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Strain Name:
C57BL/6J-MtgxR9588Btlr/Mmmh
Stock Number:
069381-MU
Citation ID:
RRID:MMRRC_069381-MU
Other Names:
R9588 (G1)
Major Collection:

Strain Information

Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Tfdp2
Name: transcription factor Dp 2
Synonyms: DP3, DP-3, DP3, A330080J22Rik, 1110029I05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 211586
Homologene: 4578
Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894
Bcat1
Name: branched chain aminotransferase 1, cytosolic
Synonyms: Eca39, BCATc, Bcat-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12035
HGNC: HGNC:976
Homologene: 20320
Kif16b
Name: kinesin family member 16B
Synonyms: N-3 kinesin, 8430434E15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16558
Homologene: 135708
Arhgap21
Name: Rho GTPase activating protein 21
Synonyms: 5530401C11Rik, ARHGAP10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71435
Homologene: 10822
Unc119b
Name: unc-119 lipid binding chaperone B
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 106840
Homologene: 43997
Cecr2
Name: CECR2, histone acetyl-lysine reader
Synonyms: 2810409N01Rik, 2610101O16Rik, Gtl4, cat eye syndrome chromosome region, candidate 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330409
HGNC: HGNC:1840
Homologene: 64662
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Ikbkb
Name: inhibitor of kappaB kinase beta
Synonyms: IKK-beta, IKK-2, IKK2, IKK[b], IKKbeta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16150
HGNC: HGNC:5960
Homologene: 7782
Dolpp1
Name: dolichyl pyrophosphate phosphatase 1
Synonyms: LSFR2, 0610011H20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57170
Homologene: 10663
Trmt44
Name: tRNA methyltransferase 44
Synonyms: 2310079F23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 78890
Homologene: 12708
Vit
Name: vitrin
Synonyms: 1700110E08Rik, 1700052E02Rik, 2810429K11Rik, AKH, akhirin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74199
VEGA: 17
Homologene: 24942
Ndst4
Name: N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
Synonyms: 4930439H17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 64580
Homologene: 11208
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, 2810003K23Rik, Dnahcl1, Dnahc17
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Chd3
Name: chromodomain helicase DNA binding protein 3
Synonyms: Mi-2 alpha, Prp9-1, Prp7, 2600010P09Rik, Chd7
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216848
HGNC: HGNC:1918
Homologene: 62693
Cpne2
Name: copine II
Synonyms: 3322401K10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234577
HGNC: HGNC:2315
Homologene: 27392
Lrrc43
Name: leucine rich repeat containing 43
Synonyms: LOC381741
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381741
Homologene: 17662
Mroh2b
Name: maestro heat-like repeat family member 2B
Synonyms: 4930455B06Rik, Heatr7b2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223825
VEGA: 15
Homologene: 128807
Dbn1
Name: drebrin 1
Synonyms: drebrin E2, drebrin A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56320
HGNC: HGNC:2695
Homologene: 3236
Ccdc61
Name: coiled-coil domain containing 61
Synonyms: LOC232933, C530028I08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232933
Homologene: 19256
Selenbp2
Name: selenium binding protein 2
Synonyms: acetaminophen-binding protein, AP56, Lpsb2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20342
Homologene: 2930
Mmp1a
Name: matrix metallopeptidase 1a (interstitial collagenase)
Synonyms: Mcol-A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83995
VEGA: 9
HGNC: HGNC:7155
Homologene: 20544
Tbc1d16
Name: TBC1 domain family, member 16
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207592
Homologene: 10380
Or1j11
Name: olfactory receptor family 1 subfamily E member 1
Synonyms: GA_x6K02T2NLDC-33116096-33117025, MOR136-3, Olfr339
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258951
Homologene: 133615
Spata17
Name: spermatogenesis associated 17
Synonyms: 4930504I07Rik, 1700065F16Rik, 4930513F16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74717
Homologene: 12551
Thsd7b
Name: thrombospondin, type I, domain containing 7B
Synonyms: 1700074E13Rik, D130067I03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210417
Homologene: 18180
Or10s1
Name: olfactory receptor family 10 subfamily S member 1
Synonyms: GA_x6K02T2PVTD-33772307-33773260, MOR223-4, Olfr982
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258853
VEGA: 9
Homologene: 17415
Or14c39
Name: olfactory receptor family 14 subfamily C member 39
Synonyms: GA_x6K02T2NHDJ-9425121-9424195, MOR220-2, Olfr292
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258613
Homologene: 115526
Lamp3
Name: lysosomal-associated membrane protein 3
Synonyms: Cd208, 1200002D17Rik, DC-LAMP, TSC403
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239739
VEGA: 16
Homologene: 8670
Vmn1r184
Name: vomeronasal 1 receptor, 184
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100312477
Homologene: 74353
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Foxc1
Name: forkhead box C1
Synonyms: frkhda, fkh1, fkh-1, FREAC3, Mf1, Fkh1, Mf4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17300
