Strain Name:
C57BL/6J-MtgxR9491Btlr/Mmmh
Stock Number:
069294-MU
Citation ID:
RRID:MMRRC_069294-MU
Other Names:
R9491 (G1)
Major Collection:

Strain Information

Adcy9
Name: adenylate cyclase 9
Synonyms: D16Wsu65e, ACtp10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11515
HGNC: HGNC:240
Homologene: 868
Eif2s2
Name: eukaryotic translation initiation factor 2 subunit 2 beta
Synonyms: 2810026E11Rik, EIF2, EIF2B, 38kDa, D2Ertd303e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67204
HGNC: HGNC:3266
Homologene: 2904
Pipox
Name: pipecolic acid oxidase
Synonyms: Pso
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19193
Homologene: 40640
Foxo3
Name: forkhead box O3
Synonyms: Foxo3a, Fkhr2, FKHRL1, 1110048B16Rik, 2010203A17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56484
Homologene: 31039
Kazn
Name: kazrin, periplakin interacting protein
Synonyms: 2310007B04Rik, 9030409G11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 71529
Homologene: 16235
Setx
Name: senataxin
Synonyms: Als4, A930037J23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Gtse1
Name: G two S phase expressed protein 1
Synonyms: Gtse-1, B99
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 29870
VEGA: 15
Homologene: 8489
Prcc
Name: papillary renal cell carcinoma (translocation-associated)
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 94315
HGNC: HGNC:9343
Homologene: 38120
Smchd1
Name: SMC hinge domain containing 1
Synonyms: MommeD1, 4931400A14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74355
Homologene: 23665
Mcm5
Name: minichromosome maintenance complex component 5
Synonyms: mCD46, Cdc46, Mcmd5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 17218
HGNC: HGNC:6948
Homologene: 4904
Ank3
Name: ankyrin 3, epithelial
Synonyms: Ank-3, AnkG, 2900054D09Rik, Ankyrin-3, Ankyrin-G
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Parp4
Name: poly (ADP-ribose) polymerase family, member 4
Synonyms: p193, PH5P, Adprtl1, E230037B21Rik, C030027K23Rik, VPARP, VAULT3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328417
HGNC: HGNC:271
Homologene: 124423
Acy1
Name: aminoacylase 1
Synonyms: 1110014J22Rik, Acy-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109652
HGNC: HGNC:177
Homologene: 110440
Hnrnpk
Name: heterogeneous nuclear ribonucleoprotein K
Synonyms: hnRNPK, Hnrpk, KBBP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15387
HGNC: HGNC:5044
Homologene: 81909
Pdgfrb
Name: platelet derived growth factor receptor, beta polypeptide
Synonyms: Pdgfr, CD140b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18596
HGNC: HGNC:8804
Homologene: 1960
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Ddx3y
Name: DEAD box helicase 3, Y-linked
Synonyms: D1Pas1-rs1, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked, Dby, 8030469F12Rik
Type: Gene
Species: Mouse
Chromosome: Y
NCBI: 26900
HGNC: HGNC:2699
Homologene: 55839
Dapk1
Name: death associated protein kinase 1
Synonyms: 2810425C21Rik, DAP-Kinase, D13Ucla1, 2310039H24Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69635
VEGA: 13
HGNC: HGNC:2674
Homologene: 3626
Clstn1
Name: calsyntenin 1
Synonyms: alcadein alpha, calsyntenin-1, 1810034E21Rik, Cst-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Zfp653
Name: zinc finger protein 653
Synonyms: E430039K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319601
VEGA: 9
Homologene: 16346
Hectd4
Name: HECT domain E3 ubiquitin protein ligase 4
Synonyms: Gm15800
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269700
Homologene: 28297
Ncoa1
Name: nuclear receptor coactivator 1
Synonyms: KAT13A, bHLHe74, SRC-1, SRC-a/NCoA-1, steroid receptor coactivator-1, SRC1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17977
VEGA: 12
HGNC: HGNC:7668
Homologene: 7859
Prrg2
Name: proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
Synonyms: 2510041M06Rik, 1600014G02Rik, N4WBP1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 65116
