Strain Name:
C57BL/6J-MtgxR9488Btlr/Mmmh
Stock Number:
069291-MU
Citation ID:
RRID:MMRRC_069291-MU
Other Names:
R9488 (G1)
Major Collection:

Strain Information

Tnpo1
Name: transportin 1
Synonyms: D13Ertd688e, Kpnb2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238799
HGNC: HGNC:6401
Homologene: 5358
Cdk17
Name: cyclin dependent kinase 17
Synonyms: 6430598J10Rik, Pctk2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237459
VEGA: 10
HGNC: HGNC:8750
Homologene: 55666
Drd2
Name: dopamine receptor D2
Synonyms: Drd-2, D2R, D2 receptor
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Mga
Name: MAX gene associated
Synonyms: D030062C11Rik, Mad5, C130042M01Rik, Mga
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 29808
Homologene: 49351
Jam2
Name: junction adhesion molecule 2
Synonyms: JAM-2, VE-JAM, 2410030G21Rik, Jcam2, 2410167M24Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67374
Homologene: 10929
Cdk18
Name: cyclin dependent kinase 18
Synonyms: Pctk3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18557
HGNC: HGNC:8751
Homologene: 1949
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: D17Rp17e, Tas, MAPKKK4, D17Rp17, Mekk4, RP17, T-associated sex reversal, MTK1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Prep
Name: prolyl endopeptidase
Synonyms: Pop, prolyl oligopeptidase, D10Wsu136e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19072
VEGA: 10
HGNC: HGNC:9358
Homologene: 2042
Ubap2l
Name: ubiquitin-associated protein 2-like
Synonyms: A430103N23Rik, NICE-4, 4932431F02Rik, 3110083O19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74383
Homologene: 136291
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67958
Homologene: 13964
Hnrnpll
Name: heterogeneous nuclear ribonucleoprotein L-like
Synonyms: Hnrpll, 2510028H02Rik, 2810036L13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72692
Homologene: 26701
Tpp2
Name: tripeptidyl peptidase II
Synonyms: TppII
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22019
Homologene: 2471
Thoc1
Name: THO complex 1
Synonyms: NMP-84, 3110002N20Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225160
VEGA: 18
Homologene: 38012
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: Ayu17-449, E130014J05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, XAP8, Hbxap, C030033M12Rik, p325
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Git2
Name: GIT ArfGAP 2
Synonyms: ARF GTPase activating protein 2, 5830420E16Rik, Cat-2, B230104M05Rik, Cool associated tyrosine phosphorylated-2, 1500036H07Rik, 9630056M03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26431
HGNC: HGNC:4273
Homologene: 41336
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hypothroid, pet, hyt
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Eif2d
Name: eukaryotic translation initiation factor 2D
Synonyms: D1Ertd5e, Lgtn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16865
HGNC: HGNC:6583
Homologene: 38244
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA2, Rpo1-2, RPA116, D630020H17Rik, 128kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, 2300002E22Rik, DP, rul
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Lama5
Name: laminin, alpha 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16776
HGNC: HGNC:6485
Homologene: 4060
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, 2310042E16Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: sema, Semaq, A730020P05Rik, VIa, Sema6A-1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 20358
Homologene: 32426
Lmo7
Name: LIM domain only 7
Synonyms: FBXO20, LOC380928
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380928
HGNC: HGNC:6646
Homologene: 83924
Tnc
Name: tenascin C
Synonyms: Hxb, tenascin-C, C130033P17Rik, cytotactin, TN-C, hexabrachion, TN
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21923
HGNC: HGNC:5318
Homologene: 55636
Prss58
Name: serine protease 58
Synonyms: BC048599
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232717
Homologene: 65285
Clca4a
Name: chloride channel accessory 4A
Synonyms: Clca6, 9130020L07Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99663
HGNC: HGNC:2018
Homologene: 40808
Man2a1
Name: mannosidase 2, alpha 1
Synonyms: Mana-2, Mana2, Map-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17158
