Strain Name:
C57BL/6J-MtgxR0737Btlr/Mmmh
Stock Number:
038918-MU
Citation ID:
RRID:MMRRC_038918-MU
Other Names:
R0737 (G1), C57BL/6J-MtgxR0737Btlr
Major Collection:

Strain Information

Txndc2
Name: thioredoxin domain containing 2 (spermatozoa)
Synonyms: Sptrx-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213272
VEGA: 17
Homologene: 41856
Bahcc1
Name: BAH domain and coiled-coil containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268515
Homologene: 129585
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Ankrd11
Name: ankyrin repeat domain 11
Synonyms: 9530048I21Rik, Yod, 3010027A04Rik, 2410104C19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 77087
Homologene: 69134
Baz2a
Name: bromodomain adjacent to zinc finger domain, 2A
Synonyms: Walp3, C030005G16Rik, Tip5
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 116848
VEGA: 10
HGNC: HGNC:962
Homologene: 8393
Cdk5rap2
Name: CDK5 regulatory subunit associated protein 2
Synonyms: an, 2900018K03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 214444
Homologene: 49533
Tex264
Name: testis expressed gene 264 ER-phagy receptor
Synonyms: TEG-264
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21767
Homologene: 7975
Smg6
Name: SMG6 nonsense mediated mRNA decay factor
Synonyms: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103677
Homologene: 23024
Lamb2
Name: laminin, beta 2
Synonyms: Lams, npht, Lamb-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16779
HGNC: HGNC:6487
Homologene: 1723
Aff4
Name: AF4/FMR2 family, member 4
Synonyms: Alf4, Laf4l
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 93736
Homologene: 8683
Phldb1
Name: pleckstrin homology like domain, family B, member 1
Synonyms: D330037A14Rik, LL5A
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102693
Homologene: 15903
Cit
Name: citron
Synonyms: citron kinase, Cit-k, CRIK-SK, C030025P15Rik, citron-N
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12704
HGNC: HGNC:1985
Homologene: 21404
Smarcd2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
Synonyms: Baf60b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83796
Homologene: 20671
Rasal2
Name: RAS protein activator like 2
Synonyms: A330066M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226525
HGNC: HGNC:9874
Homologene: 35217
Il2ra
Name: interleukin 2 receptor, alpha chain
Synonyms: Ly-43, Il2r, IL-2R alpha chain, CD25
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16184
HGNC: HGNC:6008
Homologene: 360
Nup88
Name: nucleoporin 88
Synonyms: Prei2, Nup84
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19069
HGNC: HGNC:8067
Homologene: 1901
Dync2h1
Name: dynein cytoplasmic 2 heavy chain 1
Synonyms: Dnchc2, m152Asp, m407Asp, b2b414Clo, D030010H02Rik, D330044F14Rik, 4432416O06Rik, DHC1b, DHC2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110350
HGNC: HGNC:2962
Homologene: 14468
Nsun6
Name: NOL1/NOP2/Sun domain family member 6
Synonyms: 4933403D21Rik, NOPD1, 4933414E04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74455
Homologene: 12564
Tsc1
Name: TSC complex subunit 1
Synonyms: tuberous sclerosis 1, hamartin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64930
Homologene: 314
Garnl3
Name: GTPase activating RANGAP domain-like 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99326
Homologene: 13003
Tmem64
Name: transmembrane protein 64
Synonyms: 9630015D15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100201
Homologene: 45636
Tnks1bp1
Name: tankyrase 1 binding protein 1
Synonyms: TAB182
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228140
Homologene: 14117
Mocos
Name: molybdenum cofactor sulfurase
Synonyms: 1110018O12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 68591
VEGA: 18
Homologene: 9931
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Pico, Acz
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Letmd1
Name: LETM1 domain containing 1
Synonyms: HCCR1, 1110019O13Rik, HCCR-2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68614
VEGA: 15
Homologene: 9128
Krt35
Name: keratin 35
Synonyms: Krt1-24, Ha5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53617
HGNC: HGNC:6453
Homologene: 1715
Rab11fip4
Name: RAB11 family interacting protein 4 (class II)
Synonyms: A730072L08Rik, RAB11-FIP4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268451
Homologene: 8803
Degs1l
Name: delta 4-desaturase, sphingolipid 1 like
Synonyms: 9130409I23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 619326
Homologene: 134522
Ermap
Name: erythroblast membrane-associated protein
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 27028
Homologene: 22782
Col6a3
Name: collagen, type VI, alpha 3
Synonyms: Col6a-3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12835
