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Strain Name:
C57BL/6J-MtgxR9681Btlr/Mmmh
Stock Number:
069474-MU
Citation ID:
RRID:MMRRC_069474-MU
Other Names:
R9681 (G1)
Major Collection:

Strain Information

Limch1
Name: LIM and calponin homology domains 1
Synonyms: 3732412D22Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 77569
Homologene: 18953
Nrcam
Name: neuronal cell adhesion molecule
Synonyms: Bravo, C030017F07Rik, C130076O07Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319504
VEGA: 12
HGNC: HGNC:7994
Homologene: 21041
Cr1l
Name: complement C3b/C4b receptor 1 like
Synonyms: mCRY, Crry
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12946
Homologene: 128275
Ark2n
Name: arkadia (RNF111) N-terminal like PKA signaling regulator 2N
Synonyms: Ark2N, 8030462N17Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 212163
VEGA: 18
Homologene: 17035
Mfap4
Name: microfibrillar-associated protein 4
Synonyms: 1110007F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76293
HGNC: HGNC:7035
Homologene: 134529
Mcm7
Name: minichromosome maintenance complex component 7
Synonyms: mCDC47, Mcmd7
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17220
HGNC: HGNC:6950
Homologene: 4323
Ano1
Name: anoctamin 1, calcium activated chloride channel
Synonyms: Tmem16a
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101772
Homologene: 75079
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • G to T, chromosome 1 at 92,886,160 bp (GRCm38)
  • A to G, chromosome 1 at 127,822,360 bp (GRCm38)
  • A to T, chromosome 1 at 131,753,953 bp (GRCm38)
  • T to A, chromosome 1 at 180,738,517 bp (GRCm38)
  • T to C, chromosome 1 at 181,734,849 bp (GRCm38)
  • T to C, chromosome 1 at 195,117,841 bp (GRCm38)
  • A to G, chromosome 2 at 21,826,504 bp (GRCm38)
  • A to G, chromosome 2 at 32,370,962 bp (GRCm38)
  • T to C, chromosome 2 at 76,782,379 bp (GRCm38)
  • G to T, chromosome 2 at 79,865,121 bp (GRCm38)
  • A to T, chromosome 2 at 168,951,760 bp (GRCm38)
  • A to T, chromosome 3 at 29,979,654 bp (GRCm38)
  • C to T, chromosome 3 at 58,884,830 bp (GRCm38)
  • A to G, chromosome 3 at 106,130,680 bp (GRCm38)
  • T to C, chromosome 3 at 116,923,471 bp (GRCm38)
  • T to A, chromosome 4 at 58,084,959 bp (GRCm38)
  • G to A, chromosome 4 at 101,161,888 bp (GRCm38)
  • A to G, chromosome 5 at 29,437,625 bp (GRCm38)
  • T to C, chromosome 5 at 64,097,048 bp (GRCm38)
  • T to C, chromosome 5 at 65,651,244 bp (GRCm38)
  • A to G, chromosome 5 at 66,969,079 bp (GRCm38)
  • A to T, chromosome 5 at 88,954,864 bp (GRCm38)
  • T to A, chromosome 5 at 98,329,355 bp (GRCm38)
  • A to T, chromosome 5 at 122,102,720 bp (GRCm38)
  • A to T, chromosome 5 at 138,165,958 bp (GRCm38)
  • A to G, chromosome 6 at 72,347,467 bp (GRCm38)
  • T to A, chromosome 6 at 91,173,086 bp (GRCm38)
  • T to A, chromosome 6 at 121,856,295 bp (GRCm38)
  • T to A, chromosome 7 at 5,221,070 bp (GRCm38)
  • T to A, chromosome 7 at 22,498,943 bp (GRCm38)
  • T to A, chromosome 7 at 26,766,903 bp (GRCm38)
  • T to C, chromosome 7 at 29,150,262 bp (GRCm38)
  • C to T, chromosome 7 at 44,753,932 bp (GRCm38)
  • T to C, chromosome 7 at 45,830,049 bp (GRCm38)
  • G to C, chromosome 7 at 56,293,875 bp (GRCm38)
  • A to G, chromosome 7 at 100,374,455 bp (GRCm38)
  • T to A, chromosome 7 at 103,717,268 bp (GRCm38)
  • T to C, chromosome 7 at 104,924,868 bp (GRCm38)
  • T to G, chromosome 7 at 120,078,388 bp (GRCm38)
  • T to C, chromosome 7 at 127,330,250 bp (GRCm38)
  • A to G, chromosome 7 at 144,590,156 bp (GRCm38)
  • T to C, chromosome 8 at 22,628,330 bp (GRCm38)
  • T to C, chromosome 8 at 119,566,342 bp (GRCm38)
  • A to C, chromosome 9 at 37,423,262 bp (GRCm38)
  • T to A, chromosome 9 at 37,427,791 bp (GRCm38)
  • T to A, chromosome 9 at 65,134,576 bp (GRCm38)
  • T to A, chromosome 9 at 123,516,838 bp (GRCm38)
  • T to A, chromosome 10 at 69,342,619 bp (GRCm38)
  • T to C, chromosome 10 at 72,657,280 bp (GRCm38)
  • T to A, chromosome 10 at 77,716,046 bp (GRCm38)
  • G to A, chromosome 10 at 79,035,743 bp (GRCm38)
  • A to T, chromosome 10 at 129,570,795 bp (GRCm38)
  • T to A, chromosome 11 at 49,970,213 bp (GRCm38)
  • T to A, chromosome 11 at 61,486,099 bp (GRCm38)
  • A to G, chromosome 11 at 103,368,124 bp (GRCm38)
  • T to A, chromosome 11 at 106,234,853 bp (GRCm38)
  • G to T, chromosome 12 at 4,633,499 bp (GRCm38)
  • C to A, chromosome 12 at 44,551,350 bp (GRCm38)
  • T to C, chromosome 12 at 85,136,825 bp (GRCm38)
  • T to A, chromosome 12 at 95,778,651 bp (GRCm38)
  • A to G, chromosome 14 at 110,750,826 bp (GRCm38)
  • C to A, chromosome 15 at 75,809,621 bp (GRCm38)
  • T to A, chromosome 16 at 36,708,387 bp (GRCm38)
  • T to A, chromosome 16 at 58,823,813 bp (GRCm38)
  • T to A, chromosome 16 at 85,802,610 bp (GRCm38)
  • T to C, chromosome 17 at 6,224,225 bp (GRCm38)
  • A to T, chromosome 17 at 19,378,627 bp (GRCm38)
  • A to G, chromosome 17 at 56,318,083 bp (GRCm38)
  • A to T, chromosome 18 at 3,268,067 bp (GRCm38)
  • A to T, chromosome 18 at 77,635,293 bp (GRCm38)
  • T to C, chromosome 19 at 8,713,862 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9681 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069474-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.