Strain Name:
C57BL/6J-MtgxR9447Btlr/Mmmh
Stock Number:
069250-MU
Citation ID:
RRID:MMRRC_069250-MU
Other Names:
R9447 (G1)
Major Collection:

Strain Information

Ighm
Name: immunoglobulin heavy constant mu
Synonyms: Ig mu, Igh6, IgM, muH, Igh-M
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16019
HGNC: HGNC:5541
Nedd4
Name: neural precursor cell expressed, developmentally down-regulated 4
Synonyms: E430025J12Rik, Nedd4a, Nedd4, Nedd4-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17999
HGNC: HGNC:7727
Homologene: 134533
Ntsr1
Name: neurotensin receptor 1
Synonyms: NT-1R, Ntsr1, NTR-1, NTR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18216
HGNC: HGNC:8039
Homologene: 68261
Sec24d
Name: SEC24 homolog D, COPII coat complex component
Synonyms: LOC383951, 2310020L09Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 69608
Homologene: 40986
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: GMAP-210, 6030460N08Rik, TRIP230, 2610511G22Rik, 3110031G15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109181
Homologene: 20897
Plekha5
Name: pleckstrin homology domain containing, family A member 5
Synonyms: PEPP2, 2810431N21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 109135
Homologene: 10377
Lpin2
Name: lipin 2
Synonyms: 2610511G02Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 64898
Homologene: 8769
Tlr2
Name: toll-like receptor 2
Synonyms: Ly105
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24088
Homologene: 20695
Rad17
Name: RAD17 checkpoint clamp loader component
Synonyms: MmRad24, 9430035O09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19356
VEGA: 13
HGNC: HGNC:9807
Homologene: 32117
Taf6
Name: TATA-box binding protein associated factor 6
Synonyms: 80kDa, p80, Taf2e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21343
Homologene: 7561
Rnf181
Name: ring finger protein 181
Synonyms: 2500002L14Rik, 1700047F16Rik, 6230415N01Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66510
Homologene: 9537
Fcho1
Name: FCH domain only 1
Synonyms: 3322402E17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74015
Homologene: 22869
Tnfrsf10b
Name: tumor necrosis factor receptor superfamily, member 10b
Synonyms: Killer/Dr5, DR5, Ly98, KILLER, TRICK2A, TRAIL-R2, TRICKB, TRAILR2, TRICK2B, Trail Receptor
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21933
VEGA: 14
Homologene: 129806
Fhip1b
Name: FHF complex subunit HOOK interacting protein 1B
Synonyms: Fam160a2, 4632419K20Rik, 6530415H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74349
Homologene: 75329
Dnaaf5
Name: dynein, axonemal assembly factor 5
Synonyms: Heatr2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 433956
Homologene: 41198
Hpf1
Name: histone PARylation factor 1
Synonyms: 2700029M09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72612
Homologene: 32374
Ganab
Name: alpha glucosidase 2 alpha neutral subunit
Synonyms: G2an, GluII
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 14376
VEGA: 19
HGNC: HGNC:4138
Homologene: 5426
Enpp6
Name: ectonucleotide pyrophosphatase/phosphodiesterase 6
Synonyms: B830047L21Rik, Npp6, D8Ertd514e, 4833421B01Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320981
Homologene: 62657
Lrrc4
Name: leucine rich repeat containing 4
Synonyms: Nag14, NGL2, NGL-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192198
Homologene: 36403
Pcca
Name: propionyl-Coenzyme A carboxylase, alpha polypeptide
Synonyms: C79630
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110821
HGNC: HGNC:8653
Homologene: 236
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
Synonyms: 2810411E22Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66313
Homologene: 41490
Tm7sf3
Name: transmembrane 7 superfamily member 3
Synonyms: 2010003B14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67623
Homologene: 9560
Ubqln4
Name: ubiquilin 4
Synonyms: UBIN
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94232
HGNC: HGNC:1237
Homologene: 41346
Prss22
Name: serine protease 22
Synonyms: 4733401N09Rik, SP001LA, BSSP-4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70835
VEGA: 17
Homologene: 23344
Cox16
Name: cytochrome c oxidase assembly protein 16
Synonyms: 1810020G14Rik, 1810055I05Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66272
Homologene: 9520
Ttn
Name: titin
Synonyms: connectin, 1100001C23Rik, D330041I19Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, 2310057K23Rik, shru, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Dhx57
Name: DExH-box helicase 57
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106794
VEGA: 17
