Strain Name:
C57BL/6J-MtgxR9592Btlr/Mmmh
Stock Number:
069385-MU
Citation ID:
RRID:MMRRC_069385-MU
Other Names:
R9592 (G1)
Major Collection:

Strain Information

Ap4e1
Name: adaptor-related protein complex AP-4, epsilon 1
Synonyms: 2310033A20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108011
HGNC: HGNC:573
Homologene: 22397
Nsd1
Name: nuclear receptor-binding SET-domain protein 1
Synonyms: KMT3B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18193
VEGA: 13
Homologene: 32543
Pdzd2
Name: PDZ domain containing 2
Synonyms: LOC223364, A930022H17Rik, 4930537L06Rik, Pdzk3, Gm21706
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68070
Homologene: 23393
Kcnq2
Name: potassium voltage-gated channel, subfamily Q, member 2
Synonyms: Nmf134, KQT2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16536
HGNC: HGNC:6296
Homologene: 26174
Senp2
Name: SUMO/sentrin specific peptidase 2
Synonyms: 2310007L05Rik, 4930538C18Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75826
VEGA: 16
Homologene: 11005
Usp15
Name: ubiquitin specific peptidase 15
Synonyms: E430033I05Rik, 4921514G19Rik, Gcap18
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14479
VEGA: 10
Homologene: 101542
Nsrp1
Name: nuclear speckle regulatory protein 1
Synonyms: Ccdc55, NSpr70
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237859
Homologene: 134095
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22722
Homologene: 7604
Rsf1
Name: remodeling and spacing factor 1
Synonyms: 4832420A03Rik, p325, C030033M12Rik, Hbxap, XAP8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Secisbp2l
Name: SECIS binding protein 2-like
Synonyms: 3110001I20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70354
Homologene: 18923
Adat1
Name: adenosine deaminase, tRNA-specific 1
Synonyms: mADAT1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 30947
HGNC: HGNC:228
Homologene: 8096
Bnip3l
Name: BCL2/adenovirus E1B interacting protein 3-like
Synonyms: D14Ertd719e, Nip3L, Nix
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12177
HGNC: HGNC:1085
Homologene: 3195
Syt2
Name: synaptotagmin II
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20980
Homologene: 22516
Apc
Name: APC, WNT signaling pathway regulator
Synonyms: adenomatosis polyposis coli, CC1, Min
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 11789
HGNC: HGNC:583
Homologene: 30950
Aasdhppt
Name: aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Synonyms: CGI-80, 2810407B07Rik, AASD-PPT, LYS2, LYS5, 2010309J24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67618
Homologene: 9130
Siglecf
Name: sialic acid binding Ig-like lectin F
Synonyms: Siglec5, mSiglec-F
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233186
Homologene: 50482
Atp2b4
Name: ATPase, Ca++ transporting, plasma membrane 4
Synonyms: PMCA4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381290
HGNC: HGNC:817
Homologene: 48034
Ckap4
Name: cytoskeleton-associated protein 4
Synonyms: P63, 5630400A09Rik, CLIMP-63
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216197
VEGA: 10
Homologene: 4970
Myof
Name: myoferlin
Synonyms: 2310051D19Rik, E030042N20Rik, Fer1l3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226101
VEGA: 19
HGNC: HGNC:3656
Homologene: 40882
Scin
Name: scinderin
Synonyms: adseverin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20259
Homologene: 36296
Ksr2
Name: kinase suppressor of ras 2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 333050
Homologene: 45469
Tecta
Name: tectorin alpha
Synonyms: [a]-tectorin, Tctna
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21683
Homologene: 3955
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC5/6A, PC6, b2b1549Clo, SPC6, PC5A, b2b585Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Cdhr3
Name: cadherin-related family member 3
Synonyms: 1110049B09Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68764
VEGA: 12
Homologene: 45146
Or5b105
Name: olfactory receptor family 5 subfamily B member 105
Synonyms: GA_x6K02T2RE5P-3430689-3429787, Olfr1458, EG667271, MOR202-24
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667271
HGNC: HGNC:8324
Pnp2
Name: purine-nucleoside phosphorylase 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 667034
HGNC: HGNC:7892
Homologene: 227
Fem1b
Name: fem 1 homolog b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14155
VEGA: 9
HGNC: HGNC:3649
Homologene: 7714
Pglyrp3
Name: peptidoglycan recognition protein 3
Synonyms: LOC242100
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242100
Homologene: 71559
Megf8
Name: multiple EGF-like-domains 8
Synonyms: m687Ddg, b2b288Clo, b2b1702Clo, Egfl4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269878
HGNC: HGNC:3233
Homologene: 15988
Tns1
Name: tensin 1
Synonyms: 1200014E20Rik, E030037J05Rik, 1110018I21Rik, Tns, E030018G17Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21961
Homologene: 11219
Thbs2
Name: thrombospondin 2
Synonyms: Thrombospondin-2, Thbs-2, TSP2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 21826
