Strain Name:
C57BL/6J-MtgxR9218Btlr/Mmmh
Stock Number:
069054-MU
Citation ID:
RRID:MMRRC_069054-MU
Other Names:
R9218 (G1)
Major Collection:

Strain Information

Slc6a12
Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Synonyms: Gabt2, BGT1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14411
Homologene: 128225
Odc1
Name: ornithine decarboxylase, structural 1
Synonyms: ODC
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18263
VEGA: 12
HGNC: HGNC:8109
Homologene: 1906
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Dock9
Name: dedicator of cytokinesis 9
Synonyms: B230309H04Rik, D14Wsu89e, Zizimin1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105445
Homologene: 41026
Tyw5
Name: tRNA-yW synthesizing protein 5
Synonyms: 1110034B05Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68736
Homologene: 72085
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: Zfp262, 6330503C17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Zfhx3
Name: zinc finger homeobox 3
Synonyms: Atbf1, WBP9, A230102L03Rik, Sci
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Tnpo2
Name: transportin 2 (importin 3, karyopherin beta 2b)
Synonyms: Kpnb2b, TRN2, 1110034O24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212999
Homologene: 8381
Ap3b1
Name: adaptor-related protein complex 3, beta 1 subunit
Synonyms: rim2, Hps2, recombination induced mutation 2, beta3A, AP-3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 11774
VEGA: 13
HGNC: HGNC:566
Homologene: 68125
Tut4
Name: terminal uridylyl transferase 4
Synonyms: Tent3a, 6030404K05Rik, 9230115F04Rik, Zcchc11
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230594
Homologene: 35279
Bltp3a
Name: bridge-like lipid transfer protein family member 3A
Synonyms: 1110020K19Rik, F830021D11Rik, Uhrf1bp1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224648
Homologene: 9816
4833420G17Rik
Name: RIKEN cDNA 4833420G17 gene
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67392
VEGA: 13
Homologene: 18889
Vamp2
Name: vesicle-associated membrane protein 2
Synonyms: sybII, Syb-2, synaptobrevin II, Syb2, synaptobrevin-2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22318
Homologene: 7591
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Alx4
Name: aristaless-like homeobox 4
Synonyms: Aristaless-like 4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11695
HGNC: HGNC:450
Homologene: 7229
Pms2
Name: PMS1 homolog2, mismatch repair system component
Synonyms: DNA mismatch repair, mismatch repair
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18861
Homologene: 133560
Iqcd
Name: IQ motif containing D
Synonyms: 4933433C09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75732
Homologene: 49921
Rab37
Name: RAB37, member RAS oncogene family
Synonyms: B230331O03Rik, B230354I04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 58222
Homologene: 23303
Smcr8
Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Synonyms: 2310076G09Rik, D030073L15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237782
Homologene: 16989
Siglece
Name: sialic acid binding Ig-like lectin E
Synonyms: mSiglec-E, Siglec5, Siglecl1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 83382
Homologene: 130669
Cdh6
Name: cadherin 6
Synonyms: K-cadherin, cad6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12563
VEGA: 15
HGNC: HGNC:1765
Homologene: 21027
Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
Synonyms: Noxa
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58801
VEGA: 18
HGNC: HGNC:9108
Homologene: 75166
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Psmd5
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
Synonyms: S5b, 1500032A03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66998
HGNC: HGNC:9563
Homologene: 37999
Abcb4
Name: ATP-binding cassette, sub-family B member 4
Synonyms: mdr-2, Mdr2, Pgy-2, Pgy2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18670
HGNC: HGNC:45
Homologene: 136368
Pkd1l3
Name: polycystic kidney disease 1 like 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244646
Homologene: 14627
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Plpp2
