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Strain Name:
C57BL/6J-MtgxR9271Btlr/Mmmh
Stock Number:
069091-MU
Citation ID:
RRID:MMRRC_069091-MU
Other Names:
R9271 (G1)
Major Collection:

Strain Information

Nrp2
Name: neuropilin 2
Synonyms: NP2, Npn-2, Npn2, NP-2, 1110048P06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18187
HGNC: HGNC:8005
Homologene: 2875
Sema3b
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Synonyms: SemA, semaV, sema5, SemA, LUCA-1, Semaa
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20347
Homologene: 20972
Cdon
Name: cell adhesion molecule-related/down-regulated by oncogenes
Synonyms: CAM-related/down-regulated by oncogenes, CDO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57810
Homologene: 22996
Dap3
Name: death associated protein 3
Synonyms: 4921514D13Rik, DAP-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 65111
HGNC: HGNC:2673
Homologene: 3404
Zmym6
Name: zinc finger, MYM-type 6
Synonyms: D4Wsu24e, 9330177P20Rik, Zfp258
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100177
Homologene: 5186
Msra
Name: methionine sulfoxide reductase A
Synonyms: MSR-A, 2310045J23Rik, 6530413P12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110265
HGNC: HGNC:7377
Homologene: 5812
Dock6
Name: dedicator of cytokinesis 6
Synonyms: 2410095B20Rik, 4931431C02Rik, C330023D02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319899
VEGA: 9
Homologene: 83291
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 22,428,522 bp (GRCm38)
  • A to G, chromosome 1 at 43,954,651 bp (GRCm38)
  • A to G, chromosome 1 at 58,420,153 bp (GRCm38)
  • G to T, chromosome 1 at 59,203,030 bp (GRCm38)
  • A to C, chromosome 1 at 62,745,511 bp (GRCm38)
  • C to T, chromosome 1 at 110,949,217 bp (GRCm38)
  • A to G, chromosome 1 at 150,756,558 bp (GRCm38)
  • G to T, chromosome 1 at 166,204,855 bp (GRCm38)
  • T to C, chromosome 1 at 170,794,676 bp (GRCm38)
  • A to T, chromosome 1 at 181,769,760 bp (GRCm38)
  • A to G, chromosome 1 at 191,162,956 bp (GRCm38)
  • C to T, chromosome 2 at 3,223,506 bp (GRCm38)
  • C to A, chromosome 2 at 127,116,634 bp (GRCm38)
  • T to C, chromosome 2 at 153,131,265 bp (GRCm38)
  • A to G, chromosome 2 at 157,114,285 bp (GRCm38)
  • T to A, chromosome 3 at 67,461,318 bp (GRCm38)
  • T to C, chromosome 3 at 88,933,606 bp (GRCm38)
  • G to T, chromosome 3 at 89,149,960 bp (GRCm38)
  • C to A, chromosome 3 at 89,408,551 bp (GRCm38)
  • T to C, chromosome 3 at 104,015,948 bp (GRCm38)
  • T to C, chromosome 3 at 107,331,996 bp (GRCm38)
  • C to T, chromosome 4 at 20,484,897 bp (GRCm38)
  • C to T, chromosome 4 at 41,756,777 bp (GRCm38)
  • T to A, chromosome 4 at 42,773,486 bp (GRCm38)
  • T to C, chromosome 4 at 121,147,554 bp (GRCm38)
  • T to A, chromosome 4 at 127,124,061 bp (GRCm38)
  • C to T, chromosome 4 at 135,778,168 bp (GRCm38)
  • T to A, chromosome 5 at 27,598,834 bp (GRCm38)
  • T to C, chromosome 5 at 96,223,887 bp (GRCm38)
  • A to G, chromosome 5 at 104,479,093 bp (GRCm38)
  • A to T, chromosome 5 at 129,865,022 bp (GRCm38)
  • G to T, chromosome 6 at 55,967,066 bp (GRCm38)
  • A to G, chromosome 6 at 83,059,043 bp (GRCm38)
  • T to C, chromosome 6 at 113,392,635 bp (GRCm38)
  • C to T, chromosome 6 at 142,089,849 bp (GRCm38)
  • T to A, chromosome 7 at 3,816,998 bp (GRCm38)
  • A to T, chromosome 7 at 13,085,015 bp (GRCm38)
  • A to T, chromosome 7 at 21,162,869 bp (GRCm38)
  • A to T, chromosome 7 at 26,562,519 bp (GRCm38)
  • C to T, chromosome 7 at 43,776,530 bp (GRCm38)
  • A to T, chromosome 7 at 57,179,638 bp (GRCm38)
  • T to C, chromosome 7 at 79,660,856 bp (GRCm38)
  • T to C, chromosome 7 at 98,091,074 bp (GRCm38)
  • A to C, chromosome 7 at 118,212,563 bp (GRCm38)