HGNC: HGNC:6824
Homologene: 1777
Pum3
Name: pumilio RNA-binding family member 3
Synonyms: 1110069H02Rik, D19Bwg1357e
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 52874
VEGA: 19
Homologene: 5762
Tbl2
Name: transducin (beta)-like 2
Synonyms: C76179, WS-bTRP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27368
Homologene: 8260
Zfp949
Name: zinc finger protein 949
Synonyms: 4930422I07Rik, Nczf
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71640
Homologene: 129930
Wdr6
Name: WD repeat domain 6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83669
Homologene: 117682
Taf6l
Name: TATA-box binding protein associated factor 6 like
Synonyms: C530024J06Rik, 2810417N14Rik, PAF65A
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225895
Homologene: 4728
Lhx8
Name: LIM homeobox protein 8
Synonyms: L3, Lhx7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16875
Homologene: 62661
Clvs2
Name: clavesin 2
Synonyms: Rlbp1l2, A330019N05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215890
Homologene: 27894
Slc39a5
Name: solute carrier family 39 (metal ion transporter), member 5
Synonyms: 1810013D05Rik, 2010205A06Rik, Zip5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 72002
VEGA: 10
Homologene: 57083
Ankrd35
Name: ankyrin repeat domain 35
Synonyms: 4732436F15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213121
Homologene: 16977
P2rx5
Name: purinergic receptor P2X, ligand-gated ion channel, 5
Synonyms: P2X5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 94045
HGNC: HGNC:8536
Homologene: 1924
Prg4
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)
Synonyms: lubricin, MSF, DOL54, SZP
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 96875
HGNC: HGNC:9364
Homologene: 137352
Slc15a2
Name: solute carrier family 15 (H+/peptide transporter), member 2
Synonyms: 8430408C16Rik, Pept2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 57738
Homologene: 56912
Galntl5
Name: UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 5
Synonyms: 1700021B12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67909
Homologene: 12210
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Gm7455, Col6a5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: 8030451F13Rik, Slow-type C-protein
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Slc13a3
Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Synonyms: NaDC-3, NaDC3, SDCT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 114644
Homologene: 11266
Arhgap40
Name: Rho GTPase activating protein 40
Synonyms: Gm14203
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545481
Homologene: 53500
Irag2
Name: inositol 1,4,5-triphosphate receptor associated 2
Synonyms: D6Int7, Jaw1, D6Int3, D6Int4, D6Int5, D6Int8, Lrmp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16970
HGNC: HGNC:6690
Homologene: 4483
Nfasc
Name: neurofascin
Synonyms: D430023G06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269116
Homologene: 24945
Spata31f1a
Name: spermatogenesis associated 31 subfamily F member 1A
Synonyms: Gm12429, Fam205a1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 433698
Homologene: 79022
Prr14
Name: proline rich 14
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233895
Homologene: 11424
Pcdhb3
Name: protocadherin beta 3
Synonyms: PcdhbC
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93874
HGNC: HGNC:8688
Homologene: 115665
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: Semaf, Semai, Semacl1, M-Sema F, Semacl1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20353
Homologene: 23047
Usp44
Name: ubiquitin specific peptidase 44
Synonyms: E430004F17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 327799
VEGA: 10
Homologene: 12961
4930433I11Rik
Name: RIKEN cDNA 4930433I11 gene
Synonyms: LOC243944
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243944
Homologene: 77912
Ncald
Name: neurocalcin delta
Synonyms: D030020D09Rik, D15Ertd412e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 52589
HGNC: HGNC:7655
Homologene: 49978
Vmn1r225
Name: vomeronasal 1 receptor 225
Synonyms: V1re5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171228
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
Krt27
Name: keratin 27
Synonyms: Krt1-c29, stpm, mIRSa3.1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16675