HGNC: HGNC:9470
Homologene: 735
Ptchd3
Name: patched domain containing 3
Synonyms: 4933440L20Rik, 4930451E13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74675
Homologene: 111041
Duox1
Name: dual oxidase 1
Synonyms: 9930101G15Rik, NOXEF1, THOX1, LNOX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Cap2
Name: cyclase associated actin cytoskeleton regulatory protein 2
Synonyms: 2810452G09Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67252
Homologene: 101397
Tdrd12
Name: tudor domain containing 12
Synonyms: EG434165, 2410004F06Rik, G1-476-14, 2410070K17Rik, repro23, ecat8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71981
Homologene: 87053
Trp63
Name: transformation related protein 63
Synonyms: p63, p51/p63, p73L, Trp53rp1, KET protein, TAp63, deltaNp63
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22061
Homologene: 31189
Grik1
Name: glutamate receptor, ionotropic, kainate 1
Synonyms: GluK5, D16Ium24, Glurbeta1, Glur-5, D16Ium24e, A830007B11Rik, Glur5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14805
HGNC: HGNC:4579
Homologene: 68992
Wdhd1
Name: WD repeat and HMG-box DNA binding protein 1
Synonyms: AND-1, D630024B06Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218973
Homologene: 56019
Zdhhc23
Name: zinc finger, DHHC domain containing 23
Synonyms: LOC385651, LOC332175
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 332175
VEGA: 16
Homologene: 17840
Irgc
Name: immunity related GTPase cinema
Synonyms: LOC210145, F630044M05Rik, LOC381989, Iigp5, Irgc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210145
Homologene: 10486
Lmln
Name: leishmanolysin-like (metallopeptidase M8 family)
Synonyms: 5330415H22Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239833
Homologene: 13198
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19731
Homologene: 9039
Cfap43
Name: cilia and flagella associated protein 43
Synonyms: 4632415N18Rik, D19Ertd652e, 4930428C11Rik, Wdr96, 4930463G05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 100048534
Homologene: 36425
Cluap1
Name: clusterin associated protein 1
Synonyms: 2310030D15Rik, 2610111M03Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 76779
Homologene: 14831
Or8c10
Name: olfactory receptor family 8 subfamily C member 10
Synonyms: MOR170-14, MOR170-8, GA_x6K02T2PVTD-32060891-32061865, Olfr899, Olfr250, GA_x6K02T2MYUG-19447-18473
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404312
VEGA: 9
Homologene: 74151
Tmem8b
Name: transmembrane protein 8B
Synonyms: 4930500O05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242409
Homologene: 72894
Tbpl2
Name: TATA box binding protein like 2
Synonyms: Trf3, LOC227606
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227606
Homologene: 133152
Clip2
Name: CAP-GLY domain containing linker protein 2
Synonyms: CLIP-115, WSCR4, Cyln2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269713
HGNC: HGNC:2586
Homologene: 20718
Nkd1
Name: naked cuticle 1
Synonyms: 9030215G15Rik, 2810434J10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93960
Homologene: 12343
Cmbl
Name: carboxymethylenebutenolidase homolog
Synonyms: 2310016A09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 69574
Homologene: 100714
Or5an1c
Name: olfactory receptor family 5 subfamily AN member 1C
Synonyms: MOR214-9, Olfr262, GA_x6K02T2N4A9-18144-19082, MOR214-1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258683
H6pd
Name: hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
Synonyms: G6pd1, Gpd1, Gpd-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100198
HGNC: HGNC:4795
Homologene: 48275
Mdfic
Name: MyoD family inhibitor domain containing
Synonyms: Kdt1, clone 1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16543
Homologene: 18404
Tpmt
Name: thiopurine methyltransferase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22017
Homologene: 313
Gpr156
Name: G protein-coupled receptor 156
Synonyms: Gababl
