Strain Name:
C57BL/6J-MtgxR0684Btlr/Mmmh
Stock Number:
038869-MU
Citation ID:
RRID:MMRRC_038869-MU
Other Names:
R0684 (G1), C57BL/6J-MtgxR0684Btlr
Major Collection:

Gene Information

Hps5
Name: HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
Synonyms: Hermansky-Pudlak syndrome 5, ruby eye 2, ru-2, ru2
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 246694
Homologene: 35333
Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Ptprk
Name: protein tyrosine phosphatase, receptor type, K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Pigf
Name: phosphatidylinositol glycan anchor biosynthesis, class F
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 18701
HGNC: HGNC:8962
Homologene: 31103
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, A130069E23Rik, 4933425K22Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 81702
Homologene: 82403
Zfp609
Name: zinc finger protein 609
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 214812
Homologene: 72220
Kat6b
Name: K(lysine) acetyltransferase 6B
Synonyms: Myst4, Morf, B130044K16Rik, monocytic leukemia, qkf, querkopf
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 54169
Homologene: 136480
Copz1
Name: coatomer protein complex, subunit zeta 1
Synonyms: 5930435A22Rik, D4Ertd360e, nonclathrin coat protein zeta1-COP
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 56447
VEGA: 15
HGNC: HGNC:2243
Homologene: 9366
Mier1
Name: MEIR1 treanscription regulator
Synonyms: 4933425I22Rik, 5830411K19Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 4
Alteration at locus: Chemically Induced
NCBI: 71148
Homologene: 136176
Asxl1
Name: additional sex combs like 1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 228790
Homologene: 9098
Slc38a2
Name: solute carrier family 38, member 2
Synonyms: 5033402L14Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 67760
VEGA: 15
Homologene: 23132
Xdh
Name: xanthine dehydrogenase
Synonyms: xanthine oxidase, Xox-1, XO, Xox1, Xor
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 22436
VEGA: 17
Homologene: 324
Wdr12
Name: WD repeat domain 12
Synonyms: Ytm1, Ytm1p, 4933402C23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 57750
Homologene: 10098
Syt9
Name: synaptotagmin IX
Synonyms: Sytv
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 60510
Homologene: 11062
Clock
Name: circadian locomotor output cycles kaput
Synonyms: KAT13D, bHLHe8, 5330400M04Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Tsr1
Name: TSR1 20S rRNA accumulation
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 104662
Homologene: 5576
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 233410
Homologene: 8759
Muc15
Name: mucin 15
Synonyms: D730046L02Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 269328
Homologene: 51680
Ncoa2
Name: nuclear receptor coactivator 2
Synonyms: SRC-2, TIF-2, D1Ertd433e, TIF2, Grip1, bHLHe75, glucocorticoid receptor-interacting protein 1, KAT13C, TIF2/GRIP-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 1
Alteration at locus: Chemically Induced
NCBI: 17978
HGNC: HGNC:7669
Homologene: 4768
Midn
Name: midnolin
Synonyms: 3000003C15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 10
Alteration at locus: Chemically Induced
NCBI: 59090
Homologene: 32510
Rae1
Name: ribonucleic acid export 1
Synonyms: D2Ertd342e, MNRP41, MNRP, 41
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 66679
HGNC: HGNC:9828
Homologene: 2676
Efl1
Name: elongation factor like GTPase 1
Synonyms: Eftud1, 4932434J20Rik, 6030468D11Rik, D7Ertd791e
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 101592
Homologene: 11599
Bsph1
Name: binder of sperm protein homolog 1
Synonyms: LOC330470
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 330470
Homologene: 86818
Pate14
Name: prostate and testis expressed 14
Synonyms: Sslp-1, A630095E13Rik, LOC235973
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 235973
Emid1
Name: EMI domain containing 1
Synonyms: Emu1, CO-5
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 140703
Homologene: 135639
Chdh
Name: choline dehydrogenase
