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Strain Name:
C57BL/6J-MtgxR9325Btlr/Mmmh
Stock Number:
069137-MU
Citation ID:
RRID:MMRRC_069137-MU
Other Names:
R9325 (G1)
Major Collection:

Strain Information

Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Dlc1
Name: deleted in liver cancer 1
Synonyms: p122-RhoGAP, STARD12, Arhgap7, A730069N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50768
HGNC: HGNC:2897
Homologene: 4442
Prkci
Name: protein kinase C, iota
Synonyms: Pkcl, Pkci, 2310021H13Rik, Prkcl, aPKClambda, PKClambda
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18759
HGNC: HGNC:9404
Homologene: 37667
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Slc6a4
Name: solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Synonyms: 5-HTT, Htt, Sert
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15567
Homologene: 817
Lrrfip2
Name: leucine rich repeat (in FLII) interacting protein 2
Synonyms: 5133400F20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71268
HGNC: HGNC:6703
Homologene: 22476
Ddx4
Name: DEAD box helicase 4
Synonyms: mvh / m'vasa, VASA, Mvh, DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13206
VEGA: 13
Homologene: 49227
Mcm3
Name: minichromosome maintenance complex component 3
Synonyms: p1.m, P1, Mcmd
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17215
HGNC: HGNC:6945
Homologene: 1791
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70797
Homologene: 19076
Tyw1
Name: tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Synonyms: Rsafd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100929
Homologene: 7068
Nefl
Name: neurofilament, light polypeptide
Synonyms: NF-L, CMT2E, NF68, Nfl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18039
HGNC: HGNC:7739
Homologene: 4487
Mmp14
Name: matrix metallopeptidase 14 (membrane-inserted)
Synonyms: Membrane type 1-MMP, MT1-MMP, sabe
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17387
HGNC: HGNC:7160
Homologene: 21040
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
Muc2
Name: mucin 2
Synonyms: 2010015E03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17831
HGNC: HGNC:7512
Homologene: 136755
Lrrn2
Name: leucine rich repeat protein 2, neuronal
Synonyms: NLRR-2, 5730406J09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16980
Homologene: 21274
Eng
Name: endoglin
Synonyms: CD105, Endo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13805
HGNC: HGNC:3349
Homologene: 92
Hspg2
Name: perlecan (heparan sulfate proteoglycan 2)
Synonyms: per, Pcn, Plc, perlecan
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 15530
HGNC: HGNC:5273
Homologene: 68473
Tmem131l
Name: transmembrane 131 like
Synonyms: D930015E06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229473
Homologene: 9057
Slc4a4
Name: solute carrier family 4 (anion exchanger), member 4
Synonyms: NBC, NBC1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 54403
Homologene: 55776
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: MDHC7, E030034C22Rik, B230373P09Rik, Dnahc1, G1-415-19, ferf1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Smarcc2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: 5930405J04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68094
VEGA: 10
Homologene: 2312
Isl1
Name: ISL1 transcription factor, LIM/homeodomain
Synonyms: Islet 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16392
HGNC: HGNC:6132
Homologene: 1661
F7
Name: coagulation factor VII
Synonyms: FVII, Cf7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14068
HGNC: HGNC:3544
Homologene: 7710
Dchs1
Name: dachsous cadherin related 1
Synonyms: C130033F22Rik, 3110041P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233651
Homologene: 2771
Polr2g
Name: polymerase (RNA) II (DNA directed) polypeptide G
Synonyms: RBP7, 2410046K11Rik, A230108L04Rik, Rpo2-7l
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67710
VEGA: 19
HGNC: HGNC:9194
Homologene: 2019
Kif5c
Name: kinesin family member 5C
Synonyms: Khc
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16574
HGNC: HGNC:6325
Homologene: 56234
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Bpifa3
Name: BPI fold containing family A, member 3
