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Strain Name:
C57BL/6J-MtgxR9608Btlr/Mmmh
Stock Number:
069401-MU
Citation ID:
RRID:MMRRC_069401-MU
Other Names:
R9608 (G1)
Major Collection:

Strain Information

Fgf4
Name: fibroblast growth factor 4
Synonyms: Hst1, kFGF, Fgf-4, Hstf-1, Fgfk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 14175
HGNC: HGNC:3682
Homologene: 1522
Eya1
Name: EYA transcriptional coactivator and phosphatase 1
Synonyms: bor
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14048
HGNC: HGNC:3519
Homologene: 74943
Exoc6b
Name: exocyst complex component 6B
Synonyms: 4930569O18Rik, G430127E12Rik, Sec15b, Sec15l2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75914
Homologene: 44781
Spidr
Name: scaffolding protein involved in DNA repair
Synonyms: 2310008H04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224008
VEGA: 16
Homologene: 51693
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230935
Homologene: 14558
Zfp42
Name: zinc finger protein 42
Synonyms: Rex-1, Zfp-42, Rex1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 22702
Homologene: 7601
Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Synonyms: DNA-PKcs, slip, DNAPDcs, XRCC7, DNA-PK, DOXNPH, dxnph
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19090
HGNC: HGNC:9413
Homologene: 5037
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • C to T, chromosome 1 at 6,248,304 bp (GRCm38)
  • A to T, chromosome 1 at 14,302,805 bp (GRCm38)
  • A to T, chromosome 1 at 75,185,095 bp (GRCm38)
  • G to A, chromosome 1 at 86,545,702 bp (GRCm38)
  • G to A, chromosome 1 at 150,599,552 bp (GRCm38)
  • A to G, chromosome 1 at 155,223,389 bp (GRCm38)
  • T to C, chromosome 2 at 66,322,343 bp (GRCm38)
  • C to T, chromosome 2 at 129,036,630 bp (GRCm38)
  • A to G, chromosome 2 at 160,755,751 bp (GRCm38)
  • A to T, chromosome 2 at 172,549,844 bp (GRCm38)
  • T to C, chromosome 2 at 181,187,875 bp (GRCm38)
  • T to C, chromosome 3 at 89,359,135 bp (GRCm38)
  • G to A, chromosome 3 at 96,033,670 bp (GRCm38)
  • C to A, chromosome 3 at 108,867,281 bp (GRCm38)
  • G to T, chromosome 4 at 107,908,144 bp (GRCm38)
  • A to G, chromosome 4 at 130,013,559 bp (GRCm38)
  • A to G, chromosome 4 at 151,950,521 bp (GRCm38)
  • T to A, chromosome 5 at 29,437,752 bp (GRCm38)
  • T to G, chromosome 5 at 134,726,477 bp (GRCm38)
  • T to A, chromosome 5 at 135,057,672 bp (GRCm38)
  • G to A, chromosome 5 at 135,346,173 bp (GRCm38)
  • A to G, chromosome 5 at 144,843,318 bp (GRCm38)
  • T to A, chromosome 5 at 149,215,060 bp (GRCm38)
  • T to A, chromosome 6 at 48,427,842 bp (GRCm38)
  • T to C, chromosome 6 at 52,245,244 bp (GRCm38)
  • T to A, chromosome 6 at 55,380,801 bp (GRCm38)
  • C to T, chromosome 6 at 65,114,334 bp (GRCm38)
  • T to A, chromosome 6 at 70,864,527 bp (GRCm38)
  • C to T, chromosome 6 at 83,107,101 bp (GRCm38)
  • C to T, chromosome 6 at 84,625,124 bp (GRCm38)
  • A to G, chromosome 6 at 112,329,824 bp (GRCm38)
  • A to C, chromosome 6 at 124,309,204 bp (GRCm38)
