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Strain Name:
C57BL/6J-MtgxR4802Btlr/Mmmh
Stock Number:
042424-MU
Citation ID:
RRID:MMRRC_042424-MU
Other Names:
R4802 (G1), C57BL/6J-MtgxR4802Btlr
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Rgs9
Name: regulator of G-protein signaling 9
Synonyms: Rgs9-2, RGS9-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19739
Homologene: 2845
Erbb4
Name: erb-b2 receptor tyrosine kinase 4
Synonyms: ErbB4, Her4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13869
HGNC: HGNC:3432
Homologene: 21084
Olr1
Name: oxidized low density lipoprotein (lectin-like) receptor 1
Synonyms: LOX-1, Scare1, SR-EI
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 108078
HGNC: HGNC:8133
Homologene: 1910
Rgs14
Name: regulator of G-protein signaling 14
Synonyms: Rap1/rap2 interacting protein
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 51791
HGNC: HGNC:9996
Homologene: 4735
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 20,810,156 bp
  • G to A, chromosome 1 at 52,709,596 bp
  • T to C, chromosome 1 at 54,762,316 bp
  • G to T, chromosome 1 at 68,330,246 bp
  • T to A, chromosome 1 at 92,596,998 bp
  • T to A, chromosome 1 at 116,821,896 bp
  • A to T, chromosome 1 at 127,996,943 bp
  • A to T, chromosome 1 at 159,168,418 bp
  • T to C, chromosome 1 at 160,145,033 bp
  • A to T, chromosome 1 at 186,628,913 bp
  • T to A, chromosome 1 at 189,651,220 bp
  • C to T, chromosome 1 at 195,163,311 bp
  • T to G, chromosome 2 at 9,951,123 bp
  • T to G, chromosome 2 at 25,399,764 bp
  • T to A, chromosome 2 at 29,146,373 bp
  • T to A, chromosome 2 at 37,793,756 bp
  • T to C, chromosome 2 at 52,200,703 bp
  • T to A, chromosome 2 at 69,655,614 bp
  • T to A, chromosome 2 at 76,964,646 bp
  • T to A, chromosome 2 at 85,664,278 bp
  • T to A, chromosome 2 at 87,388,209 bp
  • T to A, chromosome 2 at 88,274,879 bp
  • T to A, chromosome 2 at 111,257,152 bp
  • T to C, chromosome 2 at 119,675,228 bp
  • T to C, chromosome 2 at 120,042,054 bp
  • T to G, chromosome 2 at 121,052,472 bp
  • T to C, chromosome 2 at 150,473,308 bp
  • T to C, chromosome 2 at 155,858,106 bp
  • G to T, chromosome 2 at 181,719,253 bp
  • G to A, chromosome 3 at 37,405,354 bp
  • A to T, chromosome 3 at 40,721,545 bp
  • T to C, chromosome 3 at 57,294,679 bp
  • G to A, chromosome 3 at 81,954,240 bp
  • G to T, chromosome 3 at 88,355,692 bp
  • C to G, chromosome 3 at 116,115,935 bp
  • A to T, chromosome 3 at 122,529,594 bp
  • T to C, chromosome 3 at 135,411,141 bp
  • A to T, chromosome 3 at 144,807,351 bp
  • A to T, chromosome 3 at 155,187,970 bp
  • T to C, chromosome 4 at 24,649,698 bp
  • G to T, chromosome 4 at 41,719,904 bp
  • A to T, chromosome 4 at 62,292,632 bp
  • C to T, chromosome 4 at 73,401,267 bp
  • T to A, chromosome 4 at 82,916,628 bp
  • C to A, chromosome 4 at 86,819,884 bp
  • T to C, chromosome 4 at 106,447,569 bp
