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Strain Name:
C57BL/6J-MtgxR0610Btlr/Mmmh
Stock Number:
038799-MU
Citation ID:
RRID:MMRRC_038799-MU
Other Names:
R0610 (G1), C57BL/6J-MtgxR0610Btlr
Major Collection:

Strain Information

Pdpk1
Name: 3-phosphoinositide dependent protein kinase 1
Synonyms: Pkb kinase, Pdk1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18607
Homologene: 37643
Oxtr
Name: oxytocin receptor
Synonyms: OTR
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 18430
HGNC: HGNC:8529
Homologene: 20255
Igf2bp2
Name: insulin-like growth factor 2 mRNA binding protein 2
Synonyms: IMP-2, C330012H03Rik, IMP2
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 319765
Homologene: 4774
Adgrl3
Name: adhesion G protein-coupled receptor L3
Synonyms: lectomedin 3, LEC3, D130075K09Rik, 5430402I23Rik, Lphn3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 319387
Homologene: 22878
Suco
Name: SUN domain containing ossification factor
Synonyms: osteopotentia, Opt, AI848100
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226551
HGNC: HGNC:1240
Homologene: 32212
Snx6
Name: sorting nexin 6
Synonyms: 2610032J07Rik, 2010006G21Rik, 2810425K19Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 72183
VEGA: 12
Homologene: 12304
Hmmr
Name: hyaluronan mediated motility receptor (RHAMM)
Synonyms: CD168, Rhamm
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15366
HGNC: HGNC:5012
Homologene: 8271
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,165,506 bp
  • C to A, chromosome 1 at 90,142,731 bp
  • A to G, chromosome 1 at 123,352,699 bp
  • G to A, chromosome 1 at 139,701,846 bp
  • T to G, chromosome 1 at 161,859,503 bp
  • A to G, chromosome 1 at 161,864,032 bp
  • T to A, chromosome 1 at 191,822,515 bp
  • T to C, chromosome 1 at 191,909,424 bp
  • T to A, chromosome 2 at 36,907,659 bp
  • C to T, chromosome 2 at 37,584,077 bp
  • C to A, chromosome 2 at 74,655,987 bp
  • T to A, chromosome 2 at 118,792,236 bp
  • G to A, chromosome 2 at 119,382,960 bp
  • T to A, chromosome 2 at 158,632,456 bp
  • A to G, chromosome 2 at 178,449,898 bp
  • A to C, chromosome 3 at 40,779,400 bp
  • T to C, chromosome 3 at 108,204,774 bp
  • T to G, chromosome 4 at 4,016,116 bp
  • T to A, chromosome 4 at 43,706,400 bp
  • C to A, chromosome 4 at 48,051,903 bp
  • A to G, chromosome 4 at 108,204,857 bp
  • T to A, chromosome 5 at 38,379,942 bp
  • A to G, chromosome 5 at 48,275,674 bp
  • T to C, chromosome 5 at 81,693,716 bp
  • G to A, chromosome 5 at 86,707,347 bp
  • A to G, chromosome 5 at 104,310,134 bp
  • T to A, chromosome 6 at 29,326,577 bp
  • G to T, chromosome 6 at 34,504,349 bp
  • A to G, chromosome 6 at 66,716,420 bp
  • C to T, chromosome 6 at 112,477,177 bp
  • A to G, chromosome 6 at 141,918,461 bp
  • A to T, chromosome 6 at 143,833,439 bp
  • T to A, chromosome 7 at 5,803,064 bp
  • G to T, chromosome 7 at 13,025,784 bp
  • C to T, chromosome 7 at 27,989,394 bp
  • C to A, chromosome 7 at 28,186,634 bp
  • A to T, chromosome 7 at 29,190,619 bp
  • A to T, chromosome 7 at 40,993,056 bp
  • A to T, chromosome 7 at 90,380,853 bp
  • A to T, chromosome 7 at 104,154,445 bp
  • T to A, chromosome 7 at 109,981,083 bp
  • T to A, chromosome 7 at 109,981,085 bp
  • A to G, chromosome 7 at 120,365,786 bp
  • A to G, chromosome 7 at 126,580,189 bp
  • G to A, chromosome 8 at 10,031,661 bp
  • G to A, chromosome 8 at 15,918,208 bp
  • A to G, chromosome 8 at 125,839,687 bp
  • T to C, chromosome 8 at 128,502,618 bp
  • A to C, chromosome 9 at 15,322,754 bp
  • A to G, chromosome 9 at 39,469,823 bp
  • A to G, chromosome 9 at 77,472,206 bp
  • A to T, chromosome 9 at 79,707,848 bp
  • A to T, chromosome 9 at 83,399,739 bp
  • T to C, chromosome 9 at 107,023,788 bp
  • T to C, chromosome 9 at 122,852,981 bp
  • G to T, chromosome 10 at 33,474,453 bp
  • A to G, chromosome 10 at 83,283,728 bp
  • A to T, chromosome 10 at 89,576,626 bp
  • A to G, chromosome 10 at 117,237,730 bp
  • G to T, chromosome 11 at 40,715,902 bp
  • A to C, chromosome 11 at 49,863,573 bp
  • G to T, chromosome 11 at 75,185,957 bp
  • T to C, chromosome 11 at 110,301,527 bp
  • A to C, chromosome 12 at 16,696,442 bp
  • T to A, chromosome 12 at 26,478,056 bp
  • T to C, chromosome 12 at 51,610,448 bp
  • T to C, chromosome 12 at 54,751,789 bp
  • T to A, chromosome 12 at 108,319,402 bp
  • T to C, chromosome 12 at 113,271,743 bp
  • T to A, chromosome 13 at 3,838,320 bp
  • T to A, chromosome 13 at 11,622,952 bp
  • A to G, chromosome 13 at 21,495,663 bp
  • C to T, chromosome 13 at 23,855,858 bp
  • A to C, chromosome 14 at 59,417,470 bp
  • G to A, chromosome 14 at 63,986,265 bp
  • A to G, chromosome 14 at 66,637,792 bp
  • G to A, chromosome 15 at 77,389,254 bp
  • A to T, chromosome 15 at 91,815,416 bp
  • C to T, chromosome 15 at 95,624,897 bp
  • C to A, chromosome 15 at 99,698,899 bp
  • C to T, chromosome 16 at 14,142,534 bp
  • T to C, chromosome 16 at 18,472,882 bp
  • A to G, chromosome 16 at 22,070,309 bp
  • T to A, chromosome 16 at 23,000,594 bp
  • T to C, chromosome 16 at 46,153,901 bp
  • C to T, chromosome 16 at 91,583,286 bp
  • T to A, chromosome 17 at 23,387,312 bp
  • T to C, chromosome 17 at 23,475,514 bp
  • T to C, chromosome 17 at 24,098,171 bp
  • C to T, chromosome 17 at 25,035,803 bp
  • C to A, chromosome 17 at 88,635,281 bp
  • A to G, chromosome 18 at 20,837,188 bp
  • G to T, chromosome 19 at 9,007,878 bp
  • A to G, chromosome 19 at 10,271,558 bp
  • T to A, chromosome 19 at 26,691,391 bp
  • T to A, chromosome 19 at 46,654,670 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0610 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038799-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.