Strain Name:
C57BL/6J-MtgxR9708Btlr/Mmmh
Stock Number:
069955-MU
Citation ID:
RRID:MMRRC_069955-MU
Other Names:
R9708 (G1)
Major Collection:

Strain Information

Gba1
Name: glucosylceramidase beta 1
Synonyms: glucocerebrosidase, GC, GCase, GBA1, betaGC, Gba
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14466
HGNC: HGNC:4177
Homologene: 68040
Nrxn2
Name: neurexin II
Synonyms: neurexin II beta, neurexin II alpha, 6430591O13Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Mov10
Name: Mov10 RISC complex RNA helicase
Synonyms: Mov-10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 17454
HGNC: HGNC:7200
Homologene: 10365
Tsc22d1
Name: TSC22 domain family, member 1
Synonyms: TSC-22, Egr5, Tgfb1i4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21807
Homologene: 7573
Phkb
Name: phosphorylase kinase beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102093
HGNC: HGNC:8927
Homologene: 247
Uhrf1
Name: ubiquitin-like, containing PHD and RING finger domains, 1
Synonyms: ICBP90, Np95
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18140
Homologene: 7866
Robo2
Name: roundabout guidance receptor 2
Synonyms: 9430089E08Rik, D230004I22Rik, 2600013A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 268902
Homologene: 43188
Iqgap3
Name: IQ motif containing GTPase activating protein 3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 404710
Homologene: 26400
Lrrk2
Name: leucine-rich repeat kinase 2
Synonyms: cI-46, LOC381026, 9330188B09Rik, D630001M17Rik, 4921513O20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66725
Homologene: 18982
Gm4924
Name: predicted gene 4924
Synonyms: mIF1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237412
Zranb1
Name: zinc finger, RAN-binding domain containing 1
Synonyms: D7Wsu87e, 9330160G10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 360216
Homologene: 9728
Tpbg
Name: trophoblast glycoprotein
Synonyms: 5T4, 5T4 oncofetal antigen
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21983
Homologene: 4859
Asph
Name: aspartate-beta-hydroxylase
Synonyms: cI-37, 2310005F16Rik, aspartyl beta-hydroxylase, calsequestrin-binding protein, Junctin, jumbug, BAH, 3110001L23Rik, junctate
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65973
HGNC: HGNC:757
Homologene: 20910
Nek3
Name: NIMA (never in mitosis gene a)-related expressed kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23954
HGNC: HGNC:7746
Homologene: 1869
Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18705
HGNC: HGNC:8973
Homologene: 3362
Naip2
Name: NLR family, apoptosis inhibitory protein 2
Synonyms: Naip-rs6, Naip2, Birc1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17948
HGNC: HGNC:7634
Homologene: 136092
Kng2
Name: kininogen 2
Synonyms: Kininogen-II
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385643
HGNC: HGNC:6383
Homologene: 88343
Vwf
Name: Von Willebrand factor
Synonyms: B130011O06Rik, 6820430P06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Lrp4
Name: low density lipoprotein receptor-related protein 4
Synonyms: 6430526J12Rik, Megf7, mdig
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228357
HGNC: HGNC:6696
Homologene: 17964
Mogat1
Name: monoacylglycerol O-acyltransferase 1
Synonyms: 0610030A14Rik, mDC2, MGAT1, 1110064N14Rik, Dgat2l1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68393
Homologene: 105237
Acss1
Name: acyl-CoA synthetase short-chain family member 1
Synonyms: 1110032O15Rik, AceCS2, Acas2, Acas2l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68738
Homologene: 56037
Odad2
Name: outer dynein arm docking complex subunit 2
Synonyms: 4930463I21Rik, Armc4, b2b227.1Clo, b2b643Clo
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 74934
VEGA: 18
Homologene: 9992
Btn2a2
Name: butyrophilin, subfamily 2, member A2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238555
Homologene: 56012
Paox
Name: polyamine oxidase (exo-N4-amino)
Synonyms: Pao, 2410012F02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212503
