Strain Name:
C57BL/6J-MtgxR9549Btlr/Mmmh
Stock Number:
069345-MU
Citation ID:
RRID:MMRRC_069345-MU
Other Names:
R9549 (G1)
Major Collection:

Strain Information

Lrig2
Name: leucine-rich repeats and immunoglobulin-like domains 2
Synonyms: 4632419I10Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 269473
Homologene: 8882
Lrrn1
Name: leucine rich repeat protein 1, neuronal
Synonyms: NLRR-1, 2810047E21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16979
Homologene: 32036
Pip5k1b
Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
Synonyms: Pipk5b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18719
HGNC: HGNC:8995
Homologene: 100644
Mapk14
Name: mitogen-activated protein kinase 14
Synonyms: p38 MAPK, p38a, p38 alpha, Csbp1, p38MAPK, p38-alpha, Crk1, Mxi2, p38, p38alpha, p38 MAP kinase alpha, CSBP2, p38 MAP Kinase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26416
HGNC: HGNC:6876
Homologene: 31777
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, Depdc2, C030045D06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Rlf
Name: rearranged L-myc fusion sequence
Synonyms: MommeD8, 9230110M18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 109263
Homologene: 8243
St13
Name: suppression of tumorigenicity 13
Synonyms: 1110007I03Rik, PRO0786, HSPABP1, SNC6, p48, Hsp70 interacting protein, 3110002K08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70356
Homologene: 2921
Smg1
Name: SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Synonyms: 5430435M13Rik, C130002K18Rik, SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans), 2610207I05Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233789
Homologene: 56697
Fbxo15
Name: F-box protein 15
Synonyms: ecat3, Fbx15
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50764
VEGA: 18
Homologene: 17644
Ccnt1
Name: cyclin T1
Synonyms: CycT1, 2810478G24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12455
HGNC: HGNC:1599
Homologene: 947
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Fam171b
Name: family with sequence similarity 171, member B
Synonyms: D430039N05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241520
Homologene: 18462
Crebbp
Name: CREB binding protein
Synonyms: KAT3A, CBP
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 12914
HGNC: HGNC:2348
Homologene: 68393
Thra
Name: thyroid hormone receptor alpha
Synonyms: Rvr, 6430529J03Rik, Nr1a1, Thra2, Thra1, T3R[a], T3Ralpha, Erba, TR alpha 2, c-erbAalpha, TR alpha 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21833
Homologene: 37747
Mlec
Name: malectin
Synonyms: ESTM19, 2410014A08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 109154
Homologene: 8823
Zfp445
Name: zinc finger protein 445
Synonyms: ZNF168
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235682
VEGA: 9
Homologene: 27832
Ehbp1
Name: EH domain binding protein 1
Synonyms: KIAA0903-like, Flj21950
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216565
Homologene: 22880
Uxs1
Name: UDP-glucuronate decarboxylase 1
Synonyms: 1600025I13Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67883
Homologene: 41609
Nfkb2
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
Synonyms: NF kappaB2, p52
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18034
VEGA: 19
HGNC: HGNC:7795
Homologene: 1873
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Plekhb2
Name: pleckstrin homology domain containing, family B (evectins) member 2
Synonyms: Phdc, evt-2, 2310009M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226971
Homologene: 9938
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: EG56544, V2r83
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56544
Homologene: 84832
Nr1h5
Name: nuclear receptor subfamily 1, group H, member 5
Synonyms: FXRB
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 381463
Homologene: 131277
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242838
Homologene: 18247
Maz
Name: MYC-associated zinc finger protein (purine-binding transcription factor)
Synonyms: Pur-1, SAF-1, PUR1, SAF-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17188
HGNC: HGNC:6914
Homologene: 106451
Rmdn2
Name: regulator of microtubule dynamics 2
Synonyms: Fam82a1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381110
VEGA: 17
Homologene: 71930
Mto1
Name: mitochondrial tRNA translation optimization 1
Synonyms: 2310039H01Rik, 5730419A02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68291
Homologene: 5876
Vmn2r105
Name: vomeronasal 2, receptor 105
Synonyms: EG627743
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627743
Homologene: 129680
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Pkn1
Name: protein kinase N1
Synonyms: PAK1, Pkn, Prkcl1, F730027O18Rik, Stk3, PRK1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 320795
HGNC: HGNC:9405
Homologene: 48130
Plekhh3
Name: pleckstrin homology domain containing, family H (with MyTH4 domain) member 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217198
Homologene: 11787
Isoc2a
Name: isochorismatase domain containing 2a
Synonyms: Isoc2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 664994
Homologene: 86122
Sdk1
Name: sidekick cell adhesion molecule 1
Synonyms: 6720466O15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330222
Homologene: 27395
Vmn1r61
Name: vomeronasal 1 receptor 61
