Strain Name:
C57BL/6J-MtgxR9456Btlr/Mmmh
Stock Number:
069259-MU
Citation ID:
RRID:MMRRC_069259-MU
Other Names:
R9456 (G1)
Major Collection:

Strain Information

Septin3
Name: septin 3
Synonyms: Sep3, Sept3, 3110018K01Rik, B530002E20Rik, Gm46500
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 24050
VEGA: 15
Homologene: 99740
Cltc
Name: clathrin heavy chain
Synonyms: CHC
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67300
HGNC: HGNC:2092
Homologene: 3572
Zfp609
Name: zinc finger protein 609
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214812
Homologene: 72220
Tnpo2
Name: transportin 2 (importin 3, karyopherin beta 2b)
Synonyms: 1110034O24Rik, Kpnb2b, TRN2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212999
Homologene: 8381
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: 3110032K11Rik, MEB1, Tcf18, [delta]EF1, Zfhep, Zfx1a, Tw, Nil2, AREB6, Zfhx1a, ZEB, Tcf8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21417
Homologene: 31779
Hectd1
Name: HECT domain E3 ubiquitin protein ligase 1
Synonyms: b2b327Clo, A630086P08Rik, opm
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 207304
VEGA: 12
Homologene: 9115
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Abhd3
Name: abhydrolase domain containing 3
Synonyms: LABH3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106861
Homologene: 14055
Pygo1
Name: pygopus 1
Synonyms: 2600014C22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72135
Homologene: 41050
Jph4
Name: junctophilin 4
Synonyms: JP-4, 9330157P13Rik, JPHL1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319984
Homologene: 13034
Klk8
Name: kallikrein related-peptidase 8
Synonyms: Nrpn, Prss19, BSP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259277
HGNC: HGNC:6369
Homologene: 21410
Lrrc8a
Name: leucine rich repeat containing 8A VRAC subunit A
Synonyms: Lrrc8, ebo, SWELL1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241296
Homologene: 18617
Itfg1
Name: integrin alpha FG-GAP repeat containing 1
Synonyms: D8Wsu49e, 2310047C21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71927
Homologene: 12423
Fam219a
Name: family with sequence similarity 219, member A
Synonyms: 2310028H24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71901
Homologene: 51830
Arhgdia
Name: Rho GDP dissociation inhibitor alpha
Synonyms: 5330430M07Rik, Rho-GDI, Rho GDIalpha
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192662
HGNC: HGNC:678
Homologene: 908
Rnf214
Name: ring finger protein 214
Synonyms: D130054N24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235315
Homologene: 109357
Tmprss2
Name: transmembrane protease, serine 2
Synonyms: epitheliasin, D16Ertd61e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50528
VEGA: 16
Homologene: 4136
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Gm4560, 5530401A10Rik, Jhdm1a, lalina, Fbxl11, Fbl7, Cxxc8
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225876
Homologene: 56564
Atp2a3
Name: ATPase, Ca++ transporting, ubiquitous
Synonyms: Serca3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53313
HGNC: HGNC:813
Homologene: 69131
Myo15a
Name: myosin XVA
Synonyms: Myo15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17910
HGNC: HGNC:7594
Homologene: 56504
Hmcn1
Name: hemicentin 1
Synonyms: EG545370, LOC240793
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Ush2a
Name: usherin
Synonyms: Ushrn, LOC269160, Ush2a, LOC381317, MUSH2A, A930037M10Rik, A930011D15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22283
Homologene: 66151
Clcn2
Name: chloride channel, voltage-sensitive 2
Synonyms: nmf240, Clc2, ClC-2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12724
