Strain Name:
C57BL/6J-MtgxR0284Btlr/Mmmh
Stock Number:
038505-MU
Citation ID:
RRID:MMRRC_038505-MU
Other Names:
R0284 (G1), C57BL/6J-MtgxR0284Btlr
Major Collection:

Gene Information

Ednrb
Name: endothelin receptor type B
Synonyms: ETb, Sox10m1, ETR-b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Vps41
Name: VPS41 HOPS complex subunit
Synonyms: Vam2, mVam2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 218035
VEGA: 13
Homologene: 69165
Crabp1
Name: cellular retinoic acid binding protein I
Synonyms: Rbp-5, Crabp-1, CrabpI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12903
HGNC: HGNC:2338
Homologene: 3222
Gk5
Name: glycerol kinase 5 (putative)
Synonyms: G630067D24Rik, C330018K18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235533
Homologene: 15141
Mllt6
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6
Synonyms: Af17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 246198
HGNC: HGNC:7138
Homologene: 31347
Prpf40a
Name: pre-mRNA processing factor 40A
Synonyms: FBP11, 2810012K09Rik, Fnbp3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56194
Homologene: 6377
Exoc2
Name: exocyst complex component 2
Synonyms: Sec5, 2410030I24Rik, Sec5l1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 66482
Homologene: 10122
Arid2
Name: AT rich interactive domain 2 (ARID, RFX-like)
Synonyms: 4432409D24Rik, zipzap/p200, 1700124K17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 77044
Homologene: 14601
Plekhf2
Name: pleckstrin homology domain containing, family F (with FYVE domain) member 2
Synonyms: ZFYVE18, 1110070J07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 71801
Homologene: 11620
Kri1
Name: KRI1 homolog
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 215194
Homologene: 133742
Cklf
Name: chemokine-like factor
Synonyms: CKLF5, chemokine-like factor 4, Cklf6, HSPC224, UCK-1, CKLF4, CKLF3, CKLF2, CKLF1, C32, 1700001C14Rik, A730028G07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 75458
Homologene: 9663
Pdcd6ip
Name: programmed cell death 6 interacting protein
Synonyms: Alix, AIP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18571
HGNC: HGNC:8766
Homologene: 22614
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 230895
Homologene: 15583
Incenp
Name: inner centromere protein
Synonyms: 2700067E22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 16319
VEGA: 19
HGNC: HGNC:6058
Homologene: 9624
Ccdc171
Name: coiled-coil domain containing 171
Synonyms: 4930418J05Rik, A330015D16Rik, 4930473A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 320226
Homologene: 27942
Trerf1
Name: transcriptional regulating factor 1
Synonyms: Trep132, Trep-132, 9430096I18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 224829
Homologene: 14129
Kat6a
Name: K(lysine) acetyltransferase 6A
Synonyms: MOZ, Zfp220, 9930021N24Rik, Myst3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 244349
Homologene: 4924
Itpkc
Name: inositol 1,4,5-trisphosphate 3-kinase C
Synonyms: 9130023N17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233011
Homologene: 11868
Nsl1
Name: NSL1, MIS12 kinetochore complex component
Synonyms: LOC381318, 4833432M17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 381318
Homologene: 22898
Rag2
Name: recombination activating gene 2
Synonyms: Rag-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 19374
HGNC: HGNC:9832
Homologene: 7507
Akap2
Name: A kinase (PRKA) anchor protein 2
Synonyms: B230340M18Rik, AKAP-KL
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Man1a2
Name: mannosidase, alpha, class 1A, member 2
Synonyms: Man1b
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 17156
HGNC: HGNC:6822
Homologene: 55982
Cacna1a
Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
Synonyms: Cacnl1a4, alpha1A, Ccha1a, SCA6, nmf352, smrl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 12286
HGNC: HGNC:1388
Homologene: 56383
Alox12e
Name: arachidonate lipoxygenase, epidermal
Synonyms: 8-LOX, e-LOX1, Alox12-ps1, Aloxe, Alox12-ps2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 11685
Homologene: 105868
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22138
Homologene: 130650
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: ASK1, Mekk5, 7420452D20Rik, ASK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Vmn1r28
