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Strain Name:
C57BL/6J-MtgxR9204Btlr/Mmmh
Stock Number:
069044-MU
Citation ID:
RRID:MMRRC_069044-MU
Other Names:
R9204 (G1)
Major Collection:

Strain Information

Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Synonyms: [b]2-nAchR, Acrb-2, Acrb2, C030030P04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11444
HGNC: HGNC:1962
Homologene: 595
Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Synonyms: 2610509C24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108147
HGNC: HGNC:794
Homologene: 2983
Ccdc88c
Name: coiled-coil domain containing 88C
Synonyms: Daple, 0610010D24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68339
VEGA: 12
Homologene: 18903
Gid4
Name: GID complex subunit 4, VID24 homolog
Synonyms: 4933439F18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66771
Homologene: 5971
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Tbc1d22a
Name: TBC1 domain family, member 22a
Synonyms: D15Ertd781e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223754
VEGA: 15
HGNC: HGNC:1309
Homologene: 105406
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 71,564,477 bp (GRCm38)
  • T to A, chromosome 1 at 150,734,511 bp (GRCm38)
  • T to A, chromosome 1 at 180,111,895 bp (GRCm38)
  • A to T, chromosome 2 at 20,881,005 bp (GRCm38)
  • A to G, chromosome 2 at 31,388,365 bp (GRCm38)
  • A to T, chromosome 2 at 33,228,330 bp (GRCm38)
  • T to G, chromosome 2 at 89,881,138 bp (GRCm38)
  • T to C, chromosome 3 at 89,760,821 bp (GRCm38)
  • T to C, chromosome 3 at 100,962,564 bp (GRCm38)
  • A to G, chromosome 3 at 104,480,122 bp (GRCm38)
  • G to T, chromosome 3 at 122,947,419 bp (GRCm38)
  • T to C, chromosome 4 at 24,581,153 bp (GRCm38)
  • C to G, chromosome 4 at 75,954,078 bp (GRCm38)
  • G to A, chromosome 5 at 96,735,163 bp (GRCm38)
  • T to A, chromosome 5 at 115,988,439 bp (GRCm38)
  • G to A, chromosome 5 at 130,269,224 bp (GRCm38)
  • A to T, chromosome 5 at 148,301,483 bp (GRCm38)
  • A to C, chromosome 6 at 29,452,354 bp (GRCm38)
  • T to G, chromosome 6 at 123,853,133 bp (GRCm38)
  • T to A, chromosome 7 at 90,452,818 bp (GRCm38)
  • A to G, chromosome 7 at 103,732,849 bp (GRCm38)
  • A to T, chromosome 7 at 108,124,728 bp (GRCm38)
  • T to C, chromosome 7 at 109,341,479 bp (GRCm38)
  • A to T, chromosome 7 at 121,899,299 bp (GRCm38)
  • T to A, chromosome 7 at 127,385,160 bp (GRCm38)
  • T to A, chromosome 7 at 141,856,392 bp (GRCm38)
  • T to C, chromosome 8 at 15,042,623 bp (GRCm38)
  • T to C, chromosome 8 at 60,543,532 bp (GRCm38)
  • T to C, chromosome 8 at 83,933,890 bp (GRCm38)
  • A to G, chromosome 8 at 122,576,616 bp (GRCm38)
  • T to C, chromosome 9 at 19,318,699 bp (GRCm38)
  • C to A, chromosome 9 at 37,919,374 bp (GRCm38)
  • A to G, chromosome 9 at 58,031,105 bp (GRCm38)
  • G to A, chromosome 9 at 61,961,544 bp (GRCm38)
  • A to G, chromosome 9 at 95,405,102 bp (GRCm38)
  • G to A, chromosome 9 at 104,042,106 bp (GRCm38)
  • C to T, chromosome 10 at 75,694,716 bp (GRCm38)
  • G to C, chromosome 10 at 130,180,697 bp (GRCm38)
  • A to G, chromosome 11 at 45,933,962 bp (GRCm38)
  • T to C, chromosome 11 at 60,417,828 bp (GRCm38)
  • A to G, chromosome 11 at 60,778,031 bp (GRCm38)
  • T to C, chromosome 12 at 100,938,063 bp (GRCm38)
  • T to A, chromosome 12 at 111,671,435 bp (GRCm38)
  • C to G, chromosome 13 at 73,268,530 bp (GRCm38)
  • A to T, chromosome 13 at 100,222,500 bp (GRCm38)
  • T to C, chromosome 15 at 80,001,755 bp (GRCm38)
  • T to C, chromosome 15 at 86,214,602 bp (GRCm38)
  • C to A, chromosome 16 at 44,487,714 bp (GRCm38)
  • T to A, chromosome 17 at 35,974,727 bp (GRCm38)
  • G to T, chromosome 17 at 75,363,430 bp (GRCm38)
  • G to T, chromosome 17 at 86,809,445 bp (GRCm38)
  • T to C, chromosome 18 at 68,407,596 bp (GRCm38)
  • A to G, chromosome 19 at 29,719,538 bp (GRCm38)
  • A to T, chromosome 19 at 39,739,127 bp (GRCm38)
  • G to A, chromosome 19 at 42,563,862 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9204 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069044-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.