Strain Name:
C57BL/6J-MtgxR0392Btlr/Mmmh
Stock Number:
038598-MU
Citation ID:
RRID:MMRRC_038598-MU
Other Names:
R0392 (G1), C57BL/6J-MtgxR0392Btlr
Major Collection:

Gene Information

Epha4
Name: Eph receptor A4
Synonyms: Sek, Sek1, Tyro1, Hek8, Cek8, 2900005C20Rik, rb
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 13838
HGNC: HGNC:3388
Homologene: 20933
Map4
Name: microtubule-associated protein 4
Synonyms: MAP 4, Mtap4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 17758
HGNC: HGNC:6862
Homologene: 1780
Pcnt
Name: pericentrin (kendrin)
Synonyms: Pcnt2, m275Asp, m239Asp
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 18541
VEGA: 10
Rsf1
Name: remodeling and spacing factor 1
Synonyms: p325, XAP8, Hbxap, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 233532
Homologene: 41142
Ddx39a
Name: DEAD box helicase 39a
Synonyms: 2610307C23Rik, BAT1, Ddx39
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
NCBI: 68278
Homologene: 68487
Slitrk5
Name: SLIT and NTRK-like family, member 5
Synonyms: 2610019D03Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 75409
VEGA: 14
Homologene: 9193
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: LOC381341, Dnahc7, Dnahc7a
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
NCBI: 627872
Homologene: 41287
Casp12
Name: caspase 12
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 12364
Homologene: 7654
Lamp5
Name: lysosomal-associated membrane protein family, member 5
Synonyms: 3110035N03Rik, BAD-LAMP, 6330527O06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 76161
Homologene: 8173
Bcan
Name: brevican
Synonyms: Cspg7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12032
Homologene: 7244
St8sia5
Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
Synonyms: ST8SiaV, Siat8e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 225742
Homologene: 8331
Pafah1b2
Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 2
Synonyms: mus[b], Pafahb, PAF-AH 30
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 18475
VEGA: 9
HGNC: HGNC:8575
Homologene: 1932
Dcbld1
Name: discoidin, CUB and LCCL domain containing 1
Synonyms: 4631413K11Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
NCBI: 66686
Homologene: 12010
Cyp2j7
Name: cytochrome P450, family 2, subfamily j, polypeptide 7
Synonyms: OTTMUSG00000007941, Cyp2j7-ps
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
NCBI: 546837
Cyp2b13
Name: cytochrome P450, family 2, subfamily b, polypeptide 13
Synonyms: phenobarbital inducible, type c
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 13089
Homologene: 74933
Otog
Name: otogelin
Synonyms: Otgn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 18419
HGNC: HGNC:8516
Homologene: 8421
Ccdc61
Name: coiled-coil domain containing 61
Synonyms: LOC232933, C530028I08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 232933
Homologene: 19256
Pold2
Name: polymerase (DNA directed), delta 2, regulatory subunit
Synonyms: p50, po1D2, 50kDa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 18972
HGNC: HGNC:9176
Homologene: 4538
Cd53
Name: CD53 antigen
Synonyms: Ox-44, Tspan25
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
NCBI: 12508
HGNC: HGNC:1686
Homologene: 20152
Olfr1025-ps1
Name: olfactory receptor 1025, pseudogene 1
Synonyms: GA_x6K02T2Q125-47397266-47398205, MOR196-6_p, MOR196-5P
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 258083
Pcdhb12
Name: protocadherin beta 12
Synonyms: Pcdhb5F, PcdhbL, Pcdh3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 18
NCBI: 93883
Homologene: 87126
4930527J03Rik
Name: RIKEN cDNA 4930527J03 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Emilin3
Name: elastin microfibril interfacer 3
Synonyms: Emilin5, 1110013O17Rik, EMILIN-T
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
NCBI: 280635
Homologene: 18817
Dgki
Name: diacylglycerol kinase, iota
Synonyms: C130010K08Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
NCBI: 320127
HGNC: HGNC:2855
Homologene: 37956
Sult2b1
Name: sulfotransferase family, cytosolic, 2B, member 1
Synonyms: SULT2B, Gm5897
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
NCBI: 54200
Homologene: 49487
S1pr5
Name: sphingosine-1-phosphate receptor 5
Synonyms: lpB4, S1P5, Edg8
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 94226
Homologene: 11031
Rtp3
Name: receptor transporter protein 3
Synonyms: Tmem7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
NCBI: 235636
Homologene: 135957
Slc47a1
Name: solute carrier family 47, member 1
Synonyms: 1300013J15Rik, MATE1, mMATE1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
NCBI: 67473
Homologene: 34364
AC073561.4
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Ift88
Name: intraflagellar transport 88
Synonyms: Tg737, Oak Ridge polycystic kidneys, polaris, orpk, fxo, IFT88, TgN737Rpw, Tg737Rpw, Ttc10
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
NCBI: 21821
Homologene: 4761
4930451G09Rik
Name: RIKEN cDNA 4930451G09 gene
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 74684
VEGA: 16
Mir99ahg
Name: Mir99a and Mirlet7c-1 host gene (non-protein coding)
Synonyms: 2810055G20Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
NCBI: 77994
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 53,504,198 bp
  • T to C, chromosome 1 at 77,506,973 bp
  • ACCC to ACC, chromosome 1 at 178,276,503 bp
  • T to A, chromosome 2 at 85,918,762 bp
  • T to C, chromosome 2 at 136,060,897 bp
  • A to G, chromosome 2 at 160,910,879 bp
  • T to A, chromosome 3 at 87,993,562 bp
  • A to T, chromosome 3 at 106,763,276 bp
  • T to C, chromosome 4 at 96,199,434 bp
  • T to A, chromosome 6 at 37,000,178 bp
  • T to C, chromosome 7 at 18,891,102 bp
  • T to C, chromosome 7 at 26,085,883 bp
  • G to T, chromosome 7 at 45,733,638 bp
  • T to C, chromosome 7 at 46,250,075 bp
  • T to A, chromosome 7 at 97,679,005 bp
  • T to G, chromosome 8 at 83,721,737 bp
  • T to A, chromosome 9 at 5,348,973 bp
  • T to A, chromosome 9 at 21,244,981 bp
  • T to C, chromosome 9 at 45,968,853 bp
  • T to C, chromosome 9 at 110,078,045 bp
  • A to T, chromosome 9 at 110,989,553 bp
  • T to C, chromosome 10 at 52,317,134 bp
  • T to C, chromosome 10 at 76,384,826 bp
  • T to C, chromosome 11 at 5,876,776 bp
  • A to G, chromosome 11 at 61,371,782 bp
  • A to G, chromosome 12 at 114,523,840 bp
  • A to T, chromosome 14 at 57,496,160 bp
  • G to A, chromosome 14 at 111,679,033 bp
  • T to C, chromosome 16 at 4,977,499 bp
  • T to A, chromosome 16 at 77,597,166 bp
  • A to G, chromosome 18 at 37,436,958 bp
  • G to A, chromosome 18 at 77,254,406 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0392 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038598-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.