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Strain Information

Name: a disintegrin and metallopeptidase domain 17; mutation 1, Bruce Beutler
Synonyms: wavedX
Type: Allele
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
Name: a disintegrin and metallopeptidase domain 17
Synonyms: Tace, CD156b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 11491
Homologene: 2395
Genetic Alterations
The wavedX mutation has been identified as a T-to-A transversion at nucleotide position 1186 of the gene, in the ninth of its 19 exons. It changes phenylalanine to isoleucine at amino acid position 343 of the protein (F343I).

HGVS nomenclature:
  • Genbank RefSeq - mRNA: NM_009615.6
  • Genbank RefSeq, protein: NP_033745.4
  • Variant, nucleic acid level: c.1027T>A
  • Variant, amino acid level, predicted: p.Phe343Ile (F343I)
    Check this variant: LUMC Mutalyzer
Genotype Determination
Homozygous: Mice homozygous for the mutation are viable and are characterized by open eyelids and curly vibrissae at birth; adult animals display wavy coats and corneal opacities. These animals are susceptible to dextran sulfate sodium (DSS)-induced colitis and exhibit severe weight loss as a result of DSS administration. The donating investigator indicates that homozygous males are fertile, however, homozygous females do not breed. This mutant mouse strain may be useful in studies of inflammatory bowel disease.

For additional information, see The Scripps Research Institute Mutagenix website.

Heterozygous: Not evaluated, the phenotype is presumed to be normal.

Mammalian Phenotype Terms
Allelic Composition: Adam17m1Btlr/Adam17m1Btlr (Genetic Background: C57BL/6J-Adam17m1Btlr )

MeSH Terms
  • Adaptor Proteins, Vesicular Transport/deficiency
  • Amphiregulin
  • Animals
  • Colitis/chemically induced
  • Colitis/metabolism
  • Colitis/prevention & control
  • Dextran Sulfate
  • EGF Family of Proteins
  • Epidermal Growth Factor/metabolism
  • Epiregulin
  • Glycoproteins/metabolism
  • Hematopoietic System/cytology
  • Intercellular Signaling Peptides and Proteins/metabolism
  • Ligands
  • Lipopolysaccharides/pharmacology
  • Metagenome/drug effects
  • Mice
  • Mice, Inbred C57BL
  • Mutation/genetics
  • Myeloid Differentiation Factor 88/deficiency
  • Myeloid Differentiation Factor 88/metabolism
  • Phenotype
  • Receptor, Epidermal Growth Factor/metabolism
  • Signal Transduction/drug effects
  • Toll-Like Receptors/metabolism
Strain Development
This missense point mutation was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males. Mutagenized males were outcrossed to C57BL/6J females. Upon arrival, mice were bred to C57BL/6J for at least 1 generation to establish the colony.
Suggested Control Mice
Wild-type littermates
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact Older strains may not have this information.
  • Immunology and Inflammation
  • Dermatology
  • Developmental Biology
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
  • Brandl K, Sun L, Neppl C, Siggs OM, Le Gall SM, Tomisato W, Li X, Du X, Maennel DN, Blobel CP, Beutler B, Myd88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands, PNAS 2010, Nov 16;107(46):19967-72 (Medline PMID: 21041656)

For additional information see: Mutagenetix, a catalog of mutations identified in the Beutler Laboratory at The Scripps Research Institute, La Jolla, CA.

Colony and Husbandry Information

While maintaining a live colony, these mice are bred as heterozygote female x homozygote male. Females homozygous for the mutation do not breed.
Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email .
Coat Color
Wavy coat and corneal opacities
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
1 female X 1 male
Overall Breeding Performance
Viability and Fertility: Female Male Comments
Homozygotes are viable: Yes Yes
Homozygotes are fertile: No Yes
Heterozygotes are fertile: Yes Yes
Age Reproductive Decline: Unknown Unknown
Bred to Homozygosity
Average litter size
6 pups
Recommended wean age
3 weeks
Average Pups Weaned
6 pups

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
034295-JAX-SPERM Cryo-preserved spermatozoa $437.00 / Non-Profit Aliquot Approximate quantity3
034295-JAX-RESUS Litter recovered from cryo-archive $2,022.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to for more information.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.