Strain Name:
C57BL/6J-MtgxR0033Btlr/Mmmh
Stock Number:
038327-MU
Citation ID:
RRID:MMRRC_038327-MU
Other Names:
R0033 (G1), C57BL/6J-MtgxR0033Btlr
Major Collection:

Strain Information

Hapln1
Name: hyaluronan and proteoglycan link protein 1
Synonyms: LP-1, cartilage linking protein 1, Crtl1l, link protein, Crtl1, CLP
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12950
VEGA: 13
HGNC: HGNC:2380
Homologene: 1420
Slc12a1
Name: solute carrier family 12, member 1
Synonyms: mBSC1, urehr3, D630042G03Rik, Nkcc2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Ank2
Name: ankyrin 2, brain
Synonyms: Ankyrin-2, Ankyrin-B, ankyrin B, Gm4392, Ank-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Rarg
Name: retinoic acid receptor, gamma
Synonyms: RARgamma2, RAR gamma 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 19411
HGNC: HGNC:9866
Homologene: 20263
Snrnp200
Name: small nuclear ribonucleoprotein 200 (U5)
Synonyms: Ascc3l1, U5-200KD, HELIC2, A330064G03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320632
Homologene: 5859
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: Txndc4, 1110001E24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76299
Homologene: 12638
Auts2
Name: autism susceptibility candidate 2
Synonyms: 2700063G02Rik, D830032G16Rik, A730011F23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319974
Homologene: 22907
Celf1
Name: CUGBP, Elav-like family member 1
Synonyms: CUG-BP1, Cugbp1, CUG-BP, Brunol2, D2Wsu101e, 1600010O03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13046
HGNC: HGNC:2549
Homologene: 134102
Ankib1
Name: ankyrin repeat and IBR domain containing 1
Synonyms: 2310061P20Rik, 4631416I11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70797
Homologene: 19076
Tdp1
Name: tyrosyl-DNA phosphodiesterase 1
Synonyms: E430034L06Rik, Gm40556, 2810481F14Rik, 4921509N21Rik, SCAN1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104884
Homologene: 5424
Zfp64
Name: zinc finger protein 64
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22722
Homologene: 7604
Xdh
Name: xanthine dehydrogenase
Synonyms: XO, Xox1, xanthine oxidase, Xox-1, Xor
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Unc13d
Name: unc-13 homolog D
Synonyms: Jinx, Munc13-4, 2610108D09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70450
Homologene: 26714
Thra
Name: thyroid hormone receptor alpha
Synonyms: c-erbAalpha, 6430529J03Rik, Erba, Rvr, Thra1, T3R[a], Thra2, TR alpha 2, TR alpha 1, T3Ralpha, Nr1a1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 21833
Homologene: 37747
Agr3
Name: anterior gradient 3
Synonyms: E030025L21Rik, LOC380754
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 403205
Homologene: 45551
Cpxm2
Name: carboxypeptidase X, M14 family member 2
Synonyms: 4632435C11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 55987
Homologene: 69259
Kirrel3
Name: kirre like nephrin family adhesion molecule 3
Synonyms: 2900036G11Rik, Neph2, 1500010O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67703
Homologene: 57050
Lrrc8a
Name: leucine rich repeat containing 8A VRAC subunit A
Synonyms: ebo, Lrrc8, SWELL1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241296
Homologene: 18617
Slc12a4
Name: solute carrier family 12, member 4
Synonyms: KCC1, K-Cl Co-transporter-1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20498
Homologene: 21056
Tut1
Name: terminal uridylyl transferase 1, U6 snRNA-specific
Synonyms: 2700038E08Rik, PAPD2, Tent1, Rbm21, TUTase6
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70044
VEGA: 19
Homologene: 69361
Hibch
Name: 3-hydroxyisobutyryl-Coenzyme A hydrolase
Synonyms: HIBYL-COA-H, 2610509I15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227095
HGNC: HGNC:4908
Homologene: 5607
Katnip
Name: katanin interacting protein
Synonyms: D430042O09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233865
Homologene: 45841
Sv2b
Name: synaptic vesicle glycoprotein 2b
Synonyms: A830038F04Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 64176
Homologene: 32236
Zfp420
Name: zinc finger protein 420
Synonyms: B230312I18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233058
Homologene: 129731
Ttn
Name: titin
Synonyms: connectin, 1100001C23Rik, D330041I19Rik, D830007G01Rik, 2310074I15Rik, 2310036G12Rik, mdm, 2310057K23Rik, shru, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myo16
Name: myosin XVI
Synonyms: Nyap3, C230040D10Rik, BM140241
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244281