Synonyms: D630034H06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 218865
Homologene: 41261
Prpsap1
Name: phosphoribosyl pyrophosphate synthetase-associated protein 1
Synonyms: PAP39, 5730409F23Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 67763
HGNC: HGNC:9466
Homologene: 55687
Ermp1
Name: endoplasmic reticulum metallopeptidase 1
Synonyms: D19Wsu12e, D19Ertd410e, b2b2633Clo
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 226090
Homologene: 121891
Ecsit
Name: ECSIT signalling integrator
Synonyms: Sitpec
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 9
Alteration at locus: Chemically Induced
NCBI: 26940
Homologene: 8080
Sema3a
Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: sema III, Semad, collapsin-1, SemD, semaphorin III
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 5
Alteration at locus: Chemically Induced
NCBI: 20346
Homologene: 31358
Smgc
Name: submandibular gland protein C
Synonyms: Sfc21, DXImx49e, 2310010P21Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223809
Hsd17b3
Name: hydroxysteroid (17-beta) dehydrogenase 3
Synonyms: 17(beta)HSD type 3
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 13
Alteration at locus: Chemically Induced
NCBI: 15487
VEGA: 13
HGNC: HGNC:5212
Homologene: 20089
Cd96
Name: CD96 antigen
Synonyms: Tactile, 1700109I12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 16
Alteration at locus: Chemically Induced
NCBI: 84544
Homologene: 68489
Olfr136
Name: olfactory receptor 136
Synonyms: GA_x6K02T2PSCP-2779375-2780313, MOR256-7
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 258803
Homologene: 119758
Atp8a2
Name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Synonyms: agil, wl, Ib
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 14
Alteration at locus: Chemically Induced
NCBI: 50769
Homologene: 4443
Slc22a22
Name: solute carrier family 22 (organic cation transporter), member 22
Synonyms: BC026439, OAT-PG
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 210463
Homologene: 18166
Zfp955b
Name: zinc finger protein 955B
Synonyms: C430039G02Rik, Gm4455, A430003O12Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 17
Alteration at locus: Chemically Induced
NCBI: 100043468
VEGA: 17
Homologene: 104925
Atxn1l
Name: ataxin 1-like
Synonyms: ENSMUSG00000069895, C330011L24Rik, D8Ertd587e, Boat
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 8
Alteration at locus: Chemically Induced
NCBI: 52335
Homologene: 19471
Olfr667
Name: olfactory receptor 667
Synonyms: MOR34-11, MOR34-2, GA_x6K02T2PBJ9-7546146-7545166
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259062
Homologene: 121559
Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 19
Alteration at locus: Chemically Induced
NCBI: 13097
HGNC: HGNC:2622
Homologene: 117948
Olfr713
Name: olfactory receptor 713
Synonyms: P3, GA_x6K02T2PBJ9-9415724-9416677, MOR263-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 259036
Homologene: 17470
Adam4
Name: a disintegrin and metallopeptidase domain 4
Synonyms: tMDCV
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 12
Alteration at locus: Chemically Induced
NCBI: 11498
Homologene: 86950
Dhrs13
Name: dehydrogenase/reductase (SDR family) member 13
Synonyms: 2610209N15Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 70451
Homologene: 64807
Thnsl1
Name: threonine synthase-like 1 (bacterial)
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 2
Alteration at locus: Chemically Induced
NCBI: 208967
Homologene: 32609
Bdh2
Name: 3-hydroxybutyrate dehydrogenase, type 2
Synonyms: 1810026B04Rik, Dhrs6
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 3
Alteration at locus: Chemically Induced
NCBI: 69772
Homologene: 134268
Tgoln1
Name: trans-golgi network protein
Synonyms: TGN38, D6Ertd384e, Ttgn1, TGN38A
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 6
Alteration at locus: Chemically Induced
NCBI: 22134
Homologene: 137224
Zfp94
Name: zinc finger protein 94
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 22756
Homologene: 86846
Bcl2l12
Name: BCL2-like 12 (proline rich)