Homologene: 72096
Nol4
Name: nucleolar protein 4
Synonyms: 4930568N03Rik, LOC383304, 1700013J13Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 319211
HGNC: HGNC:7870
Homologene: 36142
Or4a71
Name: olfactory receptor family 4 subfamily A member 71
Synonyms: GA_x6K02T2Q125-50972538-50971621, MOR231-4, Olfr1243
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258971
Homologene: 27317
Fanca
Name: Fanconi anemia, complementation group A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14087
HGNC: HGNC:3582
Homologene: 108
Vmn2r13
Name: vomeronasal 2, receptor 13
Synonyms: Gm4867
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231589
Homologene: 129606
Armc2
Name: armadillo repeat containing 2
Synonyms: 2610018I05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 213402
Homologene: 41848
Or5b124
Name: olfactory receptor family 5 subfamily B member 124
Synonyms: GA_x6K02T2RE5P-3965668-3966609, MOR202-19, Olfr1489
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258628
Homologene: 45021
Zfp616
Name: zinc finger protein 616
Synonyms: Gm12330
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327963
Homologene: 88945
Alox5
Name: arachidonate 5-lipoxygenase
Synonyms: 5LO, 5-LOX, 5LX
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 11689
HGNC: HGNC:435
Homologene: 561
Slfn8
Name: schlafen 8
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276950
Homologene: 45432
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: MRP, Mdrap, Mrp1, Abcc1b, Abcc1a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Cfap221
Name: cilia and flagella associated protein 221
Synonyms: Pcdp1, Gm101
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226356
Homologene: 88578
Rnf144b
Name: ring finger protein 144B
Synonyms: E130105P19Rik, Ibrdc2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218215
VEGA: 13
Homologene: 27092
Shcbp1l
Name: Shc SH2-domain binding protein 1-like
Synonyms: 1700012A16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71836
Homologene: 12800
Tent5a
Name: terminal nucleotidyltransferase 5A
Synonyms: D930050G01Rik, BAP014, Fam46a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 212943
Homologene: 23032
Stard13
Name: StAR related lipid transfer domain containing 13
Synonyms: GT650, DLC2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243362
Homologene: 64844
Scrn2
Name: secernin 2
Synonyms: SES2, D11Moh48
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217140
Homologene: 26698
B4galnt4
Name: beta-1,4-N-acetyl-galactosaminyl transferase 4
Synonyms: LOC381951
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330671
Homologene: 27982
Or2ab1
Name: olfactory receptor family 2 subfamily AB member 1
Synonyms: GA_x6K02T2NKPP-822947-822000, MOR102-2, Olfr324
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257892
Homologene: 79395
Ccdc112
Name: coiled-coil domain containing 112
Synonyms: 8430438M01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240261
VEGA: 18
Homologene: 17617
Asb3
Name: ankyrin repeat and SOCS box-containing 3
Synonyms: 2400011J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 65257
Homologene: 9391
Or5p6
Name: olfactory receptor family 5 subfamily P member 6
Synonyms: GA_x6K02T2PBJ9-10361879-10360935, MOR204-13, Olfr478
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258729
Homologene: 128076
Irx5
Name: Iroquois homeobox 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 54352
Homologene: 38105
Mtmr11
Name: myotubularin related protein 11
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 194126
Homologene: 82382
Pde6h
Name: phosphodiesterase 6H, cGMP-specific, cone, gamma
Synonyms: PDEgamma, A930033D18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 78600
HGNC: HGNC:8790
Homologene: 4522
Catsper2
Name: cation channel, sperm associated 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 212670
Homologene: 77423
Gem
Name: GTP binding protein overexpressed in skeletal muscle