Homologene: 34710
Or9s23
Name: olfactory receptor family 9 subfamily S member 23
Synonyms: Olfr1413, MOR208-1, GA_x6K02T2R7CC-81180849-81179878
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 259039
Homologene: 128165
Ltbp1
Name: latent transforming growth factor beta binding protein 1
Synonyms: LTBP-1, Ltbp1L, b2b1000Clo, 9430031G15Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268977
HGNC: HGNC:6714
Homologene: 522
Emilin2
Name: elastin microfibril interfacer 2
Synonyms: FOAP-10, basilin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 246707
VEGA: 17
Homologene: 36483
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: C79217, D-LTCC, 8430418G19Rik, Cchl1a2, Cacnl1a2, Cchl1a, Cav1.3alpha1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Ctss
Name: cathepsin S
Synonyms: Cat S
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13040
HGNC: HGNC:2545
Homologene: 20867
Csf3r
Name: colony stimulating factor 3 receptor
Synonyms: Csfgr, Cd114, G-CSFR
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12986
HGNC: HGNC:2439
Homologene: 601
Kcnh4
Name: potassium voltage-gated channel, subfamily H (eag-related), member 4
Synonyms: BEC2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380728
HGNC: HGNC:6253
Homologene: 8180
3110009E18Rik
Name: RIKEN cDNA 3110009E18 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73103
Homologene: 41754
Nckap5
Name: NCK-associated protein 5
Synonyms: LOC380609, E030049G20Rik, D130011D22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 210356
Homologene: 35542
Myoc
Name: myocilin
Synonyms: GLC1A, TIGR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17926
HGNC: HGNC:7610
Homologene: 220
Aldh9a1
Name: aldehyde dehydrogenase 9, subfamily A1
Synonyms: ESTM40, TMABA-DH
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56752
HGNC: HGNC:412
Homologene: 55483
Tmx4
Name: thioredoxin-related transmembrane protein 4
Synonyms: 2810417D04Rik, 4930500L08Rik, Txndc13, D2Bwg1356e
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 52837
Homologene: 10901
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Fbxl4
Name: F-box and leucine-rich repeat protein 4
Synonyms: FBL5, FBL4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269514
Homologene: 8128
Gbp6
Name: guanylate binding protein 6
Synonyms: Mpa2l
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100702
Homologene: 128731
Kdm7a
Name: lysine (K)-specific demethylase 7A
Synonyms: Kdm7a, A630082K20Rik, ENSMUSG00000073143, Jhdm1d
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 338523
Homologene: 25281
Gstk1
Name: glutathione S-transferase kappa 1
Synonyms: 0610025I19Rik, DsbA-L
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 76263
Homologene: 41075
Klra13-ps
Name: killer cell lectin-like receptor subfamily A, member 13, pseudogene
Synonyms: Ly49M
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 16631
Nlrp12
Name: NLR family, pyrin domain containing 12
Synonyms: Nalp12
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 378425
Homologene: 16972
Vmn1r58
Name: vomeronasal 1 receptor 58
Synonyms: V1rd4, V3R4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81014
Homologene: 41799
Vmn1r59
Name: vomeronasal 1 receptor 59
Synonyms: V1rd10
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404284
Homologene: 41799
Rnf225
Name: ring finger protein 225
Synonyms: 2310014L17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 381845
Homologene: 78604
Ceacam12
Name: CEA cell adhesion molecule 12
Synonyms: Ceacam12-C1, Ceacam12-C3, 1600031J20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67315
Homologene: 137375
Or5p62
Name: olfactory receptor family 5 subfamily P member 62
Synonyms: Olfr486, GA_x6K02T2PBJ9-10501920-10500976, MOR204-19
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258489
Homologene: 110483
Pwwp2b
Name: PWWP domain containing 2B
Synonyms: D930023J19Rik, D7Ertd517e, Pwwp2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101631
Homologene: 19056
Uba5
Name: ubiquitin-like modifier activating enzyme 5
Synonyms: 5730525G14Rik, Ube1dc1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 66663
Homologene: 11738
Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Synonyms: LOC380698, OTTMUSG00000005786
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380698
Homologene: 70869
Macc1
Name: metastasis associated in colon cancer 1
Synonyms: 4732474O15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238455