Synonyms: 1700058C13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 73388
Homologene: 52268
Rin2
Name: Ras and Rab interactor 2
Synonyms: RASSF4, 4632403N06Rik, 2010003K16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74030
Homologene: 32430
Or8c13
Name: olfactory receptor family 8 subfamily C member 13
Synonyms: GA_x6K02T2PVTD-31862167-31861217, MOR170-9, Olfr891
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258471
Homologene: 74210
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Lox
Name: lysyl oxidase
Synonyms: ras recision gene (rrg), TSC-160
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 16948
VEGA: 18
HGNC: HGNC:6664
Homologene: 1741
Vmn2r102
Name: vomeronasal 2, receptor 102
Synonyms: EG224572
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224572
Homologene: 115024
Adamts9
Name: ADAM metallopeptidase with thrombospondin type 1 motif 9
Synonyms: 1810011L16Rik, E030027K14Rik, 8430403M15Rik, Mhdaund4, Gsfund3, UND3, Mhdaund3, UND4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101401
Homologene: 18821
Cdh17
Name: cadherin 17
Synonyms: HPT-1, BILL-cadherin, LI-cadherin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12557
HGNC: HGNC:1756
Homologene: 56859
Ahnak
Name: AHNAK nucleoprotein
Synonyms: DY6, 2310047C17Rik, 1110004P15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 66395
VEGA: 19
HGNC: HGNC:347
Homologene: 67425
Klk7
Name: kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
Synonyms: Prss6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23993
HGNC: HGNC:6368
Homologene: 37998
Stox2
Name: storkhead box 2
Synonyms: 4933409N07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71069
Homologene: 18414
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22313
Homologene: 129751
Aadacl2fm1
Name: AADACL2 family member 1
Synonyms: C130079G13Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229333
Cnih3
Name: cornichon family AMPA receptor auxiliary protein 3
Synonyms: 2900075G08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72978
Homologene: 12486
Ceacam20
Name: CEA cell adhesion molecule 20
Synonyms: 9130012D09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71601
Homologene: 19010
Zfp820
Name: zinc finger protein 820
Synonyms: 2610036F08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75424
VEGA: 17
Cers5
Name: ceramide synthase 5
Synonyms: 2310081H14Rik, Trh4, CerS5, Lass5
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71949
Homologene: 23634
Fcgr4
Name: Fc receptor, IgG, low affinity IV
Synonyms: CD16-2, 4833442P21Rik, FcgammaRIV, Fcgr3a
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 246256
Homologene: 477
Tmem168
Name: transmembrane protein 168
Synonyms: 5730526F17Rik, 8430437G11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101118
Homologene: 11202
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Arhgap9
Name: Rho GTPase activating protein 9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216445
VEGA: 10
Homologene: 13041
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: cytoplasmic linker protein 50, Clip50, CLIP-170, 1110007I12Rik, 4631429H07Rik, Rsn, Clip 170, restin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
Cuta
Name: cutA divalent cation tolerance homolog
Synonyms: 1810060C03Rik, 1810022E02Rik, 2700094G22Rik, 0610039D01Rik, CutA
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 67675
VEGA: 17
Homologene: 9305
Nlrp4e
Name: NLR family, pyrin domain containing 4E
Synonyms: Nalp-epsilon, Nalp4e, 4930406H16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 446099
Homologene: 75315
Coro2b
Name: coronin, actin binding protein, 2B
Synonyms: E130012P22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235431
HGNC: HGNC:2256
Homologene: 21228
Hyal6
Name: hyaluronoglucosaminidase 6
Synonyms: 4932701A20Rik, Hyal-ps1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 74409
HGNC: HGNC:5324
Homologene: 78028
Usp36
Name: ubiquitin specific peptidase 36
Synonyms: 2700002L06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72344
Homologene: 11828
Fmod
Name: fibromodulin
Synonyms: SLRR2E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14264
