Strain Name:
C57BL/6J-MtgxR0318Btlr/Mmmh
Stock Number:
038528-MU
Citation ID:
RRID:MMRRC_038528-MU
Other Names:
R0318 (G1), C57BL/6J-MtgxR0318Btlr
Major Collection:

Strain Information

Acadl
Name: acyl-Coenzyme A dehydrogenase, long-chain
Synonyms: LCAD, C79855
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11363
HGNC: HGNC:88
Homologene: 37498
Frrs1
Name: ferric-chelate reductase 1
Synonyms: Sdfr2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20321
Homologene: 40653
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Add1
Name: adducin 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11518
HGNC: HGNC:243
Homologene: 22758
Ddx50
Name: DExD box helicase 50
Synonyms: GU2, RH-II/Gubeta, 4933429B04Rik, 8430408E17Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 94213
VEGA: 10
Homologene: 56986
Usp19
Name: ubiquitin specific peptidase 19
Synonyms: 8430421I07Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71472
Homologene: 41730
Coro7
Name: coronin 7
Synonyms: 0610011B16Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78885
Homologene: 11573
Chaf1a
Name: chromatin assembly factor 1, subunit A
Synonyms: CAF-1, p150
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 27221
VEGA: 17
HGNC: HGNC:1910
Homologene: 4003
Polr1a
Name: polymerase (RNA) I polypeptide A
Synonyms: mRPA1, RPA194, 194kDa, 3010014K16Rik, Rpo1-4, 2900087K15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 20019
Homologene: 7033
Snapc1
Name: small nuclear RNA activating complex, polypeptide 1
Synonyms: 2700033G17Rik, 9630050P21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 75627
VEGA: 12
Homologene: 2317
Marf1
Name: meiosis regulator and mRNA stability 1
Synonyms: 4921513D23Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223989
VEGA: 16
Homologene: 40967
Fam83h
Name: family with sequence similarity 83, member H
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105732
VEGA: 15
Homologene: 15890
Psmd9
Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Synonyms: P27, 1500011J20Rik, Bridge-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67151
HGNC: HGNC:9567
Homologene: 2106
Got2
Name: glutamatic-oxaloacetic transaminase 2, mitochondrial
Synonyms: mAspAT, mitochondrial aspartate aminotransferase, FABP-pm, plasma membrane fatty acid binding protein, Kyat4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14719
HGNC: HGNC:4433
Homologene: 1572
Dnmt3l
Name: DNA methyltransferase 3-like
Synonyms: D6Ertd14e, ecat7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54427
HGNC: HGNC:2980
Homologene: 8362
C3
Name: complement component 3
Synonyms: complement factor 3, acylation stimulating protein, Plp
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 12266
HGNC: HGNC:1318
Homologene: 68031
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Dnpep
Name: aspartyl aminopeptidase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13437
HGNC: HGNC:2981
Homologene: 6110
Tbc1d10b
Name: TBC1 domain family, member 10b
Synonyms: 1110003P22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68449
Homologene: 9177
Zfyve26
Name: zinc finger, FYVE domain containing 26
Synonyms: 9330197E15Rik, LOC380767, A630028O16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 211978
VEGA: 12
Homologene: 9102
Nptx1
Name: neuronal pentraxin 1
Synonyms: Np1, D11Bwg1004e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18164
HGNC: HGNC:7952
Homologene: 1891
Colec12
Name: collectin sub-family member 12
Synonyms: SRCL, CL-P1, Scara4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 140792
VEGA: 18
Homologene: 34248
Ttll5
Name: tubulin tyrosine ligase-like family, member 5
Synonyms: 4930556H18Rik, 2310009M18Rik, 1700048H13Rik, D630041K24Rik, STAMP
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320244
Homologene: 9013
Htr7
Name: 5-hydroxytryptamine (serotonin) receptor 7
Synonyms: 5-HT7
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 15566
HGNC: HGNC:5302
Homologene: 20244
Gpr152
Name: G protein-coupled receptor 152
Synonyms: LOC269053, A930009H15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 269053
VEGA: 19
Homologene: 35474
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: 9330101J02Rik, Ttc40
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Maml2
