Strain Name:
C57BL/6J-MtgxR9315Btlr/Mmmh
Stock Number:
069128-MU
Citation ID:
RRID:MMRRC_069128-MU
Other Names:
R9315 (G1)
Major Collection:

Strain Information

Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Synonyms: p55alpha, p85alpha, p50alpha, PI3K
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18708
HGNC: HGNC:8979
Homologene: 7889
Ifng
Name: interferon gamma
Synonyms: Ifg, IFN-gamma
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 15978
VEGA: 10
HGNC: HGNC:5438
Homologene: 55526
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Ints4
Name: integrator complex subunit 4
Synonyms: 2610034N24Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101861
Homologene: 69427
Myo9b
Name: myosin IXb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17925
HGNC: HGNC:7609
Homologene: 3058
Mdn1
Name: midasin AAA ATPase 1
Synonyms: 4833432B22Rik, LOC213784, D4Abb1e
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100019
Homologene: 39689
Lamb2
Name: laminin, beta 2
Synonyms: Lams, npht, Lamb-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Ddx52
Name: DExD box helicase 52
Synonyms: 2700029C06Rik, ROK1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78394
Homologene: 5093
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: Alix, AIP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Ldlr
Name: low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16835
VEGA: 9
HGNC: HGNC:6547
Homologene: 55469
Rrn3
Name: RRN3 RNA polymerase I transcription factor homolog (yeast)
Synonyms: E130302O19Rik, TIF-1A
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 106298
VEGA: 16
Homologene: 39531
Clec4e
Name: C-type lectin domain family 4, member e
Synonyms: Mincle, Clecsf9
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56619
Homologene: 22809
Glb1
Name: galactosidase, beta 1
Synonyms: Bge, Bgt, Bgl-t, C130097A14Rik, Bgl-e, Bgl-s, Bgl, Bgs
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12091
VEGA: 9
HGNC: HGNC:4298
Homologene: 47922
Rab6a
Name: RAB6A, member RAS oncogene family
Synonyms: Rab6, 2610028L11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19346
HGNC: HGNC:9786
Homologene: 55697
Coa7
Name: cytochrome c oxidase assembly factor 7
Synonyms: D4Ertd796e, 2010305A19Rik, Selrc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69893
Homologene: 11317
Tmprss3
Name: transmembrane protease, serine 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 140765
Homologene: 56985
Col1a2
Name: collagen, type I, alpha 2
Synonyms: Cola2, Cola-2, Col1a-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12843
HGNC: HGNC:2198
Homologene: 69
Dnah11
Name: dynein, axonemal, heavy chain 11
Synonyms: b2b1203Clo, Dnahc11, avc4, b2b1289Clo, b2b1279Clo, lrd, b2b598Clo, b2b1727Clo
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13411
HGNC: HGNC:2942
Homologene: 2801
Wdr11
Name: WD repeat domain 11
Synonyms: 2900055P10Rik, Brwd2, Wdr11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207425
Homologene: 41229
Mrc1
Name: mannose receptor, C type 1
Synonyms: MR, CD206
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Rab33b
Name: RAB33B, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19338
Homologene: 9642
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Fads2b
Name: fatty acid desaturase 2B
Synonyms: 4833423E24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228151
Homologene: 105643
Tns1
Name: tensin 1
Synonyms: Tns, E030018G17Rik, E030037J05Rik, 1110018I21Rik, 1200014E20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Nepn
Name: nephrocan
Synonyms: periolin, Npn, 5730521E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66650
Homologene: 23549
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Pcnx2
Name: pecanex homolog 2
Synonyms: Pcnxl2, E330039K12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 270109
HGNC: HGNC:8736
Homologene: 8987
Cyp2j6
Name: cytochrome P450, family 2, subfamily j, polypeptide 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13110
HGNC: HGNC:2634
Homologene: 68091
Cacna2d4
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 4
Synonyms: 5730412N02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319734
Homologene: 26544
Or14c46
Name: olfactory receptor family 14 subfamily C member 46
Synonyms: GA_x6K02T2NHDJ-9838699-9839697, Olfr310, MOR227-6P
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258222
Homologene: 128066
Abcc3
Name: ATP-binding cassette, sub-family C member 3