Name: phospholipid phosphatase 2
Synonyms: Ppap2c, Lpp2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50784
HGNC: HGNC:9230
Homologene: 2752
Cdcp3
Name: CUB domain containing protein 3
Synonyms: 5430419D17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71395
Homologene: 138430
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Fsip2
Name: fibrous sheath-interacting protein 2
Synonyms: OTTMUSG00000013335
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241516
Homologene: 110349
Hc
Name: hemolytic complement
Synonyms: C5a, C5, He, Hfib2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Tmem62
Name: transmembrane protein 62
Synonyms: B830009D23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 96957
Homologene: 11801
Hsd3b5
Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
Synonyms: 3(beta)HSDV
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15496
Homologene: 104115
Sema4f
Name: sema domain, immunoglobulin domain (Ig), TM domain, and short cytoplasmic domain
Synonyms: Sema W
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20355
Homologene: 3147
Dennd5a
Name: DENN domain containing 5A
Synonyms: ORF37, 1500012B19Rik, Rab6ip1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19347
Homologene: 14584
Pitpnm2
Name: phosphatidylinositol transfer protein, membrane-associated 2
Synonyms: Rdgb2, RDGBA2, NIR3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19679
Homologene: 7915
Abhd18
Name: abhydrolase domain containing 18
Synonyms: 3110057O12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269423
Homologene: 105457
Ctrb1
Name: chymotrypsinogen B1
Synonyms: Prt-2, 2200008D09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66473
Homologene: 88564
Vmn2r80
Name: vomeronasal 2, receptor 80
Synonyms: EG624765
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 624765
Homologene: 83483
Txlnb
Name: taxilin beta
Synonyms: 2310001N14Rik, Mdp77
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 378431
Homologene: 44534
Adamtsl4
Name: ADAMTS-like 4
Synonyms: Tsrc1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229595
Homologene: 23141
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Il18rap
Name: interleukin 18 receptor accessory protein
Synonyms: AcPL accessory protein-like)
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16174
HGNC: HGNC:5989
Homologene: 2859
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78771
Homologene: 75211
Or4e1
Name: olfactory receptor family 4 subfamily E member 1
Synonyms: GA_x6K02T2RJGY-520647-521579, MOR10, Olfr1508, MOR244-2, MOR244-4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 57270
HGNC: HGNC:8296
Homologene: 10737
Dmrt2
Name: doublesex and mab-3 related transcription factor 2
Synonyms: Terra
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226049
VEGA: 19
HGNC: HGNC:2935
Homologene: 17111
Kcnh1
Name: potassium voltage-gated channel, subfamily H (eag-related), member 1
Synonyms: Kv10.1, Eag1, ether a go-go
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16510
HGNC: HGNC:6250
Homologene: 68242
Stt3a
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Synonyms: Itm1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16430
HGNC: HGNC:6172
Homologene: 40617
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: EG629699, 2610204M08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Cts3
Name: cathepsin 3
Synonyms: 1600000I23Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 117066
VEGA: 13
Fxn
Name: frataxin
Synonyms: Frda
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14297
HGNC: HGNC:3951
Homologene: 47908
Iqck
Name: IQ motif containing K
Synonyms: A230094G09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434232
Homologene: 45162
Arsj
Name: arylsulfatase J
Synonyms: 9330196J05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271970
Homologene: 35257
Vps9d1
Name: VPS9 domain containing 1
Synonyms: 1300018I17Rik, 2410004N05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72325
Homologene: 21021
Dcst1
Name: DC-STAMP domain containing 1
Synonyms: A330106H01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77772
Homologene: 14981
Sh3tc2