HGNC: HGNC:2213
Homologene: 37917
Slco1a8
Name: solute carrier organic anion transporter family, member 1a8
Synonyms: Gm6614
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 625716
Homologene: 87075
Dnah9
Name: dynein, axonemal, heavy chain 9
Synonyms: Dnahc9, D11Ertd686e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237806
HGNC: HGNC:2953
Homologene: 20357
Zan
Name: zonadhesin
Synonyms: Zan
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22635
Homologene: 124417
Zkscan3
Name: zinc finger with KRAB and SCAN domains 3
Synonyms: Zfp307, 2810435N07Rik, Zfp306, Skz1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72739
Homologene: 130732
Efna5
Name: ephrin A5
Synonyms: RAGS, Ephrin-A5, Epl7, AL-1, EFL-5, LERK-7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13640
HGNC: HGNC:3225
Homologene: 1482
Epas1
Name: endothelial PAS domain protein 1
Synonyms: HRF, MOP2, hypoxia inducible transcription factor 2alpha, HIF-2alpha, HLF, Hif like protein, HIF2A, bHLHe73
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13819
VEGA: 17
HGNC: HGNC:3374
Homologene: 1095
Elac1
Name: elaC ribonuclease Z 1
Synonyms: 2610018O07Rik, 8430417G19Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 114615
Homologene: 10272
Gm7168
Name: predicted gene 7168
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 635895
Homologene: 133217
Tmco6
Name: transmembrane and coiled-coil domains 6
Synonyms: 2410015B03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 71983
VEGA: 18
Homologene: 12431
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71310
Homologene: 57079
Krt81
Name: keratin 81
Synonyms: Krt2-19
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 64818
VEGA: 15
HGNC: HGNC:6458
Homologene: 55645
Kynu
Name: kynureninase
Synonyms: L-kynurenine hydrolase, 4432411A05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70789
HGNC: HGNC:6469
Homologene: 2925
Vmn2r94
Name: vomeronasal 2, receptor 94
Synonyms: EG665227
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 665227
Homologene: 129751
Ppfibp1
Name: PTPRF interacting protein, binding protein 1 (liprin beta 1)
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67533
HGNC: HGNC:9249
Homologene: 2685
Gadl1
Name: glutamate decarboxylase-like 1
Synonyms: 1110027M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73748
Homologene: 45812
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Or4c29
Name: olfactory receptor family 4 subfamily C member 29
Synonyms: GA_x6K02T2Q125-50386882-50385950, MOR230-7, Olfr1209
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258453
Homologene: 128155
Col17a1
Name: collagen, type XVII, alpha 1
Synonyms: Bpag, BP180, BPAg2, Bpag2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12821
HGNC: HGNC:2194
Homologene: 7276
Pcdhb12
Name: protocadherin beta 12
Synonyms: PcdhbL, Pcdh3, Pcdhb5F
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93883
HGNC: HGNC:8690
Homologene: 87126
Hs6st3
Name: heparan sulfate 6-O-sulfotransferase 3
Synonyms: 6OST3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 50787
VEGA: 14
Homologene: 89201
Slc41a1
Name: solute carrier family 41, member 1
Synonyms: B230315F01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98396
Homologene: 14871
Ccdc33
Name: coiled-coil domain containing 33
Synonyms: 4930535E21Rik, LOC382077
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 382077
Homologene: 19641
Hdac7
Name: histone deacetylase 7
Synonyms: 5830434K02Rik, Hdac7a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 56233
Homologene: 9124
Or14c45
Name: olfactory receptor family 14 subfamily C member 45
Synonyms: Olfr297, MOR220-3, GA_x6K02T2NHDJ-9587747-9586815
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258611
Homologene: 115526
Or13p5
Name: olfactory receptor family 13 subfamily P member 5
Synonyms: MOR258-2, GA_x6K02T2QD9B-18815145-18814198, Olfr1339
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258851
Homologene: 27280
Ppp4r3c2
Name: protein phosphatase 4 regulatory subunit 3C2
Synonyms: 4932429P05Rik
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 245509
Homologene: 87617
Clip4
Name: CAP-GLY domain containing linker protein family, member 4
Synonyms: 1700024K14Rik, 1700074B05Rik, 4833417L20Rik, 5830409B12Rik, Rsnl2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 78785
VEGA: 17
Homologene: 11662
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
Spata4
Name: spermatogenesis associated 4
Synonyms: SRG2, 1700001N01Rik, TSARG2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 69281
Homologene: 15868
Kcnmb1
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 1
Synonyms: BK channel beta subunit, BKbeta1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16533
