Strain Name:
C57BL/6J-MtgxR9706Btlr/Mmmh
Stock Number:
069953-MU
Citation ID:
RRID:MMRRC_069953-MU
Other Names:
R9706 (G1)
Major Collection:

Strain Information

Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Prrc2b
Name: proline-rich coiled-coil 2B
Synonyms: Bat2l, 5830434P21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227723
Homologene: 106649
Camsap3
Name: calmodulin regulated spectrin-associated protein family, member 3
Synonyms: Nezha, 2310057J16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69697
Homologene: 18966
Rbpms2
Name: RNA binding protein with multiple splicing 2
Synonyms: 2400008B06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71973
VEGA: 9
Homologene: 49895
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: B130021D15Rik, D630001B22Rik, Af10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17354
Homologene: 20973
Stk38l
Name: serine/threonine kinase 38 like
Synonyms: 4930473A22Rik, Ndr2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232533
Homologene: 56299
R3hdm2
Name: R3H domain containing 2
Synonyms: 1300003K24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71750
Homologene: 8954
Atg16l1
Name: autophagy related 16 like 1
Synonyms: APG16L, WDR30, 1500009K01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77040
Homologene: 41786
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Sqle
Name: squalene epoxidase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20775
Homologene: 2355
Atad3a
Name: ATPase family, AAA domain containing 3A
Synonyms: 2400004H09Rik, Tob3
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 108888
Homologene: 10059
Inpp5j
Name: inositol polyphosphate 5-phosphatase J
Synonyms: Pib5pa, Pipp
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170835
HGNC: HGNC:8956
Homologene: 8682
Nup50
Name: nucleoporin 50
Synonyms: 1700030K07Rik, Npap60
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18141
VEGA: 15
HGNC: HGNC:8065
Homologene: 5190
Lrrc47
Name: leucine rich repeat containing 47
Synonyms: 2900010D03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72946
Homologene: 10795
Adam20
Name: a disintegrin and metallopeptidase domain 20
Synonyms: 4930529F22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 384806
HGNC: HGNC:199
Homologene: 128364
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Creb3
Name: cAMP responsive element binding protein 3
Synonyms: Luman, LZIP-2, LZIP-1, LZIP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12913
HGNC: HGNC:2347
Homologene: 31375
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Decr2
Name: 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26378
HGNC: HGNC:2754
Homologene: 22223
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Hc
Name: hemolytic complement
Synonyms: C5, He, Hfib2, C5a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15139
HGNC: HGNC:1331
Homologene: 20412
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Ephb3
Name: Eph receptor B3
Synonyms: Sek4, MDK5, Tyro6, Etk2, HEK2, Cek10
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13845
HGNC: HGNC:3394
Homologene: 20938
Ptchd4
Name: patched domain containing 4
Synonyms: 3110082D06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627626
VEGA: 17
Homologene: 78322
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: Gm1557, 4930503E15Rik, LOC380658
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Or52e18
Name: olfactory receptor family 52 subfamily E member 18
Synonyms: GA_x6K02T2PBJ9-7589577-7588639, MOR32-8, Olfr670
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384703
Homologene: 105163
Pik3r5
Name: phosphoinositide-3-kinase regulatory subunit 5
Synonyms: p101, Foap2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320207
Homologene: 8627
Sacs
Name: sacsin
Synonyms: E130115J16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50720
Cldn10
Name: claudin 10
Synonyms: D14Ertd728e, Cldn10b, Cldn10a, 6720456I16Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58187
HGNC: HGNC:2033
Homologene: 5076
Efcab14
Name: EF-hand calcium binding domain 14
Synonyms: 4732418C07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230648
Homologene: 8858
H2-T24
Name: histocompatibility 2, T region locus 24
Synonyms: H-2T24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15042
Homologene: 69019
Vmn2r58
Name: vomeronasal 2, receptor 58
Synonyms: EG628422
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628422
Crocc
Name: ciliary rootlet coiled-coil, rootletin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230872
Homologene: 16811
Sec16b
Name: SEC16 homolog B, endoplasmic reticulum export factor
Synonyms: Lztr2, Rgpr, Rgpr-p117
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 89867
Homologene: 13227
Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Synonyms: 1200002L24Rik, 72kDa
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64436
Homologene: 56863
Gm15446
Name: predicted gene 15446
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100642166
Or13a21
Name: olfactory receptor family 13 subfamily A member 21
Synonyms: Olfr532, MOR251-1, GA_x6K02T2PBJ9-42570051-42569122
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259028
Homologene: 133605
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
Masp2
Name: MBL associated serine protease 2
Synonyms: MASP-2, MAp19
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17175
HGNC: HGNC:6902
Homologene: 4819
