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Strain Name:
C57BL/6J-MtgxR9688Btlr/Mmmh
Stock Number:
069481-MU
Citation ID:
RRID:MMRRC_069481-MU
Other Names:
R9688 (G1)
Major Collection:

Strain Information

Rc3h1
Name: RING CCCH (C3H) domains 1
Synonyms: roquin, 5730557L09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381305
Homologene: 19036
Gjd2
Name: gap junction protein, delta 2
Synonyms: connexin36, Cx36, Gja9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14617
Homologene: 7734
Camk1g
Name: calcium/calmodulin-dependent protein kinase I gamma
Synonyms: CLICK-III, CaMKIgamma
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 215303
Homologene: 48706
Setx
Name: senataxin
Synonyms: A930037J23Rik, Als4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 269254
HGNC: HGNC:445
Homologene: 41003
Ercc6
Name: excision repair cross-complementing rodent repair deficiency, complementation group 6
Synonyms: CS group B correcting gene, CSB, C130058G22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319955
VEGA: 14
HGNC: HGNC:3438
Homologene: 133552
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 58,017,578 bp (GRCm38)
  • A to G, chromosome 1 at 160,942,664 bp (GRCm38)
  • T to A, chromosome 1 at 193,348,721 bp (GRCm38)
  • G to C, chromosome 2 at 25,434,447 bp (GRCm38)
  • A to T, chromosome 2 at 29,146,316 bp (GRCm38)
  • A to C, chromosome 2 at 86,786,661 bp (GRCm38)
  • A to G, chromosome 2 at 114,011,628 bp (GRCm38)
  • A to T, chromosome 2 at 140,168,175 bp (GRCm38)
  • T to C, chromosome 2 at 146,036,838 bp (GRCm38)
  • A to T, chromosome 2 at 162,948,777 bp (GRCm38)
  • G to T, chromosome 3 at 53,009,107 bp (GRCm38)
  • G to T, chromosome 3 at 55,649,744 bp (GRCm38)
  • T to G, chromosome 3 at 88,984,717 bp (GRCm38)
  • A to T, chromosome 3 at 99,326,392 bp (GRCm38)
  • A to G, chromosome 4 at 32,745,590 bp (GRCm38)
  • C to A, chromosome 4 at 88,676,637 bp (GRCm38)
  • C to A, chromosome 4 at 130,264,340 bp (GRCm38)
  • T to C, chromosome 5 at 24,526,512 bp (GRCm38)
  • T to A, chromosome 5 at 32,897,932 bp (GRCm38)
  • A to T, chromosome 5 at 62,714,766 bp (GRCm38)
  • A to T, chromosome 5 at 65,164,587 bp (GRCm38)
  • A to T, chromosome 5 at 65,654,853 bp (GRCm38)
  • A to G, chromosome 5 at 65,892,313 bp (GRCm38)
  • T to C, chromosome 5 at 137,468,455 bp (GRCm38)
  • A to G, chromosome 6 at 3,377,087 bp (GRCm38)
  • A to T, chromosome 6 at 58,307,754 bp (GRCm38)
  • G to A, chromosome 6 at 87,137,352 bp (GRCm38)
  • G to T, chromosome 7 at 5,146,670 bp (GRCm38)
  • A to T, chromosome 7 at 18,610,622 bp (GRCm38)
  • A to G, chromosome 7 at 107,719,241 bp (GRCm38)
  • G to T, chromosome 7 at 115,476,990 bp (GRCm38)
  • T to C, chromosome 7 at 126,587,491 bp (GRCm38)
  • T to C, chromosome 8 at 31,154,251 bp (GRCm38)
  • T to C, chromosome 8 at 61,226,314 bp (GRCm38)
  • A to T, chromosome 8 at 104,964,672 bp (GRCm38)
  • A to G, chromosome 8 at 107,094,911 bp (GRCm38)
  • A to G, chromosome 9 at 27,056,053 bp (GRCm38)
  • G to A, chromosome 9 at 27,098,908 bp (GRCm38)
  • C to A, chromosome 9 at 95,229,054 bp (GRCm38)
  • T to C, chromosome 10 at 29,196,695 bp (GRCm38)
  • T to A, chromosome 10 at 77,311,265 bp (GRCm38)
  • A to T, chromosome 10 at 89,344,644 bp (GRCm38)
  • T to C, chromosome 10 at 117,215,681 bp (GRCm38)
  • C to A, chromosome 10 at 129,437,098 bp (GRCm38)
  • C to T, chromosome 11 at 20,829,442 bp (GRCm38)
  • A to G, chromosome 11 at 23,519,067 bp (GRCm38)
  • T to A, chromosome 11 at 69,970,599 bp (GRCm38)
  • C to T, chromosome 11 at 70,688,984 bp (GRCm38)
  • T to C, chromosome 11 at 75,543,286 bp (GRCm38)
  • T to C, chromosome 11 at 83,298,431 bp (GRCm38)
  • T to A, chromosome 11 at 102,107,273 bp (GRCm38)
  • T to A, chromosome 11 at 103,239,233 bp (GRCm38)
  • T to C, chromosome 11 at 106,459,010 bp (GRCm38)
  • T to C, chromosome 11 at 109,429,939 bp (GRCm38)
  • T to C, chromosome 11 at 116,234,160 bp (GRCm38)
  • A to T, chromosome 12 at 57,673,816 bp (GRCm38)
  • A to G, chromosome 12 at 112,908,944 bp (GRCm38)
  • A to G, chromosome 13 at 69,507,080 bp (GRCm38)
  • A to C, chromosome 14 at 32,575,798 bp (GRCm38)
  • A to T, chromosome 14 at 79,335,869 bp (GRCm38)
  • T to C, chromosome 14 at 122,464,023 bp (GRCm38)
  • A to C, chromosome 15 at 96,415,927 bp (GRCm38)
  • T to C, chromosome 17 at 26,974,920 bp (GRCm38)
  • A to G, chromosome 17 at 36,548,162 bp (GRCm38)
  • T to A, chromosome 17 at 74,499,083 bp (GRCm38)
  • A to G, chromosome 18 at 37,144,575 bp (GRCm38)
  • G to C, chromosome 18 at 84,637,857 bp (GRCm38)
  • T to C, chromosome 19 at 11,276,694 bp (GRCm38)
  • A to C, chromosome 19 at 42,766,708 bp (GRCm38)
  • G to A, chromosome 19 at 59,345,251 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9688 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069481-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.