Name: mastermind like transcriptional coactivator 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270118
Homologene: 134147
Tamm41
Name: TAM41 mitochondrial translocator assembly and maintenance homolog
Synonyms: 1500001M20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68971
Homologene: 13754
Srp72
Name: signal recognition particle 72
Synonyms: 72kDa, 5730576P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 66661
Homologene: 38254
Ces2a
Name: carboxylesterase 2A
Synonyms: 9130231C15Rik, Ces6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102022
HGNC: HGNC:1864
Homologene: 136396
Mapkapk2
Name: MAP kinase-activated protein kinase 2
Synonyms: MAPKAP kinase 2, Rps6kc1, MK2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17164
HGNC: HGNC:6887
Homologene: 56412
Irs1
Name: insulin receptor substrate 1
Synonyms: IRS-1, G972R
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16367
HGNC: HGNC:6125
Homologene: 4049
Dbn1
Name: drebrin 1
Synonyms: drebrin E2, drebrin A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56320
HGNC: HGNC:2695
Homologene: 3236
Csmd3
Name: CUB and Sushi multiple domains 3
Synonyms: 4930500N14Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239420
Homologene: 65982
Gucy2g
Name: guanylate cyclase 2g
Synonyms: 2410077I05Rik, GC-G
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 73707
Homologene: 44544
Xcr1
Name: chemokine (C motif) receptor 1
Synonyms: XCR1, GPR5, C motif-1/lymphotactin receptor, Ccxcr1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 23832
HGNC: HGNC:1625
Homologene: 21095
Slc17a3
Name: solute carrier family 17 (sodium phosphate), member 3
Synonyms: Npt4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105355
Homologene: 21319
Grm5
Name: glutamate receptor, metabotropic 5
Synonyms: mGluR5, Gprc1e, 6430542K11Rik, Glu5R
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 108071
HGNC: HGNC:4597
Homologene: 37354
Cps1
Name: carbamoyl-phosphate synthetase 1
Synonyms: CPS, CPSase I, 4732433M03Rik, D1Ucla3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227231
HGNC: HGNC:2323
Homologene: 68208
Or2z8
Name: olfactory receptor family 2 subfamily Z member 8
Synonyms: GA_x6K02T2NUPS-191522-192466, MOR282-1, Olfr372
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 404315
Homologene: 17287
Sipa1l2
Name: signal-induced proliferation-associated 1 like 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244668
Homologene: 18956
Irgc
Name: immunity related GTPase cinema
Synonyms: LOC210145, LOC381989, F630044M05Rik, Iigp5, Irgc1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210145
Homologene: 10486
Zfp286
Name: zinc finger protein 286
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192651
Homologene: 56892
Blk
Name: B lymphoid kinase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12143
VEGA: 14
HGNC: HGNC:1057
Homologene: 1297
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20401
Homologene: 7534
Vmn1r230
Name: vomeronasal 1 receptor 230
Synonyms: V1re8
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 171231
Homologene: 136306
Fnip2
Name: folliculin interacting protein 2
Synonyms: D630023B12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329679
Homologene: 46417
9130401M01Rik
Name: RIKEN cDNA 9130401M01 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75758
Homologene: 12622
Veph1
Name: ventricular zone expressed PH domain-containing 1
Synonyms: Veph, 2810471M23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72789
Homologene: 11624
Ankrd23
Name: ankyrin repeat domain 23
Synonyms: MARP3, Darp, MARP3, 2310041C05Rik, 1110058D09Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 78321
Homologene: 14025
Fam163a
Name: family with sequence similarity 163, member A
Synonyms: A230106N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329274
Homologene: 18306
Fcna
Name: ficolin A
Synonyms: ficolin A, Fcn1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14133
Homologene: 117949
Or5ak25
Name: olfactory receptor family 5 subfamily AK member 25
Synonyms: GA_x6K02T2Q125-46915844-46914897, MOR203-3, Olfr995
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258426
Homologene: 105170
Slc25a24
Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
Synonyms: 2610016M12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229731
Homologene: 92693
Thoc2l