Fam184a
Name: family with sequence similarity 184, member A
Synonyms: 4930589M24Rik, 3110012E06Rik, 4930438C08Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75906
Homologene: 11600
Or5ar1
Name: olfactory receptor family 5 subfamily AR member 1
Synonyms: GA_x6K02T2Q125-47320309-47319377, MOR180-1, Olfr1019
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259017
Homologene: 17464
Spire1
Name: spire type actin nucleation factor 1
Synonyms: 6030430B19Rik, Spir-1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68166
VEGA: 18
Homologene: 35507
Tbx5
Name: T-box 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21388
Homologene: 160
Lingo3
Name: leucine rich repeat and Ig domain containing 3
Synonyms: LERN2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237403
VEGA: 10
Homologene: 78065
Krt79
Name: keratin 79
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223917
Homologene: 89169
Muc1
Name: mucin 1, transmembrane
Synonyms: CD227, EMA, Muc-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17829
HGNC: HGNC:7508
Homologene: 137248
Pcsk1
Name: proprotein convertase subtilisin/kexin type 1
Synonyms: SPC3, prohormone convertase 1/3, Nec1, Nec-1, Phpp-1, PC1, PC3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 18548
HGNC: HGNC:8743
Homologene: 379
R3hdm4
Name: R3H domain containing 4
Synonyms: C030046I01Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109284
VEGA: 10
Homologene: 16343
Dnaaf6rt
Name: dynein axonemal assembly factor 6, retrotransposed
Synonyms: 4930521A18Rik, Dnaaf6, Pih1d3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74708
Homologene: 16553
Crb2
Name: crumbs family member 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241324
Homologene: 45474
Fcrlb
Name: Fc receptor-like B
Synonyms: FREB2, Fcry, FcRL2, FREB-2, mFCRL2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 435653
Homologene: 83202
H2-Q4
Name: histocompatibility 2, Q region locus 4
Synonyms: H-2Q4, Qb1, Qat-4, Qa4, Qa-4, Qb-1, H2-Gs10
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15015
Homologene: 128352
Or4p20
Name: olfactory receptor family 4 subfamily P member 20
Synonyms: MOR225-9P, Olfr1181, GA_x6K02T2Q125-49911636-49910701
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258060
Homologene: 86666
Defb22
Name: defensin beta 22
Synonyms: 9230002F21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 442835
Homologene: 83152
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to C, chromosome 1 at 31,223,171 bp (GRCm38)
  • T to C, chromosome 1 at 87,786,255 bp (GRCm38)
  • G to A, chromosome 1 at 157,551,125 bp (GRCm38)
  • T to A, chromosome 1 at 170,907,905 bp (GRCm38)
  • T to C, chromosome 2 at 18,146,844 bp (GRCm38)
  • T to A, chromosome 2 at 26,402,114 bp (GRCm38)
  • G to A, chromosome 2 at 31,415,267 bp (GRCm38)
  • T to C, chromosome 2 at 32,217,288 bp (GRCm38)
  • A to C, chromosome 2 at 35,024,184 bp (GRCm38)
  • G to A, chromosome 2 at 37,791,203 bp (GRCm38)
  • T to A, chromosome 2 at 85,841,314 bp (GRCm38)
  • T to A, chromosome 2 at 88,423,435 bp (GRCm38)
  • T to C, chromosome 2 at 152,485,900 bp (GRCm38)
  • T to A, chromosome 3 at 89,231,581 bp (GRCm38)
  • T to A, chromosome 4 at 43,565,520 bp (GRCm38)
  • T to A, chromosome 4 at 115,768,704 bp (GRCm38)
  • C to A, chromosome 4 at 141,018,735 bp (GRCm38)
  • A to G, chromosome 4 at 148,612,140 bp (GRCm38)
  • T to G, chromosome 4 at 154,012,030 bp (GRCm38)
  • C to T, chromosome 4 at 155,750,472 bp (GRCm38)
  • A to T, chromosome 5 at 14,855,669 bp (GRCm38)
  • A to T, chromosome 5 at 109,943,295 bp (GRCm38)
  • C to A, chromosome 5 at 119,841,844 bp (GRCm38)
  • G to A, chromosome 6 at 125,624,573 bp (GRCm38)
  • C to T, chromosome 6 at 146,775,606 bp (GRCm38)
  • A to T, chromosome 7 at 41,860,576 bp (GRCm38)
  • A to G, chromosome 7 at 104,959,988 bp (GRCm38)
  • A to T, chromosome 7 at 140,419,353 bp (GRCm38)
  • C to T, chromosome 8 at 3,608,689 bp (GRCm38)
  • G to A, chromosome 8 at 40,795,453 bp (GRCm38)
  • C to T, chromosome 9 at 65,651,003 bp (GRCm38)
  • T to C, chromosome 10 at 53,699,153 bp (GRCm38)
  • C to T, chromosome 10 at 76,476,518 bp (GRCm38)
  • A to T, chromosome 10 at 79,916,821 bp (GRCm38)
  • A to T, chromosome 10 at 80,834,454 bp (GRCm38)
  • A to G, chromosome 10 at 103,046,041 bp (GRCm38)
  • A to G, chromosome 10 at 127,498,429 bp (GRCm38)
  • A to G, chromosome 11 at 3,499,960 bp (GRCm38)
  • C to A, chromosome 11 at 68,490,600 bp (GRCm38)
  • A to T, chromosome 11 at 118,126,200 bp (GRCm38)
  • G to A, chromosome 13 at 55,384,121 bp (GRCm38)
  • G to T, chromosome 13 at 75,099,354 bp (GRCm38)
  • C to T, chromosome 14 at 61,208,373 bp (GRCm38)
  • T to A, chromosome 14 at 118,861,777 bp (GRCm38)
  • A to T, chromosome 15 at 59,329,776 bp (GRCm38)
  • G to A, chromosome 15 at 84,927,447 bp (GRCm38)
  • T to G, chromosome 15 at 101,930,761 bp (GRCm38)
  • A to T, chromosome 16 at 21,220,443 bp (GRCm38)
  • T to C, chromosome 17 at 19,589,663 bp (GRCm38)
  • A to T, chromosome 17 at 26,083,895 bp (GRCm38)
  • A to T, chromosome 17 at 35,380,153 bp (GRCm38)
  • A to T, chromosome 17 at 36,014,843 bp (GRCm38)
  • A to G, chromosome 17 at 42,503,915 bp (GRCm38)
  • C to T, chromosome 18 at 67,503,438 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9706 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069953-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.