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239845
VEGA: 16
Homologene: 17683
Gmppa
Name: GDP-mannose pyrophosphorylase A
Synonyms: 1810012N01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69080
Homologene: 8346
Pheta1
Name: PH domain containing endocytic trafficking adaptor 1
Synonyms: Fam109a, Ses1, A230106M15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231717
Homologene: 16966
Gadd45a
Name: growth arrest and DNA-damage-inducible 45 alpha
Synonyms: Ddit1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13197
HGNC: HGNC:4095
Homologene: 1449
Vstm5
Name: V-set and transmembrane domain containing 5
Synonyms: 2200002K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69137
VEGA: 9
Homologene: 45982
Asmt
Name: acetylserotonin O-methyltransferase
Synonyms: Hiomt
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 107626
VEGA: X
HGNC: HGNC:750
Pcdhgb4
Name: protocadherin gamma subfamily B, 4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93701
HGNC: HGNC:8711
Homologene: 74507
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 75,438,958 bp (GRCm38)
  • A to G, chromosome 1 at 152,549,118 bp (GRCm38)
  • T to C, chromosome 2 at 24,096,520 bp (GRCm38)
  • T to A, chromosome 2 at 29,147,823 bp (GRCm38)
  • T to A, chromosome 2 at 122,326,426 bp (GRCm38)
  • T to C, chromosome 2 at 154,892,710 bp (GRCm38)
  • A to G, chromosome 3 at 87,867,364 bp (GRCm38)
  • C to T, chromosome 4 at 43,673,938 bp (GRCm38)
  • C to T, chromosome 4 at 142,118,125 bp (GRCm38)
  • T to C, chromosome 4 at 149,647,472 bp (GRCm38)
  • T to A, chromosome 4 at 149,995,909 bp (GRCm38)
  • T to G, chromosome 5 at 121,314,918 bp (GRCm38)
  • G to A, chromosome 5 at 121,852,988 bp (GRCm38)
  • C to T, chromosome 5 at 134,504,762 bp (GRCm38)
  • T to A, chromosome 6 at 15,799,853 bp (GRCm38)
  • A to T, chromosome 6 at 67,035,746 bp (GRCm38)
  • C to T, chromosome 7 at 24,432,924 bp (GRCm38)
  • T to A, chromosome 7 at 35,489,264 bp (GRCm38)
  • T to A, chromosome 7 at 45,056,794 bp (GRCm38)
  • C to T, chromosome 8 at 75,117,540 bp (GRCm38)
  • A to G, chromosome 8 at 88,574,247 bp (GRCm38)
  • T to G, chromosome 9 at 15,257,290 bp (GRCm38)
  • T to A, chromosome 9 at 22,058,326 bp (GRCm38)
  • T to C, chromosome 9 at 38,367,675 bp (GRCm38)
  • G to A, chromosome 9 at 106,435,795 bp (GRCm38)
  • C to T, chromosome 10 at 42,197,025 bp (GRCm38)
  • A to C, chromosome 10 at 70,002,509 bp (GRCm38)
  • T to A, chromosome 11 at 77,881,533 bp (GRCm38)
  • T to C, chromosome 11 at 121,842,987 bp (GRCm38)
  • T to A, chromosome 12 at 4,290,912 bp (GRCm38)
  • C to T, chromosome 13 at 46,637,890 bp (GRCm38)
  • A to T, chromosome 13 at 47,027,276 bp (GRCm38)
  • G to T, chromosome 13 at 58,393,236 bp (GRCm38)
  • A to G, chromosome 13 at 60,729,555 bp (GRCm38)
  • A to T, chromosome 14 at 47,268,159 bp (GRCm38)
  • G to A, chromosome 14 at 56,595,371 bp (GRCm38)
  • G to T, chromosome 15 at 31,581,973 bp (GRCm38)
  • C to T, chromosome 15 at 85,871,533 bp (GRCm38)
  • G to A, chromosome 16 at 3,940,868 bp (GRCm38)
  • T to C, chromosome 16 at 4,418,188 bp (GRCm38)
  • A to G, chromosome 16 at 25,876,722 bp (GRCm38)
  • A to G, chromosome 16 at 33,069,988 bp (GRCm38)
  • A to T, chromosome 16 at 38,005,342 bp (GRCm38)
  • A to C, chromosome 16 at 43,973,699 bp (GRCm38)
  • A to T, chromosome 16 at 87,950,107 bp (GRCm38)
  • A to G, chromosome 17 at 71,360,025 bp (GRCm38)
  • T to A, chromosome 18 at 37,721,842 bp (GRCm38)
  • A to G, chromosome 18 at 61,078,984 bp (GRCm38)
  • T to C, chromosome 19 at 9,876,777 bp (GRCm38)
  • T to C, chromosome 19 at 12,241,242 bp (GRCm38)
  • A to T, chromosome 19 at 47,812,066 bp (GRCm38)
  • G to A, chromosome X at 170,674,670 bp (GRCm38)
  • T to A, chromosome Y at 1,279,465 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9491 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069294-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.