Name: THO complex subunit 2-like
Synonyms: Gm3179, BC005561
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100042165
Or10ah1-ps1
Name: olfactory receptor family 10 subfamily AH member 1, pseudogene 1
Synonyms: GA_x6K02T2PH54-2346206-2347174, MOR0-10P, Olfr718-ps1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 258006
Tas2r122
Name: taste receptor, type 2, member 122
Synonyms: Tas2r22, mGR22, T2R22
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 630845
Homologene: 105455
Smg9
Name: SMG9 nonsense mediated mRNA decay factor
Synonyms: N28092, 1500002O20Rik, smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71997
Homologene: 10426
Timd4
Name: T cell immunoglobulin and mucin domain containing 4
Synonyms: B430010N18Rik, Tim4, TIM-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276891
Homologene: 51381
Stc1
Name: stanniocalcin 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20855
VEGA: 14
Homologene: 2374
Cerk
Name: ceramide kinase
Synonyms: D330016D08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223753
Homologene: 11247
Fpr-rs3
Name: formyl peptide receptor, related sequence 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14290
HGNC: HGNC:3827
Homologene: 130087
Pcgf5
Name: polycomb group ring finger 5
Synonyms: 5830443C21Rik, 9530023M17Rik, 1110054A01Rik, 0610009F02Rik, 5830406C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76073
VEGA: 19
Homologene: 12632
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 36,534,072 bp
  • A to T, chromosome 1 at 66,831,532 bp
  • T to A, chromosome 1 at 67,177,014 bp
  • A to G, chromosome 1 at 75,316,626 bp
  • A to T, chromosome 1 at 82,288,660 bp
  • A to G, chromosome 1 at 131,097,335 bp
  • A to G, chromosome 1 at 156,079,969 bp
  • A to G, chromosome 2 at 25,625,059 bp
  • C to A, chromosome 2 at 85,438,237 bp
  • G to T, chromosome 3 at 66,057,259 bp
  • A to T, chromosome 3 at 79,512,378 bp
  • A to G, chromosome 3 at 109,157,000 bp
  • A to G, chromosome 3 at 116,883,037 bp
  • T to C, chromosome 5 at 34,625,340 bp
  • C to T, chromosome 5 at 76,984,200 bp
  • T to C, chromosome 5 at 104,517,753 bp
  • C to A, chromosome 5 at 123,234,649 bp
  • A to T, chromosome 5 at 143,137,597 bp
  • T to C, chromosome 6 at 71,917,864 bp
  • G to A, chromosome 6 at 115,012,148 bp
  • T to C, chromosome 6 at 132,711,832 bp
  • T to C, chromosome 7 at 24,420,888 bp
  • T to C, chromosome 7 at 24,432,471 bp
  • A to T, chromosome 7 at 87,602,967 bp
  • A to G, chromosome 7 at 127,199,034 bp
  • T to C, chromosome 7 at 139,654,566 bp
  • C to T, chromosome 8 at 72,058,400 bp
  • A to G, chromosome 8 at 95,872,009 bp
  • G to A, chromosome 8 at 104,740,824 bp
  • G to A, chromosome 8 at 125,447,697 bp
  • C to T, chromosome 9 at 13,620,594 bp
  • T to A, chromosome 9 at 42,081,954 bp
  • A to T, chromosome 9 at 53,519,979 bp
  • T to C, chromosome 9 at 108,496,243 bp
  • A to G, chromosome 9 at 123,856,154 bp
  • A to T, chromosome 10 at 62,642,837 bp
  • G to A, chromosome 10 at 78,055,055 bp
  • T to A, chromosome 11 at 46,837,071 bp
  • T to C, chromosome 11 at 62,784,962 bp
  • C to T, chromosome 11 at 119,542,541 bp
  • C to T, chromosome 12 at 73,975,032 bp
  • C to T, chromosome 12 at 79,276,281 bp
  • T to G, chromosome 12 at 85,876,594 bp
  • C to T, chromosome 13 at 23,855,858 bp
  • C to T, chromosome 13 at 55,474,916 bp
  • A to G, chromosome 14 at 63,374,197 bp
  • A to T, chromosome 14 at 69,038,418 bp
  • A to T, chromosome 15 at 47,659,153 bp
  • A to T, chromosome 15 at 58,028,974 bp
  • A to G, chromosome 15 at 76,003,629 bp
  • A to G, chromosome 15 at 78,911,707 bp
  • C to T, chromosome 15 at 86,151,565 bp
  • T to A, chromosome 16 at 4,675,807 bp
  • C to T, chromosome 16 at 14,142,534 bp
  • T to C, chromosome 17 at 20,624,148 bp
  • T to C, chromosome 17 at 20,846,816 bp
  • C to T, chromosome 17 at 56,062,227 bp
  • C to T, chromosome 17 at 57,224,709 bp
  • A to G, chromosome 18 at 9,848,446 bp
  • T to C, chromosome 19 at 4,143,542 bp
  • C to T, chromosome 19 at 35,969,486 bp
  • A to T, chromosome 19 at 36,412,190 bp
  • A to G, chromosome 19 at 55,237,798 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0318 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038528-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.