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14579
HGNC: HGNC:4234
Homologene: 38024
Map2k7
Name: mitogen-activated protein kinase kinase 7
Synonyms: MKK7, sek2, MAP kinase kinase 7, Jnkk2, Prkmk7, 5930412N11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26400
HGNC: HGNC:6847
Homologene: 56548
Sap30l
Name: SAP30-like
Synonyms: L55, 2310079P12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50724
Homologene: 11632
Pcdha8
Name: protocadherin alpha 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 353235
HGNC: HGNC:8675
Homologene: 129614
Foxl1
Name: forkhead box L1
Synonyms: fkh6, fkh-6, FREAC7, Fkh6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14241
HGNC: HGNC:3817
Homologene: 48335
D030056L22Rik
Name: RIKEN cDNA D030056L22 gene
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225995
VEGA: 19
Homologene: 49520
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 78,511,996 bp (GRCm38)
  • T to A, chromosome 1 at 119,932,889 bp (GRCm38)
  • A to T, chromosome 1 at 153,452,265 bp (GRCm38)
  • T to C, chromosome 2 at 89,527,870 bp (GRCm38)
  • A to T, chromosome 2 at 91,511,731 bp (GRCm38)
  • A to G, chromosome 2 at 121,406,840 bp (GRCm38)
  • G to T, chromosome 2 at 150,629,832 bp (GRCm38)
  • C to A, chromosome 3 at 88,108,869 bp (GRCm38)
  • T to C, chromosome 3 at 89,205,494 bp (GRCm38)
  • T to C, chromosome 3 at 96,169,087 bp (GRCm38)
  • C to T, chromosome 3 at 104,797,297 bp (GRCm38)
  • G to A, chromosome 4 at 9,542,233 bp (GRCm38)
  • G to A, chromosome 4 at 11,711,154 bp (GRCm38)
  • G to T, chromosome 4 at 148,044,521 bp (GRCm38)
  • T to A, chromosome 5 at 109,174,141 bp (GRCm38)
  • C to T, chromosome 5 at 151,063,496 bp (GRCm38)
  • A to G, chromosome 6 at 116,415,576 bp (GRCm38)
  • T to A, chromosome 6 at 125,657,090 bp (GRCm38)
  • T to G, chromosome 6 at 136,959,361 bp (GRCm38)
  • T to A, chromosome 6 at 139,629,867 bp (GRCm38)
  • T to C, chromosome 7 at 108,032,052 bp (GRCm38)
  • G to T, chromosome 7 at 132,982,871 bp (GRCm38)
  • C to T, chromosome 7 at 140,132,446 bp (GRCm38)
  • A to G, chromosome 7 at 141,067,744 bp (GRCm38)
  • C to A, chromosome 8 at 4,245,806 bp (GRCm38)
  • C to T, chromosome 8 at 22,128,726 bp (GRCm38)
  • T to G, chromosome 8 at 86,056,490 bp (GRCm38)
  • A to T, chromosome 8 at 92,360,490 bp (GRCm38)
  • A to G, chromosome 8 at 121,128,338 bp (GRCm38)
  • C to A, chromosome 8 at 123,274,524 bp (GRCm38)
  • A to G, chromosome 9 at 85,325,214 bp (GRCm38)
  • A to G, chromosome 9 at 85,844,521 bp (GRCm38)
  • A to T, chromosome 10 at 41,963,748 bp (GRCm38)
  • T to G, chromosome 10 at 82,379,158 bp (GRCm38)
  • A to T, chromosome 11 at 31,101,075 bp (GRCm38)
  • A to G, chromosome 11 at 57,806,110 bp (GRCm38)
  • G to A, chromosome 11 at 58,598,101 bp (GRCm38)
  • G to A, chromosome 11 at 74,085,457 bp (GRCm38)
  • T to C, chromosome 11 at 83,003,441 bp (GRCm38)
  • C to T, chromosome 11 at 97,032,102 bp (GRCm38)
  • G to A, chromosome 13 at 23,478,737 bp (GRCm38)
  • A to G, chromosome 13 at 47,244,436 bp (GRCm38)
  • T to C, chromosome 13 at 100,161,579 bp (GRCm38)
  • T to A, chromosome 14 at 76,417,224 bp (GRCm38)
  • C to A, chromosome 15 at 91,750,279 bp (GRCm38)
  • A to T, chromosome 16 at 14,436,553 bp (GRCm38)
  • G to T, chromosome 16 at 22,997,051 bp (GRCm38)
  • C to T, chromosome 16 at 73,973,309 bp (GRCm38)
  • A to G, chromosome 17 at 56,322,357 bp (GRCm38)
  • G to T, chromosome 18 at 7,288,633 bp (GRCm38)
  • G to T, chromosome 18 at 22,694,996 bp (GRCm38)
  • A to G, chromosome 18 at 36,992,495 bp (GRCm38)
  • G to A, chromosome 18 at 46,311,713 bp (GRCm38)
  • A to G, chromosome 19 at 6,531,852 bp (GRCm38)
  • G to A, chromosome 19 at 13,633,396 bp (GRCm38)
  • T to G, chromosome 19 at 18,713,412 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9708 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069955-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.