Strain Name:
C57BL/6J-MtgxR0305Btlr/Mmmh
Stock Number:
038516-MU
Citation ID:
RRID:MMRRC_038516-MU
Other Names:
R0305 (G1), C57BL/6J-MtgxR0305Btlr
Major Collection:

Gene Information

Eomes
Name: eomesodermin
Synonyms: Tbr2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 13813
HGNC: HGNC:3372
Homologene: 3971
Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Synonyms: p110beta, 1110001J02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 74769
HGNC: HGNC:8976
Homologene: 21250
Slc17a5
Name: solute carrier family 17 (anion/sugar transporter), member 5
Synonyms: 4631416G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235504
Homologene: 56571
Nrxn2
Name: neurexin II
Synonyms: 6430591O13Rik, neurexin II beta, neurexin II alpha
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 18190
HGNC: HGNC:8009
Homologene: 86984
Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Synonyms: Aloxe2, e-LOX2, 12R-LOX
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11686
HGNC: HGNC:430
Homologene: 884
Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
Synonyms: 4930470P14Rik, 9530057A13Rik, Specc1l, Cytsa, 4932439K10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 74392
VEGA: 10
Homologene: 15610
Kpna6
Name: karyopherin (importin) alpha 6
Synonyms: IPOA7, importin alpha 7, NPI-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 16650
HGNC: HGNC:6399
Homologene: 22472
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, S-afadin, Mllt4, I-afadin, 5033403D15Rik, Afadin
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Aimp1
Name: aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
Synonyms: 9830137A06Rik, AIMP1/p43, Emap2, Scye1, EMAPII
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 13722
Homologene: 31260
Sema4d
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
Synonyms: CD100, coll-4, semaphorin H, Semcl2, M-sema G, Semaj, Semacl2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 20354
Homologene: 21282
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 69748
Homologene: 34938
Dcps
Name: decapping enzyme, scavenger
Synonyms: 1700001E16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 69305
Homologene: 32202
Cpt1a
Name: carnitine palmitoyltransferase 1a, liver
Synonyms: L-CPT I, Cpt1, CPTI
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 12894
VEGA: 19
HGNC: HGNC:2328
Homologene: 1413
Pgr
Name: progesterone receptor
Synonyms: ENSMUSG00000074510, 9930019P03Rik, PR-B, NR3C3, PR-A, PR
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 18667
HGNC: HGNC:8910
Homologene: 713
Kcnh5
Name: potassium voltage-gated channel, subfamily H (eag-related), member 5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238271
VEGA: 12
HGNC: HGNC:6254
Homologene: 15858
Unc5b
Name: unc-5 netrin receptor B
Synonyms: Unc5h2, 6330415E02Rik, D10Bwg0792e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 107449
VEGA: 10
Homologene: 32538
Apob
Name: apolipoprotein B
Synonyms: apob-48, apob-100
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Arhgap23
Name: Rho GTPase activating protein 23
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 58996
Homologene: 104145
Lifr
Name: LIF receptor alpha
Synonyms: soluble differentiation-stimulating factor receptor, A230075M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 16880
VEGA: 15
HGNC: HGNC:6597
Homologene: 1735
Map2
Name: microtubule-associated protein 2
Synonyms: repro4, Mtap2, G1-397-34, MAP-2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17756
HGNC: HGNC:6839
Homologene: 1779
Dsg2
Name: desmoglein 2
Synonyms: D18Ertd293e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
Alteration at locus: Chemically Induced
NCBI: 13511
HGNC: HGNC:3049
Homologene: 1464
2310022A10Rik
Name: RIKEN cDNA 2310022A10 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 66367
Homologene: 35272
Cab39l
Name: calcium binding protein 39-like
Synonyms: 1500031K13Rik, MO2L, 4930520C08Rik, 2810425O13Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 69008
VEGA: 14
Homologene: 69422