VEGA: 17
Homologene: 2438
Nsun4
Name: NOL1/NOP2/Sun domain family, member 4
Synonyms: 2310010O12Rik, 2810405F18Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72181
Homologene: 12455
Zfp820
Name: zinc finger protein 820
Synonyms: 2610036F08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75424
VEGA: 17
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Or51q1
Name: olfactory receptor family 51 subfamily Q member 1
Synonyms: GA_x6K02T2PBJ9-6713641-6714588, MOR5-2, Olfr635
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259122
Homologene: 133592
Zfr2
Name: zinc finger RNA binding protein 2
Synonyms: 2010013I23Rik, 9130206N08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103406
Homologene: 88124
Smpdl3b
Name: sphingomyelin phosphodiesterase, acid-like 3B
Synonyms: 1110054A24Rik, Asml3b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100340
Homologene: 8708
Tmtc4
Name: transmembrane and tetratricopeptide repeat containing 4
Synonyms: 4930403J22Rik, 5730419O14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70551
Homologene: 32796
Cyp11a1
Name: cytochrome P450, family 11, subfamily a, polypeptide 1
Synonyms: Cyp11a, P450scc, cholesterol side chain cleavage, D9Ertd411e, Scc, cscc
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13070
HGNC: HGNC:2590
Homologene: 37347
Krt83
Name: keratin 83
Synonyms: 5430421N21Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 100126226
Homologene: 68248
Gm5464
Name: predicted gene 5464
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 432870
VEGA: 14
Prr27
Name: proline rich 27
Synonyms: 4930432K09Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 73779
Homologene: 136277
Pcdha7
Name: protocadherin alpha 7
Synonyms: Cnr4, Crnr4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12939
HGNC: HGNC:8673
Homologene: 117962
Rnf166
Name: ring finger protein 166
Synonyms: Zfp313l, 1110031E24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 68718
Homologene: 35335
Rmdn1
Name: regulator of microtubule dynamics 1
Synonyms: 5730501K14Rik, Fam82b, 5033415E11Rik, 2410005O16Rik, 6430576D04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66302
Homologene: 41093
Igkv12-41
Name: immunoglobulin kappa chain variable 12-41
Synonyms: Gm16848
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 619960
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 73,990,394 bp (GRCm38)
  • A to G, chromosome 1 at 133,731,830 bp (GRCm38)
  • G to A, chromosome 1 at 134,744,035 bp (GRCm38)
  • C to A, chromosome 2 at 125,740,641 bp (GRCm38)
  • A to G, chromosome 2 at 127,061,668 bp (GRCm38)
  • A to T, chromosome 2 at 168,926,198 bp (GRCm38)
  • T to C, chromosome 2 at 181,087,020 bp (GRCm38)
  • T to C, chromosome 3 at 92,031,552 bp (GRCm38)
  • T to C, chromosome 4 at 19,599,660 bp (GRCm38)
  • A to T, chromosome 4 at 116,051,655 bp (GRCm38)
  • G to A, chromosome 4 at 132,757,127 bp (GRCm38)
  • C to A, chromosome 5 at 87,843,135 bp (GRCm38)
  • G to A, chromosome 5 at 117,756,279 bp (GRCm38)
  • G to A, chromosome 6 at 69,858,595 bp (GRCm38)
  • C to T, chromosome 7 at 25,328,803 bp (GRCm38)
  • C to A, chromosome 7 at 43,352,272 bp (GRCm38)
  • CGGCGGCGG to CGGCGGCGGGGGCGGCGG, chromosome 7 at 97,579,911 bp (GRCm38)
  • T to C, chromosome 7 at 103,979,972 bp (GRCm38)
  • G to T, chromosome 8 at 111,982,682 bp (GRCm38)
  • A to T, chromosome 8 at 122,470,309 bp (GRCm38)
  • G to T, chromosome 9 at 4,309,312 bp (GRCm38)
  • G to T, chromosome 9 at 42,338,942 bp (GRCm38)
  • G to A, chromosome 9 at 58,018,322 bp (GRCm38)
  • A to T, chromosome 9 at 62,797,677 bp (GRCm38)
  • A to T, chromosome 10 at 81,233,746 bp (GRCm38)
  • G to A, chromosome 10 at 84,528,311 bp (GRCm38)
  • C to A, chromosome 10 at 123,163,617 bp (GRCm38)
  • A to T, chromosome 11 at 77,049,278 bp (GRCm38)
  • A to G, chromosome 12 at 33,086,008 bp (GRCm38)
  • C to T, chromosome 12 at 40,081,747 bp (GRCm38)
  • T to G, chromosome 13 at 55,276,542 bp (GRCm38)
  • T to A, chromosome 14 at 50,959,522 bp (GRCm38)
  • C to A, chromosome 14 at 50,959,524 bp (GRCm38)
  • T to A, chromosome 14 at 66,868,917 bp (GRCm38)
  • G to A, chromosome 14 at 67,008,765 bp (GRCm38)
  • T to C, chromosome 14 at 122,933,403 bp (GRCm38)
  • G to C, chromosome 15 at 12,458,020 bp (GRCm38)
  • T to C, chromosome 15 at 101,488,179 bp (GRCm38)
  • G to A, chromosome 16 at 22,026,685 bp (GRCm38)
  • A to T, chromosome 17 at 14,678,821 bp (GRCm38)
  • G to T, chromosome 17 at 21,819,596 bp (GRCm38)
  • T to A, chromosome 18 at 34,310,770 bp (GRCm38)
  • A to T, chromosome 18 at 36,975,992 bp (GRCm38)
  • G to A, chromosome 18 at 37,296,213 bp (GRCm38)
  • A to G, chromosome 19 at 13,102,542 bp (GRCm38)
  • G to T, chromosome 19 at 17,675,535 bp (GRCm38)
  • A to T, chromosome 19 at 38,043,289 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9592 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069385-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.