Homologene: 56267
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, A530024P18Rik, 2310003D02Rik, Cmya3, myomaxin, 2310008C07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Ugt2a3
Name: UDP glucuronosyltransferase 2 family, polypeptide A3
Synonyms: 2010321J07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72094
Homologene: 55988
Ksr1
Name: kinase suppressor of ras 1
Synonyms: D11Bhm184e, B-KSR1, D11Bhm183e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16706
HGNC: HGNC:6465
Homologene: 8410
Nrxn3
Name: neurexin III
Synonyms: neurexin III alpha, neurexin III beta, 9330112C09Rik, neurexin III alpha, D12Bwg0831e, 4933401A11Rik, neurexin III beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18191
HGNC: HGNC:8010
Homologene: 83225
Aadacl2fm2
Name: AADACL2 family member 2
Synonyms: Gm5538
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 433597
Homologene: 79018
Sqor
Name: sulfide quinone oxidoreductase
Synonyms: 0610039J17Rik, 4930557M22Rik, Sqrdl, flavo-binding protein
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 59010
Homologene: 10921
Ago4
Name: argonaute RISC catalytic subunit 4
Synonyms: 5730550L01Rik, Eif2c4, argonaute 4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76850
Homologene: 41184
Mctp1
Name: multiple C2 domains, transmembrane 1
Synonyms: 2810465F10Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 78771
Homologene: 75211
Cadps2
Name: Ca2+-dependent activator protein for secretion 2
Synonyms: cpd2, Caps2, A230044C21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320405
Homologene: 23060
Ddt
Name: D-dopachrome tautomerase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13202
Homologene: 1038
Dnase2a
Name: deoxyribonuclease II alpha
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13423
HGNC: HGNC:2960
Homologene: 68179
Osbpl3
Name: oxysterol binding protein-like 3
Synonyms: 1200014M06Rik, OSBP3, 6720421I08Rik, ORP3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71720
Homologene: 49422
Ncf4
Name: neutrophil cytosolic factor 4
Synonyms: p40phox
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17972
HGNC: HGNC:7662
Homologene: 525
Zfp821
Name: zinc finger protein 821
Synonyms: 4930566A11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75871
Homologene: 32345
Daxx
Name: Fas death domain-associated protein
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13163
HGNC: HGNC:2681
Homologene: 1033
Dytn
Name: dystrotelin
Synonyms: LOC241073
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241073
Homologene: 104042
Morn5
Name: MORN repeat containing 5
Synonyms: 1700010A17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75495
Homologene: 16510
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242409
Homologene: 72894
Gm57858
Name: gene model 57858
Synonyms: Ccdc144b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 241943
Homologene: 87263
Fstl4
Name: follistatin-like 4
Synonyms: B230374F23Rik, SPIG1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320027
Homologene: 18543
Hs3st2
Name: heparan sulfate (glucosamine) 3-O-sulfotransferase 2
Synonyms: A830061E14Rik, 6430516N12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 195646
HGNC: HGNC:5195
Homologene: 21220
Akr1c19
Name: aldo-keto reductase family 1, member C19
Synonyms: 1810010N06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432720
HGNC: HGNC:387
Homologene: 134145
Siae
Name: sialic acid acetylesterase
Synonyms: Ysg2, clone 165, LSE
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22619
Homologene: 8001
Cyp2t4
Name: cytochrome P450, family 2, subfamily t, polypeptide 4
Synonyms: LOC384724
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384724
Homologene: 76639
Cd47
Name: CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
Synonyms: IAP, Itgp, B430305P08Rik, 9130415E20Rik, integrin-associated protein
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16423
HGNC: HGNC:1682
Homologene: 1346
Nras
Name: neuroblastoma ras oncogene
Synonyms: N-ras
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18176
HGNC: HGNC:7989
Homologene: 55661
Tas2r109
Name: taste receptor, type 2, member 109
Synonyms: mGR09, Tas2r9, T2R09, mt2r62
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387343
Homologene: 87292
Ube2r2
Name: ubiquitin-conjugating enzyme E2R 2
Synonyms: Ubc3b, Cdc34b, 1200003M11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67615
Homologene: 3210
Gkn1
Name: gastrokine 1
Synonyms: AMP-18, 2200002K21Rik, BRICD1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66283
Homologene: 10487
Zfp935
Name: zinc finger protein 935