Name: vomeronasal 1 receptor 28
Synonyms: V1rc25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 171198
Homologene: 138094
Mipol1
Name: mirror-image polydactyly 1
Synonyms: 1700081O04Rik, 6030439O22Rik, D12Ertd19e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 73490
Homologene: 16340
Miox
Name: myo-inositol oxygenase
Synonyms: RSOR, 0610009I10Rik, C85427, Aldrl6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 56727
Homologene: 9732
Prdm1
Name: PR domain containing 1, with ZNF domain
Synonyms: PRDI-BF1, Blimp1, Blimp-1, b2b1765Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 12142
HGNC: HGNC:9346
Homologene: 925
Ncoa6
Name: nuclear receptor coactivator 6
Synonyms: PRIP, ASC2, RAP250, AIB3, NRC, ASC-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 56406
Homologene: 137337
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: D-LTCC, Cchl1a, Cchl1a2, Cacnl1a2, 8430418G19Rik, Cav1.3alpha1, C79217
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Fbn2
Name: fibrillin 2
Synonyms: sy, Sne, Fib-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Cspg4
Name: chondroitin sulfate proteoglycan 4
Synonyms: NG2, AN2, 4732461B14Rik, Cspg4a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 121021
VEGA: 9
HGNC: HGNC:2466
Homologene: 20445
Olfr736
Name: olfactory receptor 736
Synonyms: GA_x6K02T2PMLR-6089963-6090901, MOR106-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 258660
Homologene: 64902
Tmem144
Name: transmembrane protein 144
Synonyms: 1110057I03Rik, 5730537D05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 70652
Homologene: 41250
Lipn
Name: lipase, family member N
Synonyms: 2210418G03Rik, Lipl4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 70166
Homologene: 66969
Synpo2
Name: synaptopodin 2
Synonyms: myopodin, Myo, 1110069I04Rik, 9530006G20Rik, 2310068J10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 118449
Homologene: 15400
Gys1
Name: glycogen synthase 1, muscle
Synonyms: Gys3, MGS
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 14936
HGNC: HGNC:4706
Homologene: 113557
Prpf40b
Name: pre-mRNA processing factor 40B
Synonyms: 2610317D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 54614
Homologene: 81828
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Tgtp1
Name: T cell specific GTPase 1
Synonyms: Mg21, Gtp2, Tgtp, Irgb6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 21822
Homologene: 129991
Zfp518b
Name: zinc finger protein 518B
Synonyms: 6820424L24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100515
Homologene: 19115
Slc24a4
Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
Synonyms: NCKX4, A930002M03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 238384
Homologene: 17798
Efcab5
Name: EF-hand calcium binding domain 5
Synonyms: 4930563A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 319634
Homologene: 63366
Bmp2k
Name: BMP2 inducible kinase
Synonyms: BIKE, 4933417M22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 140780
Homologene: 34134
Serpinb8
Name: serine (or cysteine) peptidase inhibitor, clade B, member 8
Synonyms: ovalbumin, CAP-2, CAP2, Spi8, NK10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 20725
HGNC: HGNC:8952
Homologene: 74445
Olfr1278
Name: olfactory receptor 1278
Synonyms: GA_x6K02T2Q125-72343713-72344654, MOR245-11
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258389
Homologene: 74061
Zscan29
Name: zinc finger SCAN domains 29
Synonyms: Zfp690
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 99334
Homologene: 17586
Kiz
Name: kizuna centrosomal protein
Synonyms: LOC228730, Ncrna00153, Gm114, Plk1s1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228730
Homologene: 10219
S100a5
Name: S100 calcium binding protein A5
Synonyms: S100D9
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 20199
Homologene: 2224
1110017D15Rik
Name: RIKEN cDNA 1110017D15 gene
Synonyms: Smrp1, Cbe1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73721
Homologene: 13074
Nipsnap3a
Name: nipsnap homolog 3A
Synonyms: 1700054F22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 73398
Homologene: 136268
Foxo6
Name: forkhead box O6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 329934
Homologene: 82395
Cyp3a41b