  • T to A, chromosome 4 at 107,993,040 bp
  • T to C, chromosome 4 at 109,324,217 bp
  • A to G, chromosome 4 at 110,206,602 bp
  • T to C, chromosome 4 at 116,122,924 bp
  • C to T, chromosome 4 at 116,817,029 bp
  • G to A, chromosome 4 at 118,210,329 bp
  • T to C, chromosome 4 at 123,016,638 bp
  • C to T, chromosome 4 at 127,123,216 bp
  • A to G, chromosome 4 at 128,751,598 bp
  • A to T, chromosome 4 at 130,950,025 bp
  • A to G, chromosome 4 at 144,456,232 bp
  • A to G, chromosome 4 at 156,000,721 bp
  • T to A, chromosome 5 at 14,675,815 bp
  • T to C, chromosome 5 at 48,231,869 bp
  • G to T, chromosome 5 at 92,943,086 bp
  • A to G, chromosome 5 at 100,393,363 bp
  • G to A, chromosome 5 at 108,585,396 bp
  • C to T, chromosome 5 at 114,124,226 bp
  • T to C, chromosome 5 at 137,365,506 bp
  • T to A, chromosome 5 at 145,573,651 bp
  • A to T, chromosome 6 at 42,486,679 bp
  • G to A, chromosome 6 at 57,323,190 bp
  • T to C, chromosome 6 at 70,887,893 bp
  • G to A, chromosome 6 at 71,976,070 bp
  • A to G, chromosome 6 at 73,089,698 bp
  • A to G, chromosome 6 at 124,513,768 bp
  • A to G, chromosome 6 at 129,488,090 bp
  • T to A, chromosome 6 at 141,845,497 bp
  • T to C, chromosome 6 at 146,371,331 bp
  • T to A, chromosome 7 at 12,152,964 bp
  • A to G, chromosome 7 at 19,096,969 bp
  • A to G, chromosome 7 at 29,291,526 bp
  • T to G, chromosome 7 at 30,977,090 bp
  • G to T, chromosome 7 at 31,291,573 bp
  • T to C, chromosome 7 at 35,556,139 bp
  • T to C, chromosome 7 at 45,642,418 bp
  • A to C, chromosome 7 at 48,021,211 bp
  • A to T, chromosome 7 at 49,545,852 bp
  • T to A, chromosome 7 at 73,810,025 bp
  • T to A, chromosome 7 at 96,906,245 bp
  • C to G, chromosome 7 at 99,926,446 bp
  • T to A, chromosome 7 at 113,539,453 bp
  • T to A, chromosome 8 at 13,836,970 bp
  • T to C, chromosome 8 at 61,490,079 bp
  • C to T, chromosome 8 at 68,121,148 bp
  • CAAAAA to CAAAA, chromosome 8 at 84,716,247 bp
  • T to A, chromosome 8 at 91,270,177 bp
  • T to A, chromosome 8 at 104,797,032 bp
  • T to A, chromosome 8 at 112,773,590 bp
  • G to A, chromosome 8 at 119,577,361 bp
  • A to G, chromosome 8 at 123,966,527 bp
  • G to A, chromosome 8 at 125,762,922 bp
  • C to G, chromosome 8 at 126,474,889 bp
  • C to T, chromosome 9 at 14,357,023 bp
  • A to G, chromosome 9 at 33,728,772 bp
  • T to G, chromosome 9 at 39,572,858 bp
  • T to C, chromosome 9 at 45,101,064 bp
  • T to C, chromosome 9 at 67,964,282 bp
  • A to G, chromosome 9 at 104,175,727 bp
  • T to A, chromosome 9 at 108,050,217 bp
  • T to A, chromosome 9 at 110,035,257 bp
  • G to T, chromosome 10 at 18,591,906 bp
  • A to G, chromosome 10 at 24,108,843 bp
  • A to G, chromosome 10 at 28,761,511 bp
  • A to G, chromosome 10 at 28,983,926 bp
  • G to A, chromosome 10 at 58,573,643 bp
  • A to G, chromosome 10 at 62,261,548 bp
  • A to C, chromosome 10 at 62,822,663 bp
  • G to A, chromosome 10 at 80,359,304 bp