Synonyms: Gm7186
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 636731
Homologene: 41799
Fam83c
Name: family with sequence similarity 83, member C
Synonyms: 5530400B04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71405
Homologene: 18669
Acan
Name: aggrecan
Synonyms: Cspg1, Agc1, b2b183Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11595
HGNC: HGNC:319
Homologene: 137204
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: Gm1564, LOC268491, LOC380729
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Grip1
Name: glutamate receptor interacting protein 1
Synonyms: eb, 4931400F03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74053
Homologene: 12938
Trim41
Name: tripartite motif-containing 41
Synonyms: RINCK
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 211007
Homologene: 14140
Krtap5-21
Name: keratin associated protein 5-21
Synonyms: Gm7579
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 105243090
Fez1
Name: fasciculation and elongation protein zeta 1
Synonyms: UNC-76, zygin I, UNC76
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235180
HGNC: HGNC:3659
Homologene: 21063
Serpina1e
Name: serine (or cysteine) peptidase inhibitor, clade A, member 1E
Synonyms: PI5, Spi1-5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20704
HGNC: HGNC:8941
Homologene: 20103
Paqr5
Name: progestin and adipoQ receptor family member V
Synonyms: mPRg, 0610010I15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74090
Homologene: 9788
Map3k9
Name: mitogen-activated protein kinase kinase kinase 9
Synonyms: Mlk1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 338372
VEGA: 12
HGNC: HGNC:6861
Homologene: 76377
B3gnt6
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
Synonyms: Core-3, Core3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272411
Homologene: 16339
Setbp1
Name: SET binding protein 1
Synonyms: Seb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240427
Homologene: 9192
Or5an11
Name: olfactory receptor family 5 subfamily AN member 11
Synonyms: GA_x6K02T2LL2P-1028-792, Olfr235, Olfr245, GA_x6K02T03CT6-1-477, MOR214-3, GA_x6K02T057QT-4025-4642, Olfr232, MOR214-3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258681
Vash1
Name: vasohibin 1
Synonyms: D930046M13Rik, G630009D10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238328
Homologene: 8941
Bnip5
Name: BCL2 interacting protein 5
Synonyms: 4930539E08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 207819
Homologene: 52098
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 11,186,691 bp (GRCm38)
  • A to G, chromosome 1 at 34,863,471 bp (GRCm38)
  • A to T, chromosome 1 at 43,771,732 bp (GRCm38)
  • G to T, chromosome 2 at 83,812,855 bp (GRCm38)
  • T to A, chromosome 2 at 155,834,752 bp (GRCm38)
  • G to A, chromosome 3 at 28,071,232 bp (GRCm38)
  • A to G, chromosome 3 at 64,090,072 bp (GRCm38)
  • T to C, chromosome 3 at 102,941,021 bp (GRCm38)
  • A to G, chromosome 3 at 104,490,875 bp (GRCm38)
  • T to C, chromosome 4 at 121,148,123 bp (GRCm38)
  • T to A, chromosome 5 at 3,851,473 bp (GRCm38)
  • A to G, chromosome 5 at 115,150,212 bp (GRCm38)
  • A to C, chromosome 5 at 141,954,902 bp (GRCm38)
  • A to G, chromosome 6 at 107,569,017 bp (GRCm38)
  • G to A, chromosome 6 at 121,881,803 bp (GRCm38)
  • A to G, chromosome 7 at 4,892,059 bp (GRCm38)
  • A to C, chromosome 7 at 5,611,186 bp (GRCm38)
  • A to G, chromosome 7 at 79,092,328 bp (GRCm38)
  • G to T, chromosome 7 at 98,194,449 bp (GRCm38)
  • A to G, chromosome 7 at 118,196,031 bp (GRCm38)
  • A to G, chromosome 7 at 127,026,406 bp (GRCm38)
  • CTGTGTG to CTGTG, chromosome 7 at 142,211,999 bp (GRCm38)
  • T to C, chromosome 8 at 83,692,845 bp (GRCm38)
  • G to A, chromosome 9 at 36,868,915 bp (GRCm38)
  • A to T, chromosome 9 at 61,956,261 bp (GRCm38)
  • G to A, chromosome 9 at 78,461,679 bp (GRCm38)
  • T to C, chromosome 9 at 122,856,779 bp (GRCm38)
  • G to A, chromosome 10 at 120,038,664 bp (GRCm38)
  • T to G, chromosome 11 at 22,062,788 bp (GRCm38)
  • TTCCTCCTCCTCCTCCTCCTCCTCCTCC to TTCCTCCTCCTCCTCCTCCTCCTCC, chromosome 11 at 48,816,257 bp (GRCm38)
  • T to C, chromosome 11 at 98,762,946 bp (GRCm38)
  • T to A, chromosome 11 at 101,165,189 bp (GRCm38)
  • C to T, chromosome 11 at 102,665,724 bp (GRCm38)
  • T to C, chromosome 12 at 81,724,481 bp (GRCm38)
  • T to C, chromosome 12 at 85,266,475 bp (GRCm38)
  • A to T, chromosome 12 at 86,689,096 bp (GRCm38)
  • A to T, chromosome 12 at 103,950,984 bp (GRCm38)
  • G to A, chromosome 15 at 81,374,862 bp (GRCm38)
  • A to G, chromosome 15 at 98,543,693 bp (GRCm38)
  • T to C, chromosome 16 at 4,085,247 bp (GRCm38)
  • T to C, chromosome 17 at 20,227,761 bp (GRCm38)
  • T to A, chromosome 17 at 28,715,441 bp (GRCm38)
  • A to T, chromosome 17 at 28,905,673 bp (GRCm38)
  • T to G, chromosome 17 at 79,627,910 bp (GRCm38)
  • T to A, chromosome 18 at 78,859,414 bp (GRCm38)
  • T to C, chromosome 18 at 84,962,680 bp (GRCm38)
  • T to A, chromosome 19 at 12,269,044 bp (GRCm38)
  • C to T, chromosome 19 at 18,876,030 bp (GRCm38)
  • C to A, chromosome 19 at 24,379,049 bp (GRCm38)
  • T to A, chromosome 19 at 46,309,672 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9549 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069345-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.