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Strain Name:
C57BL/6J-MtgxR9617Btlr/Mmmh
Stock Number:
069410-MU
Citation ID:
RRID:MMRRC_069410-MU
Other Names:
R9617 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Map3k4
Name: mitogen-activated protein kinase kinase kinase 4
Synonyms: MTK1, MAPKKK4, D17Rp17, RP17, D17Rp17e, Mekk4, T-associated sex reversal, Tas
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26407
VEGA: 17
HGNC: HGNC:6856
Homologene: 31346
Rorb
Name: RAR-related orphan receptor beta
Synonyms: RZR-beta, Nr1f2, Rorbeta, hstp
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225998
Homologene: 38250
Eif4g3
Name: eukaryotic translation initiation factor 4 gamma, 3
Synonyms: eIF4GII, 1500002J22Rik, 4930523M17Rik, G1-419-52, repro8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230861
HGNC: HGNC:3298
Homologene: 2789
Myh10
Name: myosin, heavy polypeptide 10, non-muscle
Synonyms: nonmuscle myosin heavy chain II-B, NMHC-B, SMemb, nonmuscle myosin heavy chain IIB, 9330167F11Rik, 5730504C04Rik, NMHC II-B, Myhn2, Myosin IIB, Myhn-2, myosin IIB, Fltn, Fltn
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 77579
HGNC: HGNC:7568
Homologene: 55941
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to C, chromosome 1 at 16,068,827 bp (GRCm38)
  • T to C, chromosome 1 at 59,058,689 bp (GRCm38)
  • T to C, chromosome 1 at 65,063,210 bp (GRCm38)
  • G to T, chromosome 1 at 74,379,882 bp (GRCm38)
  • A to G, chromosome 1 at 88,095,230 bp (GRCm38)
  • A to G, chromosome 1 at 133,914,678 bp (GRCm38)
  • A to T, chromosome 1 at 140,162,980 bp (GRCm38)
  • C to T, chromosome 1 at 162,321,785 bp (GRCm38)
  • T to A, chromosome 2 at 35,145,065 bp (GRCm38)
  • A to G, chromosome 2 at 66,562,465 bp (GRCm38)
  • T to A, chromosome 2 at 85,590,935 bp (GRCm38)
  • T to C, chromosome 2 at 90,758,394 bp (GRCm38)
  • T to A, chromosome 2 at 150,238,532 bp (GRCm38)
  • A to T, chromosome 2 at 151,593,502 bp (GRCm38)
  • C to A, chromosome 2 at 152,688,953 bp (GRCm38)
  • T to C, chromosome 2 at 174,300,195 bp (GRCm38)
  • C to T, chromosome 3 at 68,870,069 bp (GRCm38)
  • G to A, chromosome 3 at 86,359,862 bp (GRCm38)
  • A to G, chromosome 3 at 107,477,369 bp (GRCm38)
  • G to T, chromosome 3 at 108,375,636 bp (GRCm38)
  • T to A, chromosome 4 at 48,636,940 bp (GRCm38)
  • T to C, chromosome 4 at 98,505,754 bp (GRCm38)
  • T to A, chromosome 4 at 120,483,630 bp (GRCm38)
  • A to G, chromosome 4 at 138,096,879 bp (GRCm38)
  • T to C, chromosome 5 at 5,589,164 bp (GRCm38)
  • A to T, chromosome 5 at 8,747,353 bp (GRCm38)
  • C to T, chromosome 5 at 21,670,563 bp (GRCm38)
  • T to A, chromosome 5 at 110,251,543 bp (GRCm38)
  • A to T, chromosome 5 at 146,493,183 bp (GRCm38)
  • A to G, chromosome 6 at 41,619,324 bp (GRCm38)
  • T to C, chromosome 6 at 95,126,893 bp (GRCm38)
  • T to C, chromosome 6 at 119,796,941 bp (GRCm38)
  • G to A, chromosome 6 at 149,144,246 bp (GRCm38)
  • A to G, chromosome 7 at 45,498,735 bp (GRCm38)
  • T to C, chromosome 7 at 92,438,076 bp (GRCm38)
  • A to G, chromosome 9 at 39,719,382 bp (GRCm38)
  • C to T, chromosome 9 at 110,097,118 bp (GRCm38)
  • G to A, chromosome 9 at 121,789,125 bp (GRCm38)
  • T to C, chromosome 9 at 122,367,970 bp (GRCm38)
  • A to C, chromosome 10 at 7,129,021 bp (GRCm38)
  • C to T, chromosome 10 at 81,183,142 bp (GRCm38)
  • A to T, chromosome 10 at 117,757,333 bp (GRCm38)
  • A to T, chromosome 10 at 129,332,925 bp (GRCm38)
  • A to G, chromosome 11 at 3,347,715 bp (GRCm38)
  • T to A, chromosome 11 at 16,995,311 bp (GRCm38)
  • T to A, chromosome 11 at 68,791,989 bp (GRCm38)
  • A to G, chromosome 11 at 70,557,118 bp (GRCm38)
  • G to T, chromosome 11 at 101,964,066 bp (GRCm38)
  • G to T, chromosome 11 at 118,333,174 bp (GRCm38)
  • T to A, chromosome 12 at 51,598,251 bp (GRCm38)
  • A to T, chromosome 12 at 55,089,276 bp (GRCm38)
  • T to G, chromosome 12 at 87,056,587 bp (GRCm38)
  • C to T, chromosome 12 at 103,456,424 bp (GRCm38)
  • T to A, chromosome 12 at 117,658,310 bp (GRCm38)
  • A to G, chromosome 13 at 38,060,040 bp (GRCm38)
  • T to A, chromosome 13 at 49,038,977 bp (GRCm38)
  • T to C, chromosome 13 at 100,433,313 bp (GRCm38)
  • A to G, chromosome 14 at 32,238,612 bp (GRCm38)
  • T to C, chromosome 15 at 98,776,728 bp (GRCm38)
  • A to T, chromosome 16 at 56,151,289 bp (GRCm38)
  • A to G, chromosome 17 at 12,257,984 bp (GRCm38)
  • T to C, chromosome 17 at 21,286,791 bp (GRCm38)
  • T to A, chromosome 17 at 24,581,367 bp (GRCm38)
  • T to A, chromosome 17 at 37,590,162 bp (GRCm38)
  • C to T, chromosome 17 at 46,447,072 bp (GRCm38)
  • G to A, chromosome 17 at 56,661,252 bp (GRCm38)
  • A to T, chromosome 17 at 65,500,185 bp (GRCm38)
  • T to C, chromosome 17 at 79,621,361 bp (GRCm38)
  • C to A, chromosome 18 at 34,547,110 bp (GRCm38)
  • T to C, chromosome 18 at 35,213,437 bp (GRCm38)
  • A to G, chromosome 18 at 37,485,165 bp (GRCm38)
  • T to C, chromosome 18 at 39,774,549 bp (GRCm38)
  • A to G, chromosome 18 at 49,865,161 bp (GRCm38)
  • T to C, chromosome 18 at 63,115,037 bp (GRCm38)
  • A to T, chromosome 18 at 80,449,747 bp (GRCm38)
  • G to A, chromosome 19 at 18,962,135 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9617 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069410-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.