNC: HGNC:4915
Homologene: 55923
Itgbl1
Name: integrin, beta-like 1
Synonyms: with EGF-like repeat domains, B930011D01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223272
HGNC: HGNC:6164
Homologene: 3519
Bag6
Name: BCL2-associated athanogene 6
Synonyms: Scythe, 2410045D21Rik, G3, D17H6S52E, Bat3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224727
Homologene: 3409
Iqub
Name: IQ motif and ubiquitin domain containing
Synonyms: Trs4, 4932408B21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 214704
Homologene: 44790
Hexb
Name: hexosaminidase B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15212
VEGA: 13
HGNC: HGNC:4879
Homologene: 437
Krtap26-1
Name: keratin associated protein 26-1
Synonyms: 2310002B14Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 69533
VEGA: 16
Homologene: 88911
Prr27
Name: proline rich 27
Synonyms: 4930432K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73779
Homologene: 136277
Dusp13b
Name: dual specificity phosphatase 13B
Synonyms: LOC382853, Dusp13, TS-DSP6, LMW-DSP6, TMDP
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 27389
Homologene: 121602
Or4f59
Name: olfactory receptor family 4 subfamily F member 59
Synonyms: GA_x6K02T2Q125-73090482-73089529, MOR245-20, Olfr1312
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258359
Homologene: 128122
Ccnl1
Name: cyclin L1
Synonyms: ania-6a, 2610030E23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56706
Homologene: 10541
Oxct2a
Name: 3-oxoacid CoA transferase 2A
Synonyms: Oxct2, Scot-t1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 64059
Homologene: 137359
Tbc1d30
Name: TBC1 domain family, member 30
Synonyms: 4930505D03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74694
VEGA: 10
Homologene: 18930
Cd164
Name: CD164 antigen
Synonyms: MGC-24, A24, A115
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 53599
HGNC: HGNC:1632
Homologene: 38129
Pgls
Name: 6-phosphogluconolactonase
Synonyms: 1110030K05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66171
HGNC: HGNC:8903
Homologene: 6037
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to A, chromosome 1 at 36,779,751 bp (GRCm38)
  • C to T, chromosome 1 at 133,292,433 bp (GRCm38)
  • C to A, chromosome 1 at 152,508,652 bp (GRCm38)
  • A to G, chromosome 1 at 164,193,901 bp (GRCm38)
  • T to C, chromosome 2 at 104,471,094 bp (GRCm38)
  • C to A, chromosome 2 at 112,042,750 bp (GRCm38)
  • T to A, chromosome 2 at 140,148,872 bp (GRCm38)
  • A to G, chromosome 2 at 181,234,664 bp (GRCm38)
  • T to C, chromosome 3 at 65,958,005 bp (GRCm38)
  • T to C, chromosome 3 at 108,044,733 bp (GRCm38)
  • A to T, chromosome 3 at 152,220,516 bp (GRCm38)
  • A to G, chromosome 4 at 118,385,091 bp (GRCm38)
  • C to A, chromosome 4 at 123,322,668 bp (GRCm38)
  • T to A, chromosome 5 at 22,547,946 bp (GRCm38)
  • C to A, chromosome 5 at 87,843,135 bp (GRCm38)
  • G to A, chromosome 5 at 110,252,744 bp (GRCm38)
  • C to A, chromosome 5 at 137,393,548 bp (GRCm38)
  • T to C, chromosome 5 at 142,787,733 bp (GRCm38)
  • C to A, chromosome 6 at 8,537,826 bp (GRCm38)
  • A to T, chromosome 6 at 24,450,767 bp (GRCm38)
  • T to C, chromosome 6 at 24,664,616 bp (GRCm38)
  • C to T, chromosome 6 at 113,710,164 bp (GRCm38)
  • T to A, chromosome 6 at 122,075,289 bp (GRCm38)
  • T to C, chromosome 7 at 4,629,726 bp (GRCm38)
  • T to A, chromosome 7 at 25,527,788 bp (GRCm38)
  • T to C, chromosome 7 at 46,788,946 bp (GRCm38)
  • T to C, chromosome 7 at 102,088,285 bp (GRCm38)
  • A to T, chromosome 8 at 35,815,475 bp (GRCm38)
  • C to T, chromosome 8 at 46,191,628 bp (GRCm38)
  • T to C, chromosome 8 at 71,596,189 bp (GRCm38)
  • G to T, chromosome 8 at 83,290,643 bp (GRCm38)
  • G to A, chromosome 8 at 91,101,378 bp (GRCm38)
  • C to A, chromosome 9 at 57,257,189 bp (GRCm38)
  • A to T, chromosome 9 at 57,794,934 bp (GRCm38)
  • T to C, chromosome 9 at 72,856,877 bp (GRCm38)
  • T to A, chromosome 9 at 96,133,416 bp (GRCm38)
  • T to C, chromosome 10 at 12,614,574 bp (GRCm38)
  • C to A, chromosome 10 at 41,528,699 bp (GRCm38)
  • G to A, chromosome 10 at 60,307,527 bp (GRCm38)
  • T to C, chromosome 10 at 110,944,420 bp (GRCm38)
  • T to C, chromosome 10 at 121,275,734 bp (GRCm38)
  • A to T, chromosome 11 at 42,487,373 bp (GRCm38)
  • C to T, chromosome 11 at 77,859,021 bp (GRCm38)
  • T to A, chromosome 12 at 118,190,897 bp (GRCm38)
  • T to A, chromosome 13 at 12,421,346 bp (GRCm38)
  • A to G, chromosome 13 at 54,578,807 bp (GRCm38)
  • T to A, chromosome 13 at 94,208,174 bp (GRCm38)
  • A to C, chromosome 13 at 97,189,328 bp (GRCm38)
  • T to C, chromosome 13 at 100,299,882 bp (GRCm38)
  • A to T, chromosome 14 at 21,748,495 bp (GRCm38)
  • A to G, chromosome 14 at 70,534,753 bp (GRCm38)
  • G to A, chromosome 14 at 123,857,558 bp (GRCm38)
  • T to A, chromosome 15 at 79,727,536 bp (GRCm38)
  • T to C, chromosome 16 at 18,251,169 bp (GRCm38)
  • C to A, chromosome 16 at 88,647,721 bp (GRCm38)
  • T to C, chromosome 17 at 24,604,888 bp (GRCm38)
  • C to T, chromosome 17 at 35,144,691 bp (GRCm38)
  • G to T, chromosome 17 at 46,245,707 bp (GRCm38)
  • A to T, chromosome 17 at 65,593,512 bp (GRCm38)
  • T to C, chromosome 18 at 36,634,330 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9186 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069034-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.