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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR9563Btlr/Mmmh
Stock Number:
069357-MU
Citation ID:
RRID:MMRRC_069357-MU
Other Names:
R9563 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Shprh
Name: SNF2 histone linker PHD RING helicase
Synonyms: 2610103K11Rik, D230017O13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268281
Homologene: 6489

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Map4k5
Name: mitogen-activated protein kinase kinase kinase kinase 5
Synonyms: MAPKKKK5, GCKR, KHS, 4432415E19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399510
HGNC: HGNC:6867
Homologene: 38199

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Itga8
Name: integrin alpha 8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241226
HGNC: HGNC:6144
Homologene: 37396

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Espl1
Name: extra spindle pole bodies 1, separase
Synonyms: separase, SSE, ESP1, PRCE, PRCE, Cerp
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105988
VEGA: 15
Homologene: 32151

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Nrtn
Name: neurturin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18188
VEGA: 17
HGNC: HGNC:8007
Homologene: 7450

Additional Resources
IMPC
Google
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Monarch
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ClinGen
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to G, chromosome 1 at 6,244,115 bp (GRCm38)
  • T to A, chromosome 1 at 15,709,513 bp (GRCm38)
  • A to C, chromosome 1 at 36,165,546 bp (GRCm38)
  • T to A, chromosome 1 at 136,149,428 bp (GRCm38)
  • T to A, chromosome 1 at 150,105,668 bp (GRCm38)
  • C to T, chromosome 1 at 161,020,270 bp (GRCm38)
  • G to T, chromosome 1 at 181,055,245 bp (GRCm38)
  • T to A, chromosome 1 at 182,448,813 bp (GRCm38)
  • T to A, chromosome 2 at 12,160,408 bp (GRCm38)
  • T to A, chromosome 2 at 35,719,903 bp (GRCm38)
  • T to A, chromosome 2 at 41,295,699 bp (GRCm38)
  • A to T, chromosome 2 at 65,461,251 bp (GRCm38)
  • A to G, chromosome 2 at 86,828,754 bp (GRCm38)
  • G to A, chromosome 2 at 128,664,060 bp (GRCm38)
  • G to A, chromosome 2 at 157,060,262 bp (GRCm38)
  • A to G, chromosome 2 at 158,628,215 bp (GRCm38)
  • A to G, chromosome 3 at 14,499,300 bp (GRCm38)
  • A to G, chromosome 3 at 36,651,534 bp (GRCm38)
  • A to G, chromosome 3 at 60,613,294 bp (GRCm38)
  • A to T, chromosome 3 at 79,449,309 bp (GRCm38)
  • T to A, chromosome 3 at 121,734,173 bp (GRCm38)
  • T to C, chromosome 4 at 14,519,496 bp (GRCm38)
  • A to G, chromosome 4 at 47,483,049 bp (GRCm38)
  • A to G, chromosome 4 at 48,180,739 bp (GRCm38)
  • A to G, chromosome 4 at 63,394,707 bp (GRCm38)
  • A to G, chromosome 4 at 96,526,008 bp (GRCm38)
  • T to A, chromosome 4 at 117,564,816 bp (GRCm38)
  • T to C, chromosome 4 at 119,393,624 bp (GRCm38)
  • A to G, chromosome 4 at 122,864,712 bp (GRCm38)
  • C to T, chromosome 4 at 126,323,651 bp (GRCm38)
  • G to A, chromosome 5 at 34,167,956 bp (GRCm38)
  • A to C, chromosome 5 at 108,132,234 bp (GRCm38)
  • A to T, chromosome 5 at 111,223,226 bp (GRCm38)
  • T to C, chromosome 5 at 114,436,789 bp (GRCm38)
  • T to A, chromosome 5 at 140,752,378 bp (GRCm38)
  • T to C, chromosome 5 at 148,313,407 bp (GRCm38)
  • T to A, chromosome 6 at 18,367,383 bp (GRCm38)
  • A to T, chromosome 6 at 18,427,468 bp (GRCm38)
  • T to A, chromosome 6 at 40,478,034 bp (GRCm38)
  • G to T, chromosome 6 at 41,179,011 bp (GRCm38)
  • T to A, chromosome 6 at 121,668,050 bp (GRCm38)
  • T to C, chromosome 7 at 24,142,244 bp (GRCm38)
  • T to A, chromosome 7 at 80,356,353 bp (GRCm38)
  • G to A, chromosome 7 at 84,940,672 bp (GRCm38)
  • T to C, chromosome 7 at 98,000,162 bp (GRCm38)
  • A to T, chromosome 7 at 103,598,018 bp (GRCm38)
  • C to T, chromosome 7 at 104,261,121 bp (GRCm38)
  • T to C, chromosome 7 at 105,057,074 bp (GRCm38)
  • T to C, chromosome 7 at 109,038,790 bp (GRCm38)
  • A to G, chromosome 7 at 114,236,799 bp (GRCm38)
  • A to G, chromosome 7 at 118,212,985 bp (GRCm38)
  • G to A, chromosome 7 at 140,162,320 bp (GRCm38)
