Strain Name:
C57BL/6J-MtgxR9237Btlr/Mmmh
Stock Number:
069066-MU
Citation ID:
RRID:MMRRC_069066-MU
Other Names:
R9237 (G1)
Major Collection:

Strain Information

Ide
Name: insulin degrading enzyme
Synonyms: 1300012G03Rik, 4833415K22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15925
HGNC: HGNC:5381
Homologene: 3645
Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: spectrin G, Spnb-2, non-erythrocytic, brain spectrin, Spnb2, elf1, elf3, 9930031C03Rik, beta fodrin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Phb1
Name: prohibitin 1
Synonyms: Phb
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18673
HGNC: HGNC:8912
Homologene: 1980
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4833417A11Rik, 4832428G11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Exoc2
Name: exocyst complex component 2
Synonyms: Gm29675, 2410030I24Rik, Sec5l1, Sec5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66482
Homologene: 10122
Akap12
Name: A kinase anchor protein 12
Synonyms: Tsga12, SSeCKS, Srcs5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 83397
VEGA: 10
HGNC: HGNC:370
Homologene: 3740
Actn1
Name: actinin, alpha 1
Synonyms: 3110023F10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109711
VEGA: 12
HGNC: HGNC:163
Homologene: 55553
Phyhipl
Name: phytanoyl-CoA hydroxylase interacting protein-like
Synonyms: 4921522K17Rik, PHY2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70911
Homologene: 13028
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: C330002D13Rik, Coh1, 1810042B05Rik, 2310042E16Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Dars2
Name: aspartyl-tRNA synthetase 2 (mitochondrial)
Synonyms: 5830468K18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226539
Homologene: 7093
Ube2d1
Name: ubiquitin-conjugating enzyme E2D 1
Synonyms: UBCH5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216080
Homologene: 20714
Gna15
Name: guanine nucleotide binding protein, alpha 15
Synonyms: Galpha15, G[a]15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14676
HGNC: HGNC:4383
Homologene: 1563
C8b
Name: complement component 8, beta polypeptide
Synonyms: 4930439B20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110382
HGNC: HGNC:1353
Homologene: 48
Adgrf4
Name: adhesion G protein-coupled receptor F4
Synonyms: 4632435A09Rik, Gpr115
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78249
Homologene: 51953
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Mttp
Name: microsomal triglyceride transfer protein
Synonyms: 1810043K16Rik, MTP
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17777
HGNC: HGNC:7467
Homologene: 212
Fhad1
Name: forkhead-associated phosphopeptide binding domain 1
Synonyms: 2900090M10Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329977
Homologene: 77947
Stat4
Name: signal transducer and activator of transcription 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20849
Homologene: 20679
Pmfbp1
Name: polyamine modulated factor 1 binding protein 1
Synonyms: 1700016D22Rik, F77
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56523
Homologene: 23182
Map3k10
Name: mitogen-activated protein kinase kinase kinase 10
Synonyms: Mlk2, serine/threonine kinase, MKN28 kinase, mixed lineage kinase 2, MKN28 derived nonreceptor_type
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269881
HGNC: HGNC:6849
Homologene: 1834
Helt
Name: helt bHLH transcription factor
Synonyms: Heslike, megane
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234219
Homologene: 18357
Nlrc3
Name: NLR family, CARD domain containing 3
Synonyms: D230007K08Rik, Caterpiller 16.2, CLR16.2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268857
Homologene: 18720
Myom2
Name: myomesin 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17930
HGNC: HGNC:7614
Homologene: 2953
Myom1
Name: myomesin 1
Synonyms: D430047A17Rik, skelemin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17929
VEGA: 17
HGNC: HGNC:7613
Homologene: 31196
Or5m13b
Name: olfactory receptor family 5 subfamily M member 13B
Synonyms: MOR196-4, Olfr1026, GA_x6K02T2Q125-47402610-47403533
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258577
Homologene: 73971
Mcrip1
Name: MAPK regulated corepressor interacting protein 1
Synonyms: Fam195b, BC003940
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192173
Homologene: 19571
Tas2r118
Name: taste receptor, type 2, member 118
Synonyms: mGR18, mt2r40, Tas2r18, T2R18
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387347
Homologene: 9660
Fktn
Name: fukutin
Synonyms: Fukutin, Fcmd
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 246179
HGNC: HGNC:3622
Homologene: 31402
Sptlc3