Name: SH3 domain and tetratricopeptide repeats 2
Synonyms: D430044G18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225608
VEGA: 18
Homologene: 11596
Vmn1r220
Name: vomeronasal 1 receptor 220
Synonyms: V1rh12
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171271
Homologene: 110880
Sds
Name: serine dehydratase
Synonyms: SDH
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231691
Homologene: 38235
Cabp4
Name: calcium binding protein 4
Synonyms: 2410038D05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73660
VEGA: 19
HGNC: HGNC:1386
Homologene: 16927
Or51f23c-ps1
Name: olfactory receptor family 51 subfamily F member 23C, pseudogene 1
Synonyms: MOR14-5, Olfr562-ps1, GA_x6K02T2PBJ9-5498153-5499103
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259090
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 40,543,017 bp (GRCm38)
  • G to A, chromosome 1 at 57,396,789 bp (GRCm38)
  • A to T, chromosome 1 at 192,453,630 bp (GRCm38)
  • G to T, chromosome 2 at 34,857,782 bp (GRCm38)
  • A to G, chromosome 2 at 35,032,191 bp (GRCm38)
  • A to G, chromosome 2 at 52,293,626 bp (GRCm38)
  • C to T, chromosome 2 at 82,992,718 bp (GRCm38)
  • T to A, chromosome 2 at 93,642,827 bp (GRCm38)
  • A to G, chromosome 2 at 121,004,743 bp (GRCm38)
  • T to A, chromosome 2 at 142,699,663 bp (GRCm38)
  • T to C, chromosome 3 at 40,916,766 bp (GRCm38)
  • A to T, chromosome 3 at 89,365,105 bp (GRCm38)
  • A to T, chromosome 3 at 95,681,094 bp (GRCm38)
  • T to C, chromosome 3 at 98,619,038 bp (GRCm38)
  • A to C, chromosome 3 at 126,438,465 bp (GRCm38)
  • A to T, chromosome 4 at 108,512,886 bp (GRCm38)
  • A to T, chromosome 4 at 126,915,622 bp (GRCm38)
  • A to G, chromosome 5 at 8,927,960 bp (GRCm38)
  • T to A, chromosome 5 at 30,385,125 bp (GRCm38)
  • C to T, chromosome 5 at 120,483,612 bp (GRCm38)
  • C to T, chromosome 5 at 120,600,642 bp (GRCm38)
  • G to A, chromosome 5 at 124,127,281 bp (GRCm38)
  • G to A, chromosome 5 at 143,931,127 bp (GRCm38)
  • T to C, chromosome 5 at 144,217,231 bp (GRCm38)
  • A to G, chromosome 6 at 82,913,499 bp (GRCm38)
  • G to A, chromosome 6 at 121,358,664 bp (GRCm38)
  • C to T, chromosome 7 at 43,657,738 bp (GRCm38)
  • T to C, chromosome 7 at 102,782,166 bp (GRCm38)
  • G to A, chromosome 7 at 109,908,385 bp (GRCm38)
  • C to T, chromosome 7 at 118,941,679 bp (GRCm38)
  • C to T, chromosome 7 at 131,261,999 bp (GRCm38)
  • T to A, chromosome 7 at 141,807,361 bp (GRCm38)
  • C to A, chromosome 8 at 85,049,980 bp (GRCm38)
  • T to C, chromosome 8 at 108,793,869 bp (GRCm38)
  • C to A, chromosome 8 at 109,655,496 bp (GRCm38)
  • C to T, chromosome 8 at 111,689,508 bp (GRCm38)
  • G to A, chromosome 8 at 123,250,935 bp (GRCm38)
  • A to G, chromosome 9 at 36,759,260 bp (GRCm38)
  • C to T, chromosome 10 at 17,842,822 bp (GRCm38)
  • A to G, chromosome 10 at 79,194,436 bp (GRCm38)
  • A to G, chromosome 10 at 79,530,667 bp (GRCm38)
  • A to T, chromosome 11 at 60,779,879 bp (GRCm38)
  • A to G, chromosome 11 at 69,089,759 bp (GRCm38)
  • G to A, chromosome 11 at 115,160,649 bp (GRCm38)
  • T to A, chromosome 12 at 17,548,311 bp (GRCm38)
  • G to A, chromosome 12 at 112,601,424 bp (GRCm38)
  • T to A, chromosome 13 at 23,184,439 bp (GRCm38)
  • A to G, chromosome 13 at 61,568,769 bp (GRCm38)
  • A to G, chromosome 13 at 76,723,697 bp (GRCm38)
  • A to G, chromosome 13 at 94,448,451 bp (GRCm38)
  • A to G, chromosome 13 at 119,473,924 bp (GRCm38)
  • A to T, chromosome 14 at 52,463,331 bp (GRCm38)
  • G to T, chromosome 14 at 121,668,459 bp (GRCm38)
  • T to C, chromosome 15 at 13,057,470 bp (GRCm38)
  • A to G, chromosome 15 at 44,520,726 bp (GRCm38)
  • T to A, chromosome 17 at 27,895,555 bp (GRCm38)
  • T to C, chromosome 18 at 61,968,030 bp (GRCm38)
  • A to G, chromosome 18 at 66,463,299 bp (GRCm38)
  • T to A, chromosome 19 at 4,138,694 bp (GRCm38)
  • T to A, chromosome 19 at 24,262,024 bp (GRCm38)
  • T to G, chromosome 19 at 25,673,702 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9218 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069054-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.