HGNC: HGNC:2020
Homologene: 3213
Fat4
Name: FAT atypical cadherin 4
Synonyms: 6030410K14Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329628
Homologene: 14377
Or4f53
Name: olfactory receptor family 4 subfamily F member 53
Synonyms: GA_x6K02T2Q125-72308574-72309512, MOR245-10, Olfr1276
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258390
Homologene: 133614
Klhl5
Name: kelch-like 5
Synonyms: 1300013C10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71778
HGNC: HGNC:6356
Homologene: 56736
Trgv7
Name: T cell receptor gamma, variable 7
Synonyms: Tcrg-V7
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21641
Nol4
Name: nucleolar protein 4
Synonyms: 4930568N03Rik, 1700013J13Rik, LOC383304
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Ift140
Name: intraflagellar transport 140
Synonyms: Tce5, Wdtc2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106633
Homologene: 40979
Prorp
Name: protein only RNase P catalytic subunit
Synonyms: 1110008L16Rik, Mrpp3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66132
Homologene: 45935
Mdga2
Name: MAM domain containing glycosylphosphatidylinositol anchor 2
Synonyms: Mamdc1, Mdga2, 9330209L04Rik, Adp, 6720489L24Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320772
Homologene: 45659
Dennd4b
Name: DENN domain containing 4B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229541
Homologene: 28281
Zfp735
Name: zinc finger protein 735
Synonyms: 1700012C15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76390
Homologene: 88945
Dnah7b
Name: dynein, axonemal, heavy chain 7B
Synonyms: LOC227058, Dnahc7b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227058
Homologene: 41287
Tor1aip2
Name: torsin A interacting protein 2
Synonyms: 1110020D10Rik, LULL1, Ifrg15, 15kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240832
Homologene: 17028
Lrrc49
Name: leucine rich repeat containing 49
Synonyms: D430025H09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102747
Homologene: 9782
Pla2g4c
Name: phospholipase A2, group IVC (cytosolic, calcium-independent)
Synonyms: CPLA2-gamma
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232889
HGNC: HGNC:9037
Homologene: 115256
Prr5
Name: proline rich 5 (renal)
Synonyms: C030017C09Rik, Protor-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109270
Homologene: 17132
Cmbl
Name: carboxymethylenebutenolidase homolog
Synonyms: 2310016A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69574
Homologene: 100714
Klre1
Name: killer cell lectin-like receptor family E member 1
Synonyms: Klre-1, NKG2I
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243655
Homologene: 17794
Slc30a3
Name: solute carrier family 30 (zinc transporter), member 3
Synonyms: Znt3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22784
Homologene: 74470
Krt79
Name: keratin 79
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223917
Homologene: 89169
Or6c75
Name: olfactory receptor family 6 subfamily C member 75
Synonyms: GA_x6K02T2PULF-11179777-11180721, MOR112-1, Olfr790
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258935
Homologene: 74101
Socs5
Name: suppressor of cytokine signaling 5
Synonyms: SOCS-5, Cish5, 1810018L08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56468
VEGA: 17
Homologene: 10495
Pigw
Name: phosphatidylinositol glycan anchor biosynthesis, class W
Synonyms: Gwt1, 2610044A17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70325
Homologene: 6243
Lin7a
Name: lin-7 homolog A, crumbs cell polarity complex component
Synonyms: MALS-1, LIN-7A, TIP-33, Veli
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108030
VEGA: 10
Homologene: 20976