Name: serine palmitoyltransferase, long chain base subunit 3
Synonyms: C130053K05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228677
Homologene: 105590
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74053
Homologene: 12938
Rcbtb2
Name: regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
Synonyms: 2810420M18Rik, Rc/btb2, 2610028E02Rik, Chc1l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105670
HGNC: HGNC:1914
Homologene: 970
Vmn1r43
Name: vomeronasal 1 receptor 43
Synonyms: V1ra5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113847
Homologene: 130651
Or5af1
Name: olfactory receptor family 5 subfamily AF member 1
Synonyms: GA_x6K02T2NKPP-575829-574903, MOR222-4P, Olfr312
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258065
Homologene: 77375
Acat1
Name: acetyl-Coenzyme A acetyltransferase 1
Synonyms: Acat, 6330585C21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110446
HGNC: HGNC:93
Homologene: 6
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Ager
Name: advanced glycosylation end product-specific receptor
Synonyms: RAGE
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11596
HGNC: HGNC:320
Homologene: 883
P2rx3
Name: purinergic receptor P2X, ligand-gated ion channel, 3
Synonyms: P2X3, 4930513E20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228139
HGNC: HGNC:8534
Homologene: 1922
H4c12
Name: H4 clustered histone 12
Synonyms: Hist1h4k
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319160
Homologene: 134461
Trmt5
Name: TRM5 tRNA methyltransferase 5
Synonyms: 2610027O18Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76357
VEGA: 12
Homologene: 6096
Nr2f6
Name: nuclear receptor subfamily 2, group F, member 6
Synonyms: Erbal2, COUP-TF3, EAR2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13864
HGNC: HGNC:7977
Homologene: 7706
Bnip5
Name: BCL2 interacting protein 5
Synonyms: 4930539E08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 207819
Homologene: 52098
Ighg2b
Name: immunoglobulin heavy constant gamma 2B
Synonyms: gamma2b, IgG2b
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16016
Pcdha11
Name: protocadherin alpha 11
Synonyms: A830022B16Rik, Cnr7, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 52,106,914 bp (GRCm38)
  • T to G, chromosome 1 at 68,042,442 bp (GRCm38)
  • A to T, chromosome 1 at 71,279,398 bp (GRCm38)
  • G to A, chromosome 1 at 161,045,455 bp (GRCm38)
  • T to C, chromosome 2 at 85,023,552 bp (GRCm38)
  • T to A, chromosome 2 at 85,923,923 bp (GRCm38)
  • T to A, chromosome 2 at 139,566,685 bp (GRCm38)
  • T to C, chromosome 3 at 138,104,683 bp (GRCm38)
  • G to A, chromosome 4 at 53,734,854 bp (GRCm38)
  • A to G, chromosome 4 at 104,793,284 bp (GRCm38)
  • T to A, chromosome 4 at 141,905,172 bp (GRCm38)
  • G to T, chromosome 5 at 94,303,142 bp (GRCm38)
  • T to A, chromosome 6 at 23,969,618 bp (GRCm38)
  • G to A, chromosome 6 at 89,869,895 bp (GRCm38)
  • C to T, chromosome 7 at 27,658,417 bp (GRCm38)
  • T to C, chromosome 8 at 15,102,591 bp (GRCm38)
  • A to G, chromosome 8 at 46,292,499 bp (GRCm38)
  • A to C, chromosome 8 at 71,378,429 bp (GRCm38)
  • A to G, chromosome 8 at 109,520,300 bp (GRCm38)
  • C to A, chromosome 9 at 53,583,516 bp (GRCm38)
  • T to C, chromosome 10 at 4,357,231 bp (GRCm38)
  • C to A, chromosome 10 at 70,570,890 bp (GRCm38)
  • T to A, chromosome 10 at 71,262,095 bp (GRCm38)
  • T to C, chromosome 10 at 81,523,849 bp (GRCm38)
  • C to T, chromosome 10 at 120,075,405 bp (GRCm38)
  • A to T, chromosome 11 at 30,146,803 bp (GRCm38)
  • A to T, chromosome 11 at 58,831,231 bp (GRCm38)
  • T to C, chromosome 11 at 95,675,208 bp (GRCm38)
  • G to A, chromosome 11 at 120,544,716 bp (GRCm38)
  • G to T, chromosome 12 at 73,284,794 bp (GRCm38)
  • T to C, chromosome 12 at 80,193,696 bp (GRCm38)
  • A to T, chromosome 12 at 113,306,597 bp (GRCm38)
  • A to G, chromosome 13 at 21,750,364 bp (GRCm38)
  • G to A, chromosome 13 at 30,864,875 bp (GRCm38)
  • C to A, chromosome 14 at 73,174,496 bp (GRCm38)
  • C to T, chromosome 15 at 35,841,333 bp (GRCm38)
  • A to T, chromosome 16 at 3,965,209 bp (GRCm38)
  • C to T, chromosome 16 at 38,005,286 bp (GRCm38)
  • T to C, chromosome 17 at 28,904,548 bp (GRCm38)
  • T to A, chromosome 17 at 34,597,895 bp (GRCm38)
  • T to A, chromosome 17 at 42,669,891 bp (GRCm38)
  • C to T, chromosome 17 at 71,101,056 bp (GRCm38)
  • T to A, chromosome 18 at 37,012,207 bp (GRCm38)
  • G to A, chromosome 18 at 37,979,881 bp (GRCm38)
  • T to C, chromosome 19 at 37,330,499 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9237 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069066-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.