  • A to G, chromosome 8 at 3,505,771 bp (GRCm38)
  • T to C, chromosome 8 at 13,836,697 bp (GRCm38)
  • CAGCATCTGCTCGGAGCA to CAGCA, chromosome 8 at 26,160,856 bp (GRCm38)
  • T to A, chromosome 8 at 71,710,424 bp (GRCm38)
  • C to T, chromosome 8 at 106,906,225 bp (GRCm38)
  • T to A, chromosome 8 at 119,597,653 bp (GRCm38)
  • T to A, chromosome 8 at 126,025,413 bp (GRCm38)
  • T to C, chromosome 9 at 15,076,940 bp (GRCm38)
  • A to G, chromosome 9 at 21,841,500 bp (GRCm38)
  • A to G, chromosome 9 at 35,491,879 bp (GRCm38)
  • T to C, chromosome 9 at 107,598,955 bp (GRCm38)
  • C to T, chromosome 9 at 109,221,355 bp (GRCm38)
  • T to A, chromosome 9 at 111,345,479 bp (GRCm38)
  • T to A, chromosome 9 at 118,671,791 bp (GRCm38)
  • T to A, chromosome 10 at 33,513,305 bp (GRCm38)
  • C to A, chromosome 10 at 41,424,627 bp (GRCm38)
  • T to A, chromosome 10 at 53,281,574 bp (GRCm38)
  • T to A, chromosome 10 at 60,185,643 bp (GRCm38)
  • A to T, chromosome 10 at 70,189,163 bp (GRCm38)
  • T to C, chromosome 10 at 77,997,592 bp (GRCm38)
  • C to G, chromosome 10 at 80,357,996 bp (GRCm38)
  • C to A, chromosome 10 at 80,417,357 bp (GRCm38)
  • A to G, chromosome 10 at 93,474,550 bp (GRCm38)
  • T to A, chromosome 10 at 107,817,113 bp (GRCm38)
  • T to C, chromosome 10 at 108,262,363 bp (GRCm38)
  • A to G, chromosome 10 at 117,288,587 bp (GRCm38)
  • T to C, chromosome 10 at 127,860,273 bp (GRCm38)
  • T to C, chromosome 11 at 5,023,174 bp (GRCm38)
  • A to T, chromosome 11 at 9,291,698 bp (GRCm38)
  • A to G, chromosome 11 at 23,001,389 bp (GRCm38)
  • A to T, chromosome 11 at 32,423,361 bp (GRCm38)
  • A to C, chromosome 11 at 56,040,482 bp (GRCm38)
  • A to G, chromosome 11 at 59,115,817 bp (GRCm38)
  • G to A, chromosome 11 at 94,334,436 bp (GRCm38)
  • A to T, chromosome 11 at 102,146,758 bp (GRCm38)
  • A to G, chromosome 11 at 115,013,724 bp (GRCm38)
  • A to G, chromosome 11 at 115,577,961 bp (GRCm38)
  • A to T, chromosome 11 at 118,041,044 bp (GRCm38)
  • A to T, chromosome 11 at 120,011,114 bp (GRCm38)
  • A to G, chromosome 12 at 23,779,991 bp (GRCm38)
  • A to G, chromosome 12 at 76,575,920 bp (GRCm38)
  • C to A, chromosome 12 at 81,722,487 bp (GRCm38)
  • G to T, chromosome 12 at 95,779,133 bp (GRCm38)
  • G to T, chromosome 12 at 110,616,876 bp (GRCm38)
  • T to C, chromosome 13 at 43,303,385 bp (GRCm38)
  • A to G, chromosome 13 at 62,455,053 bp (GRCm38)
  • G to T, chromosome 13 at 111,691,336 bp (GRCm38)
  • A to T, chromosome 14 at 3,846,968 bp (GRCm38)
  • A to T, chromosome 14 at 16,435,235 bp (GRCm38)
  • T to A, chromosome 14 at 21,792,501 bp (GRCm38)
  • A to C, chromosome 14 at 26,947,127 bp (GRCm38)
  • T to A, chromosome 14 at 51,145,507 bp (GRCm38)
  • T to C, chromosome 14 at 64,233,820 bp (GRCm38)
  • C to T, chromosome 15 at 83,610,193 bp (GRCm38)
  • A to T, chromosome 16 at 59,344,782 bp (GRCm38)
  • A to G, chromosome 16 at 92,465,853 bp (GRCm38)
  • T to C, chromosome 17 at 3,414,736 bp (GRCm38)
  • G to A, chromosome 17 at 27,118,677 bp (GRCm38)
  • T to A, chromosome 17 at 34,895,344 bp (GRCm38)
  • C to T, chromosome 17 at 35,121,758 bp (GRCm38)
  • T to C, chromosome 17 at 53,676,903 bp (GRCm38)
  • T to A, chromosome 17 at 71,067,330 bp (GRCm38)
  • T to A, chromosome 18 at 35,657,001 bp (GRCm38)
  • T to G, chromosome 18 at 63,030,379 bp (GRCm38)
  • C to A, chromosome 18 at 63,075,719 bp (GRCm38)
  • T to A, chromosome 19 at 10,185,798 bp (GRCm38)
  • A to T, chromosome 19 at 23,994,857 bp (GRCm38)
  • C to T, chromosome 19 at 58,962,828 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9271 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069091-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.