Synonyms: Bcl2-L12, 5430429M05Rik, Bcl-L12, 2810475P17Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 7
Alteration at locus: Chemically Induced
NCBI: 75736
Homologene: 12619
Adora2b
Name: adenosine A2b receptor
Synonyms: A2b, A2b, Rs, AA2BR, A2BR, A2BAR, ARA2B
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 11541
HGNC: HGNC:264
Homologene: 20167
Zfp3
Name: zinc finger protein 3
Synonyms: Zfp-3, Fnp-1
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 11
Alteration at locus: Chemically Induced
NCBI: 193043
Homologene: 27406
Cyp2d34
Name: cytochrome P450, family 2, subfamily d, polypeptide 34
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 223706
VEGA: 15
Homologene: 86099
Syce3
Name: synaptonemal complex central element protein 3
Synonyms: 1700007E06Rik
Type: Gene
Species: Mus musculus (mouse)
Chromosome: 15
Alteration at locus: Chemically Induced
NCBI: 75459
Homologene: 85810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 13,224,651 bp
  • C to T, chromosome 1 at 60,089,366 bp
  • A to T, chromosome 1 at 71,595,809 bp
  • A to G, chromosome 2 at 21,211,666 bp
  • A to G, chromosome 2 at 110,733,815 bp
  • G to A, chromosome 2 at 153,397,522 bp
  • G to A, chromosome 2 at 173,005,164 bp
  • A to G, chromosome 3 at 135,291,013 bp
  • A to G, chromosome 4 at 103,139,434 bp
  • G to A, chromosome 5 at 13,556,527 bp
  • A to G, chromosome 5 at 76,245,518 bp
  • T to C, chromosome 5 at 90,263,998 bp
  • A to C, chromosome 6 at 72,615,991 bp
  • T to A, chromosome 7 at 13,473,063 bp
  • A to T, chromosome 7 at 24,303,070 bp
  • T to A, chromosome 7 at 44,996,601 bp
  • A to G, chromosome 7 at 46,783,469 bp
  • A to G, chromosome 7 at 81,037,875 bp
  • A to G, chromosome 7 at 82,651,886 bp
  • T to A, chromosome 7 at 104,916,634 bp
  • A to T, chromosome 7 at 107,036,682 bp
  • T to A, chromosome 7 at 107,425,136 bp
  • A to T, chromosome 8 at 109,732,384 bp
  • T to C, chromosome 9 at 22,076,500 bp
  • C to T, chromosome 9 at 36,637,880 bp
  • T to A, chromosome 9 at 65,731,201 bp
  • G to T, chromosome 10 at 28,483,298 bp
  • A to G, chromosome 10 at 80,156,502 bp
  • T to C, chromosome 11 at 5,143,866 bp
  • C to T, chromosome 11 at 62,249,169 bp
  • T to A, chromosome 11 at 70,771,569 bp
  • T to A, chromosome 11 at 74,907,941 bp
  • G to T, chromosome 11 at 78,036,963 bp
  • A to T, chromosome 11 at 116,471,491 bp
  • A to T, chromosome 12 at 81,419,654 bp
  • T to C, chromosome 13 at 64,089,068 bp
  • T to C, chromosome 14 at 21,668,781 bp
  • T to C, chromosome 14 at 30,031,613 bp
  • T to C, chromosome 14 at 60,023,144 bp
  • T to C, chromosome 15 at 57,263,362 bp
  • A to T, chromosome 15 at 82,617,550 bp
  • A to G, chromosome 15 at 89,390,445 bp
  • A to G, chromosome 15 at 91,841,467 bp
  • A to T, chromosome 15 at 96,695,287 bp
  • A to G, chromosome 15 at 103,296,531 bp
  • T to C, chromosome 16 at 46,117,790 bp
  • A to G, chromosome 17 at 33,302,973 bp
  • A to G, chromosome 17 at 38,335,844 bp
  • T to A, chromosome 17 at 73,943,891 bp
  • A to T, chromosome 17 at 87,020,495 bp
  • A to G, chromosome 19 at 29,632,541 bp
  • T to C, chromosome 19 at 39,391,056 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0684 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu .
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $) Units Notes
038869-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter1; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality of this material. We have extensive experience with recovery of mice from cryopreserved sperm and embryos of varying quality, including using techniques such as IVF and ICSI, and are confident that we will have success in most, if not all, cases. However, because of the unknown quality of these frozen samples, we will restrict recovery efforts to two attempts for each order. Subsequent attempts can be performed on a fee-for-service basis, in addition to the standard fees, upon request.

1 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

3 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.