  • A to G, chromosome 10 at 80,386,954 bp
  • A to G, chromosome 10 at 93,868,895 bp
  • G to A, chromosome 10 at 103,221,318 bp
  • A to C, chromosome 10 at 107,901,336 bp
  • G to T, chromosome 11 at 9,522,341 bp
  • T to C, chromosome 11 at 29,708,660 bp
  • T to C, chromosome 11 at 58,701,791 bp
  • C to T, chromosome 11 at 60,778,610 bp
  • T to A, chromosome 11 at 73,940,870 bp
  • G to T, chromosome 11 at 75,403,184 bp
  • T to A, chromosome 11 at 86,278,773 bp
  • T to A, chromosome 11 at 95,364,070 bp
  • C to T, chromosome 11 at 98,803,969 bp
  • T to C, chromosome 11 at 109,240,868 bp
  • G to A, chromosome 11 at 120,282,225 bp
  • G to C, chromosome 12 at 114,223,279 bp
  • T to A, chromosome 13 at 11,687,932 bp
  • T to C, chromosome 13 at 11,708,227 bp
  • A to T, chromosome 13 at 12,195,251 bp
  • T to C, chromosome 13 at 22,805,656 bp
  • T to C, chromosome 13 at 55,380,957 bp
  • T to C, chromosome 13 at 73,607,862 bp
  • T to C, chromosome 13 at 73,763,892 bp
  • T to A, chromosome 13 at 120,173,222 bp
  • T to C, chromosome 14 at 11,554,233 bp
  • C to T, chromosome 14 at 24,154,689 bp
  • G to T, chromosome 14 at 31,141,371 bp
  • A to C, chromosome 14 at 31,736,830 bp
  • A to T, chromosome 14 at 43,544,548 bp
  • T to A, chromosome 14 at 47,530,869 bp
  • A to G, chromosome 14 at 50,619,022 bp
  • A to G, chromosome 14 at 51,919,348 bp
  • A to G, chromosome 14 at 55,631,214 bp
  • A to C, chromosome 14 at 103,583,100 bp
  • T to C, chromosome 14 at 118,117,033 bp
  • G to T, chromosome 15 at 47,621,292 bp
  • C to A, chromosome 15 at 60,823,944 bp
  • T to C, chromosome 15 at 81,104,799 bp
  • C to A, chromosome 15 at 91,854,616 bp
  • T to A, chromosome 16 at 44,957,825 bp
  • A to G, chromosome 16 at 60,604,880 bp
  • T to A, chromosome 16 at 87,722,452 bp
  • A to G, chromosome 17 at 12,675,535 bp
  • T to A, chromosome 17 at 19,795,076 bp
  • T to A, chromosome 17 at 20,227,294 bp
  • G to A, chromosome 17 at 24,578,096 bp
  • C to G, chromosome 17 at 28,286,374 bp
  • T to C, chromosome 17 at 37,835,349 bp
  • A to G, chromosome 17 at 40,937,351 bp
  • T to C, chromosome 17 at 46,148,263 bp
  • A to G, chromosome 17 at 48,309,159 bp
  • A to T, chromosome 17 at 55,939,642 bp
  • A to T, chromosome 17 at 64,292,862 bp
  • G to T, chromosome 18 at 34,720,192 bp
  • T to A, chromosome 18 at 36,953,955 bp
  • T to A, chromosome 18 at 37,005,465 bp
  • A to G, chromosome 18 at 37,448,278 bp
  • T to C, chromosome 18 at 45,685,267 bp
  • T to C, chromosome 19 at 8,945,851 bp
  • G to T, chromosome 19 at 32,758,503 bp
  • T to C, chromosome 19 at 37,945,738 bp
  • A to T, chromosome 19 at 43,819,361 bp
  • A to G, chromosome 19 at 48,398,744 bp
  • T to G, chromosome Y at 825,890 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R4802 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
042424-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.