Synonyms: 1700019L09Rik, MRP3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76408
HGNC: HGNC:54
Homologene: 68364
Saxo4
Name: stabilizer of axonemal microtubules 4
Synonyms: IIIG9S, IIIG9L, Ppp1r32, IIIG9, 4930579J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67752
VEGA: 19
Homologene: 15863
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Radil
Name: Ras association and DIL domains
Synonyms: D930005D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231858
Homologene: 77648
Tas1r2
Name: taste receptor, type 1, member 2
Synonyms: T1r2, TR2, Gpr71
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 83770
Homologene: 75323
Zbtb49
Name: zinc finger and BTB domain containing 49
Synonyms: 4930518A03Rik, Zfp509
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75079
Homologene: 34825
Zfp446
Name: zinc finger protein 446
Synonyms: A630035I11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269870
Homologene: 9910
Or4d5
Name: olfactory receptor family 4 subfamily D member 5
Synonyms: Olfr984, GA_x6K02T2PVTD-33799484-33798540, MOR239-6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258601
VEGA: 9
Homologene: 17314
Epn1
Name: epsin 1
Synonyms: Ibp1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13854
Homologene: 32172
Rbm4b
Name: RNA binding motif protein 4B
Synonyms: 4921506I22Rik, Lark2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66704
Homologene: 57033
Mxd1
Name: MAX dimerization protein 1
Synonyms: Mad1, Mad
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17119
HGNC: HGNC:6761
Homologene: 1767
Or13a22
Name: olfactory receptor family 13 subfamily A member 22
Synonyms: Olfr535, GA_x6K02T2PBJ9-42641642-42642574, MOR253-7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258956
Homologene: 138320
Msantd5f3
Name: Myb/SANT DNA binding domain containing 5 family member 3
Synonyms: Gm11238
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100502896
Homologene: 128423
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 73,940,982 bp (GRCm38)
  • A to G, chromosome 1 at 90,811,257 bp (GRCm38)
  • T to A, chromosome 2 at 14,244,158 bp (GRCm38)
  • C to A, chromosome 2 at 85,488,844 bp (GRCm38)
  • T to C, chromosome 2 at 110,697,942 bp (GRCm38)
  • T to G, chromosome 3 at 51,493,579 bp (GRCm38)
  • T to C, chromosome 4 at 32,760,911 bp (GRCm38)
  • A to T, chromosome 4 at 73,657,043 bp (GRCm38)
  • A to G, chromosome 4 at 96,531,798 bp (GRCm38)
  • T to A, chromosome 4 at 108,338,384 bp (GRCm38)
  • A to G, chromosome 4 at 139,653,735 bp (GRCm38)
  • A to G, chromosome 5 at 38,200,738 bp (GRCm38)
  • G to A, chromosome 5 at 90,250,501 bp (GRCm38)
  • G to T, chromosome 5 at 142,488,499 bp (GRCm38)
  • T to A, chromosome 6 at 4,540,544 bp (GRCm38)
  • T to C, chromosome 6 at 86,650,944 bp (GRCm38)
  • G to T, chromosome 6 at 119,236,709 bp (GRCm38)
  • T to A, chromosome 6 at 121,873,771 bp (GRCm38)
  • A to G, chromosome 6 at 123,286,255 bp (GRCm38)
  • T to C, chromosome 7 at 5,093,340 bp (GRCm38)
  • A to G, chromosome 7 at 12,979,470 bp (GRCm38)
  • A to T, chromosome 7 at 86,269,287 bp (GRCm38)
  • A to G, chromosome 7 at 97,507,633 bp (GRCm38)
  • A to G, chromosome 7 at 100,631,810 bp (GRCm38)
  • A to G, chromosome 7 at 129,606,540 bp (GRCm38)
  • T to C, chromosome 7 at 140,493,022 bp (GRCm38)
  • C to A, chromosome 8 at 71,349,167 bp (GRCm38)
  • T to C, chromosome 8 at 125,887,380 bp (GRCm38)
  • T to A, chromosome 9 at 21,733,486 bp (GRCm38)
  • T to C, chromosome 9 at 40,100,974 bp (GRCm38)
  • C to T, chromosome 9 at 108,487,167 bp (GRCm38)
  • T to C, chromosome 9 at 113,659,853 bp (GRCm38)
  • A to G, chromosome 9 at 114,456,480 bp (GRCm38)
  • G to T, chromosome 10 at 5,333,553 bp (GRCm38)
  • T to A, chromosome 10 at 52,391,773 bp (GRCm38)
  • A to T, chromosome 10 at 118,442,683 bp (GRCm38)
  • T to A, chromosome 11 at 83,946,207 bp (GRCm38)
  • C to T, chromosome 11 at 94,374,750 bp (GRCm38)
  • G to A, chromosome 12 at 118,179,606 bp (GRCm38)
  • A to G, chromosome 13 at 101,757,658 bp (GRCm38)
  • A to G, chromosome 13 at 119,449,980 bp (GRCm38)
  • T to C, chromosome 16 at 13,788,826 bp (GRCm38)
  • T to C, chromosome 17 at 31,184,670 bp (GRCm38)
  • T to C, chromosome 19 at 4,762,000 bp (GRCm38)
  • T to A, chromosome 19 at 10,481,403 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9315 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069128-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.