HGNC: HGNC:3800
Homologene: 20373
Cyp3a25
Name: cytochrome P450, family 3, subfamily a, polypeptide 25
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56388
Homologene: 135775
Vmn2r81
Name: vomeronasal 2, receptor 81
Synonyms: pheromone recepter, EC1-VR2, V2rf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216144
Homologene: 83483
Or5w15
Name: olfactory receptor family 5 subfamily W member 15
Synonyms: GA_x6K02T2Q125-49242149-49241214, MOR177-8, Olfr1138
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258632
Homologene: 74082
Zfp827
Name: zinc finger protein 827
Synonyms: 2810449M09Rik, D630040G17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 622675
Homologene: 45622
Oas1c
Name: 2'-5' oligoadenylate synthetase 1C
Synonyms: Oasl5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114643
HGNC: HGNC:8086
Homologene: 110815
Hsf2bp
Name: heat shock transcription factor 2 binding protein
Synonyms: 4932437G14Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74377
HGNC: HGNC:5226
Homologene: 38263
Actr5
Name: ARP5 actin-related protein 5
Synonyms: B430109J19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 109275
Homologene: 6818
Pdilt
Name: protein disulfide isomerase-like, testis expressed
Synonyms: PDILT, 1700007B13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71830
Homologene: 18382
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: PC3, prohormone convertase 1/3, Nec-1, Nec1, PC1, SPC3, Phpp-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
Surf4
Name: surfeit gene 4
Synonyms: Surf-4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20932
Homologene: 6052
Cops5
Name: COP9 signalosome subunit 5
Synonyms: Sgn5, JUN activation binding protein, Jab1, COP9 complex S5, CSN5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26754
HGNC: HGNC:2240
Homologene: 55992
Pcdhga3
Name: protocadherin gamma subfamily A, 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93711
HGNC: HGNC:8701
Homologene: 75100
Psma4
Name: proteasome subunit alpha 4
Synonyms: C9
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 26441
HGNC: HGNC:9533
Homologene: 2083
Krtap11-1
Name: keratin associated protein 11-1
Synonyms: KAP11.1, Hacl1, PRED29
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 16693
Homologene: 45517
Fbxw27
Name: F-box and WD-40 domain protein 27
Synonyms: 1700124P09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 76998
Homologene: 110776
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to A, chromosome 1 at 10,037,997 bp (GRCm38)
  • T to G, chromosome 1 at 130,180,486 bp (GRCm38)
  • T to C, chromosome 1 at 187,117,274 bp (GRCm38)
  • C to A, chromosome 2 at 20,854,127 bp (GRCm38)
  • C to A, chromosome 2 at 26,933,610 bp (GRCm38)
  • T to A, chromosome 2 at 30,392,503 bp (GRCm38)
  • G to T, chromosome 2 at 36,421,772 bp (GRCm38)
  • G to A, chromosome 2 at 87,738,300 bp (GRCm38)
  • T to C, chromosome 2 at 110,697,997 bp (GRCm38)
  • T to A, chromosome 2 at 142,711,884 bp (GRCm38)
  • T to C, chromosome 2 at 158,626,408 bp (GRCm38)
  • A to T, chromosome 3 at 94,698,061 bp (GRCm38)
  • A to C, chromosome 3 at 125,683,159 bp (GRCm38)
  • T to C, chromosome 3 at 129,717,968 bp (GRCm38)
  • A to T, chromosome 5 at 35,569,912 bp (GRCm38)
  • G to A, chromosome 5 at 115,134,768 bp (GRCm38)
  • A to G, chromosome 5 at 120,808,137 bp (GRCm38)
  • A to T, chromosome 5 at 123,503,244 bp (GRCm38)
  • G to T, chromosome 5 at 145,984,889 bp (GRCm38)
  • A to G, chromosome 6 at 113,144,064 bp (GRCm38)
  • T to C, chromosome 6 at 120,756,809 bp (GRCm38)
  • T to C, chromosome 6 at 145,004,400 bp (GRCm38)
  • A to G, chromosome 7 at 18,910,341 bp (GRCm38)
  • T to A, chromosome 7 at 26,266,922 bp (GRCm38)
  • T to A, chromosome 7 at 86,694,740 bp (GRCm38)
  • A to T, chromosome 7 at 119,501,647 bp (GRCm38)
  • G to A, chromosome 8 at 22,661,394 bp (GRCm38)
  • T to A, chromosome 8 at 79,178,975 bp (GRCm38)
  • C to A, chromosome 8 at 94,560,153 bp (GRCm38)
  • C to T, chromosome 9 at 7,467,224 bp (GRCm38)
  • T to C, chromosome 9 at 40,075,057 bp (GRCm38)
  • A to C, chromosome 9 at 42,081,809 bp (GRCm38)
  • A to T, chromosome 9 at 54,954,961 bp (GRCm38)
  • A to G, chromosome 9 at 96,038,703 bp (GRCm38)
  • A to G, chromosome 9 at 96,287,610 bp (GRCm38)
  • ATGT to AT, chromosome 9 at 109,773,254 bp (GRCm38)
  • A to G, chromosome 10 at 79,293,371 bp (GRCm38)
  • A to G, chromosome 11 at 69,350,220 bp (GRCm38)
  • T to C, chromosome 11 at 118,121,957 bp (GRCm38)
  • G to T, chromosome 11 at 119,210,509 bp (GRCm38)
  • G to T, chromosome 12 at 119,177,019 bp (GRCm38)
  • A to T, chromosome 13 at 31,808,604 bp (GRCm38)
  • A to G, chromosome 13 at 55,474,972 bp (GRCm38)
  • A to T, chromosome 13 at 75,110,920 bp (GRCm38)
  • T to A, chromosome 15 at 4,948,648 bp (GRCm38)
  • T to A, chromosome 16 at 19,676,082 bp (GRCm38)
  • A to C, chromosome 16 at 89,571,174 bp (GRCm38)
  • A to G, chromosome 17 at 32,022,836 bp (GRCm38)
  • T to A, chromosome 17 at 78,622,650 bp (GRCm38)
  • A to G, chromosome 18 at 37,675,511 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9588 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069381-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.