Strain Name:
C57BL/6J-MtgxR9735Btlr/Mmmh
Stock Number:
069981-MU
Citation ID:
RRID:MMRRC_069981-MU
Other Names:
R9735 (G1)
Major Collection:

Strain Information

Arhgef12
Name: Rho guanine nucleotide exchange factor 12
Synonyms: 2310014B11Rik, LARG
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Dcaf4
Name: DDB1 and CUL4 associated factor 4
Synonyms: Wdr21, 1110018E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73828
VEGA: 12
Homologene: 9210
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: A430080F22Rik, ETK-1, 1600015G02Rik, C-TAK1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Lss
Name: lanosterol synthase
Synonyms: D10Ertd116e, 2810025N20Rik, Osc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16987
HGNC: HGNC:6708
Homologene: 37408
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: L-CPT I, Cpt1, CPTI
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Rnaseh2a
Name: ribonuclease H2, large subunit
Synonyms: 2400006P09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69724
Homologene: 4664
Bnip3l
Name: BCL2/adenovirus E1B interacting protein 3-like
Synonyms: Nip3L, Nix, D14Ertd719e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12177
HGNC: HGNC:1085
Homologene: 3195
Ern1
Name: endoplasmic reticulum to nucleus signalling 1
Synonyms: Ire1alpha, 9030414B18Rik, Ire1p, Ire1a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 78943
HGNC: HGNC:3449
Homologene: 55580
Spin1
Name: spindlin 1
Synonyms: Spin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20729
VEGA: 13
Homologene: 55983
Ero1a
Name: endoplasmic reticulum oxidoreductase 1 alpha
Synonyms: Ero1l
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50527
VEGA: 14
Homologene: 49392
Septin9
Name: septin 9
Synonyms: Sept9, PNUTL4, MSF1, Sint1, Msf, SL3-3 integration site 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53860
HGNC: HGNC:7323
Homologene: 90949
Vps13a
Name: vacuolar protein sorting 13A
Synonyms: 4930543C13Rik, D330038K10Rik, 4930516E05Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 271564
VEGA: 19
HGNC: HGNC:1908
Homologene: 22068
Fnip1
Name: folliculin interacting protein 1
Synonyms: A730024A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216742
Homologene: 28173
Spint1
Name: serine protease inhibitor, Kunitz type 1
Synonyms: HAI-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20732
Homologene: 9653
Tmub2
Name: transmembrane and ubiquitin-like domain containing 2
Synonyms: 2010008E23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72053
Homologene: 18581
Fcgbpl1
Name: Fc fragment of IgG binding protein like 1
Synonyms: 9530053A07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319482
Homologene: 130055
Flg2
Name: filaggrin family member 2
Synonyms: EG229574
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229574
Homologene: 134146
Nup210
Name: nucleoporin 210
Synonyms: gp190, gp210, Pom210
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54563
Homologene: 41286
Csmd2
Name: CUB and Sushi multiple domains 2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329942
Homologene: 89034
Pkd1l2
Name: polycystic kidney disease 1 like 2
Synonyms: 1700126L06Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76645
Homologene: 124481
Mylk
Name: myosin, light polypeptide kinase
Synonyms: MLCK210, 9530072E15Rik, nmMlck, telokin, Mlck, MLCK108, A930019C19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 107589
HGNC: HGNC:7590
Homologene: 14202
Or2j6
Name: olfactory receptor family 2 subfamily J member 6
Synonyms: MOR251-3, Olfr531, GA_x6K02T2PBJ9-42551260-42550346
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258955
Osbpl5
Name: oxysterol binding protein-like 5
Synonyms: ORP5, Obph1, 1110006M06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 79196
Homologene: 98024
Adcy7
Name: adenylate cyclase 7
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11513
HGNC: HGNC:238
Homologene: 866
D6Ertd527e
Name: DNA segment, Chr 6, ERATO Doi 527, expressed
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52372
Slc36a3
Name: solute carrier family 36 (proton/amino acid symporter), member 3
Synonyms: tramdorin2, PAT3, TRAMD2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 215332
Homologene: 76175
Zfp51
Name: zinc finger protein 51
Synonyms: Zfp-51, zfec12
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22709
VEGA: 17
Homologene: 134003
Cd6
Name: CD6 antigen
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12511
HGNC: HGNC:1691
Homologene: 4893
Or4p20
Name: olfactory receptor family 4 subfamily P member 20
Synonyms: MOR225-9P, Olfr1181, GA_x6K02T2Q125-49911636-49910701
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258060
Homologene: 86666
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 2 at 88,423,157 bp (GRCm38)
  • A to G, chromosome 2 at 119,246,416 bp (GRCm38)
  • A to G, chromosome 3 at 93,220,362 bp (GRCm38)
  • A to C, chromosome 4 at 128,509,108 bp (GRCm38)
  • G to C, chromosome 6 at 87,111,857 bp (GRCm38)
  • A to C, chromosome 6 at 91,053,648 bp (GRCm38)
  • T to A, chromosome 7 at 28,157,010 bp (GRCm38)
  • T to A, chromosome 7 at 140,400,465 bp (GRCm38)
  • C to T, chromosome 7 at 143,694,936 bp (GRCm38)
  • C to T, chromosome 8 at 84,960,032 bp (GRCm38)
  • T to C, chromosome 8 at 88,310,634 bp (GRCm38)
  • A to G, chromosome 8 at 117,046,081 bp (GRCm38)
  • G to A, chromosome 9 at 42,971,103 bp (GRCm38)
  • G to T, chromosome 10 at 76,546,781 bp (GRCm38)
  • A to T, chromosome 11 at 54,503,447 bp (GRCm38)
  • A to T, chromosome 11 at 55,135,278 bp (GRCm38)
  • A to G, chromosome 11 at 102,287,526 bp (GRCm38)
  • A to T, chromosome 11 at 106,421,882 bp (GRCm38)
  • T to A, chromosome 11 at 117,354,854 bp (GRCm38)
  • T to A, chromosome 12 at 83,526,165 bp (GRCm38)
  • T to C, chromosome 12 at 111,655,448 bp (GRCm38)
  • T to A, chromosome 13 at 51,139,485 bp (GRCm38)
  • T to A, chromosome 14 at 45,295,978 bp (GRCm38)
  • G to A, chromosome 14 at 67,008,765 bp (GRCm38)
  • T to C, chromosome 16 at 34,914,809 bp (GRCm38)
  • C to A, chromosome 17 at 21,465,151 bp (GRCm38)
  • A to T, chromosome 18 at 80,795,414 bp (GRCm38)
  • A to G, chromosome 19 at 3,370,825 bp (GRCm38)
  • A to G, chromosome 19 at 10,797,871 bp (GRCm38)
  • A to T, chromosome 19 at 16,723,747 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9735 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
069981-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.