HGNC: HGNC:3774
Homologene: 1530
Igsf21
Name: immunoglobulin superfamily, member 21
Synonyms: LOC230868
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230868
Homologene: 13153
Or10ag58
Name: olfactory receptor family 10 subfamily AG member 58
Synonyms: GA_x6K02T2Q125-48936945-48937901, GA_x6K02T2Q125-48935224-48935664, MOR264-24, MOR264-3, Olfr1125, Olfr1124
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259030
Homologene: 133660
Prr15
Name: proline rich 15
Synonyms: G90, E130201N16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78004
Homologene: 12689
Zscan4-ps3
Name: zinc finger and SCAN domain containing 4, pseudogene 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043042
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 20,805,338 bp (GRCm38)
  • A to T, chromosome 1 at 132,937,503 bp (GRCm38)
  • A to T, chromosome 1 at 134,040,633 bp (GRCm38)
  • T to C, chromosome 1 at 171,020,142 bp (GRCm38)
  • G to A, chromosome 1 at 181,353,507 bp (GRCm38)
  • T to A, chromosome 2 at 30,322,259 bp (GRCm38)
  • C to T, chromosome 2 at 32,671,433 bp (GRCm38)
  • A to G, chromosome 2 at 49,749,366 bp (GRCm38)
  • G to A, chromosome 2 at 87,434,946 bp (GRCm38)
  • T to C, chromosome 2 at 112,649,295 bp (GRCm38)
  • T to A, chromosome 2 at 145,885,899 bp (GRCm38)
  • C to T, chromosome 2 at 151,594,288 bp (GRCm38)
  • A to T, chromosome 2 at 154,133,680 bp (GRCm38)
  • C to T, chromosome 2 at 156,036,014 bp (GRCm38)
  • A to G, chromosome 3 at 31,031,184 bp (GRCm38)
  • T to A, chromosome 3 at 59,936,441 bp (GRCm38)
  • T to C, chromosome 3 at 83,910,461 bp (GRCm38)
  • T to C, chromosome 3 at 108,883,518 bp (GRCm38)
  • A to C, chromosome 3 at 126,981,855 bp (GRCm38)
  • A to G, chromosome 4 at 11,810,319 bp (GRCm38)
  • C to T, chromosome 4 at 137,538,241 bp (GRCm38)
  • T to A, chromosome 4 at 140,067,155 bp (GRCm38)
  • A to G, chromosome 4 at 144,362,523 bp (GRCm38)
  • A to G, chromosome 5 at 3,772,523 bp (GRCm38)
  • T to A, chromosome 5 at 89,228,897 bp (GRCm38)
  • T to C, chromosome 5 at 123,613,123 bp (GRCm38)
  • T to C, chromosome 5 at 130,262,921 bp (GRCm38)
  • T to C, chromosome 6 at 13,583,254 bp (GRCm38)
  • T to A, chromosome 6 at 24,743,456 bp (GRCm38)
  • G to A, chromosome 6 at 54,329,152 bp (GRCm38)
  • T to C, chromosome 6 at 92,872,298 bp (GRCm38)
  • A to G, chromosome 6 at 121,669,619 bp (GRCm38)
  • A to T, chromosome 6 at 136,766,994 bp (GRCm38)
  • T to C, chromosome 7 at 11,610,300 bp (GRCm38)
  • C to A, chromosome 7 at 19,986,682 bp (GRCm38)
  • C to G, chromosome 7 at 23,321,330 bp (GRCm38)
  • A to G, chromosome 7 at 43,812,013 bp (GRCm38)
  • T to C, chromosome 7 at 105,766,195 bp (GRCm38)
  • A to T, chromosome 7 at 116,391,323 bp (GRCm38)
  • G to A, chromosome 7 at 141,744,822 bp (GRCm38)
  • G to T, chromosome 8 at 13,033,430 bp (GRCm38)
  • A to T, chromosome 8 at 36,571,364 bp (GRCm38)
  • T to A, chromosome 8 at 47,194,060 bp (GRCm38)
  • T to C, chromosome 9 at 38,180,031 bp (GRCm38)
  • G to T, chromosome 9 at 62,489,327 bp (GRCm38)
  • T to A, chromosome 9 at 111,161,361 bp (GRCm38)
  • T to C, chromosome 10 at 127,325,853 bp (GRCm38)
  • T to A, chromosome 10 at 128,488,207 bp (GRCm38)
  • C to A, chromosome 11 at 77,019,173 bp (GRCm38)
  • T to G, chromosome 11 at 118,269,205 bp (GRCm38)
  • A to T, chromosome 13 at 112,599,907 bp (GRCm38)
  • A to G, chromosome 13 at 116,299,569 bp (GRCm38)
  • G to T, chromosome 14 at 31,276,203 bp (GRCm38)
  • T to C, chromosome 14 at 54,438,791 bp (GRCm38)
  • T to C, chromosome 14 at 68,085,011 bp (GRCm38)
  • A to T, chromosome 15 at 99,739,457 bp (GRCm38)
  • A to G, chromosome 17 at 19,677,296 bp (GRCm38)
  • T to C, chromosome 17 at 20,048,171 bp (GRCm38)
  • A to T, chromosome 17 at 21,819,399 bp (GRCm38)
  • A to G, chromosome 17 at 26,939,315 bp (GRCm38)
  • T to C, chromosome 18 at 52,528,328 bp (GRCm38)
  • T to A, chromosome 19 at 8,797,305 bp (GRCm38)
  • T to A, chromosome 19 at 9,013,893 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9325 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069137-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.