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Strain Name:
C57BL/6J-MtgxR9710Btlr/Mmmh
Stock Number:
069957-MU
Citation ID:
RRID:MMRRC_069957-MU
Other Names:
R9710 (G1)
Major Collection:

Strain Information

Nsmf
Name: NMDA receptor synaptonuclear signaling and neuronal migration factor
Synonyms: Jacob, Nelf
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56876
Homologene: 10648
Lasp1
Name: LIM and SH3 protein 1
Synonyms: SH3P6, Def-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16796
HGNC: HGNC:6513
Homologene: 4480
Ptpn3
Name: protein tyrosine phosphatase, non-receptor type 3
Synonyms: PTPCL, 9530011I20Rik, PTP-H1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 545622
HGNC: HGNC:9655
Homologene: 74451
Cwc27
Name: CWC27 spliceosome-associated protein
Synonyms: NY-CO-10, 3110009E13Rik, Sdccag10
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67285
Homologene: 21192
Anks1
Name: ankyrin repeat and SAM domain containing 1
Synonyms: Odin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224650
Homologene: 9068
Nsrp1
Name: nuclear speckle regulatory protein 1
Synonyms: NSpr70, Ccdc55
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237859
Homologene: 134095
Sptlc2
Name: serine palmitoyltransferase, long chain base subunit 2
Synonyms: LCB2, Spt2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20773
Homologene: 21610
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • T to A, chromosome 1 at 28,778,039 bp (GRCm38)
  • T to C, chromosome 1 at 138,080,889 bp (GRCm38)
  • C to A, chromosome 2 at 14,998,198 bp (GRCm38)
  • A to G, chromosome 2 at 25,059,065 bp (GRCm38)
  • C to T, chromosome 2 at 32,745,877 bp (GRCm38)
  • T to C, chromosome 2 at 69,897,613 bp (GRCm38)
  • G to A, chromosome 2 at 87,896,558 bp (GRCm38)
  • T to C, chromosome 2 at 90,890,007 bp (GRCm38)
  • A to C, chromosome 2 at 112,803,189 bp (GRCm38)
  • G to T, chromosome 2 at 118,760,596 bp (GRCm38)
  • A to G, chromosome 2 at 152,414,465 bp (GRCm38)
  • C to T, chromosome 2 at 174,299,339 bp (GRCm38)
  • T to C, chromosome 3 at 85,871,752 bp (GRCm38)
  • T to C, chromosome 3 at 88,621,269 bp (GRCm38)
  • T to A, chromosome 3 at 107,671,178 bp (GRCm38)
  • T to A, chromosome 3 at 144,577,609 bp (GRCm38)
  • G to A, chromosome 4 at 57,249,957 bp (GRCm38)
  • T to C, chromosome 4 at 99,986,721 bp (GRCm38)
  • T to A, chromosome 4 at 100,974,895 bp (GRCm38)
  • T to A, chromosome 4 at 115,492,150 bp (GRCm38)
  • C to A, chromosome 4 at 126,233,647 bp (GRCm38)
  • T to A, chromosome 4 at 144,272,975 bp (GRCm38)
  • C to T, chromosome 4 at 148,591,582 bp (GRCm38)
  • T to A, chromosome 4 at 149,488,684 bp (GRCm38)
  • T to C, chromosome 5 at 114,415,309 bp (GRCm38)
  • T to A, chromosome 6 at 23,654,803 bp (GRCm38)
  • T to C, chromosome 6 at 34,946,300 bp (GRCm38)
  • A to T, chromosome 6 at 85,867,701 bp (GRCm38)
  • A to G, chromosome 6 at 87,819,592 bp (GRCm38)
  • T to C, chromosome 6 at 108,405,520 bp (GRCm38)
  • C to T, chromosome 6 at 116,401,444 bp (GRCm38)
  • T to C, chromosome 6 at 122,707,840 bp (GRCm38)
  • T to C, chromosome 7 at 11,756,480 bp (GRCm38)
  • A to T, chromosome 7 at 12,629,826 bp (GRCm38)
  • T to G, chromosome 7 at 46,377,151 bp (GRCm38)