HGNC: HGNC:6285
Homologene: 3054
Arhgap27
Name: Rho GTPase activating protein 27
Synonyms: 2310069I04Rik, 5730442P18Rik, Sh3d20
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544817
Homologene: 45715
Cybc1
Name: cytochrome b 245 chaperone 1
Synonyms: BC017643
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217370
Homologene: 51645
Pdlim7
Name: PDZ and LIM domain 7
Synonyms: Enigma, 1110003B01Rik, 2410002J21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67399
Homologene: 3980
Ppp2r2b
Name: protein phosphatase 2, regulatory subunit B, beta
Synonyms: PR55-BETA, E130009M08Rik, 6330404L05Rik, 2900026H06Rik, SCA12, PP2A-PR55B
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 72930
HGNC: HGNC:9305
Homologene: 55833
4930567H17Rik
Name: RIKEN cDNA 4930567H17 gene
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 619303
Homologene: 134521
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 90,828,298 bp
  • T to C, chromosome 1 at 131,840,952 bp
  • A to G, chromosome 1 at 157,243,514 bp
  • T to A, chromosome 1 at 162,808,392 bp
  • G to A, chromosome 1 at 181,055,379 bp
  • C to T, chromosome 2 at 11,684,365 bp
  • A to T, chromosome 2 at 14,996,474 bp
  • A to G, chromosome 2 at 28,670,930 bp
  • T to A, chromosome 2 at 32,990,642 bp
  • A to G, chromosome 2 at 43,589,478 bp
  • A to G, chromosome 2 at 69,448,169 bp
  • A to G, chromosome 2 at 85,052,536 bp
  • T to C, chromosome 2 at 88,910,273 bp
  • A to G, chromosome 4 at 15,266,717 bp
  • T to C, chromosome 4 at 70,337,375 bp
  • T to C, chromosome 4 at 118,581,102 bp
  • C to T, chromosome 4 at 118,735,224 bp
  • C to A, chromosome 4 at 119,178,510 bp
  • C to A, chromosome 5 at 14,515,439 bp
  • T to A, chromosome 5 at 115,946,919 bp
  • T to C, chromosome 5 at 137,389,249 bp
  • G to T, chromosome 6 at 142,003,428 bp
  • A to G, chromosome 6 at 147,019,191 bp
  • C to T, chromosome 7 at 86,526,987 bp
  • A to T, chromosome 8 at 54,601,797 bp
  • A to T, chromosome 8 at 83,259,313 bp
  • G to T, chromosome 8 at 122,895,836 bp
  • A to T, chromosome 9 at 6,983,381 bp
  • G to A, chromosome 9 at 44,699,636 bp
  • T to A, chromosome 9 at 53,456,566 bp
  • T to C, chromosome 9 at 58,082,048 bp
  • T to C, chromosome 9 at 106,659,299 bp
  • T to A, chromosome 9 at 108,483,794 bp
  • G to A, chromosome 9 at 116,073,987 bp
  • A to G, chromosome 10 at 128,116,080 bp
  • A to T, chromosome 11 at 33,964,701 bp
  • T to A, chromosome 11 at 53,410,953 bp
  • T to C, chromosome 11 at 66,107,898 bp
  • A to G, chromosome 11 at 70,969,950 bp
  • T to A, chromosome 11 at 75,159,836 bp
  • T to C, chromosome 11 at 79,683,502 bp
  • T to C, chromosome 11 at 100,093,794 bp
  • T to G, chromosome 11 at 103,339,011 bp
  • C to T, chromosome 11 at 106,266,529 bp
  • C to A, chromosome 11 at 120,272,841 bp
  • C to T, chromosome 11 at 121,227,242 bp
  • T to C, chromosome 13 at 21,388,596 bp
  • A to T, chromosome 13 at 55,504,880 bp
  • T to C, chromosome 14 at 119,869,383 bp
  • T to C, chromosome 15 at 97,808,964 bp
  • A to G, chromosome 15 at 100,469,821 bp
  • C to A, chromosome 15 at 101,463,627 bp
  • A to G, chromosome 17 at 13,948,983 bp
  • G to A, chromosome 17 at 18,277,433 bp
  • A to T, chromosome 17 at 62,606,215 bp
  • A to G, chromosome 17 at 65,639,553 bp
  • C to T, chromosome 17 at 71,837,699 bp
  • G to T, chromosome 17 at 86,829,456 bp
  • T to C, chromosome 18 at 24,688,987 bp
  • G to A, chromosome 18 at 36,741,776 bp
  • T to A, chromosome 18 at 37,437,709 bp
  • T to C, chromosome 18 at 43,059,192 bp
  • A to T, chromosome 18 at 73,739,039 bp
  • C to T, chromosome 19 at 47,669,433 bp
  • T to A, chromosome X at 70,394,207 bp
  • A to G, chromosome X at 89,754,320 bp
Genotype Determination
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R0737 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
038918-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Some MMRRC strains were submitted by the donor as cryopreserved germplasm, and because these strains were not cryopreserved by the MMRRC, we have not assessed the quality, nor genotype, of this material. Our expertise in reviving mice from various qualities of frozen sperm and embryos, using methods like IVF and ICSI, gives us confidence in successful recoveries in most cases. However, due to the uncertain quality of these samples, we'll limit revival attempts to two per order. Additional attempts are available for a fee, on top of standard charges, if requested. It's important to note that some strains may lack the expected mutation, so we can't assure successful order fulfillment until we attempt to revive the strain.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.