Yeats4
Name: YEATS domain containing 4
Synonyms: NuBI-1, GAS41, B230215M10Rik, 4930573H17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 64050
VEGA: 10
Homologene: 4760
Tbl3
Name: transducin (beta)-like 3
Synonyms: 9430070M15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 213773
Homologene: 4711
Slc39a5
Name: solute carrier family 39 (metal ion transporter), member 5
Synonyms: 1810013D05Rik, 2010205A06Rik, Zip5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 72002
VEGA: 10
Homologene: 57083
Zfpm2
Name: zinc finger protein, multitype 2
Synonyms: FOG-2, B330005D23Rik, FOG2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 22762
VEGA: 15
Homologene: 8008
Nxph1
Name: neurexophilin 1
Synonyms: C130005L03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 18231
Homologene: 8284
Itpr2
Name: inositol 1,4,5-triphosphate receptor 2
Synonyms: Itpr5, Ip3r2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 16439
HGNC: HGNC:6181
Homologene: 37593
Vmn2r57
Name: vomeronasal 2, receptor 57
Synonyms: EG269902
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 269902
Homologene: 104832
Itgb4
Name: integrin beta 4
Synonyms: CD104
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 192897
HGNC: HGNC:6158
Homologene: 179
Vmn2r1
Name: vomeronasal 2, receptor 1
Synonyms: V2r83, EG56544
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 56544
Homologene: 84832
Lrrd1
Name: leucine rich repeats and death domain containing 1
Synonyms: 4932412H11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 242838
Homologene: 18247
Unc79
Name: unc-79 homolog
Synonyms: Mlca3, 9030205A07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 217843
Homologene: 41397
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231470
Homologene: 23516
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 219189
VEGA: 14
Homologene: 44881
Ada
Name: adenosine deaminase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 11486
HGNC: HGNC:186
Homologene: 37249
Slco1a4
Name: solute carrier organic anion transporter family, member 1a4
Synonyms: Oatp1a4, Oatp2, Slc21a5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 28250
Homologene: 130782
Dnaic2
Name: dynein, axonemal, intermediate chain 2
Synonyms: C030015H18Rik, b2b3405Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 432611
Homologene: 11311
Abca5
Name: ATP-binding cassette, sub-family A (ABC1), member 5
Synonyms: ABC13, B930033A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Slc7a13
Name: solute carrier family 7, (cationic amino acid transporter, y+ system) member 13
Synonyms: AGT-1, 0610009O04Rik, XAT2, AGT1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 74087
Homologene: 23656
Sftpc
Name: surfactant associated protein C
Synonyms: pro-SpC, Sftp2, Sftp-2, SP-C, SPC, Bricd6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 20389
VEGA: 14
Homologene: 2271
Dcbld2
Name: discoidin, CUB and LCCL domain containing 2
Synonyms: 1700055P21Rik, Esdn, CLCP1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 73379
Homologene: 12499
Alppl2
Name: alkaline phosphatase, placental-like 2
Synonyms: D1Ertd816e, Akp5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 11650
Homologene: 129600
Tafa5
Name: TAFA chemokine like family member 5
Synonyms: Tara-5, Fam19a5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 106014
VEGA: 15
Homologene: 22888
Sh3tc1
Name: SH3 domain and tetratricopeptide repeats 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 231147
Homologene: 10360
Galk2
Name: galactokinase 2
Synonyms: Gk2, 2810017M24Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 69976
HGNC: HGNC:4119
Homologene: 13654
Olfr507
Name: olfactory receptor 507
Synonyms: GA_x6K02T2PBJ9-10951546-10952496, MOR204-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 258738
Homologene: 27249
Sox1
Name: SRY (sex determining region Y)-box 1
Synonyms: Sox-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 20664
Homologene: 133765
Nod2
Name: nucleotide-binding oligomerization domain containing 2
