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Strain Name:
C57BL/6J-MtgxR9357Btlr/Mmmh
Stock Number:
069166-MU
Citation ID:
RRID:MMRRC_069166-MU
Other Names:
R9357 (G1)
Major Collection:

Strain Information

Agt
Name: angiotensinogen
Synonyms: Aogen, Serpina8, angiotensin precursor
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11606
HGNC: HGNC:333
Homologene: 14
Glo1
Name: glyoxalase 1
Synonyms: Glo-1s, Glo-1r, Glo-1, Qglo, Glo1-s, Glo1-r, 0610009E22Rik, 2510049H23Rik, 1110008E19Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 109801
VEGA: 17
HGNC: HGNC:4323
Homologene: 4880
Map1b
Name: microtubule-associated protein 1B
Synonyms: MAP5, Mtap-5, Mtap5, LC1, Mtap1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17755
VEGA: 13
HGNC: HGNC:6836
Homologene: 38111
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: Megalin, Gp330, D230004K18Rik, b2b1625.2Clo
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Cacul1
Name: CDK2 associated, cullin domain 1
Synonyms: 2810417M16Rik, D130033C15Rik, 9830127L17Rik, 2700078E11Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 78832
VEGA: 19
Homologene: 17821
Parg
Name: poly (ADP-ribose) glycohydrolase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 26430
HGNC: HGNC:8605
Homologene: 50532
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 93,785,926 bp (GRCm38)
  • T to A, chromosome 1 at 173,568,826 bp (GRCm38)
  • C to T, chromosome 1 at 188,874,950 bp (GRCm38)
  • T to C, chromosome 2 at 52,179,568 bp (GRCm38)
  • A to T, chromosome 2 at 69,506,573 bp (GRCm38)
  • A to G, chromosome 2 at 155,621,348 bp (GRCm38)
  • C to T, chromosome 3 at 95,295,279 bp (GRCm38)
  • A to G, chromosome 3 at 97,718,329 bp (GRCm38)
  • T to C, chromosome 3 at 142,543,128 bp (GRCm38)
  • T to G, chromosome 4 at 3,185,149 bp (GRCm38)
  • A to T, chromosome 4 at 103,208,136 bp (GRCm38)
  • A to G, chromosome 4 at 133,296,471 bp (GRCm38)
  • A to G, chromosome 5 at 137,612,834 bp (GRCm38)
  • T to C, chromosome 6 at 48,467,055 bp (GRCm38)
  • A to G, chromosome 6 at 121,875,491 bp (GRCm38)
  • A to G, chromosome 6 at 146,359,316 bp (GRCm38)
  • T to C, chromosome 7 at 86,231,220 bp (GRCm38)
  • T to C, chromosome 8 at 3,495,568 bp (GRCm38)
  • G to T, chromosome 8 at 124,564,326 bp (GRCm38)
  • T to C, chromosome 8 at 128,944,655 bp (GRCm38)
  • T to C, chromosome 9 at 20,889,924 bp (GRCm38)
  • A to T, chromosome 9 at 85,326,619 bp (GRCm38)
  • T to C, chromosome 9 at 106,214,901 bp (GRCm38)
  • T to C, chromosome 10 at 80,311,038 bp (GRCm38)
  • T to A, chromosome 10 at 127,877,046 bp (GRCm38)
  • A to G, chromosome 11 at 43,259,884 bp (GRCm38)
  • G to A, chromosome 11 at 59,038,766 bp (GRCm38)
  • C to T, chromosome 11 at 77,842,188 bp (GRCm38)
  • A to G, chromosome 11 at 120,010,870 bp (GRCm38)
  • A to G, chromosome 12 at 115,495,858 bp (GRCm38)
  • A to T, chromosome 13 at 40,888,256 bp (GRCm38)
  • A to T, chromosome 13 at 99,430,200 bp (GRCm38)
  • G to A, chromosome 14 at 32,274,917 bp (GRCm38)
  • C to T, chromosome 14 at 68,642,030 bp (GRCm38)
  • T to C, chromosome 15 at 63,900,347 bp (GRCm38)
  • T to A, chromosome 17 at 18,021,949 bp (GRCm38)
  • T to C, chromosome 17 at 30,612,544 bp (GRCm38)
  • T to C, chromosome 17 at 34,598,567 bp (GRCm38)
  • A to G, chromosome 17 at 73,907,716 bp (GRCm38)
  • A to C, chromosome 17 at 73,926,546 bp (GRCm38)
  • A to T, chromosome 18 at 31,960,076 bp (GRCm38)
  • A to T, chromosome 18 at 36,969,173 bp (GRCm38)
  • C to A, chromosome 18 at 61,315,868 bp (GRCm38)
  • A to C, chromosome 19 at 43,441,388 bp (GRCm38)
  • A to T, chromosome 19 at 47,272,009 bp (GRCm38)
  • A to G, chromosome 19 at 60,545,504 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9357 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069166-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.