  • CAGCGCCTGACGGAGC to CAGC, chromosome 7 at 102,430,911 bp (GRCm38)
  • A to G, chromosome 7 at 102,659,234 bp (GRCm38)
  • A to T, chromosome 7 at 119,785,601 bp (GRCm38)
  • T to A, chromosome 8 at 47,065,913 bp (GRCm38)
  • G to T, chromosome 8 at 84,594,179 bp (GRCm38)
  • T to C, chromosome 8 at 84,958,009 bp (GRCm38)
  • A to G, chromosome 9 at 21,926,291 bp (GRCm38)
  • A to T, chromosome 9 at 40,000,876 bp (GRCm38)
  • A to T, chromosome 9 at 40,984,375 bp (GRCm38)
  • A to G, chromosome 9 at 80,379,994 bp (GRCm38)
  • T to A, chromosome 9 at 103,226,018 bp (GRCm38)
  • T to C, chromosome 10 at 14,139,459 bp (GRCm38)
  • T to C, chromosome 10 at 24,076,816 bp (GRCm38)
  • C to A, chromosome 10 at 33,513,311 bp (GRCm38)
  • A to T, chromosome 10 at 69,993,240 bp (GRCm38)
  • G to T, chromosome 10 at 79,740,701 bp (GRCm38)
  • A to G, chromosome 10 at 80,021,801 bp (GRCm38)
  • A to G, chromosome 10 at 106,829,024 bp (GRCm38)
  • A to C, chromosome 10 at 121,667,658 bp (GRCm38)
  • A to G, chromosome 11 at 4,219,015 bp (GRCm38)
  • G to A, chromosome 11 at 59,052,571 bp (GRCm38)
  • A to G, chromosome 11 at 62,313,171 bp (GRCm38)
  • T to A, chromosome 11 at 65,196,341 bp (GRCm38)
  • T to A, chromosome 11 at 73,710,980 bp (GRCm38)
  • C to T, chromosome 11 at 77,076,677 bp (GRCm38)
  • A to G, chromosome 11 at 97,806,767 bp (GRCm38)
  • T to C, chromosome 11 at 98,011,371 bp (GRCm38)
  • T to C, chromosome 11 at 99,365,095 bp (GRCm38)
  • A to G, chromosome 11 at 100,768,037 bp (GRCm38)
  • A to G, chromosome 11 at 119,441,005 bp (GRCm38)
  • A to T, chromosome 12 at 87,312,759 bp (GRCm38)
  • A to T, chromosome 12 at 111,485,329 bp (GRCm38)
  • T to A, chromosome 13 at 34,899,887 bp (GRCm38)
  • A to T, chromosome 13 at 100,135,702 bp (GRCm38)
  • G to A, chromosome 13 at 104,806,650 bp (GRCm38)
  • T to C, chromosome 14 at 45,163,010 bp (GRCm38)
  • T to C, chromosome 14 at 47,531,267 bp (GRCm38)
  • C to T, chromosome 14 at 50,736,742 bp (GRCm38)
  • T to A, chromosome 14 at 53,743,453 bp (GRCm38)
  • G to A, chromosome 14 at 63,948,060 bp (GRCm38)
  • T to C, chromosome 15 at 82,062,651 bp (GRCm38)
  • T to C, chromosome 15 at 89,353,216 bp (GRCm38)
  • A to T, chromosome 16 at 4,927,876 bp (GRCm38)
  • C to T, chromosome 16 at 18,252,177 bp (GRCm38)
  • G to A, chromosome 16 at 32,794,896 bp (GRCm38)
  • G to T, chromosome 16 at 32,975,738 bp (GRCm38)
  • A to G, chromosome 16 at 33,865,547 bp (GRCm38)
  • A to G, chromosome 16 at 49,138,681 bp (GRCm38)
  • G to A, chromosome 17 at 27,909,597 bp (GRCm38)
  • A to G, chromosome 17 at 45,539,872 bp (GRCm38)
  • T to C, chromosome 17 at 46,555,345 bp (GRCm38)
  • A to T, chromosome 17 at 67,822,409 bp (GRCm38)
  • G to T, chromosome 17 at 78,303,075 bp (GRCm38)
  • T to A, chromosome 18 at 20,276,987 bp (GRCm38)
  • T to A, chromosome 18 at 63,794,246 bp (GRCm38)
  • T to A, chromosome 18 at 65,349,575 bp (GRCm38)
  • A to T, chromosome 18 at 82,405,978 bp (GRCm38)
  • A to G, chromosome 18 at 89,017,210 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9710 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069957-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.