Strain Name:
C57BL/6J-MtgxR0350Btlr/Mmmh
Stock Number:
038557-MU
Citation ID:
RRID:MMRRC_038557-MU
Other Names:
R0350 (G1), C57BL/6J-MtgxR0350Btlr
Major Collection:

Gene Information

Sox9
Name: SRY (sex determining region Y)-box 9
Synonyms: 2010306G03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 20682
Homologene: 294
Pnn
Name: pinin
Synonyms: D12Ertd512e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 18949
VEGA: 12
HGNC: HGNC:9162
Homologene: 37656
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66875
Homologene: 32355
Cdca2
Name: cell division cycle associated 2
Synonyms: 2610311M19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 108912
Homologene: 18444
Cog4
Name: component of oligomeric golgi complex 4
Synonyms: D8Ertd515e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 102339
Homologene: 7155
St7l
Name: suppression of tumorigenicity 7-like
Synonyms: St7r
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 229681
Homologene: 14910
Exd1
Name: exonuclease 3'-5' domain containing 1
Synonyms: 4932702D22Rik, Exdl1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 241624
Homologene: 17627
Nuf2
Name: NUF2, NDC80 kinetochore complex component
Synonyms: Nuf2R, Cdca1, 2410003C07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 66977
Homologene: 40205
Hsf1
Name: heat shock factor 1
Synonyms: heat shock transcription factor 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 15499
VEGA: 15
HGNC: HGNC:5224
Homologene: 74556
Taf1b
Name: TATA-box binding protein associated factor, RNA polymerase I, B
Synonyms: A230108M10Rik, mTAFI68, p63, 4930408G01Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
NCBI: 21340
VEGA: 12
Homologene: 31331
Zfp318
Name: zinc finger protein 318
Synonyms: TZF, 2610034E08Rik, D530032D06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
NCBI: 57908
Homologene: 22808
Ppp1r15a
Name: protein phosphatase 1, regulatory subunit 15A
Synonyms: Myd116, Gadd34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 17872
Homologene: 8639
Ckmt1
Name: creatine kinase, mitochondrial 1, ubiquitous
Synonyms: mi-CK, UbCKmit, Mt-CK
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 12716
Homologene: 69058
Uba6
Name: ubiquitin-like modifier activating enzyme 6
Synonyms: Ube1l2, 5730469D23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 231380
Homologene: 10080
BC052040
Name: cDNA sequence BC052040
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 399568
Homologene: 32780
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Sema6a
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
Synonyms: Semaq, VIa, sema, Sema6A-1, A730020P05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 20358
Homologene: 32426
Rbm19
Name: RNA binding motif protein 19
Synonyms: 1200009A02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 74111
Homologene: 7158
Nmd3
Name: NMD3 ribosome export adaptor
Synonyms: C87860
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 97112
Homologene: 6127
Aldh1a1
Name: aldehyde dehydrogenase family 1, subfamily A1
Synonyms: Raldh1, Ahd-2, Ahd2, E1, ALDH1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 11668
HGNC: HGNC:402
Homologene: 110441
Slc39a5
Name: solute carrier family 39 (metal ion transporter), member 5
Synonyms: 1810013D05Rik, Zip5, 2010205A06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 72002
VEGA: 10
Homologene: 57083
Trpm6
Name: transient receptor potential cation channel, subfamily M, member 6
Synonyms: CHAK2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
NCBI: 225997
VEGA: 19
Homologene: 9767
Iqch
Name: IQ motif containing H
Synonyms: 4921504K03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 78250
Homologene: 11258
Gm11639
Name: predicted gene 11639
Synonyms: Efcab15, Gm11639
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 105242472
Xpr1
Name: xenotropic and polytropic retrovirus receptor 1
Synonyms: Rmc-1, suppressor of yeast Ga deletion, Syg1, Rmc1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 19775
Homologene: 134226
Rubcnl
Name: RUN and cysteine rich domain containing beclin 1 interacting protein like
Synonyms: LOC380917, 5031414D18Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 271221
VEGA: 14
Homologene: 57021
Csf1
Name: colony stimulating factor 1 (macrophage)
Synonyms: Csfm, CSF-1, M-CSF, colony-stimulating factor-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12977
HGNC: HGNC:2432
Homologene: 7282
Rsc1a1
Name: regulatory solute carrier protein, family 1, member 1
Synonyms: RS1, mRS1, OTTMUSG00000010365
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 69994
Homologene: 130554
Mtpap
Name: mitochondrial poly(A) polymerase
Synonyms: 0610027A18Rik, Papd1, Tent6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 67440
VEGA: 18
Homologene: 10008
Vmn1r195
Name: vomeronasal 1 receptor 195
Synonyms: V1ri6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
NCBI: 171257
Homologene: 110880
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 223658
Homologene: 44882
Itgal
Name: integrin alpha L
Synonyms: Ly-21, Cd11a, LFA-1, Ly-15
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 16408
HGNC: HGNC:6148
Homologene: 1666
Olfr870
Name: olfactory receptor 870