Homologene: 7805
Cfap418
Name: cilia and flagella associated protein 418
Synonyms: 2610301B20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67157
Homologene: 18641
Gm572
Name: predicted gene 572
Synonyms: b2b1167Clo, LOC230909
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230909
Homologene: 52134
Arpin
Name: actin-related protein 2/3 complex inhibitor
Synonyms: 2610034B18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70420
Homologene: 128480
Ighv7-4
Name: immunoglobulin heavy variable 7-4
Synonyms: Gm16839
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 632654
HGNC: HGNC:5633
B020011L13Rik
Name: RIKEN cDNA B020011L13 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 547097
Homologene: 140625
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 36,551,986 bp (GRCm38)
  • A to T, chromosome 1 at 44,002,112 bp (GRCm38)
  • A to G, chromosome 1 at 117,800,994 bp (GRCm38)
  • T to A, chromosome 1 at 131,155,225 bp (GRCm38)
  • A to G, chromosome 1 at 132,121,522 bp (GRCm38)
  • T to C, chromosome 1 at 132,600,128 bp (GRCm38)
  • T to C, chromosome 1 at 150,451,273 bp (GRCm38)
  • A to G, chromosome 1 at 162,803,768 bp (GRCm38)
  • C to T, chromosome 2 at 119,964,823 bp (GRCm38)
  • T to C, chromosome 2 at 129,125,497 bp (GRCm38)
  • G to A, chromosome 2 at 150,268,557 bp (GRCm38)
  • C to T, chromosome 2 at 158,549,651 bp (GRCm38)
  • T to A, chromosome 2 at 165,408,931 bp (GRCm38)
  • T to C, chromosome 2 at 180,181,441 bp (GRCm38)
  • T to C, chromosome 3 at 90,021,349 bp (GRCm38)
  • A to T, chromosome 3 at 96,682,027 bp (GRCm38)
  • A to T, chromosome 3 at 133,487,342 bp (GRCm38)
  • T to C, chromosome 3 at 144,953,771 bp (GRCm38)
  • A to T, chromosome 3 at 154,328,127 bp (GRCm38)
  • A to G, chromosome 4 at 10,893,271 bp (GRCm38)
  • A to G, chromosome 4 at 42,850,560 bp (GRCm38)
  • A to G, chromosome 4 at 63,995,705 bp (GRCm38)
  • A to G, chromosome 4 at 148,668,456 bp (GRCm38)
  • A to G, chromosome 5 at 25,210,439 bp (GRCm38)
  • T to C, chromosome 5 at 114,766,472 bp (GRCm38)
  • T to A, chromosome 5 at 135,158,617 bp (GRCm38)
  • A to G, chromosome 6 at 40,897,448 bp (GRCm38)
  • G to A, chromosome 6 at 145,168,027 bp (GRCm38)
  • A to T, chromosome 7 at 40,993,788 bp (GRCm38)
  • T to C, chromosome 7 at 79,935,231 bp (GRCm38)
  • GCGGCGGCG to GCGGCGGCGTCGGCGGCG, chromosome 7 at 97,579,922 bp (GRCm38)
  • A to T, chromosome 7 at 127,474,515 bp (GRCm38)
  • C to A, chromosome 9 at 49,023,988 bp (GRCm38)
  • T to C, chromosome 9 at 49,399,794 bp (GRCm38)
  • C to A, chromosome 9 at 88,570,129 bp (GRCm38)
  • T to C, chromosome 9 at 95,474,482 bp (GRCm38)
  • T to C, chromosome 9 at 105,864,589 bp (GRCm38)
  • G to A, chromosome 9 at 108,575,983 bp (GRCm38)
  • T to A, chromosome 10 at 33,513,305 bp (GRCm38)
  • C to A, chromosome 10 at 45,120,711 bp (GRCm38)
  • A to T, chromosome 10 at 88,543,762 bp (GRCm38)
  • A to G, chromosome 10 at 93,208,204 bp (GRCm38)
  • A to G, chromosome 10 at 93,846,989 bp (GRCm38)
  • G to A, chromosome 10 at 128,397,759 bp (GRCm38)
  • T to A, chromosome 11 at 73,165,601 bp (GRCm38)
  • A to G, chromosome 11 at 99,348,709 bp (GRCm38)
  • T to C, chromosome 12 at 91,537,815 bp (GRCm38)
  • T to C, chromosome 12 at 114,222,999 bp (GRCm38)
  • A to G, chromosome 13 at 38,193,242 bp (GRCm38)
  • T to C, chromosome 13 at 98,853,495 bp (GRCm38)
  • C to A, chromosome 14 at 101,885,347 bp (GRCm38)
  • T to C, chromosome 15 at 35,447,734 bp (GRCm38)
  • T to A, chromosome 15 at 37,372,125 bp (GRCm38)
  • A to G, chromosome 16 at 36,759,289 bp (GRCm38)
  • A to G, chromosome 16 at 84,822,788 bp (GRCm38)
  • C to T, chromosome 17 at 12,270,973 bp (GRCm38)
  • A to G, chromosome 17 at 20,502,531 bp (GRCm38)
  • A to G, chromosome 17 at 64,733,739 bp (GRCm38)
  • T to C, chromosome 17 at 80,061,956 bp (GRCm38)
  • C to T, chromosome 18 at 9,992,168 bp (GRCm38)
  • C to A, chromosome 18 at 37,302,363 bp (GRCm38)
  • A to T, chromosome 18 at 47,304,149 bp (GRCm38)
  • T to C, chromosome 19 at 8,782,072 bp (GRCm38)
  • T to C, chromosome 19 at 27,416,788 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9488 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069291-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.