  • A to G, chromosome 6 at 137,836,878 bp (GRCm38)
  • A to G, chromosome 7 at 3,502,546 bp (GRCm38)
  • A to T, chromosome 7 at 5,488,221 bp (GRCm38)
  • A to T, chromosome 7 at 7,554,154 bp (GRCm38)
  • G to A, chromosome 7 at 24,384,078 bp (GRCm38)
  • C to T, chromosome 7 at 62,348,589 bp (GRCm38)
  • A to G, chromosome 7 at 81,372,010 bp (GRCm38)
  • A to G, chromosome 7 at 108,346,306 bp (GRCm38)
  • G to C, chromosome 7 at 109,921,506 bp (GRCm38)
  • A to G, chromosome 7 at 122,992,045 bp (GRCm38)
  • A to T, chromosome 7 at 127,807,379 bp (GRCm38)
  • A to T, chromosome 7 at 143,079,411 bp (GRCm38)
  • A to T, chromosome 7 at 144,861,598 bp (GRCm38)
  • C to T, chromosome 8 at 43,296,135 bp (GRCm38)
  • C to T, chromosome 8 at 75,117,540 bp (GRCm38)
  • T to A, chromosome 9 at 56,885,552 bp (GRCm38)
  • A to G, chromosome 10 at 13,190,696 bp (GRCm38)
  • G to A, chromosome 10 at 34,605,877 bp (GRCm38)
  • C to T, chromosome 11 at 69,454,062 bp (GRCm38)
  • A to G, chromosome 11 at 72,317,275 bp (GRCm38)
  • T to C, chromosome 11 at 72,989,040 bp (GRCm38)
  • A to G, chromosome 11 at 82,961,004 bp (GRCm38)
  • C to A, chromosome 11 at 82,961,495 bp (GRCm38)
  • T to G, chromosome 11 at 97,326,861 bp (GRCm38)
  • T to C, chromosome 11 at 99,236,155 bp (GRCm38)
  • T to C, chromosome 11 at 120,786,815 bp (GRCm38)
  • G to A, chromosome 12 at 58,973,018 bp (GRCm38)
  • A to T, chromosome 12 at 81,378,312 bp (GRCm38)
  • G to C, chromosome 13 at 38,011,395 bp (GRCm38)
  • A to T, chromosome 13 at 92,500,280 bp (GRCm38)
  • T to A, chromosome 14 at 26,912,191 bp (GRCm38)
  • T to C, chromosome 14 at 30,953,947 bp (GRCm38)
  • A to G, chromosome 14 at 50,148,598 bp (GRCm38)
  • A to T, chromosome 14 at 51,571,642 bp (GRCm38)
  • T to C, chromosome 14 at 66,053,830 bp (GRCm38)
  • T to C, chromosome 15 at 10,400,538 bp (GRCm38)
  • A to T, chromosome 15 at 10,952,482 bp (GRCm38)
  • A to T, chromosome 15 at 13,064,535 bp (GRCm38)
  • T to C, chromosome 15 at 44,578,633 bp (GRCm38)
  • G to A, chromosome 15 at 75,597,763 bp (GRCm38)
  • T to A, chromosome 15 at 89,307,605 bp (GRCm38)
  • C to A, chromosome 16 at 15,730,470 bp (GRCm38)
  • T to A, chromosome 16 at 15,730,471 bp (GRCm38)
  • G to A, chromosome 16 at 16,037,610 bp (GRCm38)
  • A to T, chromosome 17 at 27,122,735 bp (GRCm38)
  • T to C, chromosome 17 at 37,270,268 bp (GRCm38)
  • A to G, chromosome 17 at 63,907,332 bp (GRCm38)
  • G to T, chromosome 17 at 64,734,958 bp (GRCm38)
  • T to C, chromosome 17 at 85,068,893 bp (GRCm38)
  • T to A, chromosome 18 at 37,490,641 bp (GRCm38)
  • C to T, chromosome 18 at 38,197,851 bp (GRCm38)
  • T to A, chromosome 18 at 63,146,945 bp (GRCm38)
  • A to G, chromosome 19 at 5,143,834 bp (GRCm38)
  • A to T, chromosome 19 at 13,705,504 bp (GRCm38)
  • T to A, chromosome 19 at 55,284,452 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9608 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069401-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.