Synonyms: Card15, F830032C23Rik, Nlrc2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 257632
HGNC: HGNC:5331
Homologene: 11156
Gad1-ps
Name: glutamate decarboxylase 1, pseudogene
Synonyms: Gad-1ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 382407
VEGA: 10
Tmem256
Name: transmembrane protein 256
Synonyms: 1810027O10Rik, 3110009M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 69186
Homologene: 45148
Tmigd1
Name: transmembrane and immunoglobulin domain containing 1
Synonyms: 2010002A20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 66601
Homologene: 41641
Stat5b
Name: signal transducer and activator of transcription 5B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 20851
Homologene: 55718
Cenpo
Name: centromere protein O
Synonyms: 8430427C03Rik, 2810429O05Rik, D12Ertd482e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 52504
Homologene: 49760
Adam21
Name: a disintegrin and metallopeptidase domain 21
Synonyms: ADAM31
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 56622
HGNC: HGNC:200
Homologene: 68365
Sult4a1
Name: sulfotransferase family 4A, member 1
Synonyms: BR-STL-1, Sultx3, 2400007A17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 29859
VEGA: 15
Homologene: 49378
H2-T10
Name: histocompatibility 2, T region locus 10
Synonyms: H-2T10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 15024
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 66,413,094 bp
  • T to C, chromosome 1 at 87,089,602 bp
  • A to G, chromosome 2 at 125,887,888 bp
  • T to C, chromosome 2 at 163,728,157 bp
  • T to G, chromosome 3 at 64,089,666 bp
  • T to G, chromosome 3 at 132,673,986 bp
  • C to A, chromosome 4 at 19,839,401 bp
  • G to T, chromosome 4 at 129,649,249 bp
  • T to G, chromosome 5 at 3,865,707 bp
  • T to G, chromosome 5 at 35,723,999 bp
  • A to T, chromosome 5 at 96,596,888 bp
  • A to T, chromosome 6 at 9,247,754 bp
  • A to C, chromosome 6 at 141,817,753 bp
  • T to C, chromosome 6 at 146,311,103 bp
  • G to A, chromosome 7 at 27,574,636 bp
  • T to C, chromosome 7 at 41,427,543 bp
  • C to T, chromosome 7 at 45,147,979 bp
  • G to A, chromosome 7 at 108,622,585 bp
  • A to T, chromosome 8 at 12,396,736 bp
  • G to A, chromosome 8 at 88,665,323 bp
  • A to G, chromosome 9 at 8,902,087 bp
  • A to G, chromosome 9 at 35,175,769 bp
  • A to G, chromosome 9 at 78,557,537 bp
  • A to G, chromosome 9 at 99,064,076 bp
  • A to T, chromosome 9 at 118,484,757 bp
  • C to A, chromosome 10 at 60,779,658 bp
  • T to A, chromosome 10 at 75,245,829 bp
  • T to G, chromosome 10 at 99,444,803 bp
  • A to G, chromosome 10 at 117,215,836 bp
  • T to A, chromosome 10 at 128,398,396 bp
  • A to T, chromosome 11 at 69,167,379 bp
  • T to A, chromosome 11 at 69,838,911 bp
  • A to G, chromosome 11 at 76,907,134 bp
  • T to C, chromosome 11 at 97,501,109 bp
  • T to C, chromosome 11 at 100,802,503 bp
  • A to G, chromosome 11 at 110,273,311 bp
  • A to G, chromosome 11 at 114,752,894 bp
  • T to G, chromosome 11 at 115,979,412 bp
  • A to T, chromosome 12 at 4,216,660 bp
  • A to T, chromosome 12 at 8,012,210 bp
  • C to T, chromosome 12 at 75,114,397 bp
  • C to A, chromosome 12 at 81,560,285 bp
  • T to A, chromosome 12 at 103,113,200 bp
  • T to C, chromosome 13 at 51,712,728 bp
  • C to T, chromosome 14 at 59,519,579 bp
  • T to A, chromosome 14 at 70,524,078 bp
  • T to A, chromosome 14 at 79,009,273 bp
  • A to G, chromosome 15 at 7,177,501 bp
  • T to G, chromosome 15 at 40,774,035 bp
  • A to G, chromosome 15 at 84,086,667 bp
  • T to A, chromosome 15 at 87,720,508 bp
  • A to G, chromosome 16 at 58,448,939 bp
  • T to A, chromosome 17 at 13,888,514 bp
  • G to A, chromosome 17 at 24,705,461 bp
  • A to G, chromosome 17 at 36,119,368 bp
  • T to A, chromosome 18 at 20,582,695 bp
  • A to G, chromosome 19 at 3,378,455 bp
  • G to A, chromosome 19 at 6,519,283 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0305 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038516-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.