Name: cytochrome P450, family 3, subfamily a, polypeptide 41B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 100041375
HGNC: HGNC:2638
Homologene: 133568
Alkbh6
Name: alkB homolog 6
Synonyms: Abh6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233065
Homologene: 15555
Olfr830
Name: olfactory receptor 830
Synonyms: GA_x6K02T2PVTD-12618399-12619337, MOR152-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 258559
Homologene: 79360
Olfr251
Name: olfactory receptor 251
Synonyms: GA_x6K02T2MYUG-9124-8183, MOR170-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 404313
VEGA: 9
Homologene: 133654
Igfbp1
Name: insulin-like growth factor binding protein 1
Synonyms: IGFBP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16006
HGNC: HGNC:5469
Homologene: 498
Llgl1
Name: LLGL1 scribble cell polarity complex component
Synonyms: Lgl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 16897
HGNC: HGNC:6628
Homologene: 31220
Ap1g2
Name: adaptor protein complex AP-1, gamma 2 subunit
Synonyms: gamma 2-adaptin, Adtg2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 11766
HGNC: HGNC:556
Homologene: 49141
Spag6l
Name: sperm associated antigen 6-like
Synonyms: PF16, Spag6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 50525
Homologene: 8252
Fpr1
Name: formyl peptide receptor 1
Synonyms: FPR, fMLF-R
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 14293
HGNC: HGNC:3826
Homologene: 20466
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 107,602,918 bp
  • A to G, chromosome 1 at 191,065,230 bp
  • T to A, chromosome 2 at 53,150,647 bp
  • G to C, chromosome 2 at 76,846,704 bp
  • T to C, chromosome 2 at 101,630,119 bp
  • T to C, chromosome 2 at 111,292,586 bp
  • A to T, chromosome 2 at 121,166,733 bp
  • T to A, chromosome 2 at 146,863,810 bp
  • TGC to TGCGC, chromosome 2 at 155,408,291 bp
  • G to A, chromosome 3 at 79,839,273 bp
  • A to G, chromosome 3 at 90,611,574 bp
  • T to C, chromosome 3 at 100,684,786 bp
  • C to T, chromosome 3 at 123,079,734 bp
  • T to C, chromosome 4 at 10,990,595 bp
  • T to G, chromosome 4 at 41,507,538 bp
  • C to T, chromosome 4 at 52,997,178 bp
  • T to C, chromosome 4 at 57,855,207 bp
  • A to G, chromosome 4 at 83,549,738 bp
  • T to C, chromosome 4 at 120,269,002 bp
  • A to T, chromosome 4 at 145,144,802 bp
  • T to C, chromosome 5 at 38,671,740 bp
  • A to T, chromosome 5 at 97,068,455 bp
  • G to A, chromosome 5 at 145,578,204 bp
  • G to A, chromosome 6 at 58,265,717 bp
  • G to A, chromosome 7 at 27,214,543 bp
  • A to G, chromosome 7 at 30,313,988 bp
  • A to T, chromosome 7 at 45,436,719 bp
  • A to G, chromosome 8 at 22,939,803 bp
  • A to T, chromosome 8 at 84,612,285 bp
  • T to C, chromosome 8 at 104,261,575 bp
  • A to T, chromosome 9 at 18,875,552 bp
  • A to G, chromosome 9 at 21,276,552 bp
  • G to A, chromosome 9 at 38,378,584 bp
  • A to G, chromosome 9 at 54,764,926 bp
  • A to G, chromosome 9 at 56,886,139 bp
  • A to T, chromosome 9 at 96,181,770 bp
  • A to G, chromosome 9 at 113,662,504 bp
  • T to A, chromosome 10 at 20,000,613 bp
  • T to C, chromosome 10 at 44,456,626 bp
  • T to C, chromosome 11 at 7,198,103 bp
  • A to G, chromosome 11 at 48,987,143 bp
  • A to G, chromosome 11 at 60,712,141 bp
  • A to G, chromosome 11 at 70,320,899 bp
  • T to C, chromosome 11 at 77,103,527 bp
  • G to T, chromosome 11 at 97,678,605 bp
  • A to G, chromosome 12 at 57,457,069 bp
  • T to C, chromosome 12 at 102,260,481 bp
  • A to T, chromosome 13 at 18,853,440 bp
  • A to T, chromosome 13 at 30,877,625 bp
  • A to T, chromosome 14 at 30,072,105 bp
  • G to A, chromosome 14 at 50,392,995 bp
  • A to G, chromosome 14 at 55,101,692 bp
  • C to T, chromosome 14 at 103,820,013 bp
  • C to T, chromosome 15 at 89,336,274 bp
  • A to T, chromosome 15 at 96,378,967 bp
  • A to T, chromosome 15 at 99,316,393 bp
  • T to A, chromosome 16 at 16,780,766 bp
  • T to A, chromosome 17 at 17,877,356 bp
  • A to G, chromosome 17 at 47,319,545 bp
  • T to A, chromosome 18 at 20,331,627 bp
  • G to A, chromosome 18 at 58,050,290 bp
  • A to T, chromosome 19 at 9,893,993 bp
  • A to G, chromosome 19 at 34,080,706 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0284 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038505-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.