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Strain Name:
C57BL/6J-MtgxR9327Btlr/Mmmh
Stock Number:
069139-MU
Citation ID:
RRID:MMRRC_069139-MU
Other Names:
R9327 (G1)
Major Collection:

Strain Information

Tle4
Name: transducin-like enhancer of split 4
Synonyms: Grg4, ESTM13, ESTM14, Bce1, 5730411M05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21888
VEGA: 19
Homologene: 38259
Nos1
Name: nitric oxide synthase 1, neuronal
Synonyms: nNOS, bNOS, Nos-1, NO, 2310005C01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18125
HGNC: HGNC:7872
Homologene: 37327
Il21r
Name: interleukin 21 receptor
Synonyms: NILR
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 60504
HGNC: HGNC:6006
Homologene: 11040
Mtcl1
Name: microtubule crosslinking factor 1
Synonyms: t8219b25, 1110012J17Rik, Soga2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68617
Homologene: 41017
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, Ankyrin-3, AnkG, 2900054D09Rik, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Abcg1
Name: ATP binding cassette subfamily G member 1
Synonyms: White, Abc8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11307
HGNC: HGNC:73
Homologene: 21022
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57908
Homologene: 22808
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 80,532,467 bp (GRCm38)
  • A to T, chromosome 1 at 134,040,851 bp (GRCm38)
  • C to T, chromosome 3 at 87,814,297 bp (GRCm38)
  • A to T, chromosome 3 at 88,420,718 bp (GRCm38)
  • G to T, chromosome 3 at 90,515,863 bp (GRCm38)
  • A to T, chromosome 3 at 136,093,547 bp (GRCm38)
  • A to G, chromosome 4 at 35,205,883 bp (GRCm38)
  • G to T, chromosome 4 at 92,146,813 bp (GRCm38)
  • T to G, chromosome 5 at 30,116,991 bp (GRCm38)
  • A to G, chromosome 5 at 89,582,802 bp (GRCm38)
  • T to C, chromosome 5 at 108,848,975 bp (GRCm38)
  • G to C, chromosome 5 at 117,879,337 bp (GRCm38)
  • T to C, chromosome 5 at 137,363,267 bp (GRCm38)
  • T to C, chromosome 6 at 8,175,653 bp (GRCm38)
  • T to C, chromosome 7 at 8,471,533 bp (GRCm38)
  • T to A, chromosome 7 at 18,482,555 bp (GRCm38)
  • C to T, chromosome 7 at 45,524,611 bp (GRCm38)
  • T to C, chromosome 7 at 102,948,480 bp (GRCm38)
  • A to G, chromosome 7 at 104,671,535 bp (GRCm38)
  • T to A, chromosome 7 at 107,933,812 bp (GRCm38)
  • A to G, chromosome 7 at 125,626,991 bp (GRCm38)
  • A to T, chromosome 7 at 127,933,398 bp (GRCm38)
  • A to C, chromosome 7 at 141,811,692 bp (GRCm38)
  • G to T, chromosome 8 at 10,439,705 bp (GRCm38)
  • G to T, chromosome 8 at 84,010,451 bp (GRCm38)
  • T to C, chromosome 9 at 27,019,454 bp (GRCm38)
  • G to A, chromosome 9 at 48,398,684 bp (GRCm38)
  • A to G, chromosome 9 at 62,730,752 bp (GRCm38)
  • T to C, chromosome 9 at 102,590,524 bp (GRCm38)
  • T to C, chromosome 9 at 108,814,500 bp (GRCm38)
  • G to A, chromosome 10 at 69,976,256 bp (GRCm38)
  • G to T, chromosome 10 at 80,576,854 bp (GRCm38)
  • A to G, chromosome 10 at 128,485,617 bp (GRCm38)
  • A to G, chromosome 10 at 128,958,738 bp (GRCm38)
  • T to C, chromosome 11 at 74,805,263 bp (GRCm38)
  • T to A, chromosome 11 at 111,072,893 bp (GRCm38)
  • A to T, chromosome 12 at 112,784,826 bp (GRCm38)
  • C to A, chromosome 13 at 113,317,176 bp (GRCm38)
  • G to A, chromosome 14 at 34,375,516 bp (GRCm38)
  • G to A, chromosome 14 at 45,141,991 bp (GRCm38)
  • A to G, chromosome 14 at 70,567,788 bp (GRCm38)
  • T to C, chromosome 15 at 76,109,555 bp (GRCm38)
  • G to A, chromosome 17 at 6,295,773 bp (GRCm38)
  • A to G, chromosome 17 at 17,971,451 bp (GRCm38)
  • T to C, chromosome 17 at 24,158,447 bp (GRCm38)
  • T to C, chromosome 17 at 31,114,148 bp (GRCm38)
  • T to G, chromosome 17 at 46,410,966 bp (GRCm38)
  • A to T, chromosome 17 at 46,568,051 bp (GRCm38)
  • T to C, chromosome 17 at 52,839,056 bp (GRCm38)
  • A to G, chromosome 17 at 66,338,135 bp (GRCm38)
  • T to A, chromosome 17 at 94,876,996 bp (GRCm38)
  • A to G, chromosome 18 at 44,204,622 bp (GRCm38)
  • A to G, chromosome 18 at 77,948,220 bp (GRCm38)
  • A to G, chromosome 19 at 14,596,785 bp (GRCm38)
  • T to C, chromosome 19 at 22,918,640 bp (GRCm38)
  • T to A, chromosome 19 at 31,918,099 bp (GRCm38)
  • A to G, chromosome 19 at 40,090,566 bp (GRCm38)
  • T to A, chromosome 19 at 56,351,668 bp (GRCm38)
  • C to T, chromosome X at 142,237,751 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9327 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069139-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.