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Strain Name:
C57BL/6J-MtgxR9803Btlr/Mmmh
Stock Number:
070048-MU
Citation ID:
RRID:MMRRC_070048-MU
Other Names:
R9803 (G1)
Major Collection:

Strain Information

Ighm
Name: immunoglobulin heavy constant mu
Synonyms: Ig mu, Igh6, Igh-M, muH, IgM
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16019
HGNC: HGNC:5541
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Ank-2, Ankyrin-2, Ankyrin-B, Gm4392
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Phf3
Name: PHD finger protein 3
Synonyms: 2310061N19Rik, AU020177
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 213109
HGNC: HGNC:8921
Homologene: 9040
Anln
Name: anillin, actin binding protein
Synonyms: 1110037A17Rik, Scraps, 2900037I21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68743
VEGA: 9
Homologene: 41281
Daam1
Name: dishevelled associated activator of morphogenesis 1
Synonyms: 1700066F09Rik, 2310028E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208846
VEGA: 12
Homologene: 36635
Trps1
Name: transcriptional repressor GATA binding 1
Synonyms: D15Ertd586e, trichorhinophalangeal syndrome I (human)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 83925
Homologene: 8556
Lfng
Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Synonyms: lunatic fringe
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16848
HGNC: HGNC:6560
Homologene: 22475
Genetic Alterations
ENU-induced transitions at the following base pair locations:
  • A to T, chromosome 1 at 20,566,849 bp (GRCm38)
  • G to T, chromosome 1 at 30,830,791 bp (GRCm38)
  • C to T, chromosome 1 at 72,659,181 bp (GRCm38)
  • T to C, chromosome 1 at 151,192,971 bp (GRCm38)
  • A to T, chromosome 1 at 155,782,670 bp (GRCm38)
  • T to C, chromosome 2 at 13,004,389 bp (GRCm38)
  • T to A, chromosome 2 at 28,504,854 bp (GRCm38)
  • C to A, chromosome 2 at 74,668,903 bp (GRCm38)
  • A to T, chromosome 2 at 120,010,775 bp (GRCm38)
  • T to A, chromosome 2 at 120,038,503 bp (GRCm38)
  • A to G, chromosome 3 at 126,959,077 bp (GRCm38)
  • T to C, chromosome 4 at 128,369,193 bp (GRCm38)
  • T to A, chromosome 4 at 139,349,070 bp (GRCm38)
  • C to T, chromosome 4 at 155,839,825 bp (GRCm38)
  • G to A, chromosome 5 at 14,712,615 bp (GRCm38)
  • G to A, chromosome 5 at 31,300,024 bp (GRCm38)
  • A to G, chromosome 5 at 113,703,903 bp (GRCm38)
  • A to G, chromosome 5 at 114,345,936 bp (GRCm38)
  • A to G, chromosome 5 at 140,607,773 bp (GRCm38)
  • C to T, chromosome 6 at 28,662,200 bp (GRCm38)
  • T to A, chromosome 6 at 42,141,132 bp (GRCm38)
  • T to C, chromosome 6 at 113,597,977 bp (GRCm38)
  • T to A, chromosome 6 at 127,943,717 bp (GRCm38)
  • A to G, chromosome 6 at 139,500,763 bp (GRCm38)
  • G to T, chromosome 7 at 25,670,563 bp (GRCm38)
  • G to A, chromosome 7 at 44,312,918 bp (GRCm38)
  • T to C, chromosome 7 at 45,341,115 bp (GRCm38)
  • G to A, chromosome 7 at 96,553,478 bp (GRCm38)
  • A to C, chromosome 7 at 128,676,791 bp (GRCm38)
  • A to G, chromosome 7 at 141,207,607 bp (GRCm38)
  • A to G, chromosome 8 at 45,942,589 bp (GRCm38)
  • C to T, chromosome 8 at 70,108,101 bp (GRCm38)
  • G to T, chromosome 9 at 22,372,222 bp (GRCm38)
  • A to G, chromosome 9 at 45,943,614 bp (GRCm38)
  • T to A, chromosome 10 at 121,272,075 bp (GRCm38)
  • T to C, chromosome 11 at 58,778,769 bp (GRCm38)
  • G to A, chromosome 11 at 85,846,873 bp (GRCm38)
  • A to T, chromosome 12 at 71,944,148 bp (GRCm38)
  • G to A, chromosome 12 at 113,259,139 bp (GRCm38)
  • A to G, chromosome 12 at 113,419,015 bp (GRCm38)
  • C to A, chromosome 13 at 54,793,279 bp (GRCm38)
  • T to C, chromosome 13 at 61,253,322 bp (GRCm38)
  • C to A, chromosome 13 at 65,073,600 bp (GRCm38)
  • A to T, chromosome 14 at 55,941,729 bp (GRCm38)
  • T to C, chromosome 14 at 120,022,151 bp (GRCm38)
  • T to C, chromosome 15 at 50,846,694 bp (GRCm38)
  • G to A, chromosome 16 at 27,360,942 bp (GRCm38)
  • T to A, chromosome 17 at 20,583,468 bp (GRCm38)
  • C to A, chromosome 17 at 56,422,217 bp (GRCm38)
  • T to A, chromosome 17 at 73,922,460 bp (GRCm38)
  • T to A, chromosome 18 at 37,752,035 bp (GRCm38)
  • A to G, chromosome 19 at 4,841,147 bp (GRCm38)
  • A to G, chromosome 19 at 8,804,469 bp (GRCm38)
  • G to A, chromosome 19 at 10,207,273 bp (GRCm38)
  • T to A, chromosome 19 at 46,005,508 bp (GRCm38)
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R9803 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
070048-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.