Taar7d
Name: trace amine-associated receptor 7D
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 435206
Homologene: 115653
Speer3
Name: spermatogenesis associated glutamate (E)-rich protein 3
Synonyms: SPEER-3, 4933405P08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71026
Homologene: 69402
Cldn9
Name: claudin 9
Synonyms: nmf329
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56863
HGNC: HGNC:2051
Homologene: 10656
Gm3336
Name: predicted gene 3336
Synonyms: 2410018E23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502950
Homologene: 136417
Stk16
Name: serine/threonine kinase 16
Synonyms: EDPK, Krct, PKL12, Embryo-Derived Protein Kinase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20872
Homologene: 2739
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to A, chromosome 1 at 46,126,793 bp (GRCm38)
  • T to C, chromosome 1 at 75,211,160 bp (GRCm38)
  • A to T, chromosome 1 at 150,630,302 bp (GRCm38)
  • C to A, chromosome 1 at 155,868,711 bp (GRCm38)
  • C to T, chromosome 1 at 156,061,779 bp (GRCm38)
  • A to G, chromosome 1 at 188,826,392 bp (GRCm38)
  • T to A, chromosome 2 at 30,255,651 bp (GRCm38)
  • T to C, chromosome 2 at 111,258,003 bp (GRCm38)
  • T to A, chromosome 3 at 38,888,422 bp (GRCm38)
  • C to T, chromosome 3 at 90,271,208 bp (GRCm38)
  • T to C, chromosome 4 at 41,521,871 bp (GRCm38)
  • T to A, chromosome 5 at 13,796,354 bp (GRCm38)
  • AGGGCTTACCTGAGCGG to AGG, chromosome 5 at 31,089,545 bp (GRCm38)
  • T to C, chromosome 5 at 65,148,596 bp (GRCm38)
  • A to T, chromosome 6 at 129,582,405 bp (GRCm38)
  • T to C, chromosome 7 at 13,343,975 bp (GRCm38)
  • T to C, chromosome 7 at 43,803,753 bp (GRCm38)
  • A to G, chromosome 8 at 70,722,091 bp (GRCm38)
  • G to A, chromosome 8 at 85,047,386 bp (GRCm38)
  • A to G, chromosome 8 at 85,838,937 bp (GRCm38)
  • A to G, chromosome 9 at 45,867,988 bp (GRCm38)
  • A to G, chromosome 9 at 60,687,416 bp (GRCm38)
  • A to G, chromosome 9 at 65,703,843 bp (GRCm38)
  • C to T, chromosome 9 at 72,925,774 bp (GRCm38)
  • T to A, chromosome 10 at 24,027,389 bp (GRCm38)
  • C to T, chromosome 10 at 107,382,622 bp (GRCm38)
  • T to C, chromosome 10 at 129,501,646 bp (GRCm38)
  • G to A, chromosome 11 at 60,501,842 bp (GRCm38)
  • A to T, chromosome 11 at 72,980,305 bp (GRCm38)
  • A to G, chromosome 11 at 73,711,577 bp (GRCm38)
  • C to A, chromosome 11 at 84,877,214 bp (GRCm38)
  • G to A, chromosome 11 at 86,702,411 bp (GRCm38)
  • A to C, chromosome 11 at 120,579,242 bp (GRCm38)
  • A to G, chromosome 12 at 51,785,801 bp (GRCm38)
  • T to C, chromosome 12 at 55,338,230 bp (GRCm38)
  • T to C, chromosome 12 at 66,568,758 bp (GRCm38)
  • A to T, chromosome 13 at 19,178,215 bp (GRCm38)
  • A to T, chromosome 14 at 55,113,633 bp (GRCm38)
  • A to G, chromosome 15 at 31,589,802 bp (GRCm38)
  • A to G, chromosome 15 at 82,283,151 bp (GRCm38)
  • A to G, chromosome 15 at 84,701,481 bp (GRCm38)
  • T to C, chromosome 15 at 101,931,469 bp (GRCm38)
  • CCCGCCGCCGCCGCCGC to CCCGCCGCCGCCGC, chromosome 16 at 20,715,952 bp (GRCm38)
  • C to T, chromosome 16 at 97,591,469 bp (GRCm38)
  • A to T, chromosome 17 at 23,683,582 bp (GRCm38)
  • T to C, chromosome 17 at 25,035,784 bp (GRCm38)
  • C to A, chromosome 17 at 87,134,838 bp (GRCm38)
  • C to T, chromosome 18 at 5,766,709 bp (GRCm38)
  • T to C, chromosome 18 at 10,645,121 bp (GRCm38)
  • T to C, chromosome 18 at 23,039,840 bp (GRCm38)
  • C to T, chromosome 19 at 4,343,113 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9456 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069259-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.