Homologene: 18813
Cdkn3
Name: cyclin dependent kinase inhibitor 3
Synonyms: KAP, 2410006H10Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72391
VEGA: 14
HGNC: HGNC:1791
Homologene: 3805
Trav6n-5
Name: T cell receptor alpha variable 6N-5
Synonyms: Gm10894, ENSMUSG00000072087
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100126451
Oplah
Name: 5-oxoprolinase (ATP-hydrolysing)
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75475
HGNC: HGNC:8149
Homologene: 90938
Slx4
Name: SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)
Synonyms: Btbd12, D16Bwg1016e
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 52864
Homologene: 23770
Tnfrsf12a
Name: tumor necrosis factor receptor superfamily, member 12a
Synonyms: TWEAK-R, TweakR, Fn14
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27279
VEGA: 17
Homologene: 8451
Klc4
Name: kinesin light chain 4
Synonyms: 1200014P03Rik, Knsl8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74764
VEGA: 17
Homologene: 12584
Stap2
Name: signal transducing adaptor family member 2
Synonyms: STAP-2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106766
VEGA: 17
Homologene: 9798
Ppargc1b
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta
Synonyms: 4631412G21Rik, PGC-1beta/ERRL1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 170826
Homologene: 15776
Tm7sf2
Name: transmembrane 7 superfamily member 2
Synonyms: 3110041O18Rik, ANG1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73166
Homologene: 68305
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 52,905,451 bp
  • A to G, chromosome 1 at 90,802,245 bp
  • A to G, chromosome 1 at 92,573,260 bp
  • T to C, chromosome 1 at 120,188,064 bp
  • A to G, chromosome 1 at 125,940,242 bp
  • G to A, chromosome 1 at 162,648,441 bp
  • T to C, chromosome 1 at 167,356,571 bp
  • G to T, chromosome 2 at 30,255,345 bp
  • T to A, chromosome 2 at 76,742,280 bp
  • T to C, chromosome 2 at 91,001,453 bp
  • A to G, chromosome 2 at 125,214,009 bp
  • T to C, chromosome 2 at 127,238,063 bp
  • A to T, chromosome 2 at 134,600,998 bp
  • G to A, chromosome 2 at 156,024,106 bp
  • A to T, chromosome 2 at 168,925,715 bp
  • G to A, chromosome 3 at 95,545,577 bp
  • T to A, chromosome 3 at 127,104,748 bp
  • T to C, chromosome 4 at 22,377,017 bp
  • T to C, chromosome 4 at 48,241,289 bp
  • A to T, chromosome 4 at 101,941,684 bp
  • A to G, chromosome 4 at 126,031,884 bp
  • A to C, chromosome 5 at 3,769,588 bp
  • T to C, chromosome 5 at 105,276,844 bp
  • G to C, chromosome 5 at 131,440,093 bp
  • A to T, chromosome 6 at 39,165,197 bp
  • A to G, chromosome 6 at 42,246,803 bp
  • A to T, chromosome 6 at 130,301,298 bp
  • A to C, chromosome 7 at 3,240,407 bp
  • A to T, chromosome 7 at 5,410,388 bp
  • A to G, chromosome 7 at 5,454,434 bp
  • T to C, chromosome 7 at 12,928,158 bp
  • T to G, chromosome 7 at 18,069,460 bp
  • A to G, chromosome 7 at 29,874,562 bp
  • A to G, chromosome 7 at 75,117,741 bp
  • G to T, chromosome 7 at 108,171,927 bp
  • T to G, chromosome 7 at 125,761,827 bp
  • T to C, chromosome 7 at 132,062,157 bp
  • A to T, chromosome 7 at 139,254,928 bp
  • A to T, chromosome 8 at 10,370,955 bp
  • G to T, chromosome 8 at 105,947,479 bp
  • A to G, chromosome 9 at 35,000,963 bp
  • T to A, chromosome 9 at 104,054,148 bp
  • A to G, chromosome 11 at 58,994,746 bp
  • G to A, chromosome 11 at 98,764,352 bp
  • C to T, chromosome 11 at 100,746,932 bp
  • T to C, chromosome 11 at 116,069,165 bp
  • C to T, chromosome 12 at 35,928,330 bp
  • C to T, chromosome 12 at 99,935,052 bp
  • T to A, chromosome 12 at 119,446,341 bp
  • A to T, chromosome 13 at 89,601,813 bp
  • T to A, chromosome 14 at 30,105,489 bp
  • C to A, chromosome 14 at 46,768,872 bp
  • T to A, chromosome 14 at 53,104,911 bp
  • T to A, chromosome 15 at 76,297,134 bp
  • T to A, chromosome 15 at 102,238,835 bp
  • C to T, chromosome 16 at 3,988,000 bp
  • A to G, chromosome 17 at 23,676,145 bp
  • A to T, chromosome 17 at 46,635,433 bp
  • C to T, chromosome 17 at 55,999,976 bp
  • G to T, chromosome 17 at 71,275,014 bp
  • T to A, chromosome 17 at 73,907,632 bp
  • A to G, chromosome 17 at 75,276,509 bp
  • G to A, chromosome 18 at 61,307,694 bp
  • A to G, chromosome 19 at 6,066,422 bp
  • G to T, chromosome 19 at 8,962,759 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0033 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038327-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.