Synonyms: GA_x6K02T2PVTD-13912679-13911744, MOR141-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 57251
Homologene: 138319
Igfn1
Name: immunoglobulin-like and fibronectin type III domain containing 1
Synonyms: 9830123M21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 226438
Homologene: 130054
Prss37
Name: protease, serine 37
Synonyms: 1700016G05Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 67690
Homologene: 12174
Usp43
Name: ubiquitin specific peptidase 43
Synonyms: C630032K07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 216835
Homologene: 129879
Abhd13
Name: abhydrolase domain containing 13
Synonyms: 1110065L07Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68904
Homologene: 6716
Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Synonyms: LXR alpha, Unr1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 22259
HGNC: HGNC:7966
Homologene: 21165
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: OATP4C1, OATP-M1, OATP-H, C330017E21Rik, SLC21A20, PRO2176
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 227394
Homologene: 62654
Olfr1218
Name: olfactory receptor 1218
Synonyms: GA_x6K02T2Q125-50536041-50535106, MOR233-12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258815
Homologene: 73986
Olfr1272
Name: olfactory receptor 1272
Synonyms: MOR227-3, GA_x6K02T2Q125-51636504-51635578
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258982
HGNC: HGNC:8290
Homologene: 133649
Slc35c1
Name: solute carrier family 35, member C1
Synonyms: FUCT1, E430007K15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 228368
Homologene: 41258
Zfp937
Name: zinc finger protein 937
Synonyms: Gm4979
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 245174
Homologene: 136215
Cd1d1
Name: CD1d1 antigen
Synonyms: Cd1d, CD1.1, Ly-38, Cd1a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12479
HGNC: HGNC:1637
Homologene: 1337
Ppm1j
Name: protein phosphatase 1J
Synonyms: PP2Czeta, Ppp2cz, 2310008J22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 71887
Homologene: 23632
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: Gm1661, LOC381544, LOC381543, Ncrna00082
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 381544
Homologene: 28727
Mrps17
Name: mitochondrial ribosomal protein S17
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
NCBI: 66258
Homologene: 9320
Dhcr7
Name: 7-dehydrocholesterol reductase
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13360
HGNC: HGNC:2860
Homologene: 1042
Ccdc130
Name: coiled-coil domain containing 130
Synonyms: 4930527D15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 67736
Homologene: 12183
Nkd1
Name: naked cuticle 1
Synonyms: 2810434J10Rik, 9030215G15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 93960
Homologene: 12343
Apol6
Name: apolipoprotein L 6
Synonyms: 2310076O14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
NCBI: 71939
Homologene: 49940
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 96,828,849 bp
  • G to A, chromosome 1 at 135,956,767 bp
  • A to T, chromosome 1 at 151,388,783 bp
  • A to T, chromosome 1 at 155,330,468 bp
  • T to A, chromosome 1 at 169,513,543 bp
  • T to A, chromosome 2 at 89,055,356 bp
  • T to C, chromosome 2 at 90,282,582 bp
  • G to A, chromosome 2 at 91,191,825 bp
  • A to G, chromosome 2 at 92,459,032 bp
  • T to C, chromosome 2 at 115,776,930 bp
  • T to C, chromosome 2 at 119,523,566 bp
  • T to A, chromosome 2 at 121,361,242 bp
  • T to A, chromosome 2 at 150,239,302 bp
  • A to G, chromosome 3 at 69,743,574 bp
  • A to T, chromosome 3 at 86,997,573 bp
  • A to G, chromosome 3 at 104,783,371 bp
  • T to C, chromosome 3 at 104,919,507 bp
  • T to C, chromosome 3 at 107,748,606 bp
  • C to A, chromosome 4 at 117,215,556 bp
  • G to A, chromosome 4 at 141,685,523 bp
  • A to C, chromosome 5 at 86,144,378 bp
  • T to C, chromosome 5 at 120,128,307 bp
  • A to G, chromosome 5 at 129,718,145 bp
  • T to C, chromosome 6 at 40,514,959 bp
  • A to T, chromosome 7 at 45,523,018 bp
  • T to A, chromosome 7 at 127,322,081 bp
  • A to G, chromosome 7 at 143,837,770 bp
  • T to A, chromosome 8 at 9,987,600 bp
  • C to T, chromosome 8 at 84,260,648 bp
  • T to A, chromosome 8 at 88,585,216 bp
  • T to A, chromosome 8 at 110,853,696 bp
  • A to T, chromosome 9 at 20,170,736 bp
  • T to C, chromosome 9 at 63,500,876 bp
  • C to T, chromosome 10 at 128,396,750 bp
  • T to C, chromosome 11 at 60,721,857 bp
  • T to C, chromosome 11 at 67,876,498 bp
  • T to C, chromosome 11 at 104,690,880 bp
  • A to G, chromosome 11 at 112,784,876 bp
  • A to G, chromosome 12 at 24,514,885 bp
  • T to C, chromosome 12 at 59,067,117 bp
  • A to G, chromosome 13 at 22,279,233 bp
  • A to G, chromosome 14 at 67,713,119 bp
  • G to T, chromosome 14 at 75,040,891 bp
  • T to A, chromosome 15 at 76,432,249 bp
  • A to G, chromosome 15 at 76,500,479 bp
  • C to T, chromosome 15 at 77,050,947 bp
  • T to A, chromosome 17 at 46,413,198 bp
  • A to G, chromosome 18 at 4,396,195 bp
  • G to T, chromosome 18 at 47,270,718 bp
  • T to C, chromosome 19 at 18,883,957 bp
  • T to C, chromosome 19 at 20,629,049 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0350 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038557-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.