Synonyms: 8430426H19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 71508
VEGA: 13
Epm2a
Name: epilepsy, progressive myoclonic epilepsy, type 2 gene alpha
Synonyms: laforin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13853
HGNC: HGNC:3413
Homologene: 38087
Krbox5
Name: KRAB box domain containing 5
Synonyms: Gm10037, EG328280
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102637366
VEGA: 13
Efcab8
Name: EF-hand calcium binding domain 8
Synonyms: EG329541
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100504221
Vmn1r125
Name: vomeronasal 1 receptor 125
Synonyms: Gm8519
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 667215
Homologene: 104166
Cdrt4
Name: CMT1A duplicated region transcript 4
Synonyms: 1700019I23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66338
Homologene: 52147
Or1e1d-ps1
Name: olfactory receptor family 1 subfamily E member 1D, pseudogene 1
Synonyms: GA_x6K02T2P1NL-4083149-4084087, Olfr396-ps1, MOR135-19
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258208
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 63,661,143 bp (GRCm38)
  • A to T, chromosome 2 at 36,079,513 bp (GRCm38)
  • T to A, chromosome 2 at 67,508,606 bp (GRCm38)
  • C to A, chromosome 2 at 76,752,518 bp (GRCm38)
  • C to A, chromosome 2 at 122,807,600 bp (GRCm38)
  • G to C, chromosome 2 at 153,804,941 bp (GRCm38)
  • C to T, chromosome 2 at 180,538,747 bp (GRCm38)
  • A to G, chromosome 3 at 36,020,046 bp (GRCm38)
  • T to A, chromosome 3 at 59,743,630 bp (GRCm38)
  • T to A, chromosome 3 at 83,841,138 bp (GRCm38)
  • T to A, chromosome 3 at 88,556,817 bp (GRCm38)
  • T to C, chromosome 3 at 103,060,357 bp (GRCm38)
  • T to C, chromosome 3 at 123,290,513 bp (GRCm38)
  • T to C, chromosome 4 at 41,190,655 bp (GRCm38)
  • T to G, chromosome 4 at 43,685,766 bp (GRCm38)
  • G to A, chromosome 4 at 126,508,358 bp (GRCm38)
  • T to A, chromosome 5 at 87,325,471 bp (GRCm38)
  • A to T, chromosome 5 at 138,178,708 bp (GRCm38)
  • A to G, chromosome 5 at 139,177,988 bp (GRCm38)
  • A to T, chromosome 6 at 23,323,298 bp (GRCm38)
  • A to G, chromosome 6 at 28,830,651 bp (GRCm38)
  • T to A, chromosome 6 at 50,344,877 bp (GRCm38)
  • G to T, chromosome 6 at 72,360,587 bp (GRCm38)
  • A to G, chromosome 6 at 87,346,340 bp (GRCm38)
  • A to C, chromosome 6 at 132,980,307 bp (GRCm38)
  • A to G, chromosome 6 at 140,579,466 bp (GRCm38)
  • C to T, chromosome 6 at 146,623,681 bp (GRCm38)
  • A to G, chromosome 7 at 21,272,702 bp (GRCm38)
  • G to A, chromosome 7 at 27,155,292 bp (GRCm38)
  • G to T, chromosome 7 at 105,384,948 bp (GRCm38)
  • C to T, chromosome 7 at 121,393,066 bp (GRCm38)
  • A to T, chromosome 8 at 47,030,565 bp (GRCm38)
  • A to G, chromosome 8 at 60,895,584 bp (GRCm38)
  • A to G, chromosome 8 at 71,717,269 bp (GRCm38)
  • A to C, chromosome 8 at 84,909,157 bp (GRCm38)
  • G to A, chromosome 8 at 109,724,184 bp (GRCm38)
  • C to A, chromosome 9 at 37,646,447 bp (GRCm38)
  • T to C, chromosome 9 at 72,670,099 bp (GRCm38)
  • C to T, chromosome 10 at 11,448,688 bp (GRCm38)
  • A to G, chromosome 10 at 75,772,837 bp (GRCm38)
  • G to T, chromosome 11 at 53,186,339 bp (GRCm38)
  • T to G, chromosome 11 at 62,992,592 bp (GRCm38)
  • G to T, chromosome 11 at 73,928,791 bp (GRCm38)
  • T to C, chromosome 11 at 79,018,333 bp (GRCm38)
  • A to T, chromosome 11 at 106,824,722 bp (GRCm38)
  • A to T, chromosome 12 at 81,359,335 bp (GRCm38)
  • T to C, chromosome 12 at 89,254,908 bp (GRCm38)
  • T to A, chromosome 12 at 101,883,889 bp (GRCm38)
  • A to T, chromosome 12 at 113,421,174 bp (GRCm38)
  • A to G, chromosome 13 at 4,246,839 bp (GRCm38)
  • A to G, chromosome 13 at 62,455,028 bp (GRCm38)
  • A to G, chromosome 13 at 67,833,834 bp (GRCm38)
  • A to G, chromosome 13 at 76,579,785 bp (GRCm38)
  • A to T, chromosome 13 at 100,627,611 bp (GRCm38)
  • T to A, chromosome 14 at 69,776,159 bp (GRCm38)
  • T to C, chromosome 14 at 122,616,878 bp (GRCm38)
  • C to T, chromosome 15 at 4,931,341 bp (GRCm38)
  • G to T, chromosome 15 at 78,262,299 bp (GRCm38)
  • C to A, chromosome 16 at 49,895,459 bp (GRCm38)
  • T to C, chromosome 17 at 23,993,863 bp (GRCm38)
  • A to T, chromosome 17 at 33,913,273 bp (GRCm38)
  • T to C, chromosome 17 at 64,659,006 bp (GRCm38)
  • A to G, chromosome 17 at 71,232,092 bp (GRCm38)
  • A to G, chromosome 17 at 80,242,094 bp (GRCm38)
  • C to T, chromosome 19 at 8,909,530 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9447 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069250-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.