  • A to G, chromosome 7 at 141,210,788 bp (GRCm38)
  • T to A, chromosome 7 at 141,637,870 bp (GRCm38)
  • A to T, chromosome 8 at 15,108,399 bp (GRCm38)
  • G to A, chromosome 8 at 25,714,203 bp (GRCm38)
  • A to G, chromosome 8 at 61,124,123 bp (GRCm38)
  • A to G, chromosome 8 at 75,060,549 bp (GRCm38)
  • A to G, chromosome 8 at 84,137,129 bp (GRCm38)
  • A to G, chromosome 8 at 104,628,692 bp (GRCm38)
  • T to A, chromosome 8 at 123,536,440 bp (GRCm38)
  • T to C, chromosome 9 at 14,562,217 bp (GRCm38)
  • T to C, chromosome 9 at 21,794,556 bp (GRCm38)
  • A to G, chromosome 9 at 37,429,604 bp (GRCm38)
  • A to T, chromosome 9 at 38,827,718 bp (GRCm38)
  • A to G, chromosome 9 at 40,282,433 bp (GRCm38)
  • A to G, chromosome 9 at 42,046,597 bp (GRCm38)
  • T to A, chromosome 9 at 44,440,902 bp (GRCm38)
  • A to T, chromosome 9 at 45,899,843 bp (GRCm38)
  • G to T, chromosome 9 at 66,386,911 bp (GRCm38)
  • C to T, chromosome 9 at 70,573,559 bp (GRCm38)
  • G to C, chromosome 9 at 95,920,780 bp (GRCm38)
  • C to A, chromosome 9 at 105,695,753 bp (GRCm38)
  • T to C, chromosome 9 at 107,570,645 bp (GRCm38)
  • T to A, chromosome 9 at 107,984,289 bp (GRCm38)
  • T to C, chromosome 9 at 108,107,417 bp (GRCm38)
  • T to C, chromosome 9 at 108,962,741 bp (GRCm38)
  • T to C, chromosome 9 at 109,277,267 bp (GRCm38)
  • T to A, chromosome 9 at 109,654,608 bp (GRCm38)
  • C to A, chromosome 9 at 119,486,737 bp (GRCm38)
  • AC to A, chromosome 10 at 4,450,848 bp (GRCm38)
  • T to A, chromosome 10 at 11,166,491 bp (GRCm38)
  • C to T, chromosome 10 at 18,646,527 bp (GRCm38)
  • T to A, chromosome 10 at 85,876,506 bp (GRCm38)
  • T to C, chromosome 10 at 116,918,763 bp (GRCm38)
  • A to G, chromosome 10 at 126,996,171 bp (GRCm38)
  • C to T, chromosome 10 at 128,953,800 bp (GRCm38)
  • T to C, chromosome 10 at 130,017,418 bp (GRCm38)
  • T to A, chromosome 11 at 8,865,502 bp (GRCm38)
  • A to G, chromosome 11 at 46,260,880 bp (GRCm38)
  • T to A, chromosome 11 at 72,874,906 bp (GRCm38)
  • T to C, chromosome 11 at 75,185,999 bp (GRCm38)
  • T to C, chromosome 11 at 94,650,513 bp (GRCm38)
  • A to G, chromosome 11 at 98,379,971 bp (GRCm38)
  • T to A, chromosome 11 at 106,151,034 bp (GRCm38)
  • T to C, chromosome 12 at 16,724,823 bp (GRCm38)
  • G to T, chromosome 12 at 51,627,517 bp (GRCm38)
  • A to G, chromosome 12 at 69,816,393 bp (GRCm38)
  • A to G, chromosome 12 at 71,945,477 bp (GRCm38)
  • A to G, chromosome 12 at 111,299,328 bp (GRCm38)
  • T to C, chromosome 13 at 13,637,823 bp (GRCm38)
  • T to C, chromosome 13 at 21,783,051 bp (GRCm38)
  • T to C, chromosome 14 at 32,970,876 bp (GRCm38)
  • A to G, chromosome 14 at 33,955,520 bp (GRCm38)
  • A to T, chromosome 14 at 53,002,016 bp (GRCm38)
  • A to C, chromosome 14 at 103,049,673 bp (GRCm38)
  • A to T, chromosome 15 at 6,768,081 bp (GRCm38)
  • T to G, chromosome 15 at 8,187,079 bp (GRCm38)
  • A to T, chromosome 15 at 78,849,582 bp (GRCm38)
  • T to A, chromosome 15 at 91,749,840 bp (GRCm38)
  • G to A, chromosome 15 at 99,279,735 bp (GRCm38)
  • T to A, chromosome 15 at 102,319,798 bp (GRCm38)
  • T to G, chromosome 16 at 23,060,420 bp (GRCm38)
  • T to A, chromosome 16 at 31,885,051 bp (GRCm38)
  • T to C, chromosome 16 at 45,824,884 bp (GRCm38)
  • T to C, chromosome 16 at 59,329,402 bp (GRCm38)
  • C to T, chromosome 16 at 63,546,147 bp (GRCm38)
  • G to T, chromosome 17 at 8,801,878 bp (GRCm38)
  • T to A, chromosome 17 at 46,509,971 bp (GRCm38)
  • A to G, chromosome 17 at 56,751,416 bp (GRCm38)
  • A to G, chromosome 18 at 23,890,924 bp (GRCm38)
  • T to G, chromosome 18 at 46,884,439 bp (GRCm38)
  • T to C, chromosome 18 at 68,254,480 bp (GRCm38)
  • C to T, chromosome 18 at 76,858,681 bp (GRCm38)
  • C to T, chromosome 19 at 10,861,596 bp (GRCm38)
  • T to A, chromosome 19 at 12,999,619 bp (GRCm38)
  • T to C, chromosome 19 at 37,599,623 bp (GRCm38)
  • T to C, chromosome 19 at 41,608,435